Norma
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looftsabine.bsky.social
Norma
@looftsabine.bsky.social
680 followers 480 following 2.8K posts
Interessierter Laie
Wissenschaft/Forschung - Covid, LongCovid, ME/CFS - Pandemie, Endemie -
pro Ukraine

"Outbreak" - "Wag the Dog" -
"World War Z" and now
"Wayward Pines"? Human?
Posts Replies Media Videos
Reposted by Norma
sailorrooscout.bsky.social
Their efficacy was confirmed against LIVE viruses including Ebola, Marburg, Nipah, Hendra, SARS-CoV, SARS-CoV-2 (COVID-19), AND Middle East Respiratory Syndrome (MERS).

The study has been published in Science Advances. YES, it is PEER-REVIEWED.
• www.science.org/doi/10.1126/...

🧪🧵⬇️
ABSTRACT Viral pandemics continue to threaten global health and economic stability. Despite medical advances, the absence of broad-spectrum antivirals (BSAs) prevents rapid responses to emerging viral threats. This is largely due to the lack of universal drug targets across diverse viral families and high variability among viral proteins. In this study, we evaluated 57 synthetic carbohydrate receptors (SCRs) for antiviral activity in cellulo using pseudotyped virus particles (PVPs) from six high-risk viruses across three families: Paramyxoviridae, Filoviridae, and Coronaviridae. Four SCRs inhibited all tested PVPs, and their efficacy was confirmed against live viruses including SARS-CoV-2, MERS-COV, EBOV, MARV, NiV, and HeV. Notably, SCR005 and SCR007, which exhibited minimal toxicity, significantly reduced SARS-CoV-2 infection in a severe animal model with a single dose. Mechanistic studies suggested that SCRs bind viral envelope N-glycans, blocking viral attachment and/or fusion. These results identify conserved viral N-glycans as promising BSA targets and establish SCRs as candidate prophylactic agents against enveloped viruses with pandemic potential.
November 28, 2025 at 5:02 PM
looftsabine.bsky.social
"Bird flu explained" 👍
"The virus often spreads through bird droppings or the feathers of infected animals.
A single gram of droppings can contain around 100 million virus particles. It can be introduced into a poultry house via boots or clothing, vermin, or dust, where it spreads rapidly." #H5N1
November 28, 2025 at 6:16 PM
looftsabine.bsky.social
😳
November 28, 2025 at 1:06 PM
Reposted by Norma
socialinfluenza.bsky.social
bsky.app/profile/soci...
socialinfluenza.bsky.social Ed Hutchinson @socialinfluenza.bsky.social · 3d
Nine childhood vaccines…
A snowflake-like picture of the nine viruses against which, from 1st January 2026, all children in the UK will be offered free vaccines through the NHS routine childhood immunisation schedule. They are (clockwise from top L) measles virus (the cause of measles and of measles encephalitis), varicella zoster virus (chickenpox, shingles, and a potential contributor to dementia), poliovirus (poliomyelitis and paralysis), mumps virus (mumps), hepatitis B virus (hepatitis, cirrhosis and liver cancer), human papillomavirus (cervical cancer), influenza virus (influenza), rotavirus (gastroenteritis), rubella virus (German measles, miscarriage, congenital rubella syndrome). The box is 400 nm across, or a two thousand five hundredth of a millimetre.
November 28, 2025 at 9:06 AM