Michelle Vincendeau
@m-vincendeau.bsky.social
Research Group Leader @HelmholtzMunich - #StemCell #Retrotransposon #HERV #Virology #BrainDevelopment
Reposted by Michelle Vincendeau
Join us tomorrow for a Night Science Seminar Series presentation! Jennifer Oyler-Yaniv from Harvard will talk about how a scientific journey can be viewed as a mythological Hero's Quest by sharing work from her lab on how epithelial tissues restrict the spread of viruses.
cassyni.com/events/ZYQow...
cassyni.com/events/ZYQow...
November 9, 2025 at 3:37 PM
Join us tomorrow for a Night Science Seminar Series presentation! Jennifer Oyler-Yaniv from Harvard will talk about how a scientific journey can be viewed as a mythological Hero's Quest by sharing work from her lab on how epithelial tissues restrict the spread of viruses.
cassyni.com/events/ZYQow...
cassyni.com/events/ZYQow...
Reposted by Michelle Vincendeau
#TEsky #RNAsky A specialized bacterial group II intron is a highly efficient retrotransposon doi.org/10.1186/s131...
A specialized bacterial group II intron is a highly efficient retrotransposon - Mobile DNA
Mobile group II introns are site-specific retrotransposons composed of a large self-splicing ribozyme and an intron-encoded reverse transcriptase that are widespread in bacterial and organellar genome...
doi.org
November 5, 2025 at 3:08 PM
#TEsky #RNAsky A specialized bacterial group II intron is a highly efficient retrotransposon doi.org/10.1186/s131...
Reposted by Michelle Vincendeau
Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Spatial dynamics of brain development and neuroinflammation - Nature
A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.
www.nature.com
November 5, 2025 at 4:03 PM
Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Michelle Vincendeau
Writing a letter for a great undergrad researcher in the lab. Check out their awesome GitHub repo on the transposable element simulations they wrote in slim! github.com/vibhachand/s...
GitHub - vibhachand/slim-TE-demography-simulation-project
Contribute to vibhachand/slim-TE-demography-simulation-project development by creating an account on GitHub.
github.com
October 31, 2025 at 8:28 PM
Writing a letter for a great undergrad researcher in the lab. Check out their awesome GitHub repo on the transposable element simulations they wrote in slim! github.com/vibhachand/s...
Reposted by Michelle Vincendeau
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
October 31, 2025 at 9:25 AM
Reposted by Michelle Vincendeau
Even chimpanzees think rationally and weigh the evidence when making a choice ;-)
@science.org
www.science.org/doi/10.1126/...
@science.org
www.science.org/doi/10.1126/...
Chimpanzees rationally revise their beliefs
The selective revision of beliefs in light of new evidence has been considered one of the hallmarks of human-level rationality. However, tests of this ability in other species are lacking. We examined...
www.science.org
October 31, 2025 at 1:52 AM
Even chimpanzees think rationally and weigh the evidence when making a choice ;-)
@science.org
www.science.org/doi/10.1126/...
@science.org
www.science.org/doi/10.1126/...
Reposted by Michelle Vincendeau
#TEsky Do duplication-inducing elements ‘cooperate’ with genes in evolutionary arms races? A case study on cereal crop pathogenesis doi.org/10.1186/s128...
Do duplication-inducing elements ‘cooperate’ with genes in evolutionary arms races? A case study on cereal crop pathogenesis - BMC Plant Biology
Crop improvement depends on the human ability to harness naturally- or artificially-occurring gene variants. Genomic segmental duplication can create redundant gene copies that can more freely ‘explor...
doi.org
October 30, 2025 at 1:25 PM
#TEsky Do duplication-inducing elements ‘cooperate’ with genes in evolutionary arms races? A case study on cereal crop pathogenesis doi.org/10.1186/s128...
Reposted by Michelle Vincendeau
Only 6 days left to apply! We’re recruiting a PhD student to study the immunogenic roles of transposable elements in pediatric AML. The project involves working with clinical trial samples in collaboration with Dr. Richard Dillon (KCL). If interested, get in touch!
Come and join us to discover immunogenic potential of transposable elements in pediatric AML as part of CRUK CoL PhD programme.
We're offering two fantastic #PhD projects in #paediatric cancers, to start Sept 2026. Browse all our projects and apply by noon, Weds 5 Nov: https://www.colcc.ac.uk/cyp-phd-studentships/ @qmbci.bsky.social @kingslsm.bsky.social @uclmedsci.bsky.social @crick.ac.uk #CRUKFunded
October 30, 2025 at 7:18 AM
Only 6 days left to apply! We’re recruiting a PhD student to study the immunogenic roles of transposable elements in pediatric AML. The project involves working with clinical trial samples in collaboration with Dr. Richard Dillon (KCL). If interested, get in touch!
Reposted by Michelle Vincendeau
We are looking for a colleague to join us at RWTH Aachen University:
🌱 Full Professor in Stress Resilience of Plants (W3 tenured)
📌What are we looking for? Someone working with us strategically at the interface of plant biology/ physiology/ resilience
#academicjobs #facultyjobs #PlantJobs
1/4
🌱 Full Professor in Stress Resilience of Plants (W3 tenured)
📌What are we looking for? Someone working with us strategically at the interface of plant biology/ physiology/ resilience
#academicjobs #facultyjobs #PlantJobs
1/4
October 30, 2025 at 12:03 PM
We are looking for a colleague to join us at RWTH Aachen University:
🌱 Full Professor in Stress Resilience of Plants (W3 tenured)
📌What are we looking for? Someone working with us strategically at the interface of plant biology/ physiology/ resilience
#academicjobs #facultyjobs #PlantJobs
1/4
🌱 Full Professor in Stress Resilience of Plants (W3 tenured)
📌What are we looking for? Someone working with us strategically at the interface of plant biology/ physiology/ resilience
#academicjobs #facultyjobs #PlantJobs
1/4
Reposted by Michelle Vincendeau
My lab is seeking two PhD candidates to investigate the function and regulation of endogenous retroviruses in the early stages of human development 🦠👩🔬. Apply through the International Max Planck Research School (IMPRS) program: www.molgen.mpg.de/IMPRS/applic.... www.molgen.mpg.de/5094682/Fuey...
[2026] – Endogenous retroviruses in human embryogenesis
www.molgen.mpg.de
October 23, 2025 at 8:31 PM
My lab is seeking two PhD candidates to investigate the function and regulation of endogenous retroviruses in the early stages of human development 🦠👩🔬. Apply through the International Max Planck Research School (IMPRS) program: www.molgen.mpg.de/IMPRS/applic.... www.molgen.mpg.de/5094682/Fuey...
Reposted by Michelle Vincendeau
For obvious reasons, I've become fascinated with retrotransposons. So we ( @alexwhiteley.bsky.social and I) wrote an article now out in Neuron @cellpress.bsky.social on how we think retrotransposons influence brain function and health! kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
October 20, 2025 at 8:00 PM
For obvious reasons, I've become fascinated with retrotransposons. So we ( @alexwhiteley.bsky.social and I) wrote an article now out in Neuron @cellpress.bsky.social on how we think retrotransposons influence brain function and health! kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
Reposted by Michelle Vincendeau
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
October 15, 2025 at 12:22 PM
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
Reposted by Michelle Vincendeau
The @crick.ac.uk is recruiting Early Career Group Leaders
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
Early career group leaders
We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.
www.crick.ac.uk
October 10, 2025 at 8:20 AM
The @crick.ac.uk is recruiting Early Career Group Leaders
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
Reposted by Michelle Vincendeau
Ready to start your own independent research programme?
We're inviting applications for early career group leaders in all areas of biology and biomedicine @crick.ac.uk
Apply by 27 Nov 2025:
www.crick.ac.uk/careers-stud...
#EarlyCareerResearchers #GroupLeader #ScienceCareers
We're inviting applications for early career group leaders in all areas of biology and biomedicine @crick.ac.uk
Apply by 27 Nov 2025:
www.crick.ac.uk/careers-stud...
#EarlyCareerResearchers #GroupLeader #ScienceCareers
October 9, 2025 at 3:01 PM
Ready to start your own independent research programme?
We're inviting applications for early career group leaders in all areas of biology and biomedicine @crick.ac.uk
Apply by 27 Nov 2025:
www.crick.ac.uk/careers-stud...
#EarlyCareerResearchers #GroupLeader #ScienceCareers
We're inviting applications for early career group leaders in all areas of biology and biomedicine @crick.ac.uk
Apply by 27 Nov 2025:
www.crick.ac.uk/careers-stud...
#EarlyCareerResearchers #GroupLeader #ScienceCareers
Reposted by Michelle Vincendeau
🚀 We’re growing! Are you passionate about human pluripotent stem cells? We are looking for 1 PhD student + 1 Lab technician to join us ☀️
ior.usi.ch/institute/jobs
ior.usi.ch/institute/jobs
September 30, 2025 at 7:18 PM
🚀 We’re growing! Are you passionate about human pluripotent stem cells? We are looking for 1 PhD student + 1 Lab technician to join us ☀️
ior.usi.ch/institute/jobs
ior.usi.ch/institute/jobs
Reposted by Michelle Vincendeau
Interested in learning how to be a good speaker and give effective talks? Season 2 of the NYC Postdoc Night Science Club begins October 15th. Join us NYC Postdocs for a 2hr workshop and maybe also a drink at a bar! Free registration (usually ~100 come): docs.google.com/forms/d/1dII...
September 30, 2025 at 1:40 PM
Interested in learning how to be a good speaker and give effective talks? Season 2 of the NYC Postdoc Night Science Club begins October 15th. Join us NYC Postdocs for a 2hr workshop and maybe also a drink at a bar! Free registration (usually ~100 come): docs.google.com/forms/d/1dII...
Reposted by Michelle Vincendeau
Do you research endogenous retroviruses (ERVs) or want to learn more about them? 🧬🤔
Consider presenting at or attending AuusiERV - an inaugural online symposium for ERV research in Australia 🇦🇺 (and abroad) 🗺️
Abstracts due 1st October!
events.humanitix.com/aussierv-2025
#ERV #retrovirus
Consider presenting at or attending AuusiERV - an inaugural online symposium for ERV research in Australia 🇦🇺 (and abroad) 🗺️
Abstracts due 1st October!
events.humanitix.com/aussierv-2025
#ERV #retrovirus
AussiERV 2025
AussiERV: Australia’s first symposium dedicated to endogenous retroviruses. Join us for this one-day virtual event on November 7th!
events.humanitix.com
September 27, 2025 at 7:28 AM
Do you research endogenous retroviruses (ERVs) or want to learn more about them? 🧬🤔
Consider presenting at or attending AuusiERV - an inaugural online symposium for ERV research in Australia 🇦🇺 (and abroad) 🗺️
Abstracts due 1st October!
events.humanitix.com/aussierv-2025
#ERV #retrovirus
Consider presenting at or attending AuusiERV - an inaugural online symposium for ERV research in Australia 🇦🇺 (and abroad) 🗺️
Abstracts due 1st October!
events.humanitix.com/aussierv-2025
#ERV #retrovirus
Reposted by Michelle Vincendeau
Early-career researchers: want to run your own lab? 🌟Max Planck Research Groups offer 6+ years, up to €2.7M in funding, open-topic freedom, team support & tenure-track opportunities. Intrigued? 😃Apply by Oct 14, 2025! www.mpg.de/max-planck-r...
September 15, 2025 at 9:27 AM
Early-career researchers: want to run your own lab? 🌟Max Planck Research Groups offer 6+ years, up to €2.7M in funding, open-topic freedom, team support & tenure-track opportunities. Intrigued? 😃Apply by Oct 14, 2025! www.mpg.de/max-planck-r...
Reposted by Michelle Vincendeau
Another neurodegenerative disease caused by an SVA insertion. Not intron retention as seen in XPD, but aberrant splicing.
Deep Intronic SVA_E Insertion Identified as the Most Common Pathogenic Variant Associated With Canavan Disease | Neurology Genetics
Background and ObjectivesCanavan disease (CD) is a neurodegenerative disorder in which biallelic pathogenic
variants in ASPA result in spongiform degeneration of the cerebral white matter, leading to ...
www.neurology.org
September 25, 2025 at 12:23 PM
Another neurodegenerative disease caused by an SVA insertion. Not intron retention as seen in XPD, but aberrant splicing.
Reposted by Michelle Vincendeau
Dual transposon sequencing profiles the genetic interaction landscape in bacteria | Science www.science.org/doi/10.1126/...
Dual transposon sequencing profiles the genetic interaction landscape in bacteria
Gene redundancy complicates systematic characterization of gene function as single-gene deletions may not produce discernible phenotypes. We report dual transposon sequencing (dual Tn-seq), a platform...
www.science.org
September 25, 2025 at 11:19 PM
Dual transposon sequencing profiles the genetic interaction landscape in bacteria | Science www.science.org/doi/10.1126/...
Reposted by Michelle Vincendeau
Our study on the role of LTR5HS and SVAs in regulation of human neural crest migration is now published as peer-reviewed paper on @molsystbiol.org!
Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social
www.embopress.org/doi/full/10....
Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social
www.embopress.org/doi/full/10....
September 22, 2025 at 11:24 AM
Our study on the role of LTR5HS and SVAs in regulation of human neural crest migration is now published as peer-reviewed paper on @molsystbiol.org!
Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social
www.embopress.org/doi/full/10....
Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social
www.embopress.org/doi/full/10....
Reposted by Michelle Vincendeau
📣 Our department is hiring an Assistant Professor in Evolutionary Cell and Molecular Biology to join the @weillinstitute.bsky.social PLS spread the word!
academicjobsonline.org/ajo/jobs/30607
academicjobsonline.org/ajo/jobs/30607
Cornell University, Molecular Biology & Genetics
Job #AJO30607, WDR-00055221 Assistant Professor, Molecular Biology & Genetics, Cornell University, Ithaca, New York, US
academicjobsonline.org
September 23, 2025 at 12:50 PM
📣 Our department is hiring an Assistant Professor in Evolutionary Cell and Molecular Biology to join the @weillinstitute.bsky.social PLS spread the word!
academicjobsonline.org/ajo/jobs/30607
academicjobsonline.org/ajo/jobs/30607
Reposted by Michelle Vincendeau
My first postdoc paper in @m-vincendeau.bsky.social lab is out in Frontiers in Immunology.🥳
We identified that hepatitis viruses, especially HBV, upregulate specific human endogenous retrovirus (HERV) groups that are linked with autoimmune diseases.
doi.org/10.3389/fimm...
We identified that hepatitis viruses, especially HBV, upregulate specific human endogenous retrovirus (HERV) groups that are linked with autoimmune diseases.
doi.org/10.3389/fimm...
Frontiers | HERV-K10 as a mediator of immune modulation in hepatitis infections
The human genome contains ~8% of endogenous retroviruses (HERVs), whose reactivation has been implicated in diseases such as cancer and autoimmune disorders....
doi.org
September 23, 2025 at 5:00 PM
My first postdoc paper in @m-vincendeau.bsky.social lab is out in Frontiers in Immunology.🥳
We identified that hepatitis viruses, especially HBV, upregulate specific human endogenous retrovirus (HERV) groups that are linked with autoimmune diseases.
doi.org/10.3389/fimm...
We identified that hepatitis viruses, especially HBV, upregulate specific human endogenous retrovirus (HERV) groups that are linked with autoimmune diseases.
doi.org/10.3389/fimm...
Check out our new paper 🎉. Thanks to everyone who was involved 🙏🏻.
My first postdoc paper in @m-vincendeau.bsky.social lab is out in Frontiers in Immunology.🥳
We identified that hepatitis viruses, especially HBV, upregulate specific human endogenous retrovirus (HERV) groups that are linked with autoimmune diseases.
doi.org/10.3389/fimm...
We identified that hepatitis viruses, especially HBV, upregulate specific human endogenous retrovirus (HERV) groups that are linked with autoimmune diseases.
doi.org/10.3389/fimm...
Frontiers | HERV-K10 as a mediator of immune modulation in hepatitis infections
The human genome contains ~8% of endogenous retroviruses (HERVs), whose reactivation has been implicated in diseases such as cancer and autoimmune disorders....
doi.org
September 23, 2025 at 7:47 PM
Check out our new paper 🎉. Thanks to everyone who was involved 🙏🏻.
Reposted by Michelle Vincendeau
My first first-author paper is out!🎉
Here we propose a model where a silencing complex, PIWI*, assembles on target RNAs to recruit effectors and shut down transposon activity.
Huge thanks to the Brennecke and Plaschka labs, especially Julius and Clemens, and all co-authors!
Here we propose a model where a silencing complex, PIWI*, assembles on target RNAs to recruit effectors and shut down transposon activity.
Huge thanks to the Brennecke and Plaschka labs, especially Julius and Clemens, and all co-authors!
PIWI clade Argonautes are essential for transposon silencing. Without them, animals are sterile due to massive transposon activity.
But how does piRNA-guided target interaction translate into silencing?
PhD student Júlia Portell Montserrat has an intriguing answer
www.cell.com/molecular-ce...
But how does piRNA-guided target interaction translate into silencing?
PhD student Júlia Portell Montserrat has an intriguing answer
www.cell.com/molecular-ce...
September 17, 2025 at 1:00 PM
My first first-author paper is out!🎉
Here we propose a model where a silencing complex, PIWI*, assembles on target RNAs to recruit effectors and shut down transposon activity.
Huge thanks to the Brennecke and Plaschka labs, especially Julius and Clemens, and all co-authors!
Here we propose a model where a silencing complex, PIWI*, assembles on target RNAs to recruit effectors and shut down transposon activity.
Huge thanks to the Brennecke and Plaschka labs, especially Julius and Clemens, and all co-authors!