Marion C. Müller
@marioncmueller.bsky.social
Fungal genetics & genomics, plant-pathogen interactions, powdery mildews & grasses working at TU Munich
Reposted by Marion C. Müller
Did you ever wonder how #Solanum plants evolved quantitative disease resistance/ #QDR?
I am really excited to share our recently published manuscript, where we tried to contribute to addressing this question!
🌱https://tinyurl.com/2vz23ck6
I am really excited to share our recently published manuscript, where we tried to contribute to addressing this question!
🌱https://tinyurl.com/2vz23ck6
Co-option of transcription factors drives evolution of quantitative disease resistance against a necrotrophic pathogen
Quantitative disease resistance in a wild tomato genotype evolved through species-specific regulatory network rewiring, with an ancient transcription facto
tinyurl.com
November 21, 2025 at 9:00 AM
Reposted by Marion C. Müller
A wheat NLR conferring broad-spectrum resistance against powdery mildew by recognizing two structurally diverse AVR effectors. Interested? Check out our newest preprint: www.biorxiv.org/content/10.1...
Dual recognition of structurally unrelated mildew effectors underlies the broad-spectrum resistance of Pm3e in wheat
Broad-spectrum resistance genes are highly valuable for sustainable crop protection, yet the molecular basis of their activity is often unknown. The Pm3 allelic series in wheat encodes NLR receptors t...
www.biorxiv.org
November 2, 2025 at 1:29 PM
A wheat NLR conferring broad-spectrum resistance against powdery mildew by recognizing two structurally diverse AVR effectors. Interested? Check out our newest preprint: www.biorxiv.org/content/10.1...
Reposted by Marion C. Müller
Want good Bioinformatics resources for Phytopathogens?
Plant pathology community at @bspp.bsky.social and @britmycolsoc.org.uk please take the time to complete the Phytopathogen Genomics Resources Survey:-
🔗 zurl.co/gKjC1
Your input is important for FungiDB/@veupathdb.org
& Ensembl @ebi.embl.org.
Plant pathology community at @bspp.bsky.social and @britmycolsoc.org.uk please take the time to complete the Phytopathogen Genomics Resources Survey:-
🔗 zurl.co/gKjC1
Your input is important for FungiDB/@veupathdb.org
& Ensembl @ebi.embl.org.
October 30, 2025 at 4:57 PM
Want good Bioinformatics resources for Phytopathogens?
Plant pathology community at @bspp.bsky.social and @britmycolsoc.org.uk please take the time to complete the Phytopathogen Genomics Resources Survey:-
🔗 zurl.co/gKjC1
Your input is important for FungiDB/@veupathdb.org
& Ensembl @ebi.embl.org.
Plant pathology community at @bspp.bsky.social and @britmycolsoc.org.uk please take the time to complete the Phytopathogen Genomics Resources Survey:-
🔗 zurl.co/gKjC1
Your input is important for FungiDB/@veupathdb.org
& Ensembl @ebi.embl.org.
Reposted by Marion C. Müller
Our Mini-review is out now! Here we collect recent findings of RALF peptide functions, adress their (potential) roles in plant-microbe interactions and discuss the resulting emerging questions. Pls share!
dx.plos.org/10.1371/jour...
dx.plos.org/10.1371/jour...
The interplay of RALF structural and signaling functions in plant-microbe interactions
Rapid alkalinization factor (RALF) peptides are important signaling molecules binding to Catharanthus roseus receptor-like kinase 1-like (CrRLK1L)—LORELEI/LORELEI-like GPI-anchored protein complexes t...
dx.plos.org
October 26, 2025 at 3:38 PM
Our Mini-review is out now! Here we collect recent findings of RALF peptide functions, adress their (potential) roles in plant-microbe interactions and discuss the resulting emerging questions. Pls share!
dx.plos.org/10.1371/jour...
dx.plos.org/10.1371/jour...
Reposted by Marion C. Müller
Super excited to see our work on the NLRseek program finally published 🥳 Here we identify new NLRs against major wheat pathogens and present a pipeline for NLR identification. Huge thank you to all of the co-authors for bringing this work together! @matthewmoscou.bsky.social rdcu.be/eIGvv
Discovery of functional NLRs using expression level, high-throughput transformation and large-scale phenotyping
Nature Plants - Rapid discovery of functional resistance genes is enabled by a high-expression signature and high-throughput transformation. This approach identified 31 new resistance genes for...
rdcu.be
September 29, 2025 at 11:58 AM
Super excited to see our work on the NLRseek program finally published 🥳 Here we identify new NLRs against major wheat pathogens and present a pipeline for NLR identification. Huge thank you to all of the co-authors for bringing this work together! @matthewmoscou.bsky.social rdcu.be/eIGvv
Reposted by Marion C. Müller
Aurelien Tellier presenting the details of #eseb2027 which will be a hub meeting, with connected and local sessions in 4 hubs (Gothenburg, Munich, London, Istanbul) eseb2027.org #eseb2025
August 22, 2025 at 12:19 PM
Aurelien Tellier presenting the details of #eseb2027 which will be a hub meeting, with connected and local sessions in 4 hubs (Gothenburg, Munich, London, Istanbul) eseb2027.org #eseb2025
Reposted by Marion C. Müller
Das Konsortium #DataPLANT @nfdi4plants.bsky.social unter Leitung der #Unifreiburg entwickelt seit 2020 Infrastruktur für die riesigen Datenmengen, mit denen moderne #Pflanzenforschung arbeitet. Nun hat die @dfg.de die Förderung bis 2028 verlängert.
➡️ ufr.link/dataplant-foerderung
@fz-juelich.de
➡️ ufr.link/dataplant-foerderung
@fz-juelich.de
August 8, 2025 at 7:58 AM
Das Konsortium #DataPLANT @nfdi4plants.bsky.social unter Leitung der #Unifreiburg entwickelt seit 2020 Infrastruktur für die riesigen Datenmengen, mit denen moderne #Pflanzenforschung arbeitet. Nun hat die @dfg.de die Förderung bis 2028 verlängert.
➡️ ufr.link/dataplant-foerderung
@fz-juelich.de
➡️ ufr.link/dataplant-foerderung
@fz-juelich.de
Reposted by Marion C. Müller
Excited to share that our preprint has found a home in Science Advances. We show that intrinsically disordered regions determine the functional diversification of actin-regulatory SCAR proteins in Medicago. 🧵 1/3
www.science.org/doi/full/10....
#ScienceAdvances #PlantScience #IDRs
www.science.org/doi/full/10....
#ScienceAdvances #PlantScience #IDRs
Functional divergence of plant SCAR/WAVE proteins is determined by intrinsically disordered regions
Intrinsically disordered regions in SCAR/WAVE proteins drive diverse functions in root hair and leaf trichome development.
www.science.org
May 21, 2025 at 7:27 PM
Excited to share that our preprint has found a home in Science Advances. We show that intrinsically disordered regions determine the functional diversification of actin-regulatory SCAR proteins in Medicago. 🧵 1/3
www.science.org/doi/full/10....
#ScienceAdvances #PlantScience #IDRs
www.science.org/doi/full/10....
#ScienceAdvances #PlantScience #IDRs
Reposted by Marion C. Müller
A must-read!! Two exciting papers on the forces driving transposable elements evolution in natural population of Arabidopsis Lyrata
academic.oup.com/mbe/article/...
and A. thaliana academic.oup.com/plcell/artic...
academic.oup.com/mbe/article/...
and A. thaliana academic.oup.com/plcell/artic...
The Demographic History of Populations and Genomic Imprinting have Shaped the Transposon Patterns in Arabidopsis lyrata
Abstract. Purifying selection is expected to prevent the accumulation of transposable elements (TEs) within their host, especially when located in and arou
academic.oup.com
May 13, 2025 at 1:33 PM
A must-read!! Two exciting papers on the forces driving transposable elements evolution in natural population of Arabidopsis Lyrata
academic.oup.com/mbe/article/...
and A. thaliana academic.oup.com/plcell/artic...
academic.oup.com/mbe/article/...
and A. thaliana academic.oup.com/plcell/artic...
Reposted by Marion C. Müller
📜 Sexual recombination in cereal rust fungi: Knowns and unknowns of pathogen evolution and adaptation
🧑🔬 Shideh Mojerlou, @schwessinger.bsky.social, Julian Rodriguez-Algaba
📔 @plos.org Pathogens
🔗 journals.plos.org/plospathogen...
#️⃣ #PlantScience #PlantImmunity
🧑🔬 Shideh Mojerlou, @schwessinger.bsky.social, Julian Rodriguez-Algaba
📔 @plos.org Pathogens
🔗 journals.plos.org/plospathogen...
#️⃣ #PlantScience #PlantImmunity
Sexual recombination in cereal rust fungi: Knowns and unknowns of pathogen evolution and adaptation
journals.plos.org
February 6, 2025 at 7:11 AM
📜 Sexual recombination in cereal rust fungi: Knowns and unknowns of pathogen evolution and adaptation
🧑🔬 Shideh Mojerlou, @schwessinger.bsky.social, Julian Rodriguez-Algaba
📔 @plos.org Pathogens
🔗 journals.plos.org/plospathogen...
#️⃣ #PlantScience #PlantImmunity
🧑🔬 Shideh Mojerlou, @schwessinger.bsky.social, Julian Rodriguez-Algaba
📔 @plos.org Pathogens
🔗 journals.plos.org/plospathogen...
#️⃣ #PlantScience #PlantImmunity
Reposted by Marion C. Müller
Checkout Alexander’s thread describing his exciting new paper that demonstrates the combination of machine learning with large directed evolution data sets to accurately predict phenotype from genotype. Congratulations to Alexander on leading this work. We are lucky to have him on the team.
I'm very excited to share my first graduate research project! Check out our preprint which describes how data generated with directed evolution can be used to model the phenotypic effects of naturally-evolved sequence variants. (1/11) www.biorxiv.org/content/10.1...
Combining Directed Evolution with Machine Learning Enables Accurate Genotype-to-Phenotype Predictions
Linking sequence variation to phenotypic effects is critical for efficient exploitation of large genomic datasets. Here we present a novel approach combining directed evolution with protein language m...
www.biorxiv.org
January 30, 2025 at 3:28 AM
Checkout Alexander’s thread describing his exciting new paper that demonstrates the combination of machine learning with large directed evolution data sets to accurately predict phenotype from genotype. Congratulations to Alexander on leading this work. We are lucky to have him on the team.
Reposted by Marion C. Müller
Wonderful retrospective on pathogen genomics by @wagnercfagundes.bsky.social, @thorstenlangner.bsky.social et al.! Fantastic write-up and beautiful illustrations!
From lesions to lessons:
2025 marks the 20th anniversary of filamentous plant pathogen genomics. In our new review, we present lessons we learned over the past 2 decades and discuss the future of plant pathogen genomics. Take a first look!
apsjournals.apsnet.org/doi/10.1094/...
2025 marks the 20th anniversary of filamentous plant pathogen genomics. In our new review, we present lessons we learned over the past 2 decades and discuss the future of plant pathogen genomics. Take a first look!
apsjournals.apsnet.org/doi/10.1094/...
From Lesions to Lessons: Two Decades of Filamentous Plant Pathogen Genomics | Molecular Plant-Microbe Interactions®
Filamentous plant pathogens pose a severe threat to food security. Current estimates suggest up to 23% yield losses to pre- and post-harvest diseases and these losses are projected to increase due to ...
apsjournals.apsnet.org
January 20, 2025 at 10:43 AM
Wonderful retrospective on pathogen genomics by @wagnercfagundes.bsky.social, @thorstenlangner.bsky.social et al.! Fantastic write-up and beautiful illustrations!
Reposted by Marion C. Müller
To all colleagues who share an interest in sphingolipids, endomembrane trafficking & membrane domain formation, pathogen-induced cell polarization and entry control, here is another potentially interesting preprint: biorxiv.org/cgi/content/...
Identification of INOSITOL PHOSPHORYLCERAMIDE SYNTHASE 2 (IPCS2) as a new rate-limiting component in Arabidopsis pathogen entry control
INOSITOL PHOSPHORYLCERAMIDE SYNTHASE 2 (IPCS2) is involved in the biosynthesis of complex sphingolipids at the trans-Golgi network (TGN). Here, we demonstrate a role of IPCS2 in penetration resistance...
biorxiv.org
January 14, 2025 at 9:48 AM
To all colleagues who share an interest in sphingolipids, endomembrane trafficking & membrane domain formation, pathogen-induced cell polarization and entry control, here is another potentially interesting preprint: biorxiv.org/cgi/content/...
Reposted by Marion C. Müller
Obligate biotrophic fungi cause some of the most devastating diseases on cereals.
They are also highly difficult to study….
It is truely remarkable how well described the barley and what powdery mildews are.
Here you find an overview on the current knowledge and summary of great resources. Enjoy!
They are also highly difficult to study….
It is truely remarkable how well described the barley and what powdery mildews are.
Here you find an overview on the current knowledge and summary of great resources. Enjoy!
Get a First Look!
👇
🌱🌾Technical Advances Drive the Molecular Understanding of Effectors from Wheat and Barley Powdery Mildew Fungi doi.org/10.1094/MPMI...
@izzysaurlab.bsky.social
👇
🌱🌾Technical Advances Drive the Molecular Understanding of Effectors from Wheat and Barley Powdery Mildew Fungi doi.org/10.1094/MPMI...
@izzysaurlab.bsky.social
Technical Advances Drive the Molecular Understanding of Effectors from Wheat and Barley Powdery Mildew Fungi | Molecular Plant-Microbe Interactions®
Pathogens manipulate host physiology through the secretion of virulence factors (effectors) to invade and proliferate on the host. The molecular functions of effectors inside plant hosts have been of ...
doi.org
January 14, 2025 at 10:24 AM
Obligate biotrophic fungi cause some of the most devastating diseases on cereals.
They are also highly difficult to study….
It is truely remarkable how well described the barley and what powdery mildews are.
Here you find an overview on the current knowledge and summary of great resources. Enjoy!
They are also highly difficult to study….
It is truely remarkable how well described the barley and what powdery mildews are.
Here you find an overview on the current knowledge and summary of great resources. Enjoy!
Reposted by Marion C. Müller
📜 A barley MLA immune receptor is activated by a fungal nonribosomal peptide effector for disease susceptibility
🧑🔬 Yueqiang Leng, Florian Kümmel, Paul Schulze-Lefert, Shaobin Zhong, et al.
📔 @newphyt.bsky.social
🔗 nph.onlinelibrary.wiley.com/doi/10.1111/...
#️⃣ #PlantScience #PlantImmunity #Barley
🧑🔬 Yueqiang Leng, Florian Kümmel, Paul Schulze-Lefert, Shaobin Zhong, et al.
📔 @newphyt.bsky.social
🔗 nph.onlinelibrary.wiley.com/doi/10.1111/...
#️⃣ #PlantScience #PlantImmunity #Barley
A barley MLA immune receptor is activated by a fungal nonribosomal peptide effector for disease susceptibility
You have to enable JavaScript in your browser's settings in order to use the eReader.
nph.onlinelibrary.wiley.com
December 10, 2024 at 11:10 AM
📜 A barley MLA immune receptor is activated by a fungal nonribosomal peptide effector for disease susceptibility
🧑🔬 Yueqiang Leng, Florian Kümmel, Paul Schulze-Lefert, Shaobin Zhong, et al.
📔 @newphyt.bsky.social
🔗 nph.onlinelibrary.wiley.com/doi/10.1111/...
#️⃣ #PlantScience #PlantImmunity #Barley
🧑🔬 Yueqiang Leng, Florian Kümmel, Paul Schulze-Lefert, Shaobin Zhong, et al.
📔 @newphyt.bsky.social
🔗 nph.onlinelibrary.wiley.com/doi/10.1111/...
#️⃣ #PlantScience #PlantImmunity #Barley
Reposted by Marion C. Müller
🌿 Excited to share our latest research on how host proteases regulate immune activation!
Read more about how SBT5.2 releases and inactivates flg22: www.nature.com/articles/s41...
rdcu.be/d1UsT
Congratulations to all involved!
#PlantImmunity #PlantPathology #PlantChemeticsLab
Read more about how SBT5.2 releases and inactivates flg22: www.nature.com/articles/s41...
rdcu.be/d1UsT
Congratulations to all involved!
#PlantImmunity #PlantPathology #PlantChemeticsLab
Subtilase SBT5.2 inactivates flagellin immunogenicity in the plant apoplast - Nature Communications
Plants recognize bacteria by perceiving a 22-residue epitope in flagellin. Plant-secreted SBT5.2 subtilases are found to inactivate this epitope, leading to elicitor removal and reducing costly immuni...
www.nature.com
December 2, 2024 at 2:05 PM
🌿 Excited to share our latest research on how host proteases regulate immune activation!
Read more about how SBT5.2 releases and inactivates flg22: www.nature.com/articles/s41...
rdcu.be/d1UsT
Congratulations to all involved!
#PlantImmunity #PlantPathology #PlantChemeticsLab
Read more about how SBT5.2 releases and inactivates flg22: www.nature.com/articles/s41...
rdcu.be/d1UsT
Congratulations to all involved!
#PlantImmunity #PlantPathology #PlantChemeticsLab
Reposted by Marion C. Müller
Thank you so much to whoever put this very comprehensive list of #science Bsky starter packs together. This is just amazing: docs.google.com/document/d/1...
Starter packs
BIOLOGY General Science community https://go.bsky.app/HVYAMEA Research Institutions in Life Sciences https://go.bsky.app/LxXpcvJ LGBTQIA+ in STEM https://go.bsky.app/BFc4wgf LGBTQIA+ in STEM 2 h...
docs.google.com
November 26, 2024 at 2:47 AM
Thank you so much to whoever put this very comprehensive list of #science Bsky starter packs together. This is just amazing: docs.google.com/document/d/1...
Reposted by Marion C. Müller
Conserved effector families render Phytophthora species vulnerable to recognition by NLR receptors in nonhost plants
Soohyun Oh et al. 2024 rdcu.be/d1f33
Soohyun Oh et al. 2024 rdcu.be/d1f33
Conserved effector families render Phytophthora species vulnerable to recognition by NLR receptors in nonhost plants
Nature Communications - Genus Phytophthora threat various plant species including fruit, vegetable, and flower crops. The authors report that some NLRs recognize conserved effector families of...
rdcu.be
November 23, 2024 at 7:48 PM
Conserved effector families render Phytophthora species vulnerable to recognition by NLR receptors in nonhost plants
Soohyun Oh et al. 2024 rdcu.be/d1f33
Soohyun Oh et al. 2024 rdcu.be/d1f33
Reposted by Marion C. Müller
Struggling to interpret or depict extensive copy-number variations of pathogen effectors? This paper by the group of @mfseidl.bsky.social might hold some inspiration:
doi.org/10.1371/jour...
doi.org/10.1371/jour...
Pangenome graph analysis reveals extensive effector copy-number variation in spinach downy mildew
Author summary Plant pathogens are known to evolve rapidly and overcome disease resistance of newly introduced crop varieties. This swift adaptation is visible in the genomes of these pathogens, which...
doi.org
November 19, 2024 at 6:45 AM
Struggling to interpret or depict extensive copy-number variations of pathogen effectors? This paper by the group of @mfseidl.bsky.social might hold some inspiration:
doi.org/10.1371/jour...
doi.org/10.1371/jour...
Reposted by Marion C. Müller
Interesting findings about one of my favorite Transposons called ÉVADÉ:
PTGS is dispensable for the initiation of epigenetic silencing of an active transposon in Arabidopsis.
www.embopress.org/doi/full/10....
PTGS is dispensable for the initiation of epigenetic silencing of an active transposon in Arabidopsis.
www.embopress.org/doi/full/10....
November 17, 2024 at 12:29 PM
Interesting findings about one of my favorite Transposons called ÉVADÉ:
PTGS is dispensable for the initiation of epigenetic silencing of an active transposon in Arabidopsis.
www.embopress.org/doi/full/10....
PTGS is dispensable for the initiation of epigenetic silencing of an active transposon in Arabidopsis.
www.embopress.org/doi/full/10....
Reposted by Marion C. Müller
The FERONIA–RESPONSIVE TO DESSICATION 26 module regulates vascular immunity to Ralstonia solanacearum academic.oup.com/plcell/advan...
#PlantScience
#PlantScience
The FERONIA–RESPONSIVE TO DESSICATION 26 module regulates vascular immunity to Ralstonia solanacearum
The kinase FERONIA and the transcription factor RD26 drive a signaling cascade that regulates xylem lignin deposition, thereby promoting plant immunity to
academic.oup.com
November 17, 2024 at 1:35 PM
The FERONIA–RESPONSIVE TO DESSICATION 26 module regulates vascular immunity to Ralstonia solanacearum academic.oup.com/plcell/advan...
#PlantScience
#PlantScience
Reposted by Marion C. Müller
Updated version of TIPPo, our user-friendly assembler for organellar genomes from high-accuracy long read data @wenfeixian.bsky.social @zbao.bsky.social #plantscience
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 16, 2024 at 10:58 AM
Updated version of TIPPo, our user-friendly assembler for organellar genomes from high-accuracy long read data @wenfeixian.bsky.social @zbao.bsky.social #plantscience
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...