Jack - amatica health
@jackamatica.bsky.social
Extremely cool new study reports that people with Long COVID have higher levels of blood particles called extracellular vesicles (EVs). These particles also have more mannose, a type of sugar molecule.
This may allow a device called a GNA lectin filter to remove them. 🧵
This may allow a device called a GNA lectin filter to remove them. 🧵
November 25, 2025 at 3:32 PM
Extremely cool new study reports that people with Long COVID have higher levels of blood particles called extracellular vesicles (EVs). These particles also have more mannose, a type of sugar molecule.
This may allow a device called a GNA lectin filter to remove them. 🧵
This may allow a device called a GNA lectin filter to remove them. 🧵
We will be speaking tonight at 5pm GMT at the Renegade Research roundtable.
We will be discussing our mission, our approach, the 31 marker batch 2 results, RNA sequencing, and more
Everyone welcome - sign up:
us06web.zoom.us/webinar/regi...
We will be discussing our mission, our approach, the 31 marker batch 2 results, RNA sequencing, and more
Everyone welcome - sign up:
us06web.zoom.us/webinar/regi...
Welcome! You are invited to join a webinar: Amatica Health tests for Clinicians. After registering, you will receive a confirmation email about joining the webinar.
Renegade Research is hosting a clinician's roundtable. Amatica will be discussing their 31 marker results in ME/CFS & Long COVID, their RNA sequencing test, and their mission as a whole, including how...
us06web.zoom.us
November 21, 2025 at 10:53 AM
We will be speaking tonight at 5pm GMT at the Renegade Research roundtable.
We will be discussing our mission, our approach, the 31 marker batch 2 results, RNA sequencing, and more
Everyone welcome - sign up:
us06web.zoom.us/webinar/regi...
We will be discussing our mission, our approach, the 31 marker batch 2 results, RNA sequencing, and more
Everyone welcome - sign up:
us06web.zoom.us/webinar/regi...
Study in first episode psychosis found that only patients who improved on amisulpride showed clear changes in blood RNA gene expression could predict response with very high accuracy
A similar method to what we aim to do in Long COVID and ME at @amaticahealth
Paper breakdown 🧵
A similar method to what we aim to do in Long COVID and ME at @amaticahealth
Paper breakdown 🧵
November 20, 2025 at 4:29 PM
Study in first episode psychosis found that only patients who improved on amisulpride showed clear changes in blood RNA gene expression could predict response with very high accuracy
A similar method to what we aim to do in Long COVID and ME at @amaticahealth
Paper breakdown 🧵
A similar method to what we aim to do in Long COVID and ME at @amaticahealth
Paper breakdown 🧵
New paper links EBV to Lupus.
In lupus (SLE), Epstein Barr virus (EBV) infects B cells that react to the body’s own nuclear material. EBV then changes these B cells so they act like antigen presenting cells. This may help drive the autoimmune process
Breakdown 🧵
In lupus (SLE), Epstein Barr virus (EBV) infects B cells that react to the body’s own nuclear material. EBV then changes these B cells so they act like antigen presenting cells. This may help drive the autoimmune process
Breakdown 🧵
November 19, 2025 at 3:13 PM
New paper links EBV to Lupus.
In lupus (SLE), Epstein Barr virus (EBV) infects B cells that react to the body’s own nuclear material. EBV then changes these B cells so they act like antigen presenting cells. This may help drive the autoimmune process
Breakdown 🧵
In lupus (SLE), Epstein Barr virus (EBV) infects B cells that react to the body’s own nuclear material. EBV then changes these B cells so they act like antigen presenting cells. This may help drive the autoimmune process
Breakdown 🧵
Study identifies blood and kidney RNA patterns that may help predict which lupus nephritis patients respond to treatment and who may flare later.
A similar method to what we aim to do in Long COVID & ME/CFS with @amaticahealth - join:
amaticahealth.com
Paper breakdown 🧵
A similar method to what we aim to do in Long COVID & ME/CFS with @amaticahealth - join:
amaticahealth.com
Paper breakdown 🧵
November 18, 2025 at 3:11 PM
Study identifies blood and kidney RNA patterns that may help predict which lupus nephritis patients respond to treatment and who may flare later.
A similar method to what we aim to do in Long COVID & ME/CFS with @amaticahealth - join:
amaticahealth.com
Paper breakdown 🧵
A similar method to what we aim to do in Long COVID & ME/CFS with @amaticahealth - join:
amaticahealth.com
Paper breakdown 🧵
New research shows the SARS-CoV-2 spike protein alone can trigger an autoimmune attack on ACE2 - the same receptor the virus uses to enter cells - leading to lung and kidney injury even without viral infection.
November 17, 2025 at 3:04 PM
New research shows the SARS-CoV-2 spike protein alone can trigger an autoimmune attack on ACE2 - the same receptor the virus uses to enter cells - leading to lung and kidney injury even without viral infection.
New research shows ME/CFS involves measurable DNA-level changes - including genetic risk factors, mitochondrial dysfunction, oxidative stress, and epigenetic reprogramming - linking it biologically to Long COVID and pointing to new diagnostic and treatment paths.
Let’s break it down🧵
Let’s break it down🧵
November 14, 2025 at 2:09 PM
New research shows ME/CFS involves measurable DNA-level changes - including genetic risk factors, mitochondrial dysfunction, oxidative stress, and epigenetic reprogramming - linking it biologically to Long COVID and pointing to new diagnostic and treatment paths.
Let’s break it down🧵
Let’s break it down🧵
1/ New study tested blood from ME/CFS patients for 185 human viruses.
Result: healthy controls had more viral DNA than patients (Unexpected).
Only Varicella Zoster Virus (VZV) appeared more often in ME/CFS, hinting at possible reactivation in a subgroup.
Let’s break it down🧵
Result: healthy controls had more viral DNA than patients (Unexpected).
Only Varicella Zoster Virus (VZV) appeared more often in ME/CFS, hinting at possible reactivation in a subgroup.
Let’s break it down🧵
November 13, 2025 at 1:50 PM
1/ New study tested blood from ME/CFS patients for 185 human viruses.
Result: healthy controls had more viral DNA than patients (Unexpected).
Only Varicella Zoster Virus (VZV) appeared more often in ME/CFS, hinting at possible reactivation in a subgroup.
Let’s break it down🧵
Result: healthy controls had more viral DNA than patients (Unexpected).
Only Varicella Zoster Virus (VZV) appeared more often in ME/CFS, hinting at possible reactivation in a subgroup.
Let’s break it down🧵
🔬We identified five preliminary immune clusters (C1–C5) in our Long COVID & ME/CFS cohort using two RNA markers: IFI44L and FAM89A.
Research shows these genes can help distinguish bacterial from viral infections.
Let’s break down which clusters likely fall into each category.
Research shows these genes can help distinguish bacterial from viral infections.
Let’s break down which clusters likely fall into each category.
September 22, 2025 at 4:29 PM
🔬We identified five preliminary immune clusters (C1–C5) in our Long COVID & ME/CFS cohort using two RNA markers: IFI44L and FAM89A.
Research shows these genes can help distinguish bacterial from viral infections.
Let’s break down which clusters likely fall into each category.
Research shows these genes can help distinguish bacterial from viral infections.
Let’s break down which clusters likely fall into each category.
🔬Can we understand the health of the blood-brain barrier (BBB) from a simple blood draw?
According to research, yes - by sequencing RNA in whole blood, we can detect changes in genes that affect or reflect BBB function
Here’s how it works and how it’s been done in research 🧵
According to research, yes - by sequencing RNA in whole blood, we can detect changes in genes that affect or reflect BBB function
Here’s how it works and how it’s been done in research 🧵
September 20, 2025 at 2:11 PM
🔬Can we understand the health of the blood-brain barrier (BBB) from a simple blood draw?
According to research, yes - by sequencing RNA in whole blood, we can detect changes in genes that affect or reflect BBB function
Here’s how it works and how it’s been done in research 🧵
According to research, yes - by sequencing RNA in whole blood, we can detect changes in genes that affect or reflect BBB function
Here’s how it works and how it’s been done in research 🧵
How do mitochondria produce energy - and what happens when this process breaks down in disease?
This thread explains mitochondrial energy metabolism in health, cancer, neurodegenerative diseases, and metabolic disorders. 🧵
This thread explains mitochondrial energy metabolism in health, cancer, neurodegenerative diseases, and metabolic disorders. 🧵
September 19, 2025 at 3:18 PM
How do mitochondria produce energy - and what happens when this process breaks down in disease?
This thread explains mitochondrial energy metabolism in health, cancer, neurodegenerative diseases, and metabolic disorders. 🧵
This thread explains mitochondrial energy metabolism in health, cancer, neurodegenerative diseases, and metabolic disorders. 🧵
The Cell Danger Response (CDR) is a potential protective process cells use when they're under threat - from infection, toxins, or injury.
It's theorised as how your body begins healing.
But when CDR doesn’t complete properly, it can lead to chronic illness - possible ME/CFS & LC. 🧵
It's theorised as how your body begins healing.
But when CDR doesn’t complete properly, it can lead to chronic illness - possible ME/CFS & LC. 🧵
September 18, 2025 at 3:29 PM
The Cell Danger Response (CDR) is a potential protective process cells use when they're under threat - from infection, toxins, or injury.
It's theorised as how your body begins healing.
But when CDR doesn’t complete properly, it can lead to chronic illness - possible ME/CFS & LC. 🧵
It's theorised as how your body begins healing.
But when CDR doesn’t complete properly, it can lead to chronic illness - possible ME/CFS & LC. 🧵
🔬 A new study sheds light on why people with Myalgic Encephalomyelitis (ME) experience post-exertional crashes and brain fog.
It focuses on a blood protein called haptoglobin (Hp) and how its different genetic forms affect symptoms. 🧵
It focuses on a blood protein called haptoglobin (Hp) and how its different genetic forms affect symptoms. 🧵
September 17, 2025 at 3:05 PM
🔬 A new study sheds light on why people with Myalgic Encephalomyelitis (ME) experience post-exertional crashes and brain fog.
It focuses on a blood protein called haptoglobin (Hp) and how its different genetic forms affect symptoms. 🧵
It focuses on a blood protein called haptoglobin (Hp) and how its different genetic forms affect symptoms. 🧵
🔬 A new study looked at RNA inside the spinal fluid of women with neuropsychiatric Long COVID (brain fog, etc) to understand what’s going wrong in the brain.
Let’s break it down 🧵
You can also test your RNA in blood here:
amaticahealth.com/me-cfs-long-...
Let’s break it down 🧵
You can also test your RNA in blood here:
amaticahealth.com/me-cfs-long-...
September 17, 2025 at 2:01 PM
🔬 A new study looked at RNA inside the spinal fluid of women with neuropsychiatric Long COVID (brain fog, etc) to understand what’s going wrong in the brain.
Let’s break it down 🧵
You can also test your RNA in blood here:
amaticahealth.com/me-cfs-long-...
Let’s break it down 🧵
You can also test your RNA in blood here:
amaticahealth.com/me-cfs-long-...
🔬 A large genetic study just found links between specific immune receptor variants (called KIR alleles) and ME/CFS.
And into DecodeME findings.
Simplified breakdown 🧵
And into DecodeME findings.
Simplified breakdown 🧵
September 16, 2025 at 4:36 PM
🔬 A large genetic study just found links between specific immune receptor variants (called KIR alleles) and ME/CFS.
And into DecodeME findings.
Simplified breakdown 🧵
And into DecodeME findings.
Simplified breakdown 🧵
🔬Can we understand the health of the blood-brain barrier (BBB) from a simple blood draw?
According to research, yes - by sequencing RNA in whole blood, we can detect changes in genes that affect or reflect BBB function
Here’s how it works and how it’s been done in research 🧵
According to research, yes - by sequencing RNA in whole blood, we can detect changes in genes that affect or reflect BBB function
Here’s how it works and how it’s been done in research 🧵
September 16, 2025 at 3:54 PM
🔬Can we understand the health of the blood-brain barrier (BBB) from a simple blood draw?
According to research, yes - by sequencing RNA in whole blood, we can detect changes in genes that affect or reflect BBB function
Here’s how it works and how it’s been done in research 🧵
According to research, yes - by sequencing RNA in whole blood, we can detect changes in genes that affect or reflect BBB function
Here’s how it works and how it’s been done in research 🧵
Leaky gut is when the barrier in your intestines becomes too porous, letting bacteria, toxins, or food particles slip into your bloodstream.
This thread breaks down what mRNAs are involved in that process - in plain language and how you can test yourself:
amaticahealth.com/me-cfs-long-...
This thread breaks down what mRNAs are involved in that process - in plain language and how you can test yourself:
amaticahealth.com/me-cfs-long-...
September 15, 2025 at 1:06 PM
Leaky gut is when the barrier in your intestines becomes too porous, letting bacteria, toxins, or food particles slip into your bloodstream.
This thread breaks down what mRNAs are involved in that process - in plain language and how you can test yourself:
amaticahealth.com/me-cfs-long-...
This thread breaks down what mRNAs are involved in that process - in plain language and how you can test yourself:
amaticahealth.com/me-cfs-long-...
New @amaticahealth preliminary findings: elevated TIGIT in Long COVID & ME/CFS
TIGIT is found on immune cells like T & NK cells
It helps regulate the immune system by acting as a "immune system brake"
This can prevent the body from fighting cancer or infections effectively
TIGIT is found on immune cells like T & NK cells
It helps regulate the immune system by acting as a "immune system brake"
This can prevent the body from fighting cancer or infections effectively
September 12, 2025 at 2:10 PM
New @amaticahealth preliminary findings: elevated TIGIT in Long COVID & ME/CFS
TIGIT is found on immune cells like T & NK cells
It helps regulate the immune system by acting as a "immune system brake"
This can prevent the body from fighting cancer or infections effectively
TIGIT is found on immune cells like T & NK cells
It helps regulate the immune system by acting as a "immune system brake"
This can prevent the body from fighting cancer or infections effectively
A new study just showed that gut bacteria from people with fibromyalgia can cause pain when transplanted into mice.
This is the strongest evidence yet that the gut microbiome plays a direct role in fibromyalgia.
Here's a full breakdown of what they found
This is the strongest evidence yet that the gut microbiome plays a direct role in fibromyalgia.
Here's a full breakdown of what they found
September 11, 2025 at 2:24 PM
A new study just showed that gut bacteria from people with fibromyalgia can cause pain when transplanted into mice.
This is the strongest evidence yet that the gut microbiome plays a direct role in fibromyalgia.
Here's a full breakdown of what they found
This is the strongest evidence yet that the gut microbiome plays a direct role in fibromyalgia.
Here's a full breakdown of what they found
Some diseases show up together. Others rarely appear in the same person
This study looked into whether gene activity (from RNA data) can help explain why
The answer: yes - more than we thought
Relevant as we are testing RNA in LC & ME/CFS patients @amaticahealth
Breakdown:
This study looked into whether gene activity (from RNA data) can help explain why
The answer: yes - more than we thought
Relevant as we are testing RNA in LC & ME/CFS patients @amaticahealth
Breakdown:
September 10, 2025 at 1:49 PM
Some diseases show up together. Others rarely appear in the same person
This study looked into whether gene activity (from RNA data) can help explain why
The answer: yes - more than we thought
Relevant as we are testing RNA in LC & ME/CFS patients @amaticahealth
Breakdown:
This study looked into whether gene activity (from RNA data) can help explain why
The answer: yes - more than we thought
Relevant as we are testing RNA in LC & ME/CFS patients @amaticahealth
Breakdown:
New @amaticahealth preliminary findings: elevated NKG2A in Long COVID & ME/CFS
NKG2A is a receptor found on NK cells & some T cells. It acts as an "immune system brake" when on
This is useful for preventing damage to healthy tissue - but can prevent proper clearance of viruses
NKG2A is a receptor found on NK cells & some T cells. It acts as an "immune system brake" when on
This is useful for preventing damage to healthy tissue - but can prevent proper clearance of viruses
September 9, 2025 at 2:12 PM
New @amaticahealth preliminary findings: elevated NKG2A in Long COVID & ME/CFS
NKG2A is a receptor found on NK cells & some T cells. It acts as an "immune system brake" when on
This is useful for preventing damage to healthy tissue - but can prevent proper clearance of viruses
NKG2A is a receptor found on NK cells & some T cells. It acts as an "immune system brake" when on
This is useful for preventing damage to healthy tissue - but can prevent proper clearance of viruses
New research shows Long COVID and chronic fatigue syndrome (ME/CFS) share the same biological problem: their bodies struggle to use oxygen properly during exercise.
Here's a full breakdown - and what it means.
Here's a full breakdown - and what it means.
September 8, 2025 at 1:08 PM
New research shows Long COVID and chronic fatigue syndrome (ME/CFS) share the same biological problem: their bodies struggle to use oxygen properly during exercise.
Here's a full breakdown - and what it means.
Here's a full breakdown - and what it means.
Reposting as important:
🔬 Mitochondria help power cells, and they constantly split (fission) and join (fusion) to stay healthy.
Surprisingly, we can track how this is going using blood RNA.
Here’s what recent research has found in humans 🧵
🔬 Mitochondria help power cells, and they constantly split (fission) and join (fusion) to stay healthy.
Surprisingly, we can track how this is going using blood RNA.
Here’s what recent research has found in humans 🧵
September 6, 2025 at 1:02 PM
Reposting as important:
🔬 Mitochondria help power cells, and they constantly split (fission) and join (fusion) to stay healthy.
Surprisingly, we can track how this is going using blood RNA.
Here’s what recent research has found in humans 🧵
🔬 Mitochondria help power cells, and they constantly split (fission) and join (fusion) to stay healthy.
Surprisingly, we can track how this is going using blood RNA.
Here’s what recent research has found in humans 🧵
🧵 T cell exhaustion - possibly one of the drivers of chronic infections in Long COVID & ME/CFS.
What is it, what genes are involved, and how we can gain insights with available testing.
Let’s break it down. 🧵
What is it, what genes are involved, and how we can gain insights with available testing.
Let’s break it down. 🧵
September 5, 2025 at 11:02 AM
🧵 T cell exhaustion - possibly one of the drivers of chronic infections in Long COVID & ME/CFS.
What is it, what genes are involved, and how we can gain insights with available testing.
Let’s break it down. 🧵
What is it, what genes are involved, and how we can gain insights with available testing.
Let’s break it down. 🧵
🔬A major new study shows clear evidence of immune overactivation, energy metabolism failure, gut issues, and worsening after exercise in ME/CFS.
Importantly - patients separated into subgroups, a focus by us @amaticahealth
Let’s break it down in simple language 🧵
Importantly - patients separated into subgroups, a focus by us @amaticahealth
Let’s break it down in simple language 🧵
September 4, 2025 at 3:55 PM
🔬A major new study shows clear evidence of immune overactivation, energy metabolism failure, gut issues, and worsening after exercise in ME/CFS.
Importantly - patients separated into subgroups, a focus by us @amaticahealth
Let’s break it down in simple language 🧵
Importantly - patients separated into subgroups, a focus by us @amaticahealth
Let’s break it down in simple language 🧵