Excited to be at #ISMBECCB2025! I'll be presenting at RegSys on "Learning the Regulatory Genome by Destruction and Creation" (Thursday 3:15PM in Room 11BC). I'm looking forward to connecting with both new and old friends throughout the conference! 🧬 #CRISPR #Genomics #Diffusion

6/ Through OccuPIE, we find that a large fraction of TFs show periodicity in their preference to co-occupy adjacent motifs. This periodicity approximates the turn of the DNA helix. This fascinating finding unlocks a key pattern that underlies genomic TF binding site selection.

5/ The coolest feature of ACCESS-ATAC is the qualitatively new ability to analyze allelic TF occupancy and co-occupancy. We use a customized computational pipeline, OccuPIE, to generate a first-in-class allelic binding atlas of TFs across the genome.

4/ ACCESS-ATAC significantly improves TF binding site prediction, and in single-cell ACCESS-ATAC experiments, we resolve TF binding profiles at equal sensitivity to ATAC-seq with 2-3x fewer cells.

1/ 🎄 What’s the best gift under the tree for a computational biologist? 🎁 A new experimental assay that refines our view of gene regulation: ACCESS-ATAC! This creative idea from Richard Sherwood was developed collaboratively between his lab and mine. #Genomics
www.biorxiv.org/content/10.1...

Excited to visit the @humantechnopole.bsky.social 🇮🇹today to share our work on computational approaches in functional genomics! Looking forward to discussions with amazing scientists about #singlecell, #CRISPR, and #syntheticbiology. 🧬Special thanks to @nicolesoranzo for the invitation 🙏