Mickey Kosloff
@koslofflab.bsky.social
Signal transduction, protein structures, biochemistry/biophysics, computational biology, G proteins rule!
Reposted by Mickey Kosloff
🚨NEW PUBLICATION ALERT🚨: In a paper out now in
@science.org we describe a way to build synthetic phosphorylation circuits with customizable sense-and-response functions in human cells. Check it out at science.org/doi/10.1126/....
@science.org we describe a way to build synthetic phosphorylation circuits with customizable sense-and-response functions in human cells. Check it out at science.org/doi/10.1126/....
Engineering synthetic phosphorylation signaling networks in human cells
Protein phosphorylation signaling networks have a central role in how cells sense and respond to their environment. We engineered artificial phosphorylation networks in which reversible enzymatic phos...
science.org
January 7, 2025 at 8:24 AM
🚨NEW PUBLICATION ALERT🚨: In a paper out now in
@science.org we describe a way to build synthetic phosphorylation circuits with customizable sense-and-response functions in human cells. Check it out at science.org/doi/10.1126/....
@science.org we describe a way to build synthetic phosphorylation circuits with customizable sense-and-response functions in human cells. Check it out at science.org/doi/10.1126/....
At the ICRP2024 meeting, quite the impressive venue and cool science in Interlaken, Switzerland
indico.psi.ch/event/15612/
indico.psi.ch/event/15612/
November 20, 2024 at 9:06 AM
At the ICRP2024 meeting, quite the impressive venue and cool science in Interlaken, Switzerland
indico.psi.ch/event/15612/
indico.psi.ch/event/15612/
Reposted by Mickey Kosloff
The AF3 code is (finally) up - should have been 6 months ago - but better late than never!
www.science.org/content/arti...
www.science.org/content/arti...
Google DeepMind releases code behind its most advanced protein prediction program
Six months after backlash, AI company fulfills pledge to make AlphaFold3’s full computer model available for noncommercial use
www.science.org
November 11, 2024 at 1:23 PM
The AF3 code is (finally) up - should have been 6 months ago - but better late than never!
www.science.org/content/arti...
www.science.org/content/arti...
Reposted by Mickey Kosloff
Preparing for a brand new biochemistry course for 1st year bioinformatics BSc students 🧬 🖥️
They will learn bioinformatics in a world were massive and easily accessible sequence databases is the norm, but should still learn about the work by Margaret Dayhoff
www.smithsonianmag.com/science-natu...
They will learn bioinformatics in a world were massive and easily accessible sequence databases is the norm, but should still learn about the work by Margaret Dayhoff
www.smithsonianmag.com/science-natu...
How Margaret Dayhoff Brought Modern Computing to Biology
The pioneer of bioinformatics modeled Earth’s primordial atmosphere with Carl Sagan and made a vast protein database still used today
www.smithsonianmag.com
November 13, 2024 at 11:28 PM
Preparing for a brand new biochemistry course for 1st year bioinformatics BSc students 🧬 🖥️
They will learn bioinformatics in a world were massive and easily accessible sequence databases is the norm, but should still learn about the work by Margaret Dayhoff
www.smithsonianmag.com/science-natu...
They will learn bioinformatics in a world were massive and easily accessible sequence databases is the norm, but should still learn about the work by Margaret Dayhoff
www.smithsonianmag.com/science-natu...
Reposted by Mickey Kosloff
CASP16 will start later this year, so to celebrate that here is a short thread on the uncanny valley separating experimental structures & computational models of proteins. Even though the latter are extremely accurate, there are still some weird differences that are hard to pin down. 🧪🧶🧬🧵
January 3, 2024 at 9:47 AM
CASP16 will start later this year, so to celebrate that here is a short thread on the uncanny valley separating experimental structures & computational models of proteins. Even though the latter are extremely accurate, there are still some weird differences that are hard to pin down. 🧪🧶🧬🧵