Kari Hoffman
@karihoffman.bsky.social
neuroscientist @vanderbilt studying neural circuit+population rules for creating and deploying knowledge. computational neuroethology.
Pinned
Kari Hoffman
@karihoffman.bsky.social
· Apr 15
Experience reorganizes content-specific memory traces in macaques
Memory formation requires neural activity reorganization during experience that persists in sleep. How these processes promote learning while preserving established memories remains unclear. We record...
www.biorxiv.org
How does the brain integrate information from new experiences while preserving established memories? Have a look at our latest preprint,
"Experience reorganizes content-specific memory traces in macaques" 🧵
🧪🧠🤖👩🔬
www.biorxiv.org/content/10.1...
"Experience reorganizes content-specific memory traces in macaques" 🧵
🧪🧠🤖👩🔬
www.biorxiv.org/content/10.1...
correction: he *is* reviewer #3
Met an old pal at #SfN25, he's still waiting to hear back from reviewer #3
November 22, 2025 at 3:30 PM
correction: he *is* reviewer #3
Reposted by Kari Hoffman
Keep in mind, we could have already advanced so much in this field if, for political reasons, mRNA vaccines were not severely attacked over the past 5 years. We are closer than ever to a cure for #MultipleSclerosis, and that involves preventing #EBV from damaging the brain.
Common virus jab could be key in fight against multiple sclerosis
The vaccine will be trialled in patients recently diagnosed with MS
www.independent.co.uk
November 22, 2025 at 2:42 PM
Keep in mind, we could have already advanced so much in this field if, for political reasons, mRNA vaccines were not severely attacked over the past 5 years. We are closer than ever to a cure for #MultipleSclerosis, and that involves preventing #EBV from damaging the brain.
Reposted by Kari Hoffman
🚨New publication!
I am extremely happy to share this new review article in elife on #Traveling_Waves!
@erc.europa.eu
@upcite.bsky.social
elifesciences.org/articles/106...
I am extremely happy to share this new review article in elife on #Traveling_Waves!
@erc.europa.eu
@upcite.bsky.social
elifesciences.org/articles/106...
Traveling waves across scales: Different mechanisms but same canonical computation?
The review proposes a novel mechanistic distinction between first- and second-order traveling waves that subserves a same canonical computation by ordering neuronal processing to impose a computationa...
elifesciences.org
November 19, 2025 at 3:54 PM
🚨New publication!
I am extremely happy to share this new review article in elife on #Traveling_Waves!
@erc.europa.eu
@upcite.bsky.social
elifesciences.org/articles/106...
I am extremely happy to share this new review article in elife on #Traveling_Waves!
@erc.europa.eu
@upcite.bsky.social
elifesciences.org/articles/106...
Reposted by Kari Hoffman
I wrote this last week with the news of the shutdown deal, about why we need a lot more to save US science. Comments and questions are welcome.
-------------------
As a US scientist and NIH employee, I had mixed feelings about the reopening of the US government this week. 1/
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As a US scientist and NIH employee, I had mixed feelings about the reopening of the US government this week. 1/
November 19, 2025 at 12:35 PM
I wrote this last week with the news of the shutdown deal, about why we need a lot more to save US science. Comments and questions are welcome.
-------------------
As a US scientist and NIH employee, I had mixed feelings about the reopening of the US government this week. 1/
-------------------
As a US scientist and NIH employee, I had mixed feelings about the reopening of the US government this week. 1/
Happening now ss3 ss4 dentate spikes, beta, category learning in freely moving 🐒
November 17, 2025 at 4:43 PM
Happening now ss3 ss4 dentate spikes, beta, category learning in freely moving 🐒
Reposted by Kari Hoffman
For those coming to SfN, I’ll be giving a talk showing evidence of hippocampal neuronal replay 🎞️🔁 in HUMANS as part of the “Representation of Time in the Brain” minisymposium (Wednesday morning)
Our stellar group of speakers also wrote a preview of the session in @sfnjournals.bsky.social #sfn2025
🧠
Our stellar group of speakers also wrote a preview of the session in @sfnjournals.bsky.social #sfn2025
🧠
Neural Representation of Episodic Time
Inspired by recent discoveries of neural populations that track time for specific moments (time cells) and elapsed durations (temporal context and periodic time cells), this review, based on a minisym...
www.jneurosci.org
November 15, 2025 at 7:15 PM
For those coming to SfN, I’ll be giving a talk showing evidence of hippocampal neuronal replay 🎞️🔁 in HUMANS as part of the “Representation of Time in the Brain” minisymposium (Wednesday morning)
Our stellar group of speakers also wrote a preview of the session in @sfnjournals.bsky.social #sfn2025
🧠
Our stellar group of speakers also wrote a preview of the session in @sfnjournals.bsky.social #sfn2025
🧠
Reposted by Kari Hoffman
November 16, 2025 at 6:24 PM
Reposted by Kari Hoffman
Sad to miss the rest of this session, but excited to go meet with the brainfacts.org team. We have a lot of exciting new results in brain/mind research to unpack (yeah!) as well as a disturbing amount to misinformation to combat (sigh). If you aren’t following @brainfacts.org, you must!
BrainFacts
brainfacts.org
November 16, 2025 at 4:59 PM
Sad to miss the rest of this session, but excited to go meet with the brainfacts.org team. We have a lot of exciting new results in brain/mind research to unpack (yeah!) as well as a disturbing amount to misinformation to combat (sigh). If you aren’t following @brainfacts.org, you must!
Reposted by Kari Hoffman
Come hear about state-driven neural complexity today #SfN25
PP13 - "Deep cortical layer stimulation reveals state-dependent changes in neural excitability"
Poster Session 1-5 pm
Computational Approaches & Experimental Analyses I
PP13 - "Deep cortical layer stimulation reveals state-dependent changes in neural excitability"
Poster Session 1-5 pm
Computational Approaches & Experimental Analyses I
a man in a star trek uniform is sitting in front of a control panel
ALT: a man in a star trek uniform is sitting in front of a control panel
media.tenor.com
November 16, 2025 at 3:13 PM
Come hear about state-driven neural complexity today #SfN25
PP13 - "Deep cortical layer stimulation reveals state-dependent changes in neural excitability"
Poster Session 1-5 pm
Computational Approaches & Experimental Analyses I
PP13 - "Deep cortical layer stimulation reveals state-dependent changes in neural excitability"
Poster Session 1-5 pm
Computational Approaches & Experimental Analyses I
Reposted by Kari Hoffman
🧬 Evolution meets neuroscience at #SfN25!
Learn how multi-omics approaches are revealing how evolution acts on cell types, underpinning neural circuitry and behavior changes across diverse species.
📅 Tues., 11/18, 9:30am–12:00pm
📍 Rm 6CF
📲 https://www.abstractsonline.com/pp8/#!/21171/session/1213
Learn how multi-omics approaches are revealing how evolution acts on cell types, underpinning neural circuitry and behavior changes across diverse species.
📅 Tues., 11/18, 9:30am–12:00pm
📍 Rm 6CF
📲 https://www.abstractsonline.com/pp8/#!/21171/session/1213
November 15, 2025 at 10:50 PM
🧬 Evolution meets neuroscience at #SfN25!
Learn how multi-omics approaches are revealing how evolution acts on cell types, underpinning neural circuitry and behavior changes across diverse species.
📅 Tues., 11/18, 9:30am–12:00pm
📍 Rm 6CF
📲 https://www.abstractsonline.com/pp8/#!/21171/session/1213
Learn how multi-omics approaches are revealing how evolution acts on cell types, underpinning neural circuitry and behavior changes across diverse species.
📅 Tues., 11/18, 9:30am–12:00pm
📍 Rm 6CF
📲 https://www.abstractsonline.com/pp8/#!/21171/session/1213
Reposted by Kari Hoffman
And I’m a big fan of Turing, von Neumann, Shannon, Metcalfe, Hinton, Sejnowski, and all the other algorithmic and computation people. No shade.
But data limits still limit understanding of the brain. That’s why the #NIH US BRAIN Init was so important: public investment made new tools.
But data limits still limit understanding of the brain. That’s why the #NIH US BRAIN Init was so important: public investment made new tools.
November 15, 2025 at 5:33 PM
And I’m a big fan of Turing, von Neumann, Shannon, Metcalfe, Hinton, Sejnowski, and all the other algorithmic and computation people. No shade.
But data limits still limit understanding of the brain. That’s why the #NIH US BRAIN Init was so important: public investment made new tools.
But data limits still limit understanding of the brain. That’s why the #NIH US BRAIN Init was so important: public investment made new tools.
Reposted by Kari Hoffman
Landed at #SfN and we have lots of fun new results to share. See below for Yassalab poster presentations. If you want to talk #Alzheimers or #mentalhealth come chat with us.
#SfN25 #neurosky #neuroskyence #academicchatter
#SfN25 #neurosky #neuroskyence #academicchatter
November 15, 2025 at 2:45 PM
Landed at #SfN and we have lots of fun new results to share. See below for Yassalab poster presentations. If you want to talk #Alzheimers or #mentalhealth come chat with us.
#SfN25 #neurosky #neuroskyence #academicchatter
#SfN25 #neurosky #neuroskyence #academicchatter
Reposted by Kari Hoffman
Hearing a rumor that NIH/HHS may now plan to retaliate against other Bethesda Declaration signers.
I am one, but it’s not about me: we have been speaking out because of the ongoing damage to US medical research, cancer and Alzheimer’s research.
As @jenna-m-norton.bsky.social put well: 1/
I am one, but it’s not about me: we have been speaking out because of the ongoing damage to US medical research, cancer and Alzheimer’s research.
As @jenna-m-norton.bsky.social put well: 1/
November 14, 2025 at 4:17 PM
Hearing a rumor that NIH/HHS may now plan to retaliate against other Bethesda Declaration signers.
I am one, but it’s not about me: we have been speaking out because of the ongoing damage to US medical research, cancer and Alzheimer’s research.
As @jenna-m-norton.bsky.social put well: 1/
I am one, but it’s not about me: we have been speaking out because of the ongoing damage to US medical research, cancer and Alzheimer’s research.
As @jenna-m-norton.bsky.social put well: 1/
Reposted by Kari Hoffman
@markhisted.org , you have been and are incredibly brave and admirable.
I hope the rumors are false.
and: keep up the amazing work!
I hope the rumors are false.
and: keep up the amazing work!
Hearing a rumor that NIH/HHS may now plan to retaliate against other Bethesda Declaration signers.
I am one, but it’s not about me: we have been speaking out because of the ongoing damage to US medical research, cancer and Alzheimer’s research.
As @jenna-m-norton.bsky.social put well: 1/
I am one, but it’s not about me: we have been speaking out because of the ongoing damage to US medical research, cancer and Alzheimer’s research.
As @jenna-m-norton.bsky.social put well: 1/
November 15, 2025 at 12:40 AM
@markhisted.org , you have been and are incredibly brave and admirable.
I hope the rumors are false.
and: keep up the amazing work!
I hope the rumors are false.
and: keep up the amazing work!
Reposted by Kari Hoffman
BREAKING: In AAUP et al v. Trump (wall-to-wall union lawsuit challenging the administration’s unlawful use of TItle VI to reshape the University of California system), the faculty and staff of the UC system WON!!!
We were granted our preliminary injunction! @aaup.org
We were granted our preliminary injunction! @aaup.org
November 14, 2025 at 11:55 PM
BREAKING: In AAUP et al v. Trump (wall-to-wall union lawsuit challenging the administration’s unlawful use of TItle VI to reshape the University of California system), the faculty and staff of the UC system WON!!!
We were granted our preliminary injunction! @aaup.org
We were granted our preliminary injunction! @aaup.org
November 14, 2025 at 8:45 PM
Reposted by Kari Hoffman
The Society for Neuroscience meeting starts tomorrow! I prepared some microscopy images for display at the convention center in San Diego. Let me know if you see one of my images around! 🤓 🔬 🧠
@sfn.org #SfN25 #FluorescenceFriday
@sfn.org #SfN25 #FluorescenceFriday
November 14, 2025 at 6:37 PM
The Society for Neuroscience meeting starts tomorrow! I prepared some microscopy images for display at the convention center in San Diego. Let me know if you see one of my images around! 🤓 🔬 🧠
@sfn.org #SfN25 #FluorescenceFriday
@sfn.org #SfN25 #FluorescenceFriday
He’s not kidding- I predict he’ll be putting the “special” in Presidential Special Lecture. Bring popcorn.🍿
Coming to the Society for Neuroscience meeting? Come to my lecture and say hi. I'm going to be talking about some crazy stuff. #neuroscience #SFN2025
November 14, 2025 at 6:35 PM
He’s not kidding- I predict he’ll be putting the “special” in Presidential Special Lecture. Bring popcorn.🍿
Reposted by Kari Hoffman
Please also follow @safa-science.bsky.social for more updates
November 13, 2025 at 11:12 PM
Please also follow @safa-science.bsky.social for more updates
Reposted by Kari Hoffman
A bad thing is unfolding at NIH this week: It looks like the Trump administration is trying to replace key civil servant scientific leaders, the Institute Directors, with political hires. These directors control the NIH budget, tens of billions.
A bit of a video explainer here: 1/ 🧪
A bit of a video explainer here: 1/ 🧪
November 13, 2025 at 10:31 PM
A bad thing is unfolding at NIH this week: It looks like the Trump administration is trying to replace key civil servant scientific leaders, the Institute Directors, with political hires. These directors control the NIH budget, tens of billions.
A bit of a video explainer here: 1/ 🧪
A bit of a video explainer here: 1/ 🧪
Reposted by Kari Hoffman
The Preston Lab will be at @sfn.org #SfN2025! Come see what we've been working on 🧠
We'll discuss how kids & adults remember when things happen, how memory changes impact reasoning & how we learn different actions have different consequences based on the setting.
Find us Monday & Wednesday 🤘
We'll discuss how kids & adults remember when things happen, how memory changes impact reasoning & how we learn different actions have different consequences based on the setting.
Find us Monday & Wednesday 🤘
November 14, 2025 at 5:04 PM
Reposted by Kari Hoffman
Miller Lab at #SFN2025. Come by and say hi ya. #Neuroscience
November 14, 2025 at 11:53 AM
Miller Lab at #SFN2025. Come by and say hi ya. #Neuroscience