Jiorgos Kourelis
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jiorgoskourelis.bsky.social
Jiorgos Kourelis
@jiorgoskourelis.bsky.social
930 followers 310 following 1 posts
Imperial College London. Exploring plant-microbe interactions & receptor-dependent immunity. Bioinformatics, evolution, synthetic biology. #PlantScience #Bioengineering

https://profiles.imperial.ac.uk/j.kourelis
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Reposted by Jiorgos Kourelis
marischuster.bsky.social
#PlantChemetics
#2025ISMPMI
July 16, 2025 at 9:02 PM
Reposted by Jiorgos Kourelis
samtmugford.bsky.social
Chewing the fat with old colleagues @jiorgoskourelis.bsky.social #ismpmi2025
July 14, 2025 at 7:42 PM
Reposted by Jiorgos Kourelis
tolgaboz.bsky.social
Plz RT. We are looking for a postdoc to join our collborative project on AI-guided bioengineering of plant immune receptors @tolgaboz.bsky.social and @jiorgoskourelis.bsky.social labs: www.jobs.ac.uk/job/DNV032/r...
Research Associate in Programmable Plant Immunity at Imperial College London
Apply for the Research Associate in Programmable Plant Immunity role on jobs.ac.uk, the top job board for academic positions in higher education. View details and apply now.
www.jobs.ac.uk
July 7, 2025 at 3:01 PM
Reposted by Jiorgos Kourelis
alexanderforderer.bsky.social
Excited to share the first preprint from my lab @mpi-mp-potsdam.bsky.social in Potsdam! Huge thanks to @o-sulkowski.bsky.social and the whole team for their hard work and dedication.

📄 www.biorxiv.org/content/10.1...
Diversification of the "EDVID" packing motif underpins structural and functional variation in plant NLR coiled-coil domains
· Nucleotide-binding leucine-rich repeat receptors (NLRs) are critical in plant immunity and display remarkable allelic diversity. Coiled-coiled NLRs (CC-NLRs) are the most widespread group of these r...
www.biorxiv.org
June 3, 2025 at 4:54 PM
Reposted by Jiorgos Kourelis
amiralito.bsky.social
🧵 🥬 Lettuce begin! Super excited to share our new manuscript on contrasting patterns of evolution in sensor and helper NLRs in the NRC network! Tune in for some plant immunology and molecular evolution… 🌱🧬💻 (1/14)
www.biorxiv.org/content/10.1...
A hierarchical immune receptor network in lettuce reveals contrasting patterns of evolution in sensor and helper NLRs
Nucleotide-binding domain and leucine-rich repeat immune receptors (NLRs) are known for their rapid evolution, even at the intraspecific level, yet the rates of evolution differ significantly across v...
www.biorxiv.org
February 26, 2025 at 4:55 PM
Reposted by Jiorgos Kourelis
baptistebio.bsky.social
www.freepatentsonline.com/y2025/003458...
Pikobodies can directly target effectors, not only GFP or mCherry. An impressive technology from @jiorgoskourelis.bsky.social @clemmar.bsky.social @kamounlab.bsky.social
www.freepatentsonline.com
February 10, 2025 at 8:24 AM
Reposted by Jiorgos Kourelis
Abstract submission is now open for the IS-MPMI meeting in Cologne, Germany in July. You could consider submitting to the “Structure Informed Synthetic Biology: From Design to Function” session co-chaired by myself and @jiorgoskourelis.bsky.social 😁. Submission deadline 11 March.
January 27, 2025 at 10:02 PM
Reposted by Jiorgos Kourelis
synbio1.bsky.social
This pretty much settles it: we're entering the era of low-cost, on-demand binders for everything

Excited to see what people build now that "inject a llama with some junk and bleed it a month later" is no longer the cutting-edge tech
www.nature.com/articles/s41...
De novo designed proteins neutralize lethal snake venom toxins - Nature
Deep learning methods have been used to design proteins that can neutralize the effects of three-finger toxins found in snake venom, which could lead to the development of safer and more accessible an...
www.nature.com
January 15, 2025 at 9:04 PM
Reposted by Jiorgos Kourelis
tolgaboz.bsky.social
Our first annual lab Christmas/New Year dinner together with @jiorgoskourelis.bsky.social lab. Amazing food, fantastic company, and a wonderful team. Excited for another year of great discoveries ahead!
December 10, 2024 at 6:27 PM
jiorgoskourelis.bsky.social
📢 PhD Opportunity in my lab on Plant Immune Receptor Bioengineering at @imperiallifesci.bsky.social
🌱 Start: October 2025
📅 Deadline: 12th January 2025
🇬🇧 Open to UK students
💰 Fully funded
ℹ️ More info: tinyurl.com/w6ap9v9f
❗ #PlantImmunity #PlantPathology
🙏 Please share with interested candidates!
Bioengineering of plant NLR (nucleotide-binding leucine-rich repeat) immune receptors to enhance disease resistance at Imperial College London on FindAPhD.com
PhD Project - Bioengineering of plant NLR (nucleotide-binding leucine-rich repeat) immune receptors to enhance disease resistance at Imperial College London, listed on FindAPhD.com
www.findaphd.com
December 4, 2024 at 11:13 AM
Reposted by Jiorgos Kourelis
pierrebuscaill.bsky.social
🌿 Excited to share our latest research on how host proteases regulate immune activation!

Read more about how SBT5.2 releases and inactivates flg22: www.nature.com/articles/s41...
rdcu.be/d1UsT

Congratulations to all involved!
#PlantImmunity #PlantPathology #PlantChemeticsLab
Subtilase SBT5.2 inactivates flagellin immunogenicity in the plant apoplast - Nature Communications
Plants recognize bacteria by perceiving a 22-residue epitope in flagellin. Plant-secreted SBT5.2 subtilases are found to inactivate this epitope, leading to elicitor removal and reducing costly immuni...
www.nature.com
December 2, 2024 at 2:05 PM
Reposted by Jiorgos Kourelis
kamounlab.bsky.social
New!!!👇 #NLRbiology Kudos @amiralito_ @ryoheiterauchi @YuSugiharaY
November 27, 2024 at 8:05 AM
Reposted by Jiorgos Kourelis
adamrbentham.bsky.social
Can AI modelling of protein structures distinguish between sensor and helper NLR immune receptors?

biorxiv.org/cgi/content/...
Can AI modelling of protein structures distinguish between sensor and helper NLR immune receptors?
NLR immune receptors can be functionally organized in genetically linked sensor-helper pairs. However, methods to categorize paired NLRs remain limited, primarily relying on the presence of non-canoni...
biorxiv.org
November 27, 2024 at 6:11 AM
Reposted by Jiorgos Kourelis
somssich.bsky.social
📜 A nucleoside signal generated by a fungal endophyte regulates host cell death and promotes root colonization

🧑‍🔬 Nick Dunken, @algazuccaro.bsky.social, et al.

📔 Cell Host & Microbe

🔗 www.sciencedirect.com/science/arti...

#️⃣ #PlantScience #PlantImmunity
A nucleoside signal generated by a fungal endophyte regulates host cell death and promotes root colonization
The intracellular colonization of plant roots by the beneficial fungal endophyte Serendipita indica follows a biphasic strategy, including a host cell…
www.sciencedirect.com
November 27, 2024 at 10:13 AM
Reposted by Jiorgos Kourelis
parvinderkahlon.bsky.social
New Preprint!
Excited to share our method for profiling light elements in plant tissues using XRF. Fast, cost-effective, and no extraction needed—perfect for stress-related studies in plants.

Read more: www.biorxiv.org/content/10.1...

#PlantScience #XRF #Innovation
Quantitative light element (sodium and potassium) profiling in plant tissues using monochromatic X-ray fluorescence analysis
Accurately determining the elemental composition of plant tissues is essential for physiological studies on plant stress, including salinity tolerance. However, high-throughput routine analysis of lig...
www.biorxiv.org
November 22, 2024 at 10:47 AM
Reposted by Jiorgos Kourelis
kamounlab.bsky.social
Thank you Simon @SimonStael for hosting me today in Uppsala to talk to the Swedish University of Agricultural Sciences @_SLU students about GOHREP and how to science in general. Great discussions! kamounlab.medium.com/gohrep-and-p...
GOHREP and PLESI: guides to navigate through your research projects
Students can struggle to articulate the goals and rationale behind their research projects and navigate through the day to day challenges of laboratory research. GOHREP and PLESI can be helpful…
kamounlab.medium.com
November 18, 2024 at 4:29 PM
Reposted by Jiorgos Kourelis
adsteinbrenner.bsky.social
Reintroducing myself on Bluesky @adsteinbrenner.bsky.social -- I'm a plant biologist at UW Seattle (just recently made Associate Professor!)

We study the plant immune system with a special interest in recognition of chewing herbivores and host-pest molecular evolution.
November 18, 2024 at 11:20 PM
Reposted by Jiorgos Kourelis
talbotlabtsl.bsky.social
Last few days to apply for a PhD studentship in my group @thesainsburylab.bsky.social

biodtp.norwichresearchpark.ac.uk/projects/ide...
Identification of novel virulence determinants in the rice blast fungus Magnaporthe oryzae | Doctoral Training Partnership
TALBOT_S25DTP
biodtp.norwichresearchpark.ac.uk
November 19, 2024 at 4:36 PM
Reposted by Jiorgos Kourelis
frankmenke.bsky.social
📣 PhD opportunity at @thesainsburylab.bsky.social Norwich, UK.
"Investigating host penetration by the rice blast fungus" with Dr Frank Menke and Nick Talbot
@FrankMenke.bsky.social @talbotlabtsl.bsky.social

Apply before 25 Nov 2024! ⬇️
biodtp.norwichresearchpark.ac.uk/projects/inv...
November 18, 2024 at 5:45 PM
Reposted by Jiorgos Kourelis
thesainsburylab.bsky.social
📄 NEW PUBLICATION: Activation of plant immunity through conversion of a helper NLR homodimer into a resistosome
@amiralito.bsky.social @mpcontreras.bsky.social @kamounlab.bsky.social @m_selvaraj @mhz1989 @HsuanPai1

www.tsl.ac.uk/publications...
journals.plos.org/plosbiology/...
Activation of plant immunity through conversion of a helper NLR homodimer into a resistosome
Plants use NLR immune receptors, which often require downstream "helper" NLRs, for pathogen defense. This study identifies and structurally characterizes the mechanisms of NLR activation, showing that...
journals.plos.org
November 19, 2024 at 9:40 AM
Reposted by Jiorgos Kourelis
tatsuyanobori.bsky.social
Had a fantastic visit to Tübingen! Enjoyed discussions with the wonderful people at MPI @galofir.bsky.social @plantevolution.bsky.social (anyone else on this platform 🤔?). A big thank you to Shanshan Wang for nominating me for a prestigious seminar series. Special thanks to Honour for the tour!
November 18, 2024 at 7:04 PM
Reposted by Jiorgos Kourelis
pdchristine.bsky.social
We're looking for a postdoc to join our team. If you are fascinated by mechanisms of cell-to-cell communication in plants, get in touch to find out more. #PlantScience

www.jic.ac.uk/vacancies/po...
Postdoctoral Researcher (Faulkner Group) | John Innes Centre
An exciting opportunity has arisen for a Postdoctoral Researcher to join the Faulkner Group at the John Innes Centre, working on cutting-edge science in the field of Cell and Developmental Biology.
www.jic.ac.uk
October 1, 2024 at 9:28 AM
Reposted by Jiorgos Kourelis
natplants.nature.com
New Article: "The complete genome assembly of Nicotiana benthamiana reveals the genetic and epigenetic landscape of centromeres" rdcu.be/d0h6Q

...revealing the structure, epigenetic landscape and evolutionary dynamics of its centromeres following allotetraploidization. #PlantScience
November 15, 2024 at 11:15 AM
Reposted by Jiorgos Kourelis
mpcontreras.bsky.social
One bacterial NLR recognizing three different phage proteins vis direct interaction! How cool is that?

www.nature.com/articles/s41...
Diversification of molecular pattern recognition in bacterial NLR-like proteins - Nature Communications
Avs proteins are bacterial anti-phage pattern recognition receptors evolutionarily related to eukaryotic NLRs. Here, Béchon et al show that a single bacterial Avs can recognize different phage protein...
www.nature.com
November 14, 2024 at 9:25 PM
Reposted by Jiorgos Kourelis
soreklab.bsky.social
Happy to see our paper out @ Nat Comm

We discovered a bacterial NLR-like pattern recognition receptor that can sense 3 different viral proteins as a signature for infection. This explains its broad defense against different phage families

Congrats Nathalie Béchon!

www.nature.com/articles/s41...
Diversification of molecular pattern recognition in bacterial NLR-like proteins - Nature Communications
Avs proteins are bacterial anti-phage pattern recognition receptors evolutionarily related to eukaryotic NLRs. Here, Béchon et al show that a single bacterial Avs can recognize different phage protein...
www.nature.com
November 14, 2024 at 4:45 PM