Leah Biggs
@leahbiggs.bsky.social
Group leader at Max Planck Institute for Molecular Biomedicine. Cell and Developmental Biologist and Iowan.
Reposted by Leah Biggs
Happy to share our review on methodology for measuring and manipulating mechanical forces with specific focus on developmental biology! Congrats to authors @clemvilleneuve.bsky.social @mccreery.bsky.social and hats off to the community for developing awesome tools www.nature.com/articles/s41...
Measuring and manipulating mechanical forces during development - Nature Cell Biology
This Review discusses the recent advances in experimental approaches to interrogate the mechanical forces that mediate tissue deformations during development, highlighting the insights afforded at bot...
www.nature.com
March 10, 2025 at 1:33 PM
Happy to share our review on methodology for measuring and manipulating mechanical forces with specific focus on developmental biology! Congrats to authors @clemvilleneuve.bsky.social @mccreery.bsky.social and hats off to the community for developing awesome tools www.nature.com/articles/s41...
Reposted by Leah Biggs
Despite challenging times delighted to see our preprint on how stem cell-specific sphingolipid metabolism controls fate trajectories in the hair follicle published🎉 congratulations Franziska &team and thank you @dfg.de @maxplanckpress.de and UniHelsinki for support! rupress.org/jcb/article/...
Sphingolipid metabolism orchestrates establishment of the hair follicle stem cell compartment | Journal of Cell Biology | Rockefeller University Press
This study identifies a specific role for ceramide synthase 4 (CerS4) in cell fate regulation. Epidermis-specific deletion of CerS4 prevents development of
rupress.org
January 29, 2025 at 6:58 PM
Despite challenging times delighted to see our preprint on how stem cell-specific sphingolipid metabolism controls fate trajectories in the hair follicle published🎉 congratulations Franziska &team and thank you @dfg.de @maxplanckpress.de and UniHelsinki for support! rupress.org/jcb/article/...
Reposted by Leah Biggs
Interested in the cell biology of the nucleus? Join us for this unique exciting meeting that covers everything from nuclear biophysics and mechanics to signaling and evolution😍 amazing speaker list and more will be selected from abstracts 🤩
📣 Join us for #EESNucleus 🧬
Explore the dynamic world of the nucleus at the new EMBO | EMBL Symposium. From nuclear mechanics to pathomechanisms, join the conversation shaping modern cell biology.
🗓️ 18 – 21 November 2025
📥 Submit your abstract by 26 August
👉 https://s.embl.org/ees25-07-bl
Explore the dynamic world of the nucleus at the new EMBO | EMBL Symposium. From nuclear mechanics to pathomechanisms, join the conversation shaping modern cell biology.
🗓️ 18 – 21 November 2025
📥 Submit your abstract by 26 August
👉 https://s.embl.org/ees25-07-bl
January 24, 2025 at 12:11 PM
Interested in the cell biology of the nucleus? Join us for this unique exciting meeting that covers everything from nuclear biophysics and mechanics to signaling and evolution😍 amazing speaker list and more will be selected from abstracts 🤩
Reposted by Leah Biggs
Excited to share the first paper from my lab 🤩 - a great collaboration with Dani Fachinetti lab - we discover a #mechanosensitive nuclear envelope #checkpoint that arrests cells directly post chromosome mis-segregation rdcu.be/d5AC9 👇🧵 #cancer #mechanics #p53 #chromatin
January 8, 2025 at 12:14 PM
Excited to share the first paper from my lab 🤩 - a great collaboration with Dani Fachinetti lab - we discover a #mechanosensitive nuclear envelope #checkpoint that arrests cells directly post chromosome mis-segregation rdcu.be/d5AC9 👇🧵 #cancer #mechanics #p53 #chromatin
Reposted by Leah Biggs
#1 Happy to share our last work published in @NatureCellBio about a new cell cycle checkpoint that senses nuclear shape & mechanics to guarantee genome integrity
www.nature.com/articles/s41.... Great work from @sol-herve.bsky.social & Andrea Scelfo in close collaboration with @katemiro.bsky.social
www.nature.com/articles/s41.... Great work from @sol-herve.bsky.social & Andrea Scelfo in close collaboration with @katemiro.bsky.social
Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint - Nature Cell Biology
Hervé, Scelfo et al. show that chromosome mis-segregation induces mTORC2- and ATR-mediated p53 activation through a mechanosensitive checkpoint at the nuclear envelope triggered by altered heterochrom...
www.nature.com
January 8, 2025 at 12:11 PM
#1 Happy to share our last work published in @NatureCellBio about a new cell cycle checkpoint that senses nuclear shape & mechanics to guarantee genome integrity
www.nature.com/articles/s41.... Great work from @sol-herve.bsky.social & Andrea Scelfo in close collaboration with @katemiro.bsky.social
www.nature.com/articles/s41.... Great work from @sol-herve.bsky.social & Andrea Scelfo in close collaboration with @katemiro.bsky.social
Reposted by Leah Biggs
We will have upcoming vacancies in the Iden lab at Saarland University (PhD student, postdoc, technician). If you wish to join an international research team working on cell-cell communication in mammalian epithelia, contact me (please provide CV, motivation letter, contacts of 2-3 references).
January 10, 2025 at 9:48 AM
We will have upcoming vacancies in the Iden lab at Saarland University (PhD student, postdoc, technician). If you wish to join an international research team working on cell-cell communication in mammalian epithelia, contact me (please provide CV, motivation letter, contacts of 2-3 references).