Liisa Galea
@liisagalea.bsky.social
Neuroscientist, Treliving Family Chair in Women’s Mental Health, Prof U Toronto (formerly UBC), Mom, Senior Scientist CAMH
Dr Munmun Choudhury on the major paradigm shifts in mental health care/research… are we ready for the 4th paradigm shift. Does AI have a role to play? And how to challenges (I.e. access to care) create barriers to progress? The social ecology is imp. Are the algorithms sensitive enough?
November 21, 2025 at 3:12 PM
Dr Munmun Choudhury on the major paradigm shifts in mental health care/research… are we ready for the 4th paradigm shift. Does AI have a role to play? And how to challenges (I.e. access to care) create barriers to progress? The social ecology is imp. Are the algorithms sensitive enough?
Reue: Sex and gender differences in CVD. There are known differences in disease pathology for atherosclerotic plaques with thicker fibrous caps, more collagen but less lipids in women/females. Which is recapitulated in mouse models!! With both goner and chromosome effects. Super cool.
November 19, 2025 at 2:51 PM
Reue: Sex and gender differences in CVD. There are known differences in disease pathology for atherosclerotic plaques with thicker fibrous caps, more collagen but less lipids in women/females. Which is recapitulated in mouse models!! With both goner and chromosome effects. Super cool.
Similar findings in humans! With drop in omega3 FA. and reduced mitochondrial respiration but only in women/females (using ipsc).
November 19, 2025 at 2:41 PM
Similar findings in humans! With drop in omega3 FA. and reduced mitochondrial respiration but only in women/females (using ipsc).
reue: Statin adverse side effects larger in women for diabetes and myopathy. These effects are recapitulated in mice!! See how studying sex can increase translation???!! Omega 3 FA may offset these side effects through mitochondrial function.
November 19, 2025 at 2:41 PM
reue: Statin adverse side effects larger in women for diabetes and myopathy. These effects are recapitulated in mice!! See how studying sex can increase translation???!! Omega 3 FA may offset these side effects through mitochondrial function.
Reue: Same genes are conserved in humans. The Kdm5c allele shoes dose dependent side effects on fat depots and mitochondrial thermogenesis.
November 19, 2025 at 2:33 PM
Reue: Same genes are conserved in humans. The Kdm5c allele shoes dose dependent side effects on fat depots and mitochondrial thermogenesis.
Karen Reue: Using the 4 core genotype and other models: 2XX gain more rapidly on a HFHC diet than those with a Y. There is also more sc fat depots. Are those genes that escape X inactivation responsible?
November 19, 2025 at 2:33 PM
Karen Reue: Using the 4 core genotype and other models: 2XX gain more rapidly on a HFHC diet than those with a Y. There is also more sc fat depots. Are those genes that escape X inactivation responsible?
She drives the point home that gonads and XX/XY/XO/XXY complement influence health across the lifespan & are important throughout the body not just for reproductive reasons.
November 19, 2025 at 2:24 PM
She drives the point home that gonads and XX/XY/XO/XXY complement influence health across the lifespan & are important throughout the body not just for reproductive reasons.