Liisa Galea
@liisagalea.bsky.social
Neuroscientist, Treliving Family Chair in Women’s Mental Health, Prof U Toronto (formerly UBC), Mom, Senior Scientist CAMH
Dr Munmun Choudhury on the major paradigm shifts in mental health care/research… are we ready for the 4th paradigm shift. Does AI have a role to play? And how to challenges (I.e. access to care) create barriers to progress? The social ecology is imp. Are the algorithms sensitive enough?
November 21, 2025 at 3:12 PM
Dr Munmun Choudhury on the major paradigm shifts in mental health care/research… are we ready for the 4th paradigm shift. Does AI have a role to play? And how to challenges (I.e. access to care) create barriers to progress? The social ecology is imp. Are the algorithms sensitive enough?
Up next for @camhnews.bsky.social research day is Tristan Glatard on promises and pitfalls of AI for neuroscience. Two broad ways of using AI. Predictive models and conversational agents.
November 21, 2025 at 2:33 PM
Up next for @camhnews.bsky.social research day is Tristan Glatard on promises and pitfalls of AI for neuroscience. Two broad ways of using AI. Predictive models and conversational agents.
Reue: Sex and gender differences in CVD. There are known differences in disease pathology for atherosclerotic plaques with thicker fibrous caps, more collagen but less lipids in women/females. Which is recapitulated in mouse models!! With both goner and chromosome effects. Super cool.
November 19, 2025 at 2:51 PM
Reue: Sex and gender differences in CVD. There are known differences in disease pathology for atherosclerotic plaques with thicker fibrous caps, more collagen but less lipids in women/females. Which is recapitulated in mouse models!! With both goner and chromosome effects. Super cool.
Similar findings in humans! With drop in omega3 FA. and reduced mitochondrial respiration but only in women/females (using ipsc).
November 19, 2025 at 2:41 PM
Similar findings in humans! With drop in omega3 FA. and reduced mitochondrial respiration but only in women/females (using ipsc).
reue: Statin adverse side effects larger in women for diabetes and myopathy. These effects are recapitulated in mice!! See how studying sex can increase translation???!! Omega 3 FA may offset these side effects through mitochondrial function.
November 19, 2025 at 2:41 PM
reue: Statin adverse side effects larger in women for diabetes and myopathy. These effects are recapitulated in mice!! See how studying sex can increase translation???!! Omega 3 FA may offset these side effects through mitochondrial function.
Reue: Same genes are conserved in humans. The Kdm5c allele shoes dose dependent side effects on fat depots and mitochondrial thermogenesis.
November 19, 2025 at 2:33 PM
Reue: Same genes are conserved in humans. The Kdm5c allele shoes dose dependent side effects on fat depots and mitochondrial thermogenesis.
Karen Reue: Using the 4 core genotype and other models: 2XX gain more rapidly on a HFHC diet than those with a Y. There is also more sc fat depots. Are those genes that escape X inactivation responsible?
November 19, 2025 at 2:33 PM
Karen Reue: Using the 4 core genotype and other models: 2XX gain more rapidly on a HFHC diet than those with a Y. There is also more sc fat depots. Are those genes that escape X inactivation responsible?
She drives the point home that gonads and XX/XY/XO/XXY complement influence health across the lifespan & are important throughout the body not just for reproductive reasons.
November 19, 2025 at 2:24 PM
She drives the point home that gonads and XX/XY/XO/XXY complement influence health across the lifespan & are important throughout the body not just for reproductive reasons.
Dr Karen Reue’s Ori Rotstein Lecture for IMS at U Toronto - on why she studies sex differences. Look at those differences in serum metabolites, gene expression and all thing adipose related
November 19, 2025 at 2:24 PM
Dr Karen Reue’s Ori Rotstein Lecture for IMS at U Toronto - on why she studies sex differences. Look at those differences in serum metabolites, gene expression and all thing adipose related
Rodent vs human brain development (& hormone profiles) so important to understand. And one way to do this is to use hiPSCs from humans to create organoids (3D) vs 2D cultures of NPCs, neurons etc. neural organoids can be used as a model system to study brain development @ncndgroup.bsky.social
November 18, 2025 at 3:25 PM
Rodent vs human brain development (& hormone profiles) so important to understand. And one way to do this is to use hiPSCs from humans to create organoids (3D) vs 2D cultures of NPCs, neurons etc. neural organoids can be used as a model system to study brain development @ncndgroup.bsky.social
Early gene expression does show sex differences across the brain using postmortem tissue. In addition, fetal testosterone peaks 14-16w during gestation in males -does this contribute?
November 18, 2025 at 3:25 PM
Early gene expression does show sex differences across the brain using postmortem tissue. In addition, fetal testosterone peaks 14-16w during gestation in males -does this contribute?
Prevalence and treatment responses differ by sex. Over time the treatment response to antipsychotics improves in males but not females 🤯. These findings suggest it’s fruitful to look at sex as a factor. Sex hormones and chromosomes play a role.
November 18, 2025 at 3:25 PM
Prevalence and treatment responses differ by sex. Over time the treatment response to antipsychotics improves in males but not females 🤯. These findings suggest it’s fruitful to look at sex as a factor. Sex hormones and chromosomes play a role.
Deepak is giving us some lessons learned from working with organoids and studying males and females as well as how estrogens influence human development. @ncndgroup.bsky.social How & do the mechanisms of glutamergic neurons develop differ between males and females?
November 18, 2025 at 3:09 PM
Deepak is giving us some lessons learned from working with organoids and studying males and females as well as how estrogens influence human development. @ncndgroup.bsky.social How & do the mechanisms of glutamergic neurons develop differ between males and females?
We also found different brain regions had a greater influence in the overall network that depended on parity and genotype (seriously I can stare at that all day - look at all those changing eigenvalues). There is something for everyone here.. pick your region😉
October 31, 2025 at 5:59 PM
We also found different brain regions had a greater influence in the overall network that depended on parity and genotype (seriously I can stare at that all day - look at all those changing eigenvalues). There is something for everyone here.. pick your region😉
Every night I have a green rooibos tea with ginger,chili, and lemon. I’ve been doing this since I tried one in Zambia in 2018. I haven’t been feeling well and wanted to make sure I had plenty of tea on hand… did I order too much?? Or not enough. You be the judge.
October 29, 2025 at 6:26 PM
Every night I have a green rooibos tea with ginger,chili, and lemon. I’ve been doing this since I tried one in Zambia in 2018. I haven’t been feeling well and wanted to make sure I had plenty of tea on hand… did I order too much?? Or not enough. You be the judge.
Fantastic phase aligned cycle scaling available for researchers interested. PACTS. Menstrual cycles and hormone levels can be quite different and this method helps. Sucidality idealisation also follows cyclicity @clearlab.bsky.social
October 20, 2025 at 4:40 PM
Fantastic phase aligned cycle scaling available for researchers interested. PACTS. Menstrual cycles and hormone levels can be quite different and this method helps. Sucidality idealisation also follows cyclicity @clearlab.bsky.social
DSM5 ignores unique trajectories. Unique trajectories are imp to understand for treatment options ++ @clearlab.bsky.social also if people arent careful this variability will be missed and
October 20, 2025 at 4:31 PM
DSM5 ignores unique trajectories. Unique trajectories are imp to understand for treatment options ++ @clearlab.bsky.social also if people arent careful this variability will be missed and
We need to understand this disorder better & not assume that all conditions need to be met. There are many different cutoffs. @clearlab.bsky.social made CPASS to help. DSM5 excludes subthreshold cyclicity. Or with PME & this is an issue for understanding the disorder.
October 20, 2025 at 4:25 PM
We need to understand this disorder better & not assume that all conditions need to be met. There are many different cutoffs. @clearlab.bsky.social made CPASS to help. DSM5 excludes subthreshold cyclicity. Or with PME & this is an issue for understanding the disorder.
Why are some people hormone sensitive and others not? There are cultural stereotypes… that are imp to acknowledge. You need repeated measures and DAILY analyses to diagnose PMDD (~5.5%) or PME -
@clearlab.bsky.social
@clearlab.bsky.social
October 20, 2025 at 4:20 PM
Why are some people hormone sensitive and others not? There are cultural stereotypes… that are imp to acknowledge. You need repeated measures and DAILY analyses to diagnose PMDD (~5.5%) or PME -
@clearlab.bsky.social
@clearlab.bsky.social
Suicides are important to study in females too. More attempts in females. Attempts can be linked to hormones. But not all people have these hormonal sensitivities red shows severe, pink less sensitivities and black no symptoms. So why is this @clearlab.bsky.social researches searches for why
October 20, 2025 at 4:13 PM
Suicides are important to study in females too. More attempts in females. Attempts can be linked to hormones. But not all people have these hormonal sensitivities red shows severe, pink less sensitivities and black no symptoms. So why is this @clearlab.bsky.social researches searches for why
I hate wasting thyme
October 12, 2025 at 9:16 PM
I hate wasting thyme
Delighted to hear my colleague & friend Judy Illes from my old institution & get to meet my new colleague and hopeful friend and my new institution @danielbuchman.bsky.social Judy always makes my mind stretch whenever I hear her speak.
October 10, 2025 at 1:28 AM
Delighted to hear my colleague & friend Judy Illes from my old institution & get to meet my new colleague and hopeful friend and my new institution @danielbuchman.bsky.social Judy always makes my mind stretch whenever I hear her speak.
Last night I could not put this book down. The opening chapter is 🤯 and the final chapters full of great ideas about what we can collectively do to ensure women & underrepresented groups stay in science. We need diversity in science as diversity breeds discovery
October 9, 2025 at 2:17 AM
Last night I could not put this book down. The opening chapter is 🤯 and the final chapters full of great ideas about what we can collectively do to ensure women & underrepresented groups stay in science. We need diversity in science as diversity breeds discovery
This couch has a face…
September 21, 2025 at 2:59 PM
This couch has a face…
Hunsberger: benzodiazepines are prescribed to the elderly. Are they helpful or risk for AD? Controversial and equivocal findings. But is this due to lack of consideration of sex? Newly published work indicates yes.
September 15, 2025 at 4:32 PM
Hunsberger: benzodiazepines are prescribed to the elderly. Are they helpful or risk for AD? Controversial and equivocal findings. But is this due to lack of consideration of sex? Newly published work indicates yes.