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inem-necker.bsky.social
Institut Necker Enfants Malades
@inem-necker.bsky.social
200 followers 47 following 49 posts
Cutting-edge research in molecular & cellular metabolism, immunology, and beyond. Discover our work driving innovation in health and disease.
https://www.institut-necker-enfants-malades.fr/index.php?menu=team
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inem-necker.bsky.social
[PUBLICATION] The @membramics-lab.bsky.social shows how Influenza A virus rewires ER lipid metabolism to promote vRNP egress.

👏🏼 Co-1st authors: Carla Alemany & @julianedagraca.bsky.social

journals.plos.org/plosbiology/...

w/ @institutpasteur.bsky.social & IPNP
@plosbiology.org
July 17, 2025 at 12:55 PM
inem-necker.bsky.social
[PUBLICATION] NEW in @cp-cellreports.bsky.social
@julianedagraca.bsky.social et al. show that ER-endosome contacts act as hubs for phagophore formation during starvation.

📖 www.cell.com/cell-reports...
@membramics-lab.bsky.social
July 16, 2025 at 12:25 PM
inem-necker.bsky.social
[CAREER] A 3-year PhD position is open in Paris to explore how air pollution contributes to CKD. The project combines experimental and environmental science and is hosted by INEM & LISA.

📨 Apply by Sept 1.
🟢 Start Nov–Dec 2025.

www.institut-necker-enfants-malades.fr/offre-demplo...
July 10, 2025 at 1:28 PM
inem-necker.bsky.social
🚨 We're hiring! INEM is recruiting a Group Leader in #Immunology. Join a vibrant biomedical research institute with strong clinical & academic links.

🗓 Apply by Sept 20, 2025

🔗 More info: institut-necker-enfants-malades.fr/careers
July 8, 2025 at 3:02 PM
inem-necker.bsky.social
[PUBLICATION] New study with the Bharat lab @cellbiol-mrclmb.bsky.social reveals the structure of the Neisseria meningitidis filamentous phage MDAΦ. 🦠
Cryo-EM/ET show how phage bundling supports biofilm formation & pathogenesis.
@mathieucoureuil.bsky.social @pnas.org

www.pnas.org/doi/10.1073/...
July 2, 2025 at 1:08 PM
inem-necker.bsky.social
[PUBLICATION] PIK3CA mutations in Schwann cells trigger neuropathy by disrupting nearby healthy tissues. This non-cell autonomous effect shifts local metabolism toward aerobic glycolysis. Early alpelisib treatment is key. | Canaud Lab @pnas.org
🔗https://www.pnas.org/doi/10.1073/pnas.2424867122
June 30, 2025 at 1:07 PM
inem-necker.bsky.social
[PUBLICATION] Podocyte-specific YAP activation drives crescentic glomerulonephritis via cross-talk with parietal epithelial cells. 🌙
A study from @fabiolaterzi.bsky.social & @marco-pontoglio.bsky.social labs now out in Science Translational Medicine @science.org
👉 www.science.org/doi/10.1126/...
June 27, 2025 at 1:23 PM
inem-necker.bsky.social
🗓️ Join us on July 4, for a #seminar with David Sabatini, group leader at @iocbprague.bsky.social.
Dr. Sabatini will explore nutrient sensing by the mTOR pathway. Don’t miss it! @mario-pende.bsky.social
June 27, 2025 at 10:36 AM
inem-necker.bsky.social
[PUBLICATION] mTORC1 coordinates ependymal cell differentiation by regulating an alternative cell cycle and centrosomal proteins.
A new collaboration between the Pende and Spassky labs!

🔗 www.embopress.org/doi/full/10....
@mario-pende.bsky.social @ibensens.bsky.social ‪@emboreports.org
June 26, 2025 at 8:17 AM
inem-necker.bsky.social
[PUBLICATION] First report of successful pregnancies after treatment with alpelisib for PIK3CA-related overgrowth spectrum.

➡️Fertility preserved
➡️No embryotoxicity
➡️Disease remained responsive after treatment pause

📖 Read more: www.nature.com/articles/s41...
@ejhg-journal.bsky.social‬
June 19, 2025 at 2:44 PM
inem-necker.bsky.social
🗓️ Join us on June 20, for a #seminar with Jean-Emmanuel Sarry, team leader at CRCT Oncopole. Dr. Sarry will explore Mitohormesis and metabolic adaptations in response to therapeutic stress in acute myeloid leukemia. Don’t miss it!
June 13, 2025 at 12:02 PM
inem-necker.bsky.social
🗓️ Join us on June 13, for a #seminar with Han Li, Principal Investigator and leader of the cellular plasticity in age-related pathologies group at @pasteur.fr. Prof. Li will explore senescence induced-cellular plasticity in health & disease. Don’t miss it! @mario-pende.bsky.social
June 6, 2025 at 12:01 PM
inem-necker.bsky.social
🗓️ Join us on Friday, June 6, for a #seminar with Elvira Mass, Head of the Department of Developmental Biology of the Immune System at LIMES Institute @unibonn.bsky.social. ‬
Prof. Mass will explore the developmental programming of tissue-resident macrophages. Don’t miss it!
@venteclefn.bsky.social
June 3, 2025 at 10:38 AM
inem-necker.bsky.social
🚨 We're hiring! The IMMEDIAB team is looking for:
🧪 1 Postdoc
🧬 1 Research Assistant / Bioinfo/ Tech
📍 Paris | Start Sept 2025
📄 Full details + apply: www.institut-necker-enfants-malades.fr/careers
@drfalzaid.bsky.social
May 20, 2025 at 2:58 PM
inem-necker.bsky.social
[PUBLICATION] Treating patients with somatic PIK3R1 mutations using alpelisib leads to clinical and radiological improvement.
A promising step toward targeted therapy in PIK3R1-related disorders.
📄Read more: www.embopress.org/doi/full/10....
Canaud Lab @emboreports.org
May 20, 2025 at 12:12 PM
inem-necker.bsky.social
🗓️ Join us on Friday, May 16, for a #seminar with Chantal Desdouets, Head of the "Genomic Instability, Metabolism, Immunity and Liver Tumorigenesis" team at @crcordeliers.bsky.social.
Dr. Desdouets will explore Polyploidy in chronic liver diseases. Don’t miss it! @goffinlab.bsky.social
May 9, 2025 at 5:25 AM
inem-necker.bsky.social
🗓️ Join us for a special #seminar with Bing Su, Director of the Shanghai Institute of Immunology & Chair at Shanghai JiaoTong Univ. School of Medicine.
Prof. Su will explore Sin1-mTOR signaling in immune cell metabolism, growth & survival. Don't miss it! @venteclefn.bsky.social @upcite.bsky.social
April 29, 2025 at 7:48 AM
inem-necker.bsky.social
🗓️ Join us on Monday, Apr 28, for a #seminar with Christopher Goodnow, Head of the Immunogenomics Lab at @garvaninstitute.bsky.social.
Prof. Goodnow will explore how B cell tolerance breaks and resists rituximab treatment. Don’t miss it! @matthieumahevas.bsky.social
April 25, 2025 at 9:25 AM
inem-necker.bsky.social
🗓️ Join us Friday, Apr 25 for a #seminar with Brendan Manning — Professor and Chair of Molecular Metabolism at Harvard T.H. Chan School of Public Health.
He'll explore the TSC-mTOR pathway in growth and metabolism. Don’t miss it! @bdmanning.bsky.social @met-hsph.bsky.social @mario-pende.bsky.social
April 18, 2025 at 8:08 AM
inem-necker.bsky.social
🚨 Postdoc Opportunity

Join the "Host-Pathogen Integrative Biology" team at INEM to study endothelial microparticles in cardiovascular dysfunctions during bacterial sepsis.

🌐More info & application: institut-necker-enfants-malades.fr/offre-demplo...

@mathieucoureuil.bsky.social
April 15, 2025 at 11:32 AM
inem-necker.bsky.social
🗓️ Join us on Friday, April 11, for a #seminar with Prof. Philippe Sansonetti @pasteur.fr on Gut dysbiosis and colorectal cancer.
Don’t miss this talk diving into how microbial imbalances shape cancer development — and how we move from observation to mechanistic insight.
April 4, 2025 at 12:53 PM
inem-necker.bsky.social
🏆 Congrats to @julianedagraca.bsky.social! Former PhD student at INEM, Juliane has been awarded the 2025 Thesis Prize of the @clubexo-endo.bsky.social for her work on ER-endosome contact sites & autophagy regulation.
👏 Well done, Juliane! @membramics-lab.bsky.social
March 30, 2025 at 7:21 AM
inem-necker.bsky.social
🗓️ Join us on Friday, April 4, for a #seminar with Dr. Meryem Baghdadi, new team leader at INEM (StemNest Lab), on "Stem cell regulation in homeostasis and disease."
Don't miss this talk exploring how stem cells maintain tissue balance — and what happens when this goes wrong!
March 28, 2025 at 2:24 PM
inem-necker.bsky.social
🚨 New: Spleen-resident macrophages (MMMs) can directly activate CD8+ T cells to fight tumors – independently of dendritic cells. They use a vacuolar MHC-I pathway & need Batf3 for this antitumor response.
🧠 A game-changer for immunotherapy?

🔗 www.cell.com/immunity/abs... @cp-immunity.bsky.social
March 26, 2025 at 10:12 AM
inem-necker.bsky.social
🗓️ Join us on Friday, March 28, for a #seminar with Dr. @goetzjacky.bsky.social (Centre de recherche en biomédecine de Strasbourg) on "Multi-modal tracking of metastasis: from priming to inhibitory targets."
🔍 A great chance to dive into new insights on cancer metastasis. @membramics-lab.bsky.social
March 21, 2025 at 12:59 PM