Jack Bateman
@jbateman01.bsky.social
Biology professor at Bowdoin College. Genetics, flies, chromosomes, weird science 🥰
Pinned
Jack Bateman
@jbateman01.bsky.social
· Nov 12
I thought we could use a Drosophila starter pack, please let me know if you’d like to be added. (I think there is also a more general insect list out there somewhere that i cant find rn..) go.bsky.app/JGggkH3
Reposted by Jack Bateman
Some of the eggs laid by Iberian harvester ant queens contain males of another species, the builder harvester ant – and these males father all of the workers in the colony.
Queen ant makes males of another species for daughters to mate with
Bizarrely, Iberian harvester ant queens lay eggs that turn into male builder harvester ants, and some of her offspring are hybrids of the two species
www.newscientist.com
September 9, 2025 at 9:26 AM
Some of the eggs laid by Iberian harvester ant queens contain males of another species, the builder harvester ant – and these males father all of the workers in the colony.
Reposted by Jack Bateman
Identification of optimal fluorophores for use in the Drosophila embryo by Timothy E Saunders and team: www.biorxiv.org/content/10.1...
September 30, 2025 at 2:43 PM
Identification of optimal fluorophores for use in the Drosophila embryo by Timothy E Saunders and team: www.biorxiv.org/content/10.1...
Reposted by Jack Bateman
#Wolbachia has puzzled scientists with its power to rewire insect reproduction. What if I tell you that we found one of the keys Wolbachia use to rewire its host AND a small molecule inhibitor uses this key to mimic what this microbe has mastered for millions of years.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Beyond Wolbachia—Can a small molecule control insect reproduction?
Kaur et al. demonstrate reduced histone acetylation as a key mechanism underpinning
Wolbachia’s paternal-effect embryonic lethality trait in Drosophila melanogaster.
Recapitulation of this trait by in...
www.cell.com
October 3, 2025 at 12:58 PM
#Wolbachia has puzzled scientists with its power to rewire insect reproduction. What if I tell you that we found one of the keys Wolbachia use to rewire its host AND a small molecule inhibitor uses this key to mimic what this microbe has mastered for millions of years.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Site-specific DNA insertion into the human genome with engineered recombinases www.nature.com/articles/s41...
Site-specific DNA insertion into the human genome with engineered recombinases - Nature Biotechnology
Engineered DNA recombinases efficiently and specifically insert genetic cargos without the use of landing pads.
www.nature.com
November 12, 2025 at 11:10 PM
Site-specific DNA insertion into the human genome with engineered recombinases www.nature.com/articles/s41...
Heterozygosity at a conserved candidate sex determination locus is associated with female development in the clonal raider ant (Ooceraea biroi) elifesciences.org/articles/106...
Heterozygosity at a conserved candidate sex determination locus is associated with female development in the clonal raider ant (Ooceraea biroi)
A complementary sex determination locus is conserved in ants and dates back to approximately 112 million years ago.
elifesciences.org
November 10, 2025 at 1:55 PM
Heterozygosity at a conserved candidate sex determination locus is associated with female development in the clonal raider ant (Ooceraea biroi) elifesciences.org/articles/106...
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions www.cell.com/cell/fulltex...
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
Li et al. apply base-pair resolution Micro Capture-C ultra to map chromatin contacts
between individual motifs within cis-regulatory elements and reveal a unified model
of biophysically mediated enhan...
www.cell.com
November 9, 2025 at 3:42 PM
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions www.cell.com/cell/fulltex...
Bacterial tubular networks channel carbohydrates in insect endosymbiosis www.cell.com/cell/fulltex...
Bacterial tubular networks channel carbohydrates in insect endosymbiosis
Bacteria with an intracellular lifestyle need to feed from inside their host cells.
This study shows an adaptation of certain symbiotic bacteria, allowing them to actively
retrieve nutrients from the ...
www.cell.com
October 29, 2025 at 11:05 AM
Bacterial tubular networks channel carbohydrates in insect endosymbiosis www.cell.com/cell/fulltex...
Reposted by Jack Bateman
Ever noticed that #CRISPR editing results differ between cells? Awesome PhD student Moritz Schlapansky developed "scOUT-seq" to measure single cell transcriptomes + editing. 1.2 million cells, 74 cell types, living 🐭. Cell subtypes differ wildly from bulk average! www.biorxiv.org/content/10.1...
Cell-stereotyped DNA repair outcomes are widespread during genome editing
Genome editing outcomes are governed by DNA repair pathways that vary with cell type and state. We developed scOUT-seq (single-cell Outcomes Using Transcript sequencing), a scalable approach that join...
www.biorxiv.org
October 24, 2025 at 8:44 AM
Ever noticed that #CRISPR editing results differ between cells? Awesome PhD student Moritz Schlapansky developed "scOUT-seq" to measure single cell transcriptomes + editing. 1.2 million cells, 74 cell types, living 🐭. Cell subtypes differ wildly from bulk average! www.biorxiv.org/content/10.1...
Transcriptional interference gates monogenic odorant receptor expression in ants www.cell.com/current-biol...
Transcriptional interference gates monogenic odorant receptor expression in ants
Ant pheromone communication relies on an expanded odorant receptor repertoire, with
many genes in large genomic tandem arrays. Glotzer et al. describe a novel mechanism,
conserved across ants and othe...
www.cell.com
October 20, 2025 at 11:23 PM
Transcriptional interference gates monogenic odorant receptor expression in ants www.cell.com/current-biol...
Reposted by Jack Bateman
High levels of Cas9 are toxic in sensory neurons. Reducing Cas9 levels with uORFs avoids toxicity and is compatible with efficient editing. From @thompsonpeerlab.bsky.social. Fly lines @vdrc-flies.bsky.social
#CRISPR #Drosophila
www.biorxiv.org/content/10.1...
#CRISPR #Drosophila
www.biorxiv.org/content/10.1...
October 4, 2025 at 9:10 PM
High levels of Cas9 are toxic in sensory neurons. Reducing Cas9 levels with uORFs avoids toxicity and is compatible with efficient editing. From @thompsonpeerlab.bsky.social. Fly lines @vdrc-flies.bsky.social
#CRISPR #Drosophila
www.biorxiv.org/content/10.1...
#CRISPR #Drosophila
www.biorxiv.org/content/10.1...
Kinetic organization of the genome revealed by ultraresolution multiscale live imaging www.science.org/doi/10.1126/...
Kinetic organization of the genome revealed by ultraresolution multiscale live imaging
Genome function requires regulated genome motion. However, tools to directly observe this motion in vivo have been limited in coverage and resolution. Here we introduce an approach to tile mammalian c...
www.science.org
September 19, 2025 at 9:54 AM
Kinetic organization of the genome revealed by ultraresolution multiscale live imaging www.science.org/doi/10.1126/...
Reposted by Jack Bateman
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene by the @basvansteensellab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...
www.science.org
September 19, 2025 at 7:50 AM
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene by the @basvansteensellab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Jack Bateman
We’re excited to share that, after receiving many requests each year from the research community for Oligopaint DNA & RNA FISH probes, we’re piloting a service to design & prepare probes for labs.
Please share with colleagues who may benefit!
ericjoycelab.com/oligopaint-f...
Please share with colleagues who may benefit!
ericjoycelab.com/oligopaint-f...
Oligopaint Probe Requests
In an effort to make Oligopaint FISH probes more broadly available to the research community, we offer DNA and RNA FISH probe design, synthesis, and generation. By dedicating a full-time staff memb…
ericjoycelab.com
September 16, 2025 at 5:44 PM
We’re excited to share that, after receiving many requests each year from the research community for Oligopaint DNA & RNA FISH probes, we’re piloting a service to design & prepare probes for labs.
Please share with colleagues who may benefit!
ericjoycelab.com/oligopaint-f...
Please share with colleagues who may benefit!
ericjoycelab.com/oligopaint-f...
Is enhancer-driven gene regulation all wrapped up? www.nature.com/articles/s41...
Is enhancer-driven gene regulation all wrapped up? - Nature Reviews Genetics
In this Comment, Wendy Bickmore discusses mechanistic models of how 3D genome organization facilitates communication between distant enhancers and their target promoters to regulate gene expression.
www.nature.com
September 17, 2025 at 1:08 PM
Is enhancer-driven gene regulation all wrapped up? www.nature.com/articles/s41...
Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function genesdev.cshlp.org/content/39/1...
Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
genesdev.cshlp.org
September 16, 2025 at 10:56 AM
Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function genesdev.cshlp.org/content/39/1...
What makes genes burst www.cell.com/trends/cell-...
What makes genes burst
Genes burst. Instead of being monotonously transcribed by a steady stream of RNA polymerases,
active genes undergo transient and random pulses of transcription that are referred
to as gene bursting. T...
www.cell.com
September 3, 2025 at 8:45 PM
What makes genes burst www.cell.com/trends/cell-...
Reposted by Jack Bateman
[Review] Configuring the code: Enhancer-Promoter arrangement and transcriptional regulation in @jmolbiol.bsky.social #genesky
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Configuring the Code: Enhancer-Promoter Arrangement and Transcriptional Regulation
The precise spatial and temporal regulation of gene expression through enhancer-promoter (E-P) interactions represents a fundamental mechanism underly…
www.sciencedirect.com
September 3, 2025 at 8:37 AM
[Review] Configuring the code: Enhancer-Promoter arrangement and transcriptional regulation in @jmolbiol.bsky.social #genesky
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A de novo-originated gene drives rose scent diversification www.cell.com/cell/fulltex...
A de novo-originated gene drives rose scent diversification
Genomic analysis of more than 100 Rosa species uncovers a multi-step process for the
de novo origination of SCREP, a taxon-restricted gene specific to the Rosa genus,
highlighting its function in modu...
www.cell.com
September 3, 2025 at 10:36 AM
A de novo-originated gene drives rose scent diversification www.cell.com/cell/fulltex...
Driving a protective allele of the mosquito FREP1 gene to combat malaria www.nature.com/articles/s41...
Driving a protective allele of the mosquito FREP1 gene to combat malaria - Nature
Coupling of a FREP1 variant to a gene-drive system allows the spread of a host malaria resistance allele through the mosquito population.
www.nature.com
July 26, 2025 at 5:30 PM
Driving a protective allele of the mosquito FREP1 gene to combat malaria www.nature.com/articles/s41...
Nanoscale 3D DNA tracing in non-denatured cells resolves the Cohesin-dependent loop architecture of the genome in situ www.nature.com/articles/s41...
Nanoscale 3D DNA tracing in non-denatured cells resolves the Cohesin-dependent loop architecture of the genome in situ - Nature Communications
A nanoscale 3D DNA tracing workflow visualizes Cohesin-dependent loops in single, structurally well-preserved cells. Computer simulations based on the tracing data give further insight into how Cohesi...
www.nature.com
July 24, 2025 at 12:41 PM
Nanoscale 3D DNA tracing in non-denatured cells resolves the Cohesin-dependent loop architecture of the genome in situ www.nature.com/articles/s41...
Reposted by Jack Bateman
New online: A conserved coupling of transcriptional ON and OFF periods underlies bursting dynamics
A conserved coupling of transcriptional ON and OFF periods underlies bursting dynamics
Nature Structural & Molecular Biology, Published online: 15 July 2025; doi:10.1038/s41594-025-01615-4Gene activity levels predict how often and how strongly genes turn on and off. Using live imaging in fruit fly embryos, the authors uncover a conserved rule linking transcriptional bursts to gene activity across time, space and species.
go.nature.com
July 15, 2025 at 10:07 AM
New online: A conserved coupling of transcriptional ON and OFF periods underlies bursting dynamics
Range extender mediates long-distance enhancer activity www.nature.com/articles/s41...
Range extender mediates long-distance enhancer activity - Nature
The REX element is associated with long-range enhancer–promoter interactions.
www.nature.com
July 17, 2025 at 2:10 AM
Range extender mediates long-distance enhancer activity www.nature.com/articles/s41...
Reposted by Jack Bateman
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics
Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...
www.nature.com
July 9, 2025 at 10:05 AM
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Reposted by Jack Bateman
Our work bridging enhancer-promoter proximity to phenotypic outcomes in vivo is out! Shout out to @olimpiabompadre.bsky.social, to Marie Kmita's lab, and to all the co-authors. www.nature.com/articles/s41...
Liebenberg syndrome severity arises from variations in Pitx1 locus topology and proportion of ectopically transcribing cells - Nature Communications
Here the authors show that reducing enhancer-promoter distance at the Pitx1 locus increases proportion of Pitx1 forelimb expressing cells, worsening skeletal defects in Liebenberg syndrome. They also ...
www.nature.com
July 9, 2025 at 11:58 AM
Our work bridging enhancer-promoter proximity to phenotypic outcomes in vivo is out! Shout out to @olimpiabompadre.bsky.social, to Marie Kmita's lab, and to all the co-authors. www.nature.com/articles/s41...
Reposted by Jack Bateman
We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
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www.biorxiv.org/content/10.1...
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July 15, 2025 at 8:11 AM
We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
1/
www.biorxiv.org/content/10.1...
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