Report on handling of pandemic contains stinging criticism of ‘toxic and chaotic’ culture inside Boris Johnson’s No 10

SPECIAL REPORT: The ECHO lifts the lid on what life was like in the Rudakubana household after listening to every minute of the family's inquiry evidence

After nine weeks of inquiry evidence, a picture has emerged of systemic breakdown and poor information sharing

After nine weeks of inquiry evidence, a picture has emerged of systemic breakdown and poor information sharing

Last week’s attack on the synagogue in Crumpsall, Manchester, was also an assault on a model and diverse community, says Guardian features writer Simon Hattenstone

Exclusive: Concerns about apparently fanatical interest in Islam shown by Jihad al-Shamie and another family member were reported, Guardian told

Guardian’s Josh Halliday talks about Huntington’s disease, the impact it has had on his family and the hope there may now be a treatment

Exclusive: Jihad al-Shamie had been due to appear in court over alleged sexual attack earlier this year, sources say

UCL trialled hours-long surgical procedure to treat disease which causes dementia and paralysis Huntington’s disease, a devastating degenerative illness that runs in families, has been treated successfully for the first time in a breakthrough gene therapy trial. The disease, caused by a single gene defect, steadily kills brain cells leading to dementia, paralysis and ultimately death. Those with a parent with Huntington’s have a 50% chance of developing the disease, which until now has been incurable. Continue reading...

One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.

Exclusive: Ministers have vowed to fix benefit after Guardian revealed thousands had been plunged into debt for accidentally breaking rules The government is considering compensation payouts for unpaid carers who have been unfairly hit with huge financial repayments in recent years after inadvertently falling foul of harsh carer’s allowance benefit rules. Ministers vowed to fix problems with the benefit after a Guardian investigation revealed how draconian penalties coupled with Department for Work and Pensions (DWP) administrative failures had plunged hundreds of thousands of carers into debt. Continue reading...

Exclusive: Video shows veteran campaigner being dragged and handcuffed and she says bail conditions effectively confine her to her house

Exclusive: Actor says Keir Starmer’s party has caused a ‘derogation of all the principles they were supposed to represent’

The Guardian has announced a number of appointments.

As poverty deepens across Britain, the Guardian visited some of the hardest-hit places where leaders are aiming to shift healthcare from hospitals to communities

Nursery worker would not have been convicted of Genevieve Meehan’s manslaughter without footage, parents say

Nicola Green, 42, speaks out after significant legal victory against department that accused her of fraud UK politics live – latest updates