Laura Breimann
@laurabreimann.bsky.social
Genome Organization & Imaging Researcher | Postdoctoral Fellow at Harvard Medical School | Expert in Advanced Imaging, Image Analysis & Chromatin Biology
https://laurabreimann.github.io/
https://laurabreimann.github.io/
Reposted by Laura Breimann
I think about this post every day 🧪
November 7, 2025 at 12:15 PM
I think about this post every day 🧪
Reposted by Laura Breimann
Janelia is hosting a course on DL for bioimage analysis www.janelia.org/you-janelia/...
Deep Learning for Microscopy Image Analysis
Topics The following will be covered extensively during lectures, exercises, and project work: Image denoising and restoration (fully supervised and self-supervised) Image translation (e.g.,
www.janelia.org
November 6, 2025 at 5:02 PM
Janelia is hosting a course on DL for bioimage analysis www.janelia.org/you-janelia/...
Reposted by Laura Breimann
We are excited to welcome @fueyoraquel.bsky.social, @sedonamurphy.bsky.social, and @jmstein.bsky.social as new group leaders at our institute!
Read more about their work:
--> www.molgen.mpg.de/2025-10-31-n...
All three are recruiting in the IMPRS PhD Call!
--> www.molgen.mpg.de/IMPRSPhDproj...
Read more about their work:
--> www.molgen.mpg.de/2025-10-31-n...
All three are recruiting in the IMPRS PhD Call!
--> www.molgen.mpg.de/IMPRSPhDproj...
Three new research groups joining the MPIMG
www.molgen.mpg.de
November 6, 2025 at 4:00 PM
We are excited to welcome @fueyoraquel.bsky.social, @sedonamurphy.bsky.social, and @jmstein.bsky.social as new group leaders at our institute!
Read more about their work:
--> www.molgen.mpg.de/2025-10-31-n...
All three are recruiting in the IMPRS PhD Call!
--> www.molgen.mpg.de/IMPRSPhDproj...
Read more about their work:
--> www.molgen.mpg.de/2025-10-31-n...
All three are recruiting in the IMPRS PhD Call!
--> www.molgen.mpg.de/IMPRSPhDproj...
Reposted by Laura Breimann
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
October 17, 2025 at 2:56 PM
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
Reposted by Laura Breimann
Oh yes-the one and only Robert Haase @haesleinhuepf.bsky.social
From #GrandTheftAuto to the impact AI is having on #bioimaging.
+the challenges of creating AI courses for bioimage analysis, & his unique perspective as a programmer-turned-biologist.
Stream- bit.ly/microscopist...
@globias.bsky.social
From #GrandTheftAuto to the impact AI is having on #bioimaging.
+the challenges of creating AI courses for bioimage analysis, & his unique perspective as a programmer-turned-biologist.
Stream- bit.ly/microscopist...
@globias.bsky.social
The Microscopists | Robert Haase (Leipzig University)
We're thrilled to bring you the latest episode of The Microscopists, this time featuring Robert Haase, Lecturer and Training Coordinator at Leipzig University. In this episode, Robert chats about t...
bit.ly
September 19, 2025 at 11:15 AM
Oh yes-the one and only Robert Haase @haesleinhuepf.bsky.social
From #GrandTheftAuto to the impact AI is having on #bioimaging.
+the challenges of creating AI courses for bioimage analysis, & his unique perspective as a programmer-turned-biologist.
Stream- bit.ly/microscopist...
@globias.bsky.social
From #GrandTheftAuto to the impact AI is having on #bioimaging.
+the challenges of creating AI courses for bioimage analysis, & his unique perspective as a programmer-turned-biologist.
Stream- bit.ly/microscopist...
@globias.bsky.social
Reposted by Laura Breimann
We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!
register here for the entire series: us06web.zoom.us/webinar/regi...
register here for the entire series: us06web.zoom.us/webinar/regi...
September 1, 2025 at 2:59 PM
We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!
register here for the entire series: us06web.zoom.us/webinar/regi...
register here for the entire series: us06web.zoom.us/webinar/regi...
Reposted by Laura Breimann
If you like transcription regulation and its mechanisms, this WIP list is for you.
I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list.
go.bsky.app/8vTgeXB
I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list.
go.bsky.app/8vTgeXB
August 28, 2025 at 12:48 PM
If you like transcription regulation and its mechanisms, this WIP list is for you.
I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list.
go.bsky.app/8vTgeXB
I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list.
go.bsky.app/8vTgeXB
Reposted by Laura Breimann
Hello! Very excited to share our latest preprint, which is great news for us but terrible news for any diehard fans of PSNR and SSIM as image quality metrics in microscopy... (1/5)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Image quality metrics fail to accurately represent biological information in fluorescence microscopy
Image processing methods offer the potential to improve the quality of fluorescence microscopy data, allowing for image acquisition at lower, less phototoxic illumination doses. The training and evalu...
www.biorxiv.org
August 7, 2025 at 1:00 PM
Hello! Very excited to share our latest preprint, which is great news for us but terrible news for any diehard fans of PSNR and SSIM as image quality metrics in microscopy... (1/5)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Excited that our paper was published in Science Advances 🧪
Great work by first author Merrick Pierson Smela who will carry this work forward in his new start-up!
Great work by first author Merrick Pierson Smela who will carry this work forward in his new start-up!
Wyss researchers have induced human stem cells to initiate meiosis – a key step in creating eggs and sperm – in the lab for the first time. This work was published in @science.org Advances.
Recapitulating egg and sperm development in the dish
By Benjamin Boettner (BOSTON) — More than one-sixth of adults around the world experience infertility in their lifetime. There is a high unmet need not only for increased access to affordable, high-q...
wyss.harvard.edu
August 16, 2025 at 8:35 PM
Excited that our paper was published in Science Advances 🧪
Great work by first author Merrick Pierson Smela who will carry this work forward in his new start-up!
Great work by first author Merrick Pierson Smela who will carry this work forward in his new start-up!
Reposted by Laura Breimann
🚨New preprint from the lab🚨
🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK.
www.biorxiv.org/content/10.1...
🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK.
www.biorxiv.org/content/10.1...
Mechanistic and Epigenetic Partitioning of Lamina-Associated Chromatin Revealed by a Genome-Wide Imaging Screen
The nuclear periphery is a key site for heterochromatin organization in eukaryotic cells, where lamina-associated domains (LADs) promote transcriptional repression and genome stability. Despite their ...
www.biorxiv.org
August 14, 2025 at 7:01 PM
🚨New preprint from the lab🚨
🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK.
www.biorxiv.org/content/10.1...
🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK.
www.biorxiv.org/content/10.1...
Reposted by Laura Breimann
What better way to launch our new account with the publication of @jmstein.bsky.social latest paper from the lab! 🧪 Check out the 🧵 below to learn more about tkPAINT and how we use it to image proteins, DNA, and RNA in the nucleus using DNA-PAINT.
(1/n) DNA-PAINT imaging inside the nucleus at single antibody resolution using TIRF? Ultrathin sectioning makes it happen!
Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org!
doi.org/10.1073/pnas...
👇🧵
Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org!
doi.org/10.1073/pnas...
👇🧵
August 13, 2025 at 6:16 PM
What better way to launch our new account with the publication of @jmstein.bsky.social latest paper from the lab! 🧪 Check out the 🧵 below to learn more about tkPAINT and how we use it to image proteins, DNA, and RNA in the nucleus using DNA-PAINT.
Excited that tkPAINT is finally published! 🔬 Check out the latest version at @pnas.org and see this thread from @jmstein.bsky.social for the overview! Thank you for this fun collaboration! 🤗
(1/n) DNA-PAINT imaging inside the nucleus at single antibody resolution using TIRF? Ultrathin sectioning makes it happen!
Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org!
doi.org/10.1073/pnas...
👇🧵
Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org!
doi.org/10.1073/pnas...
👇🧵
August 13, 2025 at 2:38 PM
Excited that tkPAINT is finally published! 🔬 Check out the latest version at @pnas.org and see this thread from @jmstein.bsky.social for the overview! Thank you for this fun collaboration! 🤗
Reposted by Laura Breimann
Looking for an opportunity to work on cutting super-resolution microscopy and AI? There's still time to apply to the two positions!
Our goal is to develop methods to understand the dynamics of biomolecules, using the latest developments in super-resolution microscopy and AI-based image analysis. Apply here:
www.uni-goettingen.de/de/699491.html
www.uni-goettingen.de/de/699489.html
Feel free to reach out with further questions.
www.uni-goettingen.de/de/699491.html
www.uni-goettingen.de/de/699489.html
Feel free to reach out with further questions.
PhD Position in Artificial Intelligence (AI) for Dynamic Nanoscale Imaging (f/m/x) - Georg-August-Universität Göttingen
Webseiten der Georg-August-Universität Göttingen
www.uni-goettingen.de
July 23, 2025 at 6:36 AM
Looking for an opportunity to work on cutting super-resolution microscopy and AI? There's still time to apply to the two positions!
Reposted by Laura Breimann
(1/n) A simple, ultrastable, and cost-effective oxygen-scavenging system for long-term DNA-PAINT imaging
Please check out our new study on the benefits of sodium sulfite as oxygen scavenging system for DNA-PAINT.
👇🧵
#SuperResolution #DNAPAINT #SMLM #Microscopy
Please check out our new study on the benefits of sodium sulfite as oxygen scavenging system for DNA-PAINT.
👇🧵
#SuperResolution #DNAPAINT #SMLM #Microscopy
July 21, 2025 at 3:46 PM
(1/n) A simple, ultrastable, and cost-effective oxygen-scavenging system for long-term DNA-PAINT imaging
Please check out our new study on the benefits of sodium sulfite as oxygen scavenging system for DNA-PAINT.
👇🧵
#SuperResolution #DNAPAINT #SMLM #Microscopy
Please check out our new study on the benefits of sodium sulfite as oxygen scavenging system for DNA-PAINT.
👇🧵
#SuperResolution #DNAPAINT #SMLM #Microscopy
Reposted by Laura Breimann
This seems like a really important paper comparing chromosome tracing methods, demonstrating that classical denaturing DNA-FISH and chromosome tracing leads to substantial distortion of 3D genome structure, likely due to the high-temperatures involved (70-90C):
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 20, 2025 at 7:39 PM
This seems like a really important paper comparing chromosome tracing methods, demonstrating that classical denaturing DNA-FISH and chromosome tracing leads to substantial distortion of 3D genome structure, likely due to the high-temperatures involved (70-90C):
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Laura Breimann
Do you like developing new AI vision methods for microscopy image analysis? You love theory & implementation? 1 week left to apply for a fully funded PhD position in our lab in Dresden 🇩🇪! Topics: object detection/tracking, multimodal models & more. DM/email for details! #PhD #AcademicJobs #GPUsgoBrr
Vacancy ID 12244
www.verw.tu-dresden.de
July 10, 2025 at 1:49 PM
Do you like developing new AI vision methods for microscopy image analysis? You love theory & implementation? 1 week left to apply for a fully funded PhD position in our lab in Dresden 🇩🇪! Topics: object detection/tracking, multimodal models & more. DM/email for details! #PhD #AcademicJobs #GPUsgoBrr
Reposted by Laura Breimann
Nature Methods is hiring!
We are seeking a new editor with expertise in microscopy, imaging technology, and/or cell biology. The position is available in NYC/Jersey City or Shanghai/Beijing on a hybrid working model.
Apply by August 3!
springernature.wd3.myworkdayjobs.com/SpringerNatu...
We are seeking a new editor with expertise in microscopy, imaging technology, and/or cell biology. The position is available in NYC/Jersey City or Shanghai/Beijing on a hybrid working model.
Apply by August 3!
springernature.wd3.myworkdayjobs.com/SpringerNatu...
a yellow sign that says we 're hiring
ALT: a yellow sign that says we 're hiring
media.tenor.com
July 9, 2025 at 5:58 PM
Nature Methods is hiring!
We are seeking a new editor with expertise in microscopy, imaging technology, and/or cell biology. The position is available in NYC/Jersey City or Shanghai/Beijing on a hybrid working model.
Apply by August 3!
springernature.wd3.myworkdayjobs.com/SpringerNatu...
We are seeking a new editor with expertise in microscopy, imaging technology, and/or cell biology. The position is available in NYC/Jersey City or Shanghai/Beijing on a hybrid working model.
Apply by August 3!
springernature.wd3.myworkdayjobs.com/SpringerNatu...
Reposted by Laura Breimann
How to represent genomes in 3D?
In this paper (and video), we propose Geometric Diagrams of Genomes (GDG)—a visual grammar that aims at emulating the effect ribbon diagrams (Richardson et al 1981) had in protein structural biology. Time will tell.😅
👉🏼 genomebiology.biomedcentral.com/articles/10....
In this paper (and video), we propose Geometric Diagrams of Genomes (GDG)—a visual grammar that aims at emulating the effect ribbon diagrams (Richardson et al 1981) had in protein structural biology. Time will tell.😅
👉🏼 genomebiology.biomedcentral.com/articles/10....
June 27, 2025 at 8:13 AM
How to represent genomes in 3D?
In this paper (and video), we propose Geometric Diagrams of Genomes (GDG)—a visual grammar that aims at emulating the effect ribbon diagrams (Richardson et al 1981) had in protein structural biology. Time will tell.😅
👉🏼 genomebiology.biomedcentral.com/articles/10....
In this paper (and video), we propose Geometric Diagrams of Genomes (GDG)—a visual grammar that aims at emulating the effect ribbon diagrams (Richardson et al 1981) had in protein structural biology. Time will tell.😅
👉🏼 genomebiology.biomedcentral.com/articles/10....
Reposted by Laura Breimann
Our new preprint is out on bioRxiv! We show that restoring rigidity sensing via Tpm2.1 is not enough to trigger anoikis in cancer cells, thanks to compensatory AKT signaling and cell–cell adhesion.
With Anat, Nehal, and in memory of Mike Sheetz. www.biorxiv.org/content/10.1...
With Anat, Nehal, and in memory of Mike Sheetz. www.biorxiv.org/content/10.1...
www.biorxiv.org
June 16, 2025 at 11:50 AM
Our new preprint is out on bioRxiv! We show that restoring rigidity sensing via Tpm2.1 is not enough to trigger anoikis in cancer cells, thanks to compensatory AKT signaling and cell–cell adhesion.
With Anat, Nehal, and in memory of Mike Sheetz. www.biorxiv.org/content/10.1...
With Anat, Nehal, and in memory of Mike Sheetz. www.biorxiv.org/content/10.1...
I can’t take credit for this alone, but still a special moment ✨
June 13, 2025 at 10:26 PM
I can’t take credit for this alone, but still a special moment ✨
Reposted by Laura Breimann
Come and work with us!
Super exciting and relevant projects!
Become an #AI pro and do something positive for the 🌍!
👩🎓 🧑🎓
If you know someone who might be interested… please repost and/or forward this! 🙏
Super exciting and relevant projects!
Become an #AI pro and do something positive for the 🌍!
👩🎓 🧑🎓
If you know someone who might be interested… please repost and/or forward this! 🙏
🚀 Fully-funded #PhD opportunity in Computational Biology with our @florianjug.bsky.social Group through Politecnico of Milan DADS programme! Co-supervision by Francesca Ieva.
🧬 Use #AI to decode complex biological data across scales.
Apply by 9 July 👉 humantechnopole.it/en/news/1-fu...
🧬 Use #AI to decode complex biological data across scales.
Apply by 9 July 👉 humantechnopole.it/en/news/1-fu...
June 9, 2025 at 7:51 AM
Come and work with us!
Super exciting and relevant projects!
Become an #AI pro and do something positive for the 🌍!
👩🎓 🧑🎓
If you know someone who might be interested… please repost and/or forward this! 🙏
Super exciting and relevant projects!
Become an #AI pro and do something positive for the 🌍!
👩🎓 🧑🎓
If you know someone who might be interested… please repost and/or forward this! 🙏
Reposted by Laura Breimann
🚨 New #preprint alert!
We're excited to share our latest work:
"Single-Allele Chromatin Tracing Reveals Genomic Clustering of Paralogous Transcription Factors as a Mechanism for Developmental Robustness in T Cells"🔗 tinyurl.com/4ve26tbd
We're excited to share our latest work:
"Single-Allele Chromatin Tracing Reveals Genomic Clustering of Paralogous Transcription Factors as a Mechanism for Developmental Robustness in T Cells"🔗 tinyurl.com/4ve26tbd
June 2, 2025 at 8:33 PM
🚨 New #preprint alert!
We're excited to share our latest work:
"Single-Allele Chromatin Tracing Reveals Genomic Clustering of Paralogous Transcription Factors as a Mechanism for Developmental Robustness in T Cells"🔗 tinyurl.com/4ve26tbd
We're excited to share our latest work:
"Single-Allele Chromatin Tracing Reveals Genomic Clustering of Paralogous Transcription Factors as a Mechanism for Developmental Robustness in T Cells"🔗 tinyurl.com/4ve26tbd
Reposted by Laura Breimann
Are you looking to advance your bioimage analysis skills? Then don't miss the deadline for #EMBOBioImage 🔬✨
📩 Apply by 4 June
➡️ https://s.embl.org/bia25-01-bl
🗓️ 14 – 19 September
📍 EMBL Heidelberg and Virtual
📩 Apply by 4 June
➡️ https://s.embl.org/bia25-01-bl
🗓️ 14 – 19 September
📍 EMBL Heidelberg and Virtual
May 21, 2025 at 12:11 PM
Are you looking to advance your bioimage analysis skills? Then don't miss the deadline for #EMBOBioImage 🔬✨
📩 Apply by 4 June
➡️ https://s.embl.org/bia25-01-bl
🗓️ 14 – 19 September
📍 EMBL Heidelberg and Virtual
📩 Apply by 4 June
➡️ https://s.embl.org/bia25-01-bl
🗓️ 14 – 19 September
📍 EMBL Heidelberg and Virtual
Reposted by Laura Breimann
Extensive differences observed in 3D genome structure between homologous heterozygous chromosomes revealed by Genome Architecture Mapping #GAM in the @apombo1.bsky.social lab ➡️ www.embopress.org/doi/full/10....
May 15, 2025 at 5:32 PM
Extensive differences observed in 3D genome structure between homologous heterozygous chromosomes revealed by Genome Architecture Mapping #GAM in the @apombo1.bsky.social lab ➡️ www.embopress.org/doi/full/10....
I am excited to be one of this year's Leadership Academy fellows #LSA9! I am looking forward to meeting the other fellows and learning about the program. It is also a great time to visit Germany 🇩🇪 and see which opportunities exist for my research and me!
#Leadership isn’t a buzzword. It’s a #responsibility.
Our GSO Leadership Academy 9 brings together 25 researchers from 10 countries to rethink what leadership in science means - and how it can strengthen institutions, communities, and futures. #LSA9 #GSOLA
1. phase in Berlin - starting in July!
Our GSO Leadership Academy 9 brings together 25 researchers from 10 countries to rethink what leadership in science means - and how it can strengthen institutions, communities, and futures. #LSA9 #GSOLA
1. phase in Berlin - starting in July!
May 22, 2025 at 2:06 PM
I am excited to be one of this year's Leadership Academy fellows #LSA9! I am looking forward to meeting the other fellows and learning about the program. It is also a great time to visit Germany 🇩🇪 and see which opportunities exist for my research and me!