Lina Carlini
@linacarlini.bsky.social
Assistant Professor, Laufer Center for Physical & Quantitative Biology, Stony Brook University
Reposted by Lina Carlini
New paper from @zhixingchen2.bsky.social's lab!
It turns out that, in addition to its very low phototoxicity, PKmito Deep Red (PKMDR) directly reports on mitochondrial membrane potential (MMP) in live cells through its lifetime!
www.nature.com/articles/s41...
It turns out that, in addition to its very low phototoxicity, PKmito Deep Red (PKMDR) directly reports on mitochondrial membrane potential (MMP) in live cells through its lifetime!
www.nature.com/articles/s41...
December 16, 2025 at 12:11 PM
New paper from @zhixingchen2.bsky.social's lab!
It turns out that, in addition to its very low phototoxicity, PKmito Deep Red (PKMDR) directly reports on mitochondrial membrane potential (MMP) in live cells through its lifetime!
www.nature.com/articles/s41...
It turns out that, in addition to its very low phototoxicity, PKmito Deep Red (PKMDR) directly reports on mitochondrial membrane potential (MMP) in live cells through its lifetime!
www.nature.com/articles/s41...
Reposted by Lina Carlini
@simonecoppola.bsky.social has made micromorph, the first native Python application and library for measuring bacterial morphology. It runs interactively in napari or can be easily integrated into automated Python scripts. It integrates deep learning cell segmentation and is easily extended 🔬🦠🧫
Happy to finally share micromorph with everyone!
If you are interested in performing morphological measurements of bacteria, and like using Python and Napari then this is for you!
You can read about it in our preprint, and find the code on our Github repo, PyPi or directly from the napari hub!
If you are interested in performing morphological measurements of bacteria, and like using Python and Napari then this is for you!
You can read about it in our preprint, and find the code on our Github repo, PyPi or directly from the napari hub!
micromorph: a Python toolkit for measurement of microbial morphology
Detection of morphological phenotypes from light microscopy is a key part of microbiology. Despite advances in automated morphological analysis, accurate measurements still often require significant u...
www.biorxiv.org
December 11, 2025 at 9:19 AM
@simonecoppola.bsky.social has made micromorph, the first native Python application and library for measuring bacterial morphology. It runs interactively in napari or can be easily integrated into automated Python scripts. It integrates deep learning cell segmentation and is easily extended 🔬🦠🧫
Reposted by Lina Carlini
Huge congratulations to Wieczorek Lab PhD student Bin Cai and now-PI Jingwei Xu @xujwet.bsky.social on figuring out the surprisingly complex structure of the A-C linker crosslinking microtubule triplets in Tetrahymena basal body centrioles! www.science.org/doi/10.1126/...
Structure and assembly of the A-C linker connecting microtubule triplets in centrioles
Multiscale cryo-EM of centrioles reveals the structure and polymorphism of the A-C linker connecting microtubule triplets.
www.science.org
October 10, 2025 at 1:14 PM
Huge congratulations to Wieczorek Lab PhD student Bin Cai and now-PI Jingwei Xu @xujwet.bsky.social on figuring out the surprisingly complex structure of the A-C linker crosslinking microtubule triplets in Tetrahymena basal body centrioles! www.science.org/doi/10.1126/...
Reposted by Lina Carlini
Ken A. Dill to Receive Biophysical Society’s 2026 Founders Award buff.ly/OZ3VUIk
September 24, 2025 at 8:15 PM
Ken A. Dill to Receive Biophysical Society’s 2026 Founders Award buff.ly/OZ3VUIk
Stony Brook’s Laufer Center for Physical & Quantitative Biology invites applications for an endowed faculty position (assistant/ associate professor). Join a top interdisciplinary hub in quantitative biology! Apply by Dec 1: apply.interfolio.com/173357
Apply - Interfolio
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apply.interfolio.com
September 17, 2025 at 5:45 PM
Stony Brook’s Laufer Center for Physical & Quantitative Biology invites applications for an endowed faculty position (assistant/ associate professor). Join a top interdisciplinary hub in quantitative biology! Apply by Dec 1: apply.interfolio.com/173357
Reposted by Lina Carlini
It’s SHOW TIME! 🎤 Kicking off the MSK Postdoc Slam is @meganekelley.bsky.social from the @agnelsfeir.bsky.social lab, diving into how error-prone DNA repair fuels drug resistance in cancer 🧬💊
September 15, 2025 at 8:09 PM
It’s SHOW TIME! 🎤 Kicking off the MSK Postdoc Slam is @meganekelley.bsky.social from the @agnelsfeir.bsky.social lab, diving into how error-prone DNA repair fuels drug resistance in cancer 🧬💊
Reposted by Lina Carlini
📢Last few days to apply for this round of our #microscopy training grants with @jcellsci.bsky.social
Available to ECRs working on #cellbio to attend a microscopy or bioimage analysis training course.
Apply by 5 September
www.biologists.com/grants/jcs-f...
Available to ECRs working on #cellbio to attend a microscopy or bioimage analysis training course.
Apply by 5 September
www.biologists.com/grants/jcs-f...
August 29, 2025 at 1:14 PM
📢Last few days to apply for this round of our #microscopy training grants with @jcellsci.bsky.social
Available to ECRs working on #cellbio to attend a microscopy or bioimage analysis training course.
Apply by 5 September
www.biologists.com/grants/jcs-f...
Available to ECRs working on #cellbio to attend a microscopy or bioimage analysis training course.
Apply by 5 September
www.biologists.com/grants/jcs-f...
Reposted by Lina Carlini
New preprint online!
So much fun working on this project, thank you @centriolelab.bsky.social and @dudinlab.bsky.social for embarking me on this one!
Hopefully HAK-actin will become your best companion for actin staining U-ExM expanded samples.
So much fun working on this project, thank you @centriolelab.bsky.social and @dudinlab.bsky.social for embarking me on this one!
Hopefully HAK-actin will become your best companion for actin staining U-ExM expanded samples.
Trouble imaging actin in ExM? Meet HAK-Actin, a probe for U-ExM, cryo-ExM & iU-ExM. Enables post-expansion labeling for max signal. www.biorxiv.org/content/10.1...
Soon at @spirochrome.com
Led by O.Mercey and @lreymond.bsky.social, in collab with @dudinlab.bsky.social and @marinelap.bsky.social
Soon at @spirochrome.com
Led by O.Mercey and @lreymond.bsky.social, in collab with @dudinlab.bsky.social and @marinelap.bsky.social
August 28, 2025 at 7:26 AM
New preprint online!
So much fun working on this project, thank you @centriolelab.bsky.social and @dudinlab.bsky.social for embarking me on this one!
Hopefully HAK-actin will become your best companion for actin staining U-ExM expanded samples.
So much fun working on this project, thank you @centriolelab.bsky.social and @dudinlab.bsky.social for embarking me on this one!
Hopefully HAK-actin will become your best companion for actin staining U-ExM expanded samples.
Reposted by Lina Carlini
My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...
Mechanical confinement governs phenotypic plasticity in melanoma - Nature
Mechanical confinement of cancer cells at the tumour–microenvironment interface induces phenotype switching through chromatin remodelling by HMGB2, leading to a more invasive and drug-resistant state ...
www.nature.com
August 27, 2025 at 5:18 PM
My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...
Reposted by Lina Carlini
Hey #biology #postdocs out there, are you worried about the academic job market in the current climate? Do not! We are hiring, and we are an absolutely AWESOME department! 🧪
Apply now: www.stonybrook.edu/commcms/bioc...
Apply now: www.stonybrook.edu/commcms/bioc...
Opportunities | Biochemistry & Cell Biology
Department of Biochemistry and Cell Biology at Stony Brook University
www.stonybrook.edu
August 15, 2025 at 7:32 PM
Hey #biology #postdocs out there, are you worried about the academic job market in the current climate? Do not! We are hiring, and we are an absolutely AWESOME department! 🧪
Apply now: www.stonybrook.edu/commcms/bioc...
Apply now: www.stonybrook.edu/commcms/bioc...
Reposted by Lina Carlini
🚨 JOB ALERT 🚨
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...
#STEMCareers #ResearchJobs
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...
#STEMCareers #ResearchJobs
June 23, 2025 at 1:00 PM
🚨 JOB ALERT 🚨
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...
#STEMCareers #ResearchJobs
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...
#STEMCareers #ResearchJobs
Reposted by Lina Carlini
I’m excited to announce that my paper describing non-canonical mitotic mechanisms in the early mouse embryo is out in @science.org ! (link at end of 🧵)
May 23, 2025 at 7:57 PM
I’m excited to announce that my paper describing non-canonical mitotic mechanisms in the early mouse embryo is out in @science.org ! (link at end of 🧵)
Reposted by Lina Carlini
Muñoz-Hernández, Xu, et al. @mike-wieczorek.bsky.social @ethz.ch report #cryoEM structures revealing how NEDD1’s C terminus forms an α-helical tetramer that docks onto the γ-TuRC without inducing major conformational changes in the complex during its recruitment to MTOCs rupress.org/jcb/article/...
May 21, 2025 at 4:10 PM
Muñoz-Hernández, Xu, et al. @mike-wieczorek.bsky.social @ethz.ch report #cryoEM structures revealing how NEDD1’s C terminus forms an α-helical tetramer that docks onto the γ-TuRC without inducing major conformational changes in the complex during its recruitment to MTOCs rupress.org/jcb/article/...
Reposted by Lina Carlini
We've developed a single-molecule imaging approach to study how #influenza A viruses interact with live cells at the nanoscale. We found that cellular receptors show a specific organization and turnover at the virus-cell interface. 👉 www.nature.com/articles/s41...
@combinemarvproject.bsky.social
@combinemarvproject.bsky.social
May 8, 2025 at 7:19 AM
We've developed a single-molecule imaging approach to study how #influenza A viruses interact with live cells at the nanoscale. We found that cellular receptors show a specific organization and turnover at the virus-cell interface. 👉 www.nature.com/articles/s41...
@combinemarvproject.bsky.social
@combinemarvproject.bsky.social
Reposted by Lina Carlini
In developing embryos, cells move a lot! Plenty of that movement is random. Is random cell mixing a feature or bug for tissue patterning? Turns out, it’s both! Excited to share the 1st preprint from my postdoc w/ Sean Megason @seanemcgeary.bsky.social and Allon Klein. 1/20 doi.org/10.1101/2025...
April 24, 2025 at 1:19 PM
In developing embryos, cells move a lot! Plenty of that movement is random. Is random cell mixing a feature or bug for tissue patterning? Turns out, it’s both! Excited to share the 1st preprint from my postdoc w/ Sean Megason @seanemcgeary.bsky.social and Allon Klein. 1/20 doi.org/10.1101/2025...
Reposted by Lina Carlini
New lab preprint! Unveiling the Molecular Architecture of T Cells and Immune Synapses with Cryo-Expansion Microscopy (Cryo-ExM). A fantastic collaboration with Dr. Benita Wolf. Congratulations to all authors, especially Florent Lemaitre, for leading this amazing work! www.biorxiv.org/content/10.1...
April 23, 2025 at 2:04 PM
New lab preprint! Unveiling the Molecular Architecture of T Cells and Immune Synapses with Cryo-Expansion Microscopy (Cryo-ExM). A fantastic collaboration with Dr. Benita Wolf. Congratulations to all authors, especially Florent Lemaitre, for leading this amazing work! www.biorxiv.org/content/10.1...
Reposted by Lina Carlini
Happy to officially introduce FilaBuster - a strategy for rapid, light-mediated intermediate filament disassembly. Compatible with multiple IF types, modular in design, and precise enough to induce localized filament disassembly in live cells.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
April 22, 2025 at 1:02 AM
Happy to officially introduce FilaBuster - a strategy for rapid, light-mediated intermediate filament disassembly. Compatible with multiple IF types, modular in design, and precise enough to induce localized filament disassembly in live cells.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...