Sophie Janssens Lab
@janssenslab.bsky.social
dendritic cell biology lab, interested in how dendritic cells maintain the balance between tolerance and immunity, and in the role of the UPR in immune cell functioning
Our study revealed that empty LNPs do not induce immunogenic maturation of DCs, while mRNA-containing lipids do, showing that the cargo, not the lipids, determine adjuvanticity.
August 21, 2025 at 5:06 PM
Our study revealed that empty LNPs do not induce immunogenic maturation of DCs, while mRNA-containing lipids do, showing that the cargo, not the lipids, determine adjuvanticity.
By using an approach relying on the induction of homeostatic DC maturation by uptake of empty LNPs and immunogenic DC maturation by TLR ligand-adjuvanted LNPs, and performing CITE-SEQ, a flow cytometry panel was designed to assign mature DCs as immunogenic or homeostatic.
August 21, 2025 at 5:06 PM
By using an approach relying on the induction of homeostatic DC maturation by uptake of empty LNPs and immunogenic DC maturation by TLR ligand-adjuvanted LNPs, and performing CITE-SEQ, a flow cytometry panel was designed to assign mature DCs as immunogenic or homeostatic.