One strength of the Dormanns et al model is how it isolates the temporal roles of neuronal vs endothelial NO and their interactions with other signals like K⁺. It gives a structured way to test how different sources of NO contribute to CBF dynamics, something hard to dissect in vivo.
#Neuroskyence

Interestingly, the positive effects of nitrate appear to be linked to the duration of supplementation, instead of following a dose-dependent pattern!

#neurovascular #nitricoxide #neuroskyence #cognition

portlandpress.com/biochemsoctr...

This study reveals disrupted nitric oxide-dependent NVC in the hippocampus of young GK rats (T2DM animal model).
T2DM was also associated with poor spatial memory and learning
#neuroskyence