Sarah Lambert's Lab
@lambertsarahlab.bsky.social
Our team investigates the mechanisms ensuring genome maintenance in response to DNA insults and DNA replication failures.
Reposted by Sarah Lambert's Lab
How do new centromeres evolve while staying compatible with the division machinery?
Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore.
👉 doi.org/10.1038/s41586-025-09779-1
Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore.
👉 doi.org/10.1038/s41586-025-09779-1
November 26, 2025 at 4:21 PM
How do new centromeres evolve while staying compatible with the division machinery?
Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore.
👉 doi.org/10.1038/s41586-025-09779-1
Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore.
👉 doi.org/10.1038/s41586-025-09779-1
Reposted by Sarah Lambert's Lab
Join us next Tuesday, December 2 at 5pm (Rome) / 11am (NYC) for an exciting GIIN webinar featuring @peterlylab.bsky.social and @alebrambati.bsky.social!
Zoom link: uniroma1.zoom.us/j/95149984403
Register here to become part of our community: docs.google.com/forms/d/e/1F...
Zoom link: uniroma1.zoom.us/j/95149984403
Register here to become part of our community: docs.google.com/forms/d/e/1F...
November 27, 2025 at 12:16 AM
Join us next Tuesday, December 2 at 5pm (Rome) / 11am (NYC) for an exciting GIIN webinar featuring @peterlylab.bsky.social and @alebrambati.bsky.social!
Zoom link: uniroma1.zoom.us/j/95149984403
Register here to become part of our community: docs.google.com/forms/d/e/1F...
Zoom link: uniroma1.zoom.us/j/95149984403
Register here to become part of our community: docs.google.com/forms/d/e/1F...
Reposted by Sarah Lambert's Lab
👏 Félicitations au Dr Enzo Poirier, chargé de recherche @inserm.fr et chef d'équipe à l’Institut Curie qui a reçu le prix de la Fondation Joannidès de l'@academiesciences.bsky.social, saluant ses travaux de recherche sur l'immunité innée.
November 26, 2025 at 4:21 PM
👏 Félicitations au Dr Enzo Poirier, chargé de recherche @inserm.fr et chef d'équipe à l’Institut Curie qui a reçu le prix de la Fondation Joannidès de l'@academiesciences.bsky.social, saluant ses travaux de recherche sur l'immunité innée.
Reposted by Sarah Lambert's Lab
👏 Félicitations au Dr Gudrun Schleiermacher, pédiatre oncologue à l’Institut Curie distinguée par l'@academiesciences.bsky.social par la médaille de Biologie humaine et sciences médicales pour ses travaux sur les mécanismes moléculaires des cancers pédiatriques et leur résistance aux traitements.
November 26, 2025 at 4:21 PM
👏 Félicitations au Dr Gudrun Schleiermacher, pédiatre oncologue à l’Institut Curie distinguée par l'@academiesciences.bsky.social par la médaille de Biologie humaine et sciences médicales pour ses travaux sur les mécanismes moléculaires des cancers pédiatriques et leur résistance aux traitements.
Reposted by Sarah Lambert's Lab
One name appears on an award, but it truly reflects the collective effort of an exceptionally talented team. All credit to @radoncdocgee.bsky.social, @szmyd-radoslaw.bsky.social, @drmelaniew.bsky.social, @annagmanjon.bsky.social, Lucy French, Sienna Casolin, Scott Page, & our awesome collaborators.
Huge congratulations to Professor Tony Cesare, winner of the University of Sydney’s 2025 Makers and Shapers Award for Outstanding Research. @sydney.edu.au @thecesarelab.bsky.social
November 27, 2025 at 5:41 AM
One name appears on an award, but it truly reflects the collective effort of an exceptionally talented team. All credit to @radoncdocgee.bsky.social, @szmyd-radoslaw.bsky.social, @drmelaniew.bsky.social, @annagmanjon.bsky.social, Lucy French, Sienna Casolin, Scott Page, & our awesome collaborators.
Reposted by Sarah Lambert's Lab
We are recruiting a postdoctoral fellow to study mechanisms of DNA replication stress using single-molecule imaging tools. If you are excited about microscopy, replisome dynamics, and genome stability, we’d love to hear from you.
Application deadline: 24 December
www.crick.ac.uk/careers-stud...
Application deadline: 24 December
www.crick.ac.uk/careers-stud...
Postdoctoral Fellow - H Yardimci Lab
www.crick.ac.uk
November 25, 2025 at 11:55 AM
We are recruiting a postdoctoral fellow to study mechanisms of DNA replication stress using single-molecule imaging tools. If you are excited about microscopy, replisome dynamics, and genome stability, we’d love to hear from you.
Application deadline: 24 December
www.crick.ac.uk/careers-stud...
Application deadline: 24 December
www.crick.ac.uk/careers-stud...
Reposted by Sarah Lambert's Lab
New study from the lab on genetic relationship between 53BP1-RIF1 and DNA-PKcs on DSB repair outcomes. Led by PhD student @kaelamakins.bsky.social www.nature.com/articles/s41...
53BP1-RIF1 and DNA-PKcs show distinct genetic interactions with diverse chromosomal break repair outcomes - Nature Communications
DNA double strand breaks can be repaired by several pathways leading to different genetic outcomes. Here, the authors define the interplay between the DNA damage response factors 53BP1-RIF1 and core n...
www.nature.com
November 24, 2025 at 6:10 PM
New study from the lab on genetic relationship between 53BP1-RIF1 and DNA-PKcs on DSB repair outcomes. Led by PhD student @kaelamakins.bsky.social www.nature.com/articles/s41...
Reposted by Sarah Lambert's Lab
Very excited and honored that our project CenAGE with @manellab.bsky.social and Elsa Logarinho was granted! Looking forward to discover how centromere instability affects the immune cells contributing to systemic ageing. More Info here: curie.fr/actualite/no... Open positions soon, stay tuned!
November 6, 2025 at 8:59 PM
Very excited and honored that our project CenAGE with @manellab.bsky.social and Elsa Logarinho was granted! Looking forward to discover how centromere instability affects the immune cells contributing to systemic ageing. More Info here: curie.fr/actualite/no... Open positions soon, stay tuned!
Reposted by Sarah Lambert's Lab
The 21st Course on Epigenetics which will take place from March 25th to April 1st, 2026 at the Institut Curie (Paris).
The Course is open to M2 and PhD students. Application via the Advanced Training Office website before December 15th, 2025 at:
minilien.curie.fr/3avv47
The Course is open to M2 and PhD students. Application via the Advanced Training Office website before December 15th, 2025 at:
minilien.curie.fr/3avv47
Epigenetics - 21st Course on Epigenetics 2026: Towards a quantitative understanding of nuclear dynamics during development and diseases | Institut Curie Advanced Training
The aim of this course is to provide an overview of epigenetic mechanisms and their links to gene expression and chromatin dynamics, in different systems. The diverse functions of the nucleus involvin...
minilien.curie.fr
November 12, 2025 at 10:58 AM
The 21st Course on Epigenetics which will take place from March 25th to April 1st, 2026 at the Institut Curie (Paris).
The Course is open to M2 and PhD students. Application via the Advanced Training Office website before December 15th, 2025 at:
minilien.curie.fr/3avv47
The Course is open to M2 and PhD students. Application via the Advanced Training Office website before December 15th, 2025 at:
minilien.curie.fr/3avv47
Reposted by Sarah Lambert's Lab
Happy to share the “International Symposium on Chromosome Dynamics: from Structure to Cellular Function” that will be held in Japan 31st of May 2026 www.fbs.osaka-u.ac.jp/labs/fukagaw.... Registrations will open on December 1st! Plenty of opportunities to present your work! Hope to seeing you
International Symposium on Chromosome Dynamics from Structure to Cellular Function
www.fbs.osaka-u.ac.jp
November 21, 2025 at 6:33 PM
Happy to share the “International Symposium on Chromosome Dynamics: from Structure to Cellular Function” that will be held in Japan 31st of May 2026 www.fbs.osaka-u.ac.jp/labs/fukagaw.... Registrations will open on December 1st! Plenty of opportunities to present your work! Hope to seeing you
Reposted by Sarah Lambert's Lab
Exciting opportunity: we are hiring a postdoctoral fellow for a fully funded 2-year position!
November 14, 2025 at 4:03 PM
Exciting opportunity: we are hiring a postdoctoral fellow for a fully funded 2-year position!
Reposted by Sarah Lambert's Lab
New research from Valerie Garcia and colleagues:
Tel1 is recruited at chromosomal loop/axis contact sites to modulate meiotic DNA double-strand breaks interference
journals.plos.org/plosgenetics...
Tel1 is recruited at chromosomal loop/axis contact sites to modulate meiotic DNA double-strand breaks interference
journals.plos.org/plosgenetics...
November 22, 2025 at 5:03 PM
New research from Valerie Garcia and colleagues:
Tel1 is recruited at chromosomal loop/axis contact sites to modulate meiotic DNA double-strand breaks interference
journals.plos.org/plosgenetics...
Tel1 is recruited at chromosomal loop/axis contact sites to modulate meiotic DNA double-strand breaks interference
journals.plos.org/plosgenetics...
Reposted by Sarah Lambert's Lab
Our paper is out in @nature.com! Oncogenes are often copy-number amplified on extrachromosomal DNA (ecDNA) in cancer, but how is ecDNA inherited by dividing cells? Here we identified elements within ecDNA that promote its retention in dividing cells. 1/11
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Genetic elements promote retention of extrachromosomal DNA in cancer cells - Nature
A combination of genome-wide functional screening, imaging and chromatin profiling identifies a new class of highly prevalent genomic elements that help retain extrachromosomal DNA copies in dividing ...
www.nature.com
November 19, 2025 at 7:03 PM
Our paper is out in @nature.com! Oncogenes are often copy-number amplified on extrachromosomal DNA (ecDNA) in cancer, but how is ecDNA inherited by dividing cells? Here we identified elements within ecDNA that promote its retention in dividing cells. 1/11
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Sarah Lambert's Lab
Brand new preprint from my lab, showing that TnpB, the ancestor of Cas12, acts as a gene drive in plasmids! And it turns out in conjugative plasmids that it acts as a primitive anti-self defense system, providing a potential link between its transposon effect and becoming CRISPR!
What is the best strategy to win any contest?
Eliminate your opponents of course.
Recently, my friend @fernpizza.bsky.social showed how plasmids compete intracellularly (check out his paper published in Science today!). With @baym.lol, we now know they can fight.
www.biorxiv.org/content/10.1...
Eliminate your opponents of course.
Recently, my friend @fernpizza.bsky.social showed how plasmids compete intracellularly (check out his paper published in Science today!). With @baym.lol, we now know they can fight.
www.biorxiv.org/content/10.1...
November 20, 2025 at 10:17 PM
Brand new preprint from my lab, showing that TnpB, the ancestor of Cas12, acts as a gene drive in plasmids! And it turns out in conjugative plasmids that it acts as a primitive anti-self defense system, providing a potential link between its transposon effect and becoming CRISPR!
Reposted by Sarah Lambert's Lab
20 years already… It is true it looks like long ago when we started populating those empty rooms… and making the first agar plates look as normal ones…
In 2026 we are celebrating the 20th anniversary of our institute with, among others, and International Workshop "From Fundamental Mechanisms to Disease" with a top-level list of speakers. Please join us!!!
Registration open until January 31st 2026 at www.cabimer.es/workshop/
Registration open until January 31st 2026 at www.cabimer.es/workshop/
November 18, 2025 at 9:30 PM
20 years already… It is true it looks like long ago when we started populating those empty rooms… and making the first agar plates look as normal ones…
Reposted by Sarah Lambert's Lab
POSTDOCTORAL POSITION IN STRUCTURAL BIOLOGY
We need a structural biologist to work on several CryoEM datasets. For more information, please visit: www.antonylab.org
Expertise in structure refinement and model-building are required.
Please share.
We need a structural biologist to work on several CryoEM datasets. For more information, please visit: www.antonylab.org
Expertise in structure refinement and model-building are required.
Please share.
ANTONY LAB SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE
Edwin Antony Lab Website
www.antonylab.org
November 18, 2025 at 7:05 PM
POSTDOCTORAL POSITION IN STRUCTURAL BIOLOGY
We need a structural biologist to work on several CryoEM datasets. For more information, please visit: www.antonylab.org
Expertise in structure refinement and model-building are required.
Please share.
We need a structural biologist to work on several CryoEM datasets. For more information, please visit: www.antonylab.org
Expertise in structure refinement and model-building are required.
Please share.
Reposted by Sarah Lambert's Lab
Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...
November 18, 2025 at 10:18 AM
Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...
Reposted by Sarah Lambert's Lab
Why LLPS Scaffolds Cannot Exist – A Thermodynamic Thread
If you consider arguments logical, please share. Else please expose logical faults
🧵👇
If you consider arguments logical, please share. Else please expose logical faults
🧵👇
November 19, 2025 at 5:48 AM
Why LLPS Scaffolds Cannot Exist – A Thermodynamic Thread
If you consider arguments logical, please share. Else please expose logical faults
🧵👇
If you consider arguments logical, please share. Else please expose logical faults
🧵👇
Reposted by Sarah Lambert's Lab
Back home after a truly inspiring trip where I had the honor to present at the Asian meeting on radiobiology at Hiroshima and at the VII Farm-DNA in São Paulo! Had the chance to connect with amazing scientists, old and new friends! Thanks so much to the organizers for these wonderful opportunities!
November 18, 2025 at 8:22 AM
Back home after a truly inspiring trip where I had the honor to present at the Asian meeting on radiobiology at Hiroshima and at the VII Farm-DNA in São Paulo! Had the chance to connect with amazing scientists, old and new friends! Thanks so much to the organizers for these wonderful opportunities!
Reposted by Sarah Lambert's Lab
I'd also like to highlight a recent publication by @audeber.bsky.social, @enzopoirier.bsky.social, and colleagues showing FAM118B, which they term "SIRal", is essential for innate immune response in mammalian cellular models; they also have great phylogenetic analysis and insights into biochemistry.
A human homolog of SIR2 antiphage proteins mediates immunity via the Toll-like receptor pathway
Key actors of mammalian immunity originated from bacterial antiphage systems. The full extent of immune system conservation between bacteria and eukaryotes is unknown. Here, we show that the silent in...
www.science.org
November 17, 2025 at 2:16 PM
I'd also like to highlight a recent publication by @audeber.bsky.social, @enzopoirier.bsky.social, and colleagues showing FAM118B, which they term "SIRal", is essential for innate immune response in mammalian cellular models; they also have great phylogenetic analysis and insights into biochemistry.
Reposted by Sarah Lambert's Lab
Very happy to share our collaborative project on FAM118 proteins - noncanonical sirtuins that form filaments and process NAD in human and other vertebrate cells.
Filament formation and NAD processing by noncanonical human FAM118 sirtuins
Nature Structural & Molecular Biology - Baretić and Missoury et al. identify vertebrate proteins FAM118B and FAM118A as sirtuins similar to bacterial antiphage enzymes and show that...
rdcu.be
November 17, 2025 at 11:37 AM
Very happy to share our collaborative project on FAM118 proteins - noncanonical sirtuins that form filaments and process NAD in human and other vertebrate cells.
Reposted by Sarah Lambert's Lab
📣 Discovery of a cellular resistance mechanism at the origin of relapses of triple-negative breast cancer: an essential step on the path towards more preventive medicine that is able to anticipate and avoid relapses.
▶️ institut-curie.org/news/relapse...
▶️ institut-curie.org/news/relapse...
November 12, 2025 at 11:00 AM
📣 Discovery of a cellular resistance mechanism at the origin of relapses of triple-negative breast cancer: an essential step on the path towards more preventive medicine that is able to anticipate and avoid relapses.
▶️ institut-curie.org/news/relapse...
▶️ institut-curie.org/news/relapse...
Reposted by Sarah Lambert's Lab
Come and join us here in Cambridge! Applications open for a new faculty position, for a researcher in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Happy to answer questions about research, teaching and working here.
www.cam.ac.uk/jobs/faculty...
www.cam.ac.uk/jobs/faculty...
Faculty Position in Computational Biology
Applications are invited for an Assistant/ Associate Professorship in Computational Biology to commence on 1 April 2026 or shortly thereafter. This is a joint post between the Department of Applied
www.cam.ac.uk
November 11, 2025 at 9:05 PM
Come and join us here in Cambridge! Applications open for a new faculty position, for a researcher in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Happy to answer questions about research, teaching and working here.
www.cam.ac.uk/jobs/faculty...
www.cam.ac.uk/jobs/faculty...
Reposted by Sarah Lambert's Lab
📢 Don't miss @groth-anja.bsky.social from the Danish Cancer Institute, who will present her research at the #Embryo2026 🧬
"How cells copy their epigenome"
Register until Oct 31! 👇
www.molgen.mpg.de/embryo2026
Supported by the Weizmann Institute of Science
"How cells copy their epigenome"
Register until Oct 31! 👇
www.molgen.mpg.de/embryo2026
Supported by the Weizmann Institute of Science
October 29, 2025 at 12:22 PM
📢 Don't miss @groth-anja.bsky.social from the Danish Cancer Institute, who will present her research at the #Embryo2026 🧬
"How cells copy their epigenome"
Register until Oct 31! 👇
www.molgen.mpg.de/embryo2026
Supported by the Weizmann Institute of Science
"How cells copy their epigenome"
Register until Oct 31! 👇
www.molgen.mpg.de/embryo2026
Supported by the Weizmann Institute of Science
Reposted by Sarah Lambert's Lab
Chromatin fatigue: DNA repair alters the chromatin environment and introduces heritable variation in gene expression in a larger region around the lesion! Amazing achievement by @sbantele.bsky.social and Jiri Lukas published in @science.org 🙌 Happy we could contribute. See 👇
𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n
Repair of DNA double-strand breaks leaves heritable impairment to genome function
Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...
tinyurl.com
November 12, 2025 at 3:55 AM
Chromatin fatigue: DNA repair alters the chromatin environment and introduces heritable variation in gene expression in a larger region around the lesion! Amazing achievement by @sbantele.bsky.social and Jiri Lukas published in @science.org 🙌 Happy we could contribute. See 👇