Dan Landau
@landau.bsky.social
Oncologist-scientist at Weill Cornell and New York genome center. Into somatic evolution, trees and words
Shout out to Tamara Prieto, Dennis Yuan, John Zinno and @ivanraimondi.bsky.social . Thank you to our funders at @themarkfdn.bsky.social
October 14, 2025 at 2:37 PM
Shout out to Tamara Prieto, Dennis Yuan, John Zinno and @ivanraimondi.bsky.social . Thank you to our funders at @themarkfdn.bsky.social
Highlights:
- Immune cell clonal expansion & migration
- Mutational signatures change through life
- Driver acquisition, growth dynamics and impact on phenotype to enhance fitness
- CNVs in normal esophagus
- Massive selection of chr9q cnLOH with convergent acquisition multiple times through life
- Immune cell clonal expansion & migration
- Mutational signatures change through life
- Driver acquisition, growth dynamics and impact on phenotype to enhance fitness
- CNVs in normal esophagus
- Massive selection of chr9q cnLOH with convergent acquisition multiple times through life
October 14, 2025 at 2:37 PM
Highlights:
- Immune cell clonal expansion & migration
- Mutational signatures change through life
- Driver acquisition, growth dynamics and impact on phenotype to enhance fitness
- CNVs in normal esophagus
- Massive selection of chr9q cnLOH with convergent acquisition multiple times through life
- Immune cell clonal expansion & migration
- Mutational signatures change through life
- Driver acquisition, growth dynamics and impact on phenotype to enhance fitness
- CNVs in normal esophagus
- Massive selection of chr9q cnLOH with convergent acquisition multiple times through life
Reposted by Dan Landau
If you want to deep dive in to immunology you could do worse than Gabriel's evolutionary landscaping
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Replaying germinal center evolution on a quantified affinity landscape
Darwinian evolution of immunoglobulin genes within germinal centers (GC) underlies the progressive increase in antibody affinity following antigen exposure. Whereas the mechanics of how competition be...
www.biorxiv.org
September 27, 2025 at 1:41 PM
If you want to deep dive in to immunology you could do worse than Gabriel's evolutionary landscaping
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...