Luke Jostins-Dean
@lukejostins.bsky.social
Data scientist at Nightingale Health, associate professor at University of Oxford
Reposted by Luke Jostins-Dean
"The idea of deporting people with settled status is disgusting, and anyone proposing it should be immediately drummed out of polite society. Breaking promises made in good faith to our friends and neighbours is racist, extremist and immoral."
I'm basically shouting at the sky here, but still.
I'm basically shouting at the sky here, but still.
It’s racist, it’s extremist and it’s immoral
The right is still calling for deportations, and the government is still being cowardly about it. Also: London’s first green belt; some notes on a shark; and some news, on my next book.
jonn.substack.com
October 22, 2025 at 1:22 PM
"The idea of deporting people with settled status is disgusting, and anyone proposing it should be immediately drummed out of polite society. Breaking promises made in good faith to our friends and neighbours is racist, extremist and immoral."
I'm basically shouting at the sky here, but still.
I'm basically shouting at the sky here, but still.
Reposted by Luke Jostins-Dean
This project is in close collaboration with the amazing @lukejostins.bsky.social, and the student will benefit from a multi-disciplinary team! 🌟🧬🧠
🎓 New PhD opportunity in our lab @kiroxford.bsky.social @oxforduni.bsky.social We're exploring host–microbiome genetic interactions in IBD using population-scale data 🧬🦠
🔗 kennedy.ox.ac.uk/.../deciphering-host2013microbiome-genetic-interactions-in-inflammatory-bowel-disease #PhD #Genetics
🔗 kennedy.ox.ac.uk/.../deciphering-host2013microbiome-genetic-interactions-in-inflammatory-bowel-disease #PhD #Genetics
kennedy.ox.ac.uk
September 1, 2025 at 2:19 PM
This project is in close collaboration with the amazing @lukejostins.bsky.social, and the student will benefit from a multi-disciplinary team! 🌟🧬🧠
Reposted by Luke Jostins-Dean
Parquet works really well with R as well. I use it all the time to work with GWAS summary statistics that won't fit into memory (our latest metabolite GWAS tested 95M+ variants in UKBB). Here's a minimal example of how to filter data on the fly while reading into R: gist.github.com/kauralasoo/f...
Filtering parquet files with dplyr
GitHub Gist: instantly share code, notes, and snippets.
gist.github.com
September 3, 2025 at 3:01 PM
Parquet works really well with R as well. I use it all the time to work with GWAS summary statistics that won't fit into memory (our latest metabolite GWAS tested 95M+ variants in UKBB). Here's a minimal example of how to filter data on the fly while reading into R: gist.github.com/kauralasoo/f...
Reposted by Luke Jostins-Dean
🎓 New PhD opportunity in our lab @kiroxford.bsky.social @oxforduni.bsky.social We're exploring host–microbiome genetic interactions in IBD using population-scale data 🧬🦠
🔗 kennedy.ox.ac.uk/.../deciphering-host2013microbiome-genetic-interactions-in-inflammatory-bowel-disease #PhD #Genetics
🔗 kennedy.ox.ac.uk/.../deciphering-host2013microbiome-genetic-interactions-in-inflammatory-bowel-disease #PhD #Genetics
kennedy.ox.ac.uk
September 1, 2025 at 11:25 AM
🎓 New PhD opportunity in our lab @kiroxford.bsky.social @oxforduni.bsky.social We're exploring host–microbiome genetic interactions in IBD using population-scale data 🧬🦠
🔗 kennedy.ox.ac.uk/.../deciphering-host2013microbiome-genetic-interactions-in-inflammatory-bowel-disease #PhD #Genetics
🔗 kennedy.ox.ac.uk/.../deciphering-host2013microbiome-genetic-interactions-in-inflammatory-bowel-disease #PhD #Genetics
Reposted by Luke Jostins-Dean
Novartis & Roche collaborated w/ Oxford researchers at the Big Data Institute 2 develop AI model using largest collection of clinical trial data (Novartis-Oxford MS dataset) from >8000 ppl living w/ multiple sclerosis (MS) to reclassify the progression of MS www.ndm.ox.ac.uk/news/using-a... #biosky
August 25, 2025 at 5:44 PM
Novartis & Roche collaborated w/ Oxford researchers at the Big Data Institute 2 develop AI model using largest collection of clinical trial data (Novartis-Oxford MS dataset) from >8000 ppl living w/ multiple sclerosis (MS) to reclassify the progression of MS www.ndm.ox.ac.uk/news/using-a... #biosky
Both sides of this debate made me feel very warmly about the people of France. www.theguardian.com/society/2025...
Call to ban ‘intolerant’ child-free resorts and hotels in France
Debate grows as Senator Laurence Rossignol says ‘we can’t organise society by separating children off’
www.theguardian.com
August 16, 2025 at 4:17 PM
Both sides of this debate made me feel very warmly about the people of France. www.theguardian.com/society/2025...
Reposted by Luke Jostins-Dean
Welcome to our webinar “Multi-omic insights into human disease” by @jeffbarrett.eu on 4 September at 3 p.m. CEST!
Join us for an exploration of how integrating proteomics and metabolomics can deepen our understanding of human health and disease.
Learn more and sign up: www.lyyti.fi/reg/multiomi...
Join us for an exploration of how integrating proteomics and metabolomics can deepen our understanding of human health and disease.
Learn more and sign up: www.lyyti.fi/reg/multiomi...
August 14, 2025 at 12:57 PM
Welcome to our webinar “Multi-omic insights into human disease” by @jeffbarrett.eu on 4 September at 3 p.m. CEST!
Join us for an exploration of how integrating proteomics and metabolomics can deepen our understanding of human health and disease.
Learn more and sign up: www.lyyti.fi/reg/multiomi...
Join us for an exploration of how integrating proteomics and metabolomics can deepen our understanding of human health and disease.
Learn more and sign up: www.lyyti.fi/reg/multiomi...
Reposted by Luke Jostins-Dean
Amazing news! Excited to be part of this new direction of research.
Huge news! A £50M MRC CoRE will bring together Manchester & Oxford to study how environmental exposures cause chronic inflammatory disease.
The CoRE will be Directed by Prof Judi Allen (Manchester) & co-Directed by Prof Dame Fiona Powrie, Director of the KIR.
www.kennedy.ox.ac.uk/news/new-ps5...
The CoRE will be Directed by Prof Judi Allen (Manchester) & co-Directed by Prof Dame Fiona Powrie, Director of the KIR.
www.kennedy.ox.ac.uk/news/new-ps5...
New £50m MRC Centre to study how environmental exposures cause chronic inflammatory diseases
A new Medical Research Council Centre of Research Excellence (MRC CoRE) will investigate how the environment interacts with our immune system to trigger chronic inflammatory diseases, such as asthma, ...
www.kennedy.ox.ac.uk
July 16, 2025 at 6:48 PM
Amazing news! Excited to be part of this new direction of research.
Reposted by Luke Jostins-Dean
🚨New preprint just dropped 🚨
medrxiv.org/content/10.1101/2025.06.24.25330216
The main output from my PhD is finally public and we’re SUPER excited about the findings! If you’re interested in what we learnt about IBD with a massive 700+ sample sc-eQTL dataset of the gut, read on!
medrxiv.org/content/10.1101/2025.06.24.25330216
The main output from my PhD is finally public and we’re SUPER excited about the findings! If you’re interested in what we learnt about IBD with a massive 700+ sample sc-eQTL dataset of the gut, read on!
July 8, 2025 at 8:52 AM
🚨New preprint just dropped 🚨
medrxiv.org/content/10.1101/2025.06.24.25330216
The main output from my PhD is finally public and we’re SUPER excited about the findings! If you’re interested in what we learnt about IBD with a massive 700+ sample sc-eQTL dataset of the gut, read on!
medrxiv.org/content/10.1101/2025.06.24.25330216
The main output from my PhD is finally public and we’re SUPER excited about the findings! If you’re interested in what we learnt about IBD with a massive 700+ sample sc-eQTL dataset of the gut, read on!
Reposted by Luke Jostins-Dean
To see which of these underpin susceptibility, we colocalised these with IBD GWAS. Remarkably, we nominate effector genes at an enormous 74 (❗) loci where one has not previously been nominated in @OpenTargets. This therefore SUBSTANTIALLY improves on previous efforts. 10/
July 8, 2025 at 8:51 AM
To see which of these underpin susceptibility, we colocalised these with IBD GWAS. Remarkably, we nominate effector genes at an enormous 74 (❗) loci where one has not previously been nominated in @OpenTargets. This therefore SUBSTANTIALLY improves on previous efforts. 10/
Reposted by Luke Jostins-Dean
Job alert ‼️ @thomasdwkim.bsky.social and I are recruiting a postdoc in single-cell genomics via the NORPOD program of the @nordicembl.bsky.social. Collaboration between @fimm-uh.bsky.social and @dandrite.bsky.social on multimodal data integration in neurodevelopment.
jobs.helsinki.fi/job/Helsinki...
jobs.helsinki.fi/job/Helsinki...
Postdoctoral Researcher in Single-Cell Genomics through the NORPOD program
Postdoctoral Researcher in Single-Cell Genomics through the NORPOD program
jobs.helsinki.fi
June 25, 2025 at 8:36 AM
Job alert ‼️ @thomasdwkim.bsky.social and I are recruiting a postdoc in single-cell genomics via the NORPOD program of the @nordicembl.bsky.social. Collaboration between @fimm-uh.bsky.social and @dandrite.bsky.social on multimodal data integration in neurodevelopment.
jobs.helsinki.fi/job/Helsinki...
jobs.helsinki.fi/job/Helsinki...
My 7-year-old just made a knife out of Lego, and did this:
"I have a knife!"
*Does a few slashes, then poses in a fighting stance"
"and I am going to a gun fight"
Is this from something, or did he make it up himself?
"I have a knife!"
*Does a few slashes, then poses in a fighting stance"
"and I am going to a gun fight"
Is this from something, or did he make it up himself?
June 22, 2025 at 11:38 AM
My 7-year-old just made a knife out of Lego, and did this:
"I have a knife!"
*Does a few slashes, then poses in a fighting stance"
"and I am going to a gun fight"
Is this from something, or did he make it up himself?
"I have a knife!"
*Does a few slashes, then poses in a fighting stance"
"and I am going to a gun fight"
Is this from something, or did he make it up himself?
Reposted by Luke Jostins-Dean
📢 📢Job alert!📢📢
We have an exciting opportunity for a 4 year post-doc in my lab at @crick.ac.uk. This project will take a similar approach to our recent ETS2 paper, published in Nature, to better understand the mechanisms that contribute to IBD tinyurl.com/yx43upnk
We have an exciting opportunity for a 4 year post-doc in my lab at @crick.ac.uk. This project will take a similar approach to our recent ETS2 paper, published in Nature, to better understand the mechanisms that contribute to IBD tinyurl.com/yx43upnk
Postdoctoral Fellow - Lee Lab
Salary for this Role: From £45,500 with benefits, subject to skills and experience. Job Title: Postdoctoral Fellow - Lee Lab Reports to: James Lee [C] Closing Date: 23.59 GMT Job Description: Job titl...
tinyurl.com
June 9, 2025 at 3:13 PM
📢 📢Job alert!📢📢
We have an exciting opportunity for a 4 year post-doc in my lab at @crick.ac.uk. This project will take a similar approach to our recent ETS2 paper, published in Nature, to better understand the mechanisms that contribute to IBD tinyurl.com/yx43upnk
We have an exciting opportunity for a 4 year post-doc in my lab at @crick.ac.uk. This project will take a similar approach to our recent ETS2 paper, published in Nature, to better understand the mechanisms that contribute to IBD tinyurl.com/yx43upnk
If you are interested to know why I have been weighing out 15 grams of butter for my bread, and what it has to do with the metabolomics of aging, sign up to this webinar tomorrow
June 2, 2025 at 1:37 PM
If you are interested to know why I have been weighing out 15 grams of butter for my bread, and what it has to do with the metabolomics of aging, sign up to this webinar tomorrow
Reposted by Luke Jostins-Dean
📣 Our webinar “Measuring the effects of aging with metabolomic profiling” by @lukejostins.bsky.social is tomorrow! Remember to sign up and join us tomorrow at 3 p.m. CEST.
Sign up: www.lyyti.fi/reg/aging_we...
Sign up: www.lyyti.fi/reg/aging_we...
June 2, 2025 at 8:00 AM
📣 Our webinar “Measuring the effects of aging with metabolomic profiling” by @lukejostins.bsky.social is tomorrow! Remember to sign up and join us tomorrow at 3 p.m. CEST.
Sign up: www.lyyti.fi/reg/aging_we...
Sign up: www.lyyti.fi/reg/aging_we...
Reposted by Luke Jostins-Dean
We have 2-3 group leader positions opening @fimm-uh.bsky.social !!
We are looking for outstanding candidates in human genetics and precision medicine.
This time we have a focus on population health data science. E.g. AI for EHR/health data
Generous starting package 💰
shorturl.at/FAk6n
We are looking for outstanding candidates in human genetics and precision medicine.
This time we have a focus on population health data science. E.g. AI for EHR/health data
Generous starting package 💰
shorturl.at/FAk6n
FIMM-EMBL Group Leaders in Molecular Medicine
FIMM-EMBL Group Leaders in Molecular Medicine
jobs.helsinki.fi
June 1, 2025 at 3:38 PM
We have 2-3 group leader positions opening @fimm-uh.bsky.social !!
We are looking for outstanding candidates in human genetics and precision medicine.
This time we have a focus on population health data science. E.g. AI for EHR/health data
Generous starting package 💰
shorturl.at/FAk6n
We are looking for outstanding candidates in human genetics and precision medicine.
This time we have a focus on population health data science. E.g. AI for EHR/health data
Generous starting package 💰
shorturl.at/FAk6n
Reposted by Luke Jostins-Dean
NB: The Polygenic Score Catalog has just lost its NIH funding. It was substantial. We are now on auxillary funding sources.
If anyone has a spare £1m plz DM
If anyone has a spare £1m plz DM
May 29, 2025 at 8:13 PM
NB: The Polygenic Score Catalog has just lost its NIH funding. It was substantial. We are now on auxillary funding sources.
If anyone has a spare £1m plz DM
If anyone has a spare £1m plz DM
Reposted by Luke Jostins-Dean
Considering a return to study in the life/environmental sciences at Masters/PhD level after time away? Working and wondering if full/part-time study is the next step for your career? Our RePOWER workshop on 13th June in Oxford/online will provide advice and support. iles.web.ox.ac.uk/repower-retu...
RePOWER: Returning to Postgraduate Study in the Life and Environmental Sciences
iles.web.ox.ac.uk
May 19, 2025 at 1:55 PM
Considering a return to study in the life/environmental sciences at Masters/PhD level after time away? Working and wondering if full/part-time study is the next step for your career? Our RePOWER workshop on 13th June in Oxford/online will provide advice and support. iles.web.ox.ac.uk/repower-retu...
Reposted by Luke Jostins-Dean
Justified standing ovation for Nobel laureate Katalin Karikó at #ESHG2025
She shared her adventurous scientific life and life lessons like "If you want to do something, you find a way. If not, you find excuses", and reminded us scientists to thank our near and dear because "they suffer a little bit"
She shared her adventurous scientific life and life lessons like "If you want to do something, you find a way. If not, you find excuses", and reminded us scientists to thank our near and dear because "they suffer a little bit"
May 27, 2025 at 12:39 PM
Justified standing ovation for Nobel laureate Katalin Karikó at #ESHG2025
She shared her adventurous scientific life and life lessons like "If you want to do something, you find a way. If not, you find excuses", and reminded us scientists to thank our near and dear because "they suffer a little bit"
She shared her adventurous scientific life and life lessons like "If you want to do something, you find a way. If not, you find excuses", and reminded us scientists to thank our near and dear because "they suffer a little bit"
Daniel MacArthur @dgmacarthur.bsky.social, practically twitching with imposter syndrome, is giving the ESHG Award Lecture #eshg2025
May 27, 2025 at 12:27 PM
Daniel MacArthur @dgmacarthur.bsky.social, practically twitching with imposter syndrome, is giving the ESHG Award Lecture #eshg2025
Annique Claringbould @anniquec.bsky.social is talking about CRISPR interference in primary CD4 T cells for ~1000 GWAS-implicated enhancers, reading out ~2000 genes. Interfering with some key enhancers (CD28, IL2RA) impact basically every CD4-expressed gene. #eshg2025
May 26, 2025 at 8:01 AM
Annique Claringbould @anniquec.bsky.social is talking about CRISPR interference in primary CD4 T cells for ~1000 GWAS-implicated enhancers, reading out ~2000 genes. Interfering with some key enhancers (CD28, IL2RA) impact basically every CD4-expressed gene. #eshg2025
Reposted by Luke Jostins-Dean
From Adam Butterworth: worth getting embroidered:
"if you use ABO or APOE in your MR, and you are studying something other than blood group or apolipoprotein, I don't want to know"
May 25, 2025 at 5:47 PM
From Adam Butterworth: worth getting embroidered: