Here are facts and fiction behind the "breakthrough" seeding test for #Parkinsons. In this No Silver Bullet 4PD episode, I explain seeding and what a positive seeding test can and can't tell.

I end with how patients and advocates can spot hype and push for change.
www.youtube.com/watch?v=UpXe...

Beautiful.
Michael J Fox receives the Medal of Freedom.
So well deserved.

Combining hyposmia + mild DaT abnormalities helpful in picking out folks (early) who will have a potentially positive synuclein seeding assay in the spinal fluid. It will be really nice to continue to track folks. 'Hyposmic individuals with +aSynSAA at high risk for eventual clinical symptoms.'

This article discusses clinical use of biomarker tests for Alzheimer's disease pathology, including indications for testing, review of biomarker modalities (PET, CSF, blood), selection of modality based on individual factors, and interpretation and return of results. #ENDALZ
doi.org/10.1002/alz....

I'm so excited to start my reading in 2025 with Immortality by @danaschwartz.bsky.social sequel to the book "Anatomy: a love story", one of the most beautiful novels of love and female improvement in Medicine that I have read, if not the best. But look that cover, with a detailed brain included!🧠💜.

What does a positive αSyn-SAA mean?

✅It supports a Parkinson's diagnosis.

✅It does not indicate disease mechanisms, severity, progression rate, biological subtypes, or treatment response.

Important article: www.sciencedirect.com/science/arti...

@albertoespay.bsky.social @ajlees.bsky.social

This is link about article 🧠
www.neurology.org/doi/10.1212/...

Prevention and health promotion is less known to be practiced in Neurology. However, maintaining this approach transversally in Neuroscience will always be a contribution and valuable contribution for patients and health providers As always, acronyms are useful. #NeuroResolution2025

Today’s Neurology Question (AAN) on Alzheimer’s biomarkers showed that only 57% of neurologists select low CSF Ab42. Might that be the influence of a disease framework where everything “goes up,” with AD resulting from “too much” amyloid?

A neurologist with 2 APOE4 copies tells us about his experience with #Alzheimers disease
washingtonpost.com/wellness/202...

Highlighted #SONEPSYN 2024 Dr. Ray Chaudhuri @parkinsondotorg.bsky.social spoke about pain in PD, and the concept of Synucleinopenia proposed by Dr. A. Espay @albertoespay.bsky.social Dr. K. Poplawsk on PD subtypes. Dr. Matthew Broome @matthewbroome.bsky.social on psychopathology, philosophy and IA

First day at SONEPSYN 2024, the Chilean society for neurology, psychiatry and neurosurgery, and enjoyed our session on delusions. With Tamara, Felipe, Manuel

Excited to share our @natureportfolio.bsky.social Mental Health cover story!

Led by @alussier.bsky.social, we found that childhood adversity rewires DNA methylation. The twist? Early stress was linked to both depression risk AND resilience mechanisms 🧬

Paper here: www.nature.com/articles/s44...

“Brain rot” has been named 2024 Word of the Year by the Oxford University Press.

New research finds "local insulin signaling dysfunction plays a substantial role in GBA-#Parkinsons pathogenesis, exacerbating dopaminergic neuron death"; The investigators suggest anti-diabetic drug Pioglitazone rescues the cell death
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...

Can DBS improve memory in PD?

✅18 patients randomized (1:1 ratio) to either 4 or 130 Hz DBS during early NREM sleep
✅4 Hz DBS improved overnight memory retention
✅Stronger memory improvement correlated with ⬆️ cortical low frequency activity
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...