James Briscoe
@jamesbriscoe.bsky.social
Developmental Biologist working at the Francis Crick Institute. Neural tube, morphogens, and gene regulatory networks. Editor-in-chief, Development.
London · briscoelab.org
London · briscoelab.org
Pinned
Our latest: *Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding*
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
Nice summary of a recent @dev-journal.bsky.social paper
Researchers have identified gene-regulatory variants that might have contributed to Neanderthals’ beefy jaws — offering a window on how the human face developed
go.nature.com/3Ke6StJ
go.nature.com/3Ke6StJ
Neanderthal DNA reveals how human faces form
Subtle genomic variations between humans and Neanderthals provide clues to how DNA shapes our facial features.
go.nature.com
November 21, 2025 at 3:38 PM
Nice summary of a recent @dev-journal.bsky.social paper
Reposted by James Briscoe
It's always special when you find your own paper in the table of contents of the journal 😍
"The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube" -> Now out in its final form
www.cell.com/developmenta...
"The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube" -> Now out in its final form
www.cell.com/developmenta...
November 18, 2025 at 4:11 PM
It's always special when you find your own paper in the table of contents of the journal 😍
"The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube" -> Now out in its final form
www.cell.com/developmenta...
"The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube" -> Now out in its final form
www.cell.com/developmenta...
Good to see the peer reviewed version of this in print
The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube
A global temporal chromatin program operates across the vertebrate nervous system to control neural cell diversity
www.cell.com/developmenta...
The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube
A global temporal chromatin program operates across the vertebrate nervous system to control neural cell diversity
www.cell.com/developmenta...
The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube
Zhang et al. identify a global temporal chromatin program that operates across the
developing vertebrate nervous system to control neural cell diversity. This mechanism,
which involves Nr6a1 and NFIA/...
www.cell.com
November 18, 2025 at 8:59 AM
Good to see the peer reviewed version of this in print
The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube
A global temporal chromatin program operates across the vertebrate nervous system to control neural cell diversity
www.cell.com/developmenta...
The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube
A global temporal chromatin program operates across the vertebrate nervous system to control neural cell diversity
www.cell.com/developmenta...
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Closing date 27th November
www.crick.ac.uk/careers-stud...
November 17, 2025 at 11:55 AM
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Closing date 27th November
www.crick.ac.uk/careers-stud...
Check out this month's handpicked preprints in developmantal & stem cell biology on the Node
thenode.biologists.com/prelighters-...
thenode.biologists.com/prelighters-...
thenode.biologists.com
November 13, 2025 at 8:18 AM
Check out this month's handpicked preprints in developmantal & stem cell biology on the Node
thenode.biologists.com/prelighters-...
thenode.biologists.com/prelighters-...
Reposted by James Briscoe
We have a new lab photo. Busy times in the Delas Lab!
Last month Maria and Shaun joined us to start their PhDs.
Learn more about our research and our team: delaslab.com
We will be recruiting another postdoc next year so have a look through our recent work and get in touch if you are interested.
Last month Maria and Shaun joined us to start their PhDs.
Learn more about our research and our team: delaslab.com
We will be recruiting another postdoc next year so have a look through our recent work and get in touch if you are interested.
November 12, 2025 at 2:04 PM
We have a new lab photo. Busy times in the Delas Lab!
Last month Maria and Shaun joined us to start their PhDs.
Learn more about our research and our team: delaslab.com
We will be recruiting another postdoc next year so have a look through our recent work and get in touch if you are interested.
Last month Maria and Shaun joined us to start their PhDs.
Learn more about our research and our team: delaslab.com
We will be recruiting another postdoc next year so have a look through our recent work and get in touch if you are interested.
Reposted by James Briscoe
Lates from the Briscoe lab: Lineage tracing of neural progenitors in 🐤& 👤 - demonstrates sequential binary decisions & persistence of spatial identity despite temporal competence changes.
Congrats to Giulia and co 🍾🥂
Congrats to Giulia and co 🍾🥂
Thrilled to share my main postdoc work with @jamesbriscoe.bsky.social
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding
The formation of neural circuits depends on the precise spatial and temporal organisation of neuronal populations during development. In the vertebrate spinal cord, progenitors are patterned into mole...
www.biorxiv.org
November 11, 2025 at 7:36 AM
Lates from the Briscoe lab: Lineage tracing of neural progenitors in 🐤& 👤 - demonstrates sequential binary decisions & persistence of spatial identity despite temporal competence changes.
Congrats to Giulia and co 🍾🥂
Congrats to Giulia and co 🍾🥂
Reposted by James Briscoe
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
November 10, 2025 at 11:11 AM
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
BBC News - James Watson: Controversial discoverer of 'the secret of life'
www.bbc.com/news/article...
www.bbc.com/news/article...
Obituary: James Watson
James Watson, the godfather of DNA who discovered the "secrets of life" has died aged 97.
www.bbc.com
November 7, 2025 at 8:43 PM
BBC News - James Watson: Controversial discoverer of 'the secret of life'
www.bbc.com/news/article...
www.bbc.com/news/article...
Working in a biomed institute, its natural to think about health & medical impact of dev bio but there's more to dev bio
Agriculture is dev bio (plant growth, livestock breeding)
And dev bio is important to understand environment & climate impact. See e.g:
journals.biologists.com/dev/article/...
Agriculture is dev bio (plant growth, livestock breeding)
And dev bio is important to understand environment & climate impact. See e.g:
journals.biologists.com/dev/article/...
In preprints: multiomics of low temperature acclimation in the era of intensifying temperature fluctuations
In a warming world, all life forms – endotherms and ectotherms alike – are finding their homeostasis being challenged. The environmental change is challenging at all stages of life. How different orga...
journals.biologists.com
November 5, 2025 at 12:33 PM
Working in a biomed institute, its natural to think about health & medical impact of dev bio but there's more to dev bio
Agriculture is dev bio (plant growth, livestock breeding)
And dev bio is important to understand environment & climate impact. See e.g:
journals.biologists.com/dev/article/...
Agriculture is dev bio (plant growth, livestock breeding)
And dev bio is important to understand environment & climate impact. See e.g:
journals.biologists.com/dev/article/...
Development that lasts a life time. Check out the 2025 special issue of @dev-journal.bsky.social on Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
journals.biologists.com/dev/issue/15...
journals.biologists.com/dev/issue/15...
Volume 152 Issue 20 | Development | The Company of Biologists
journals.biologists.com
November 5, 2025 at 8:54 AM
Development that lasts a life time. Check out the 2025 special issue of @dev-journal.bsky.social on Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
journals.biologists.com/dev/issue/15...
journals.biologists.com/dev/issue/15...
Reposted by James Briscoe
November 5, 2025 at 2:01 AM
Looking forward to a day with the developmental biologists at WashU in St Louis.
Honoured to be giving the 44th Annual Oliver H. Lowry Lecture
4pm Jeffrey T. Fort NRB Building, Auditorium
happenings.wustl.edu/event/44th-a...
Honoured to be giving the 44th Annual Oliver H. Lowry Lecture
4pm Jeffrey T. Fort NRB Building, Auditorium
happenings.wustl.edu/event/44th-a...
44th Annual Oliver H. Lowry Lecture: 'The Dynamics of Neural Tube Development'
happenings.wustl.edu
October 30, 2025 at 1:07 PM
Looking forward to a day with the developmental biologists at WashU in St Louis.
Honoured to be giving the 44th Annual Oliver H. Lowry Lecture
4pm Jeffrey T. Fort NRB Building, Auditorium
happenings.wustl.edu/event/44th-a...
Honoured to be giving the 44th Annual Oliver H. Lowry Lecture
4pm Jeffrey T. Fort NRB Building, Auditorium
happenings.wustl.edu/event/44th-a...
Reposted by James Briscoe
New preprint out! Evolutionarily conserved transcriptional regulators control monoaminergic neuron development.
We uncover how ancient regulatory programs orchestrate the neurons that produce serotonin and dopamine across 550 million years of evolution.
doi.org/10.1101/2025...
We uncover how ancient regulatory programs orchestrate the neurons that produce serotonin and dopamine across 550 million years of evolution.
doi.org/10.1101/2025...
Evolutionarily conserved transcriptional regulators control monoaminergic neuron development
To what extent conserved developmental programs specify homologous cell types is a central question in biology. Here, we address this by focusing on reconstructing monoaminergic neuron development in ...
doi.org
October 30, 2025 at 9:42 AM
New preprint out! Evolutionarily conserved transcriptional regulators control monoaminergic neuron development.
We uncover how ancient regulatory programs orchestrate the neurons that produce serotonin and dopamine across 550 million years of evolution.
doi.org/10.1101/2025...
We uncover how ancient regulatory programs orchestrate the neurons that produce serotonin and dopamine across 550 million years of evolution.
doi.org/10.1101/2025...
Good to see this study from Ribes & co in print: PAX3/PAX7 transcription factors control neural tube patterning by simultaneously repressing ventral fates via H3K27me3 deposition at silencers & activating dorsal fates as pioneer factors at enhancers
@ribes
journals.plos.org/plosbiology/...
@ribes
journals.plos.org/plosbiology/...
Dual transcriptional activities of PAX3 and PAX7 spatially encode spinal cell fates through distinct gene networks
How do transcription factors, with pleotropic functions, generate organized cellular diversity in developing tissues? This study shows that PAX3 and PAX7 orchestrate spinal cord patterning by acting a...
journals.plos.org
October 29, 2025 at 3:21 PM
Good to see this study from Ribes & co in print: PAX3/PAX7 transcription factors control neural tube patterning by simultaneously repressing ventral fates via H3K27me3 deposition at silencers & activating dorsal fates as pioneer factors at enhancers
@ribes
journals.plos.org/plosbiology/...
@ribes
journals.plos.org/plosbiology/...
Looking forward to a day visiting friends and colleagues at @stowersinstitute.bsky.social
Seminar at noon
www.stowers.org
Seminar at noon
www.stowers.org
Home
Home
www.stowers.org
October 28, 2025 at 1:02 PM
Looking forward to a day visiting friends and colleagues at @stowersinstitute.bsky.social
Seminar at noon
www.stowers.org
Seminar at noon
www.stowers.org
Reposted by James Briscoe
Our latest: *Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding*
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
October 27, 2025 at 8:50 AM
Our latest: *Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding*
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
Reposted by James Briscoe
Beautiful, insightful study from Boezio et al. One of the best clonal analyses I’ve seen so far. We’ll dig in this week! Check it out!
October 26, 2025 at 8:22 PM
Beautiful, insightful study from Boezio et al. One of the best clonal analyses I’ve seen so far. We’ll dig in this week! Check it out!
Our latest: *Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding*
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
October 27, 2025 at 8:50 AM
Our latest: *Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding*
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
Reposted by James Briscoe
Thrilled to share my main postdoc work with @jamesbriscoe.bsky.social
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding
The formation of neural circuits depends on the precise spatial and temporal organisation of neuronal populations during development. In the vertebrate spinal cord, progenitors are patterned into mole...
www.biorxiv.org
October 26, 2025 at 5:15 PM
Thrilled to share my main postdoc work with @jamesbriscoe.bsky.social
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
Reposted by James Briscoe
Really impressive study on spinal cord development by @giulia-boezio.bsky.social and @jamesbriscoe.bsky.social. #neurodevelopment
Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding https://www.biorxiv.org/content/10.1101/2025.10.24.684328v1
October 24, 2025 at 5:23 PM
Really impressive study on spinal cord development by @giulia-boezio.bsky.social and @jamesbriscoe.bsky.social. #neurodevelopment
Reposted by James Briscoe
This week has been special for us, marking 100 years of supporting biologists and inspiring biology. We celebrated our achievements at @zoologymuseum.bsky.social last night. We want to thank all our staff, whose continual inspiration and daily support for one another make our work possible.
October 17, 2025 at 1:11 PM
This week has been special for us, marking 100 years of supporting biologists and inspiring biology. We celebrated our achievements at @zoologymuseum.bsky.social last night. We want to thank all our staff, whose continual inspiration and daily support for one another make our work possible.
Reposted by James Briscoe
Mansi Srivastava is a Guest Editor for our Special Issue on Lifelong Development #LifelongDevSI. In this interview, Mansi talks about her research path, the links between regeneration and development and the exciting questions her lab is trying to answer.
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
October 16, 2025 at 4:45 PM
Mansi Srivastava is a Guest Editor for our Special Issue on Lifelong Development #LifelongDevSI. In this interview, Mansi talks about her research path, the links between regeneration and development and the exciting questions her lab is trying to answer.
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
Reposted by James Briscoe
1953: The Company launches the Journal of Embryology and Experimental Morphology. In 1987, JEEM is renamed Development @dev-journal.bsky.social. Read their 100-year anniversary articles collection: bit.ly/42vDGED
October 15, 2025 at 12:03 PM
1953: The Company launches the Journal of Embryology and Experimental Morphology. In 1987, JEEM is renamed Development @dev-journal.bsky.social. Read their 100-year anniversary articles collection: bit.ly/42vDGED