Kavitha Scranton
@kavithascranton.bsky.social
Senior Scientific Editor at Immunity, Cell Press @cp-immunity.bsky.social; fan of science (especially immunology), space, & nature; views are my own
https://www.cell.com/immunity/home
https://www.cell.com/immunity/home
Reposted by Kavitha Scranton
We are #absolutely #thrilled to #present @cp-immunity.bsky.social - Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils: Immunity www.cell.com/immunity/ful...
Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils
Human T cell responses are often studied using blood, yet most T cells reside in tissues.
By comparing T cell receptor repertoires from millions of T cells from autologous
tonsils and blood, Sureshcha...
www.cell.com
November 26, 2025 at 3:47 PM
We are #absolutely #thrilled to #present @cp-immunity.bsky.social - Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils: Immunity www.cell.com/immunity/ful...
Reposted by Kavitha Scranton
Immunity is now on LinkedIn! Follow us if you love #immunology! And if you don't already love immunology, maybe we'll change your mind 😀https://www.linkedin.com/company/immunity-cellpress
Immunity by Cell Press | LinkedIn
Immunity by Cell Press | 45 followers on LinkedIn. Cutting-edge research in immunology from around the world, and commentaries by thought leaders. | Immunity publishes the most important advances in i...
www.linkedin.com
November 21, 2025 at 8:22 PM
Immunity is now on LinkedIn! Follow us if you love #immunology! And if you don't already love immunology, maybe we'll change your mind 😀https://www.linkedin.com/company/immunity-cellpress
Reposted by Kavitha Scranton
Our new paper reveals that chronic active MS lesions feature CD8⁺ T cell niches with lipid-laden, inflamed microglia. IFN-γ drives cholesterol buildup, linking dysregulated lipid metabolism to inflammation and meurodeg.
Check it out @cp-immunity.bsky.social
www.sciencedirect.com/science/arti...
Check it out @cp-immunity.bsky.social
www.sciencedirect.com/science/arti...
Single-cell spatial transcriptomic profiling defines a pathogenic inflammatory niche in chronic active multiple sclerosis lesions
Compartmentalized inflammation is a key driver of multiple sclerosis (MS) progression, but the mechanisms sustaining its persistence remain unclear. A…
www.sciencedirect.com
November 6, 2025 at 6:38 AM
Our new paper reveals that chronic active MS lesions feature CD8⁺ T cell niches with lipid-laden, inflamed microglia. IFN-γ drives cholesterol buildup, linking dysregulated lipid metabolism to inflammation and meurodeg.
Check it out @cp-immunity.bsky.social
www.sciencedirect.com/science/arti...
Check it out @cp-immunity.bsky.social
www.sciencedirect.com/science/arti...
Reposted by Kavitha Scranton
How is the persistence of compartmentalized inflammation sustained in MS?
Our new study in
@cp-immunity.bsky.social
offers some hints.
cell.com/immunity/ful...
Thanks and congratulations to all contributors
Our new study in
@cp-immunity.bsky.social
offers some hints.
cell.com/immunity/ful...
Thanks and congratulations to all contributors
October 29, 2025 at 3:01 PM
How is the persistence of compartmentalized inflammation sustained in MS?
Our new study in
@cp-immunity.bsky.social
offers some hints.
cell.com/immunity/ful...
Thanks and congratulations to all contributors
Our new study in
@cp-immunity.bsky.social
offers some hints.
cell.com/immunity/ful...
Thanks and congratulations to all contributors
For those of you joining us for the editors panel at #RTN2025, please bring your questions! We have more editors than I've ever seen at a single meeting, so this is your chance to get answers to all of your burning questions! @genelayinstitute.bsky.social @rtnconference.bsky.social
October 15, 2025 at 1:30 PM
For those of you joining us for the editors panel at #RTN2025, please bring your questions! We have more editors than I've ever seen at a single meeting, so this is your chance to get answers to all of your burning questions! @genelayinstitute.bsky.social @rtnconference.bsky.social
Looking forward to #RTN2025 today! Excited for some #neuroimmunology! If you'll be there, please look for me and say hello! @genelayinstitute.bsky.social @rtnconference.bsky.social
genelayinstitute.org/rtn/#program
genelayinstitute.org/rtn/#program
October 14, 2025 at 2:25 PM
Looking forward to #RTN2025 today! Excited for some #neuroimmunology! If you'll be there, please look for me and say hello! @genelayinstitute.bsky.social @rtnconference.bsky.social
genelayinstitute.org/rtn/#program
genelayinstitute.org/rtn/#program
#CSNeuroimmune25 @danmucida.bsky.social
talking about food allergy and neuroimmune response to helminth infection @cp-neuron.bsky.social
talking about food allergy and neuroimmune response to helminth infection @cp-neuron.bsky.social
September 8, 2025 at 7:02 PM
#CSNeuroimmune25 @danmucida.bsky.social
talking about food allergy and neuroimmune response to helminth infection @cp-neuron.bsky.social
talking about food allergy and neuroimmune response to helminth infection @cp-neuron.bsky.social
Reposted by Kavitha Scranton
#CSNeuroimmune25 Come learn about a novel neuro immune niche that underpins touch! Littleton Tues P2.38 13:00-14:30 youtu.be/BAtzNKj4wxA?si…
Supplemental Video 2_Littleton et al_2025
YouTube video by Daniel R. Saban
https://youtu.be/BAtzNKj4wxA?si…
September 7, 2025 at 7:43 PM
#CSNeuroimmune25 Come learn about a novel neuro immune niche that underpins touch! Littleton Tues P2.38 13:00-14:30 youtu.be/BAtzNKj4wxA?si…
Getting ready for #CSNeuroimmune25 tomorrow in NYC! Excited to see everyone, and looking forward to some cool #neuroimmunology! @cp-neuron.bsky.social @cp-immunity.bsky.social www.cell-symposia.com/neuroimmunol...
September 6, 2025 at 11:40 PM
Getting ready for #CSNeuroimmune25 tomorrow in NYC! Excited to see everyone, and looking forward to some cool #neuroimmunology! @cp-neuron.bsky.social @cp-immunity.bsky.social www.cell-symposia.com/neuroimmunol...
Reposted by Kavitha Scranton
Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @cp-immunity.bsky.social! ➡️ www.cell.com/immunity/ful...
Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease
Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains
is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets
and lose their phagocytic cap...
www.cell.com
May 19, 2025 at 6:14 PM
Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @cp-immunity.bsky.social! ➡️ www.cell.com/immunity/ful...
Reposted by Kavitha Scranton
It was a privilege and a pleasure for both myself and @menezesnmaria.bsky.social to preview a great upcoming article in @cp-immunity.bsky.social by @kamphorstlab.bsky.social showing an unexpected inhibitory role for ICOS in exhausted CD8+ T cells.
www.cell.com/immunity/abs...
www.cell.com/immunity/abs...
The high (I)COSt of costimulation for exhausted T cells
ICOS agonists are being investigated for cancer immunotherapy based on the idea that
they will reinvigorate exhausted CD8+ T cell anti-cancer immunity. Humblin et al.
unexpectedly find the opposite—th...
www.cell.com
August 13, 2025 at 11:33 AM
It was a privilege and a pleasure for both myself and @menezesnmaria.bsky.social to preview a great upcoming article in @cp-immunity.bsky.social by @kamphorstlab.bsky.social showing an unexpected inhibitory role for ICOS in exhausted CD8+ T cells.
www.cell.com/immunity/abs...
www.cell.com/immunity/abs...
Reposted by Kavitha Scranton
Thanks to Dr. Pinho-Ribeiro for previewing our latest work in the current issue of Immunity. @cp-immunity.bsky.social @kavithascranton.bsky.social
Neural tuners of lung immunity: Immunity cell.com/immunity/ful...
cell.com/immunity/ful...
Neural tuners of lung immunity: Immunity cell.com/immunity/ful...
cell.com/immunity/ful...
Neural tuners of lung immunity
Pulmonary immunity must strike a precise balance between protecting the delicate mucosal
tissue from environmental threats and preserving its vital gas-exchange function.
In this issue of Immunity, Li...
cell.com
August 12, 2025 at 3:48 PM
Thanks to Dr. Pinho-Ribeiro for previewing our latest work in the current issue of Immunity. @cp-immunity.bsky.social @kavithascranton.bsky.social
Neural tuners of lung immunity: Immunity cell.com/immunity/ful...
cell.com/immunity/ful...
Neural tuners of lung immunity: Immunity cell.com/immunity/ful...
cell.com/immunity/ful...
Reposted by Kavitha Scranton
#EpigeneticPower! 💥 #NewPaperAlert! We show @cp-immunity.bsky.social that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2 & blocking #IL10!
Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections
Upon pathogen detection, phagocytes trigger immunity. This process induces tissue
stress and the formation of host-derived molecules that further tune immune responses.
We show that host-derived oxidi...
dlvr.it
July 17, 2025 at 3:35 PM
#EpigeneticPower! 💥 #NewPaperAlert! We show @cp-immunity.bsky.social that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2 & blocking #IL10!
Reposted by Kavitha Scranton
A new function for an ancient innate immune stimulus.
Zanoni et al report that oxidized lipids control IL-10 expression, impacting host defense and disease. Kudos to the authors on this important discovery www.sciencedirect.com/science/arti...
Zanoni et al report that oxidized lipids control IL-10 expression, impacting host defense and disease. Kudos to the authors on this important discovery www.sciencedirect.com/science/arti...
Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections
Phagocytes initiate immunity to invading microorganisms by detecting pathogen-associated molecular patterns via pattern recognition receptors. Pathoge…
www.sciencedirect.com
July 17, 2025 at 4:44 PM
A new function for an ancient innate immune stimulus.
Zanoni et al report that oxidized lipids control IL-10 expression, impacting host defense and disease. Kudos to the authors on this important discovery www.sciencedirect.com/science/arti...
Zanoni et al report that oxidized lipids control IL-10 expression, impacting host defense and disease. Kudos to the authors on this important discovery www.sciencedirect.com/science/arti...
Reposted by Kavitha Scranton
#ChromatinPower #WhatADay! After our paper @cp-immunity.bsky.social (free link 👉 authors.elsevier.com/a/1lS0g3qNrU-i…) happy for our tiny contribution to @xuzhoulab.bsky.social Medzhitov &co amazing paper @cp-cell.bsky.social showing pH controls inflammation via chromatin remodeling! Free link👇
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
July 17, 2025 at 9:14 PM
#ChromatinPower #WhatADay! After our paper @cp-immunity.bsky.social (free link 👉 authors.elsevier.com/a/1lS0g3qNrU-i…) happy for our tiny contribution to @xuzhoulab.bsky.social Medzhitov &co amazing paper @cp-cell.bsky.social showing pH controls inflammation via chromatin remodeling! Free link👇
Reposted by Kavitha Scranton
Optogenetic vagal nerve stimulation attenuates heart failure by limiting the generation of monocyte-derived inflammatory CCRL2+ macrophages: @cp-immunity.bsky.social www.cell.com/immunity/ful...
Optogenetic vagal nerve stimulation attenuates heart failure by limiting the generation f monocyte-derived inflammatory CCRL2+ macrophages
Parasympathetic neuronal dysfunction is associated with heart failure, yet the underlying
mechanism is poorly understood. Here, Li et al. demonstrate that optogenetic activation
of the vagus nerve pre...
www.cell.com
June 27, 2025 at 3:10 PM
Optogenetic vagal nerve stimulation attenuates heart failure by limiting the generation of monocyte-derived inflammatory CCRL2+ macrophages: @cp-immunity.bsky.social www.cell.com/immunity/ful...
Reposted by Kavitha Scranton
Early discounted registration ends June 27th for #CSNeuroimmune25, Sept 7–9, NYC! Explore cutting-edge #neuroimmunology and engage with experts in the field. Keynotes: David Julius & Susan Kaech hubs.li/Q03qS95l0 @cp-neuron.bsky.social @kavithascranton.bsky.social @cellpress.bsky.social
June 26, 2025 at 6:21 PM
Early discounted registration ends June 27th for #CSNeuroimmune25, Sept 7–9, NYC! Explore cutting-edge #neuroimmunology and engage with experts in the field. Keynotes: David Julius & Susan Kaech hubs.li/Q03qS95l0 @cp-neuron.bsky.social @kavithascranton.bsky.social @cellpress.bsky.social
Reposted by Kavitha Scranton
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway @cp-immunity.bsky.social www.cell.com/immunity/ful...
June 23, 2025 at 8:07 PM
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway @cp-immunity.bsky.social www.cell.com/immunity/ful...
Reposted by Kavitha Scranton
Explore breakthroughs in #cancer #immunology with global leaders.
#CellSymposia: The cancer-immunity cycle
Keynotes: Ira Mellman & Carl June
Abstract submission deadline: July 25
Sitges, Spain | Nov 2–4, 2025
http://dlvr.it/TLX7WS
#CellSymposia: The cancer-immunity cycle
Keynotes: Ira Mellman & Carl June
Abstract submission deadline: July 25
Sitges, Spain | Nov 2–4, 2025
http://dlvr.it/TLX7WS
June 24, 2025 at 11:50 AM
Explore breakthroughs in #cancer #immunology with global leaders.
#CellSymposia: The cancer-immunity cycle
Keynotes: Ira Mellman & Carl June
Abstract submission deadline: July 25
Sitges, Spain | Nov 2–4, 2025
http://dlvr.it/TLX7WS
#CellSymposia: The cancer-immunity cycle
Keynotes: Ira Mellman & Carl June
Abstract submission deadline: July 25
Sitges, Spain | Nov 2–4, 2025
http://dlvr.it/TLX7WS
Reposted by Kavitha Scranton
So proud to share my first first-author paper from my postdoc in @liganlab.bsky.social out yesterday in
@cp-immunity.bsky.social! We characterized a model of the APOE3 Christchurch mutation on a tauopathy background and found downregulation of cGAS-STING-IFN pathway as a source of protection!
@cp-immunity.bsky.social! We characterized a model of the APOE3 Christchurch mutation on a tauopathy background and found downregulation of cGAS-STING-IFN pathway as a source of protection!
🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a cau…
www.sciencedirect.com
June 24, 2025 at 6:04 PM
So proud to share my first first-author paper from my postdoc in @liganlab.bsky.social out yesterday in
@cp-immunity.bsky.social! We characterized a model of the APOE3 Christchurch mutation on a tauopathy background and found downregulation of cGAS-STING-IFN pathway as a source of protection!
@cp-immunity.bsky.social! We characterized a model of the APOE3 Christchurch mutation on a tauopathy background and found downregulation of cGAS-STING-IFN pathway as a source of protection!
Reposted by Kavitha Scranton
🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a cau…
www.sciencedirect.com
June 24, 2025 at 12:58 PM
🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...
Reposted by Kavitha Scranton
Meet the keynote speakers at #CSNeuroimmune25: David Julius (UCSF) & Susan Kaech (The Salk Institute) NYC | Sept 7–9, 2025 Early registration discount ends June 27!
hubs.li/Q03sQJjj0 @tcellogic.bsky.social @cp-neuron.bsky.social @salkinstitute.bsky.social #neuroimmune
hubs.li/Q03sQJjj0 @tcellogic.bsky.social @cp-neuron.bsky.social @salkinstitute.bsky.social #neuroimmune
June 20, 2025 at 8:11 PM
Meet the keynote speakers at #CSNeuroimmune25: David Julius (UCSF) & Susan Kaech (The Salk Institute) NYC | Sept 7–9, 2025 Early registration discount ends June 27!
hubs.li/Q03sQJjj0 @tcellogic.bsky.social @cp-neuron.bsky.social @salkinstitute.bsky.social #neuroimmune
hubs.li/Q03sQJjj0 @tcellogic.bsky.social @cp-neuron.bsky.social @salkinstitute.bsky.social #neuroimmune
Reposted by Kavitha Scranton
Our new Immunity paper is in print—and that an oil painting I made was chosen for the cover 😊
It visualizes “affinity birth,” the generative force of SHM creating new antibody specificities beyond V(D)J.
#Immunology #AffinityBirth #SciArt #Bcells #SHM
It visualizes “affinity birth,” the generative force of SHM creating new antibody specificities beyond V(D)J.
#Immunology #AffinityBirth #SciArt #Bcells #SHM
June 10, 2025 at 6:06 PM
Our new Immunity paper is in print—and that an oil painting I made was chosen for the cover 😊
It visualizes “affinity birth,” the generative force of SHM creating new antibody specificities beyond V(D)J.
#Immunology #AffinityBirth #SciArt #Bcells #SHM
It visualizes “affinity birth,” the generative force of SHM creating new antibody specificities beyond V(D)J.
#Immunology #AffinityBirth #SciArt #Bcells #SHM
Had a great time at the CSHL Senescence & Aging meeting this week #cshlsymp25 @cshlmeetings.bsky.social. Enjoyed a wonderful dinner last night with scientists and supporters of CSHL, including the amazing #SusanLucci!
May 31, 2025 at 4:10 PM
Had a great time at the CSHL Senescence & Aging meeting this week #cshlsymp25 @cshlmeetings.bsky.social. Enjoyed a wonderful dinner last night with scientists and supporters of CSHL, including the amazing #SusanLucci!