Jack - amatica health
@jackamatica.bsky.social
Full paper link:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 25, 2025 at 3:32 PM
Full paper link:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The results support testing GNA lectin based filtration, such as the Hemopurifier, in Long COVID.
A clinical trial is needed to see if removing these EVs reduces symptoms.
A clinical trial is needed to see if removing these EVs reduces symptoms.
November 25, 2025 at 3:32 PM
The results support testing GNA lectin based filtration, such as the Hemopurifier, in Long COVID.
A clinical trial is needed to see if removing these EVs reduces symptoms.
A clinical trial is needed to see if removing these EVs reduces symptoms.
The study did not test whether the mannose rich EVs carry viral proteins, autoantibodies, or reactivated viruses like EBV.
These will need to be investigated in future work.
These will need to be investigated in future work.
November 25, 2025 at 3:32 PM
The study did not test whether the mannose rich EVs carry viral proteins, autoantibodies, or reactivated viruses like EBV.
These will need to be investigated in future work.
These will need to be investigated in future work.
The study has limits.
The sample size was small.
It examined only one time point.
The miRNA panel covers a fixed list of miRNAs.
Pathway effects were predicted rather than measured directly.
The sample size was small.
It examined only one time point.
The miRNA panel covers a fixed list of miRNAs.
Pathway effects were predicted rather than measured directly.
November 25, 2025 at 3:32 PM
The study has limits.
The sample size was small.
It examined only one time point.
The miRNA panel covers a fixed list of miRNAs.
Pathway effects were predicted rather than measured directly.
The sample size was small.
It examined only one time point.
The miRNA panel covers a fixed list of miRNAs.
Pathway effects were predicted rather than measured directly.
The results suggest that filtering mannose rich EVs may help rebalance immune and repair signals in Long COVID.
This is only a prediction and needs clinical testing.
This is only a prediction and needs clinical testing.
November 25, 2025 at 3:32 PM
The results suggest that filtering mannose rich EVs may help rebalance immune and repair signals in Long COVID.
This is only a prediction and needs clinical testing.
This is only a prediction and needs clinical testing.
Some inflammatory pathways like NF kB, MAPK, and TNF alpha were predicted to rise.
This may help certain Long COVID patients because some subgroups have unusually low immune responses that need restoring.
This may help certain Long COVID patients because some subgroups have unusually low immune responses that need restoring.
November 25, 2025 at 3:32 PM
Some inflammatory pathways like NF kB, MAPK, and TNF alpha were predicted to rise.
This may help certain Long COVID patients because some subgroups have unusually low immune responses that need restoring.
This may help certain Long COVID patients because some subgroups have unusually low immune responses that need restoring.
Other pathways, such as Estrogen, VEGF, EGFR, and PI3K, were predicted to increase.
These pathways can support blood vessel repair, tissue recovery, and nitric oxide production, which influences blood flow.
These pathways can support blood vessel repair, tissue recovery, and nitric oxide production, which influences blood flow.
November 25, 2025 at 3:32 PM
Other pathways, such as Estrogen, VEGF, EGFR, and PI3K, were predicted to increase.
These pathways can support blood vessel repair, tissue recovery, and nitric oxide production, which influences blood flow.
These pathways can support blood vessel repair, tissue recovery, and nitric oxide production, which influences blood flow.
Removing these miRNAs was predicted to lower activity in the JAK STAT pathway.
This pathway is often kept active by interferons, which are immune signals. Overactive interferon signaling has been suggested as a driver of persistent symptoms.
This pathway is often kept active by interferons, which are immune signals. Overactive interferon signaling has been suggested as a driver of persistent symptoms.
November 25, 2025 at 3:32 PM
Removing these miRNAs was predicted to lower activity in the JAK STAT pathway.
This pathway is often kept active by interferons, which are immune signals. Overactive interferon signaling has been suggested as a driver of persistent symptoms.
This pathway is often kept active by interferons, which are immune signals. Overactive interferon signaling has been suggested as a driver of persistent symptoms.
The 7 miRNAs each regulate specific genes. In total, they influence 32 known gene targets.
The team used these known interactions to predict how removing the miRNAs might shift biological pathways.
The team used these known interactions to predict how removing the miRNAs might shift biological pathways.
November 25, 2025 at 3:32 PM
The 7 miRNAs each regulate specific genes. In total, they influence 32 known gene targets.
The team used these known interactions to predict how removing the miRNAs might shift biological pathways.
The team used these known interactions to predict how removing the miRNAs might shift biological pathways.
Out of 827 miRNAs measured, 358 were detected in meaningful amounts. After correction for many tests, 7 miRNAs were significantly reduced by GNA treatment.
This means these 7 miRNAs were likely carried by mannose rich EVs.
This means these 7 miRNAs were likely carried by mannose rich EVs.
November 25, 2025 at 3:32 PM
Out of 827 miRNAs measured, 358 were detected in meaningful amounts. After correction for many tests, 7 miRNAs were significantly reduced by GNA treatment.
This means these 7 miRNAs were likely carried by mannose rich EVs.
This means these 7 miRNAs were likely carried by mannose rich EVs.
The team also studied miRNA.
These are short RNA sequences carried by EVs that can change how genes behave.
They measured which miRNAs were removed from plasma after GNA resin treatment.
These are short RNA sequences carried by EVs that can change how genes behave.
They measured which miRNAs were removed from plasma after GNA resin treatment.
November 25, 2025 at 3:32 PM
The team also studied miRNA.
These are short RNA sequences carried by EVs that can change how genes behave.
They measured which miRNAs were removed from plasma after GNA resin treatment.
These are short RNA sequences carried by EVs that can change how genes behave.
They measured which miRNAs were removed from plasma after GNA resin treatment.
Recovered people did not show this pattern.
Their EVs did not correlate with removal by GNA resin.
This suggests that mannose related changes are specific to Long COVID.
Their EVs did not correlate with removal by GNA resin.
This suggests that mannose related changes are specific to Long COVID.
November 25, 2025 at 3:32 PM
Recovered people did not show this pattern.
Their EVs did not correlate with removal by GNA resin.
This suggests that mannose related changes are specific to Long COVID.
Their EVs did not correlate with removal by GNA resin.
This suggests that mannose related changes are specific to Long COVID.
Small EVs from Long COVID samples were removed more by the GNA resin than small EVs from recovered people.
The more mannose positive EVs someone had, the more EVs the resin removed.
The more mannose positive EVs someone had, the more EVs the resin removed.
November 25, 2025 at 3:32 PM
Small EVs from Long COVID samples were removed more by the GNA resin than small EVs from recovered people.
The more mannose positive EVs someone had, the more EVs the resin removed.
The more mannose positive EVs someone had, the more EVs the resin removed.
Because mannose staining was harder to measure on very small EVs, researchers tested whether GNA resin could remove small EVs from the blood.
GNA resin is the same type used in the Hemopurifier device.
GNA resin is the same type used in the Hemopurifier device.
November 25, 2025 at 3:32 PM
Because mannose staining was harder to measure on very small EVs, researchers tested whether GNA resin could remove small EVs from the blood.
GNA resin is the same type used in the Hemopurifier device.
GNA resin is the same type used in the Hemopurifier device.
The researchers looked at mannose, a sugar pattern on EV surfaces.
Mannose was measured because the GNA resin binds to this sugar.
Long COVID samples had about double the amount of mannose positive EVs compared to those who recovered.
Mannose was measured because the GNA resin binds to this sugar.
Long COVID samples had about double the amount of mannose positive EVs compared to those who recovered.
November 25, 2025 at 3:32 PM
The researchers looked at mannose, a sugar pattern on EV surfaces.
Mannose was measured because the GNA resin binds to this sugar.
Long COVID samples had about double the amount of mannose positive EVs compared to those who recovered.
Mannose was measured because the GNA resin binds to this sugar.
Long COVID samples had about double the amount of mannose positive EVs compared to those who recovered.
In Long COVID, large and small EV counts rose together. This link did not appear in recovered people.
This suggests a shared process in Long COVID that increases several kinds of EVs at the same time.
This suggests a shared process in Long COVID that increases several kinds of EVs at the same time.
November 25, 2025 at 3:32 PM
In Long COVID, large and small EV counts rose together. This link did not appear in recovered people.
This suggests a shared process in Long COVID that increases several kinds of EVs at the same time.
This suggests a shared process in Long COVID that increases several kinds of EVs at the same time.
EV levels varied a lot between individuals, but people with Long COVID often had more EVs than those who recovered.
This was not statistically strong because of large differences between people.
This was not statistically strong because of large differences between people.
November 25, 2025 at 3:32 PM
EV levels varied a lot between individuals, but people with Long COVID often had more EVs than those who recovered.
This was not statistically strong because of large differences between people.
This was not statistically strong because of large differences between people.
Blood was processed to separate large EVs (100 to 500 nanometers) and small EVs (40 to 200 nanometers).
November 25, 2025 at 3:32 PM
Blood was processed to separate large EVs (100 to 500 nanometers) and small EVs (40 to 200 nanometers).
The study compared three groups:
people fully recovered after COVID
people with Long COVID
and those with Long COVID plus brain related symptoms.
Each group had 15 people.
people fully recovered after COVID
people with Long COVID
and those with Long COVID plus brain related symptoms.
Each group had 15 people.
November 25, 2025 at 3:32 PM
The study compared three groups:
people fully recovered after COVID
people with Long COVID
and those with Long COVID plus brain related symptoms.
Each group had 15 people.
people fully recovered after COVID
people with Long COVID
and those with Long COVID plus brain related symptoms.
Each group had 15 people.
EVs are tiny bubbles released by cells. They carry proteins and genetic material.
They can influence inflammation and the immune system. In Long COVID, EVs may help keep symptoms going.
They can influence inflammation and the immune system. In Long COVID, EVs may help keep symptoms going.
November 25, 2025 at 3:32 PM
EVs are tiny bubbles released by cells. They carry proteins and genetic material.
They can influence inflammation and the immune system. In Long COVID, EVs may help keep symptoms going.
They can influence inflammation and the immune system. In Long COVID, EVs may help keep symptoms going.
Full paper link: pubmed.ncbi.nlm.nih.gov/32450569/
November 20, 2025 at 4:29 PM
Full paper link: pubmed.ncbi.nlm.nih.gov/32450569/
The study also suggests that treatment has measurable biological effects in responders that are not seen in non responders, pointing to distinct biological subgroups.
November 20, 2025 at 4:29 PM
The study also suggests that treatment has measurable biological effects in responders that are not seen in non responders, pointing to distinct biological subgroups.
The results show that biological markers plus clinical data may help identify who will respond to amisulpride early in treatment, which could shorten the trial and error process.
November 20, 2025 at 4:29 PM
The results show that biological markers plus clinical data may help identify who will respond to amisulpride early in treatment, which could shorten the trial and error process.