@lucasmkc.bsky.social
5th year graduate student studying genome organization & function | Northwestern University | Backman Lab
Reposted
In effect, our genomes are a very sophisticated computer system. We take measurements of the state (salts, food, stressors), integrate it with our prior measurements (chromatin remodeling from prior exposures, epigenetic memories of our grandparents) and adapt.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Chromatin conformation, gene transcription, and nucleosome remodeling as an emergent system
Gene transcription is an emergent phenomenon of packing domain geometry in situ.
www.science.org
February 6, 2025 at 2:53 PM
In effect, our genomes are a very sophisticated computer system. We take measurements of the state (salts, food, stressors), integrate it with our prior measurements (chromatin remodeling from prior exposures, epigenetic memories of our grandparents) and adapt.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted
We hypothesized that this unique cohesin-mediated structural change in nascent chromatin domains may be caused by cohesin activity on the surface of mature chromatin domains. Using SMLM to image RAD21 and EDU-labeled chromatin, we found RAD21 primarily localized in DNA-poor areas between domains.
February 3, 2025 at 4:15 PM
We hypothesized that this unique cohesin-mediated structural change in nascent chromatin domains may be caused by cohesin activity on the surface of mature chromatin domains. Using SMLM to image RAD21 and EDU-labeled chromatin, we found RAD21 primarily localized in DNA-poor areas between domains.
