Kat Holt
@katholt.bsky.social
Scientist… pathogen genomics & antimicrobial resistance, computational biology & infectious disease epidemiology.
Co-Director LSHTM AMR Centre @lshtmamrcentre.bsky.social
holtlab.net | klebnet.org | typhoidgenomics.org | amr.lshtm.ac.uk
Co-Director LSHTM AMR Centre @lshtmamrcentre.bsky.social
holtlab.net | klebnet.org | typhoidgenomics.org | amr.lshtm.ac.uk
I don’t think we have enough evidence that presence of iuc, without iro+rmp, leads to an increase in severity and I would not call it hypervirulent. This is an area we urgently need to address with clin data.
Instead I agree with your earlier paper on this topic! www.thelancet.com/journals/lan...
Instead I agree with your earlier paper on this topic! www.thelancet.com/journals/lan...
November 20, 2025 at 5:58 PM
I don’t think we have enough evidence that presence of iuc, without iro+rmp, leads to an increase in severity and I would not call it hypervirulent. This is an area we urgently need to address with clin data.
Instead I agree with your earlier paper on this topic! www.thelancet.com/journals/lan...
Instead I agree with your earlier paper on this topic! www.thelancet.com/journals/lan...
To hear more, join us online next week (November 26) for a webinar on 🧬 Klebsiella pneumoniae Genomics to Support Neonatal Sepsis bit.ly/klebs_seminar
November 19, 2025 at 3:59 PM
To hear more, join us online next week (November 26) for a webinar on 🧬 Klebsiella pneumoniae Genomics to Support Neonatal Sepsis bit.ly/klebs_seminar
@neleshg.bsky.social and the Baby GERMS-South Africa team explored transmission clusters of ESKAPE pathogens across 6 South African hospitals, and identified large outbreaks of carbapenem-resistant #Klebsiella ST152 and Acinetobacter baumannii ST1 & ST2 www.medrxiv.org/content/10.1...
Enhanced detection of neonatal invasive infection clusters in South Africa using epidemiological and genomic surveillance data
Introduction Invasive bacterial infections, particularly those caused by the ESKAPE group, account for a substantial proportion of neonatal deaths in low- and middle-income countries, yet the contribu...
www.medrxiv.org
November 19, 2025 at 3:59 PM
@neleshg.bsky.social and the Baby GERMS-South Africa team explored transmission clusters of ESKAPE pathogens across 6 South African hospitals, and identified large outbreaks of carbapenem-resistant #Klebsiella ST152 and Acinetobacter baumannii ST1 & ST2 www.medrxiv.org/content/10.1...
In a neonatal unit Zambia, a massive outbreak of #Klebsiall ST307 affecting nearly 300 neonates was interrupted by an infection control intervention, only to be replaced later by unrelated strains of ST307 and other strains. www.medrxiv.org/content/10.1...
Transmission dynamics of Klebsiella pneumoniae in a neonatal intensive care unit in Zambia before and after an infection control bundle
Background Klebsiella pneumoniae is a leading cause of neonatal sepsis in low-and middle-income countries, with antimicrobial resistance (AMR) significantly contributing to associated mortality. Infec...
www.medrxiv.org
November 19, 2025 at 3:55 PM
In a neonatal unit Zambia, a massive outbreak of #Klebsiall ST307 affecting nearly 300 neonates was interrupted by an infection control intervention, only to be replaced later by unrelated strains of ST307 and other strains. www.medrxiv.org/content/10.1...
In a study in Botswana, @ahmedmicrobes.bsky.social and co tracked an outbreak of Kpn ST1414 in the neonatal unit to contaminated IV fluid bags 🧬🕵️https://www.medrxiv.org/content/10.1101/2025.11.06.25339637v1
Using Genomic and Traditional Epidemiologic Approaches to Define Complex Transmission Pathways of Klebsiella pneumoniae Infection in a Neonatal Unit in Botswana, 2022–2023
Background Klebsiella pneumoniae ( Kpn ) is a major cause of infant mortality worldwide, with most transmission occurring among hospitalized neonates in low-and middle-income countries where infection...
www.medrxiv.org
November 19, 2025 at 3:55 PM
In a study in Botswana, @ahmedmicrobes.bsky.social and co tracked an outbreak of Kpn ST1414 in the neonatal unit to contaminated IV fluid bags 🧬🕵️https://www.medrxiv.org/content/10.1101/2025.11.06.25339637v1
One study from KWTRP in Kenya found 81% of neonatal sepsis cases in 2 large hospitals belonged to transmission clusters, with a case fatality rate of 32%.
Most strains carried ESBL genes, and the dominant clones were ST14 and ST17 www.medrxiv.org/content/10.1...
Most strains carried ESBL genes, and the dominant clones were ST14 and ST17 www.medrxiv.org/content/10.1...
Genomic epidemiology of Klebsiella pneumoniae neonatal and infant sepsis in Kenyan hospitals
Background Klebsiella pneumoniae ( Kpn ) is a leading cause of sepsis among hospitalised neonates and commonly causes outbreaks. Lack of surveillance data from low- and middle-income countries hampers...
www.medrxiv.org
November 19, 2025 at 3:54 PM
One study from KWTRP in Kenya found 81% of neonatal sepsis cases in 2 large hospitals belonged to transmission clusters, with a case fatality rate of 32%.
Most strains carried ESBL genes, and the dominant clones were ST14 and ST17 www.medrxiv.org/content/10.1...
Most strains carried ESBL genes, and the dominant clones were ST14 and ST17 www.medrxiv.org/content/10.1...
Excitingly, some of the collaborating studies have also posted preprints reporting detailed analyses of transmission in specific settings. 🧫🧬🕵️🏥
November 19, 2025 at 3:53 PM
Excitingly, some of the collaborating studies have also posted preprints reporting detailed analyses of transmission in specific settings. 🧫🧬🕵️🏥
The meta-analysis was led by @erkison.bsky.social, with 60 wonderful co-authors contributing data, ideas and interpretations, including @neleshg.bsky.social @[email protected] @ahmedmicrobes.bsky.social @evaheinz7.bsky.social @kelwyres.bsky.social and many others not on BlueSky
November 19, 2025 at 3:52 PM
The meta-analysis was led by @erkison.bsky.social, with 60 wonderful co-authors contributing data, ideas and interpretations, including @neleshg.bsky.social @[email protected] @ahmedmicrobes.bsky.social @evaheinz7.bsky.social @kelwyres.bsky.social and many others not on BlueSky
All the data and code from the paper is available at github.com/klebgenomics...
GitHub - klebgenomics/KlebNNS_transmission
Contribute to klebgenomics/KlebNNS_transmission development by creating an account on GitHub.
github.com
November 19, 2025 at 3:52 PM
All the data and code from the paper is available at github.com/klebgenomics...
In a logistic regression model, newly detected Kpn strains with ESBL or carbapenemase genes were more likely to be associated with onward transmission in the unit 🏥. #AMR
A few STs were also significantly associated with transmission (including ST14, ST17) but no K or O types.
A few STs were also significantly associated with transmission (including ST14, ST17) but no K or O types.
November 19, 2025 at 3:52 PM
In a logistic regression model, newly detected Kpn strains with ESBL or carbapenemase genes were more likely to be associated with onward transmission in the unit 🏥. #AMR
A few STs were also significantly associated with transmission (including ST14, ST17) but no K or O types.
A few STs were also significantly associated with transmission (including ST14, ST17) but no K or O types.