Jun J Yang
@junjyang.bsky.social
Faculty member at St. Jude Children's, Love therapeutic sciences, genetics, and everything in between.
New paper alert! Our team published in @natcomms.nature.com on MeiHMM - a hidden Markov model that identifies meiotic nondisjunction error types in chromosomal abnormalities, like Down Syndrome, without parental data! #Meiosis #Genomics #ComputationalBiology #StJudeResearch
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Inferring chromosome segregation error stage and crossover in trisomic disorders with application to Down syndrome - Nature Communications
The authors report a computational framework for determining the meiotic/mitotic origin of nondisjunction (NDJ) in trisomies without parental data. Applying this to Down syndrome, they uncover links b...
doi.org
August 1, 2025 at 3:38 PM
New paper alert! Our team published in @natcomms.nature.com on MeiHMM - a hidden Markov model that identifies meiotic nondisjunction error types in chromosomal abnormalities, like Down Syndrome, without parental data! #Meiosis #Genomics #ComputationalBiology #StJudeResearch
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Big congrats to #CarolinEscherich for her work published in @bloodjournal.bsky.social!
What determines Inotuzumab sensitivity in #ALL?
New @bloodjournal.bsky.social study from C. Escherich &
@junjyang.bsky.social Lab highlights the role of B cell developmental state and EBF1. It was a pleasure to provide a commentary!
🔬 doi.org/10.1182/bloo...
🗒️ doi.org/10.1182/bloo...
New @bloodjournal.bsky.social study from C. Escherich &
@junjyang.bsky.social Lab highlights the role of B cell developmental state and EBF1. It was a pleasure to provide a commentary!
🔬 doi.org/10.1182/bloo...
🗒️ doi.org/10.1182/bloo...
July 28, 2025 at 4:00 PM
Big congrats to #CarolinEscherich for her work published in @bloodjournal.bsky.social!
Kudos to #MaudMaillard on her new paper in @jclinical-invest.bsky.social! Our findings indicate NUDT5 is a key regulator of thiopurine metabolism, offering new insights into how cells strike the balance between de novo vs salvage purine synthesis.
Thiopurines for the treatment of cancer or autoimmune disease are limited by their toxicity.
@junjyang.bsky.social & team identify germline NUDT5 variants that affect thiopurine metabolism and cytotoxicity, having implications for individualized thiopurine therapy: buff.ly/4cR6rlm
@junjyang.bsky.social & team identify germline NUDT5 variants that affect thiopurine metabolism and cytotoxicity, having implications for individualized thiopurine therapy: buff.ly/4cR6rlm
July 28, 2025 at 3:37 PM
Kudos to #MaudMaillard on her new paper in @jclinical-invest.bsky.social! Our findings indicate NUDT5 is a key regulator of thiopurine metabolism, offering new insights into how cells strike the balance between de novo vs salvage purine synthesis.
Thrilled to share our latest research published in @jclinical-invest.bsky.social! Our findings indicate NUDT5 is a key regulator of thiopurine metabolism, offering new insights into drug processing mechanisms.
JCI -
The NUDIX hydrolase NUDT5 regulates thiopurine metabolism and cytotoxicity
www.jci.org
July 16, 2025 at 10:20 PM
Thrilled to share our latest research published in @jclinical-invest.bsky.social! Our findings indicate NUDT5 is a key regulator of thiopurine metabolism, offering new insights into drug processing mechanisms.