Jiseon Min
@jiseonmin.bsky.social
Postdoctoral researcher at Northeastern University, previously @Kern-Ralph colab
Reposted by Jiseon Min
SimHumanity: Using SLiM 5.0 to run whole-genome simulations of human evolution https://www.biorxiv.org/content/10.1101/2025.09.01.673541v1
September 2, 2025 at 8:31 AM
SimHumanity: Using SLiM 5.0 to run whole-genome simulations of human evolution https://www.biorxiv.org/content/10.1101/2025.09.01.673541v1
Reposted by Jiseon Min
In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signature
Mutations reflect the net effects of myriad types of damage, replication errors, and repair mechanisms, and thus are expected to differ across cell types with distinct exposures to mutagens, division ...
www.biorxiv.org
September 2, 2025 at 11:44 AM
In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted by Jiseon Min
August 29, 2025 at 1:43 PM
Reposted by Jiseon Min
A new paper and video about levels of drug resistance in different countries
I am so happy to share a new paper and a new video (see below). The paper describes a simple mathematical model that describes levels of drug resistance. I called the model the Resistance-Acquisition-Purifying-Selection…
I am so happy to share a new paper and a new video (see below). The paper describes a simple mathematical model that describes levels of drug resistance. I called the model the Resistance-Acquisition-Purifying-Selection…
A new paper and video about levels of drug resistance in different countries
I am so happy to share a new paper and a new video (see below). The paper describes a simple mathematical model that describes levels of drug resistance. I called the model the Resistance-Acquisition-Purifying-Selection model (RAPS). While the model is simple, it wasn't easy to write the paper or to get it published. Before submitting to the journal Epidemics, I submitted to Nature (desk reject, late 2023), Science (reject after useful reviews, early 2024) and PNAS (another reject after constructive reviews, mid 2024).
abetterscientist.wordpress.com
August 29, 2025 at 12:43 PM
A new paper and video about levels of drug resistance in different countries
I am so happy to share a new paper and a new video (see below). The paper describes a simple mathematical model that describes levels of drug resistance. I called the model the Resistance-Acquisition-Purifying-Selection…
I am so happy to share a new paper and a new video (see below). The paper describes a simple mathematical model that describes levels of drug resistance. I called the model the Resistance-Acquisition-Purifying-Selection…
Reposted by Jiseon Min
My latest for @nytimes.com -- please repost so your followers can see this for free. www.nytimes.com/interactive/...
How a Puzzle About Fractions Got Brain Scans Rolling (Gift Article)
A story of bowling pins, patterns and medical miracles.
www.nytimes.com
June 30, 2025 at 10:33 AM
My latest for @nytimes.com -- please repost so your followers can see this for free. www.nytimes.com/interactive/...
Reposted by Jiseon Min
Please share this widely and encourage students to apply! Many of our current graduate students were recruited through this program -- happy to answer any questions and connect with students
bsky.app/profile/stan...
bsky.app/profile/stan...
Planning to apply to Biology PhD Programs this year? Let us help you out!! At the Stanford Biology Preview Program, we aim to support students from all backgrounds through the graduate school application process. Apply here: forms.gle/EvTyUWXFMRSL...
June 25, 2025 at 12:23 AM
Please share this widely and encourage students to apply! Many of our current graduate students were recruited through this program -- happy to answer any questions and connect with students
bsky.app/profile/stan...
bsky.app/profile/stan...
Reposted by Jiseon Min
The recording of my IDEA talk is up on the #Evol2025 YouTube channel, and I've thrown that together with a PDF copy of the slide deck and a bibliography: lab.jbyoder.org/2025/06/21/a...
A bibliography for the 2025 IDEA plenary
The recording of my talk for the 2025 IDEA plenary is now posted over on the Evolution meeting YouTube channel (there’s a bunch of dead air at the start of the recording; the action starts a …
lab.jbyoder.org
June 21, 2025 at 10:54 PM
The recording of my IDEA talk is up on the #Evol2025 YouTube channel, and I've thrown that together with a PDF copy of the slide deck and a bibliography: lab.jbyoder.org/2025/06/21/a...
Reposted by Jiseon Min
Why is sex so common if it's so costly?
Super excited to share our new preprint “Sex decreases the pleiotropic costs of local adaptation”, where we bring a new angle to this age-old evolutionary question. Co-led by Parris Humphrey, in Michael Desai's lab. Short thread here: (1/n)
Super excited to share our new preprint “Sex decreases the pleiotropic costs of local adaptation”, where we bring a new angle to this age-old evolutionary question. Co-led by Parris Humphrey, in Michael Desai's lab. Short thread here: (1/n)
Sex decreases the pleiotropic costs of local adaptation https://www.biorxiv.org/content/10.1101/2025.03.28.646016v1
April 2, 2025 at 6:59 PM
Why is sex so common if it's so costly?
Super excited to share our new preprint “Sex decreases the pleiotropic costs of local adaptation”, where we bring a new angle to this age-old evolutionary question. Co-led by Parris Humphrey, in Michael Desai's lab. Short thread here: (1/n)
Super excited to share our new preprint “Sex decreases the pleiotropic costs of local adaptation”, where we bring a new angle to this age-old evolutionary question. Co-led by Parris Humphrey, in Michael Desai's lab. Short thread here: (1/n)
Reposted by Jiseon Min
What do GWAS and rare variant burden tests discover, and why?
Do these studies find the most IMPORTANT genes? If not, how DO they rank genes?
Here we present a surprising result: these studies actually test for SPECIFICITY! A 🧵on what this means... (🧪🧬)
www.biorxiv.org/content/10.1...
Do these studies find the most IMPORTANT genes? If not, how DO they rank genes?
Here we present a surprising result: these studies actually test for SPECIFICITY! A 🧵on what this means... (🧪🧬)
www.biorxiv.org/content/10.1...
Specificity, length, and luck: How genes are prioritized by rare and common variant association studies
Standard genome-wide association studies (GWAS) and rare variant burden tests are essential tools for identifying trait-relevant genes. Although these methods are conceptually similar, we show by anal...
www.biorxiv.org
December 17, 2024 at 7:05 AM
What do GWAS and rare variant burden tests discover, and why?
Do these studies find the most IMPORTANT genes? If not, how DO they rank genes?
Here we present a surprising result: these studies actually test for SPECIFICITY! A 🧵on what this means... (🧪🧬)
www.biorxiv.org/content/10.1...
Do these studies find the most IMPORTANT genes? If not, how DO they rank genes?
Here we present a surprising result: these studies actually test for SPECIFICITY! A 🧵on what this means... (🧪🧬)
www.biorxiv.org/content/10.1...
Reposted by Jiseon Min
This is a really cool study that provides a glimpse into a distant past when humans and Neanderthal lived side by side for thousands of years. Hats off to the two first authors @leonardoiasi.bsky.social and @mchintalapati.bsky.social!
Out today in @sciencemagazine, we've journeyed into our shared history with Neandertals by analyzing over 300 present-day and ancient modern humans, including 59 individuals who lived between 2,000 and 45,000 years ago.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Neanderthal ancestry through time: Insights from genomes of ancient and present-day humans
Gene flow from Neanderthals has shaped genetic and phenotypic variation in modern humans. We generated a catalog of Neanderthal ancestry segments in more than 300 genomes spanning the past 50,000 year...
www.science.org
December 12, 2024 at 9:40 PM
This is a really cool study that provides a glimpse into a distant past when humans and Neanderthal lived side by side for thousands of years. Hats off to the two first authors @leonardoiasi.bsky.social and @mchintalapati.bsky.social!
Reposted by Jiseon Min
After a long and winding odyssey, excited to finally drop anchor in open-access waters. This preprint shows how neutral allele frequency time series can illuminate disease transmission rates between communities— key for epidemic fore- & backcasting. medrxiv.org/content/10.1... 🧵
December 6, 2024 at 10:50 PM
After a long and winding odyssey, excited to finally drop anchor in open-access waters. This preprint shows how neutral allele frequency time series can illuminate disease transmission rates between communities— key for epidemic fore- & backcasting. medrxiv.org/content/10.1... 🧵
Reposted by Jiseon Min
Since the #aDNA community is growing here, I’m sharing a new tutorial on ancient DNA, written by marine scientists with diverse backgrounds in #genomics. We share how to integrate best 'omics principles into aDNA research 🧬🧪🦑
Next up: code tutorials for aDNA packages, watch the MarineOmics space!
Next up: code tutorials for aDNA packages, watch the MarineOmics space!
Ancient and Degraded DNA
marineomics.github.io
November 14, 2024 at 12:15 AM
Reposted by Jiseon Min
Happy to share a new study from the lab led by recent graduate Cheyenne Payne & co! Cheyenne has long been interested in the role of the ecological environment in driving phenotypic evolution: www.biorxiv.org/content/10.1...
Recent evolution of large offspring size and post-fertilization nutrient provisioning in swordtails
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
December 20, 2023 at 12:23 AM
Happy to share a new study from the lab led by recent graduate Cheyenne Payne & co! Cheyenne has long been interested in the role of the ecological environment in driving phenotypic evolution: www.biorxiv.org/content/10.1...
Reposted by Jiseon Min
The origins of maize were the subject of controversy for well over a century. Even in the 1950's botanists like Edgar Anderson weren't totally sure what continent it came from!
We published today a new model for maize origins (www.science.org/doi/10.1126/...). Let me tell you how we got here. 1/
We published today a new model for maize origins (www.science.org/doi/10.1126/...). Let me tell you how we got here. 1/
November 30, 2023 at 10:23 PM
The origins of maize were the subject of controversy for well over a century. Even in the 1950's botanists like Edgar Anderson weren't totally sure what continent it came from!
We published today a new model for maize origins (www.science.org/doi/10.1126/...). Let me tell you how we got here. 1/
We published today a new model for maize origins (www.science.org/doi/10.1126/...). Let me tell you how we got here. 1/
Reposted by Jiseon Min
Delighted to announce my preprint "Partitioning the Impacts of Spatial-Temporal Variation in Demography and Dispersal on Metapopulation Growth Rates" that identifies mechanisms underlying fitness-density covariances, spatial buffering, and inflationary effects.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 10, 2023 at 5:09 PM
Delighted to announce my preprint "Partitioning the Impacts of Spatial-Temporal Variation in Demography and Dispersal on Metapopulation Growth Rates" that identifies mechanisms underlying fitness-density covariances, spatial buffering, and inflationary effects.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Jiseon Min
link-ancestors: Fast simulation of local ancestry with tree sequence software https://www.biorxiv.org/content/10.1101/2023.11.03.564476v1
link-ancestors: Fast simulation of local ancestry with tree sequence software https://www.biorxiv.org/content/10.1101/2023.11.03.564476v1
It is challenging to simulate realistic tracts of genetic ancestry on a scale suitable for simulatio
www.biorxiv.org
November 5, 2023 at 8:41 PM
link-ancestors: Fast simulation of local ancestry with tree sequence software https://www.biorxiv.org/content/10.1101/2023.11.03.564476v1
Reposted by Jiseon Min
A general and efficient representation of ancestral recombination graphs https://www.biorxiv.org/content/10.1101/2023.11.03.565466v1
A general and efficient representation of ancestral recombination graphs https://www.biorxiv.org/content/10.1101/2023.11.03.565466v1
As a result of recombination, adjacent nucleotides can have different paths of genetic inheritance a
www.biorxiv.org
November 4, 2023 at 9:33 AM
A general and efficient representation of ancestral recombination graphs https://www.biorxiv.org/content/10.1101/2023.11.03.565466v1