Institut Necker Enfants Malades
@inem-necker.bsky.social
Cutting-edge research in molecular & cellular metabolism, immunology, and beyond. Discover our work driving innovation in health and disease.
https://www.institut-necker-enfants-malades.fr/index.php?menu=team
https://www.institut-necker-enfants-malades.fr/index.php?menu=team
[PUBLICATION] The @membramics-lab.bsky.social shows how Influenza A virus rewires ER lipid metabolism to promote vRNP egress.
👏🏼 Co-1st authors: Carla Alemany & @julianedagraca.bsky.social
journals.plos.org/plosbiology/...
w/ @institutpasteur.bsky.social & IPNP
@plosbiology.org
👏🏼 Co-1st authors: Carla Alemany & @julianedagraca.bsky.social
journals.plos.org/plosbiology/...
w/ @institutpasteur.bsky.social & IPNP
@plosbiology.org
July 17, 2025 at 12:55 PM
[PUBLICATION] The @membramics-lab.bsky.social shows how Influenza A virus rewires ER lipid metabolism to promote vRNP egress.
👏🏼 Co-1st authors: Carla Alemany & @julianedagraca.bsky.social
journals.plos.org/plosbiology/...
w/ @institutpasteur.bsky.social & IPNP
@plosbiology.org
👏🏼 Co-1st authors: Carla Alemany & @julianedagraca.bsky.social
journals.plos.org/plosbiology/...
w/ @institutpasteur.bsky.social & IPNP
@plosbiology.org
[PUBLICATION] NEW in @cp-cellreports.bsky.social
@julianedagraca.bsky.social et al. show that ER-endosome contacts act as hubs for phagophore formation during starvation.
📖 www.cell.com/cell-reports...
@membramics-lab.bsky.social
@julianedagraca.bsky.social et al. show that ER-endosome contacts act as hubs for phagophore formation during starvation.
📖 www.cell.com/cell-reports...
@membramics-lab.bsky.social
July 16, 2025 at 12:25 PM
[PUBLICATION] NEW in @cp-cellreports.bsky.social
@julianedagraca.bsky.social et al. show that ER-endosome contacts act as hubs for phagophore formation during starvation.
📖 www.cell.com/cell-reports...
@membramics-lab.bsky.social
@julianedagraca.bsky.social et al. show that ER-endosome contacts act as hubs for phagophore formation during starvation.
📖 www.cell.com/cell-reports...
@membramics-lab.bsky.social
👏🏼 Proud to see @julianedagraca.bsky.social, former PhD student at INEM, honored with the 2025 Beth Levine Thesis Prize for her outstanding work on autophagy, supervised by Etienne Morel @membramics-lab.bsky.social.
🎉 Congratulations to @julianedagraca.bsky.social, recipient of the 2025 Beth Levine #ThesisPrize! Her outstanding research @membramics-lab.bsky.social on the role of ER/Endosome contact sites in the regulation of #autophagy captures the award's spirit of excellence and innovation. 👏
July 11, 2025 at 5:22 PM
👏🏼 Proud to see @julianedagraca.bsky.social, former PhD student at INEM, honored with the 2025 Beth Levine Thesis Prize for her outstanding work on autophagy, supervised by Etienne Morel @membramics-lab.bsky.social.
[CAREER] A 3-year PhD position is open in Paris to explore how air pollution contributes to CKD. The project combines experimental and environmental science and is hosted by INEM & LISA.
📨 Apply by Sept 1.
🟢 Start Nov–Dec 2025.
www.institut-necker-enfants-malades.fr/offre-demplo...
📨 Apply by Sept 1.
🟢 Start Nov–Dec 2025.
www.institut-necker-enfants-malades.fr/offre-demplo...
July 10, 2025 at 1:28 PM
[CAREER] A 3-year PhD position is open in Paris to explore how air pollution contributes to CKD. The project combines experimental and environmental science and is hosted by INEM & LISA.
📨 Apply by Sept 1.
🟢 Start Nov–Dec 2025.
www.institut-necker-enfants-malades.fr/offre-demplo...
📨 Apply by Sept 1.
🟢 Start Nov–Dec 2025.
www.institut-necker-enfants-malades.fr/offre-demplo...
🚨 We're hiring! INEM is recruiting a Group Leader in #Immunology. Join a vibrant biomedical research institute with strong clinical & academic links.
🗓 Apply by Sept 20, 2025
🔗 More info: institut-necker-enfants-malades.fr/careers
🗓 Apply by Sept 20, 2025
🔗 More info: institut-necker-enfants-malades.fr/careers
July 8, 2025 at 3:02 PM
🚨 We're hiring! INEM is recruiting a Group Leader in #Immunology. Join a vibrant biomedical research institute with strong clinical & academic links.
🗓 Apply by Sept 20, 2025
🔗 More info: institut-necker-enfants-malades.fr/careers
🗓 Apply by Sept 20, 2025
🔗 More info: institut-necker-enfants-malades.fr/careers
[PUBLICATION] New study with the Bharat lab @cellbiol-mrclmb.bsky.social reveals the structure of the Neisseria meningitidis filamentous phage MDAΦ. 🦠
Cryo-EM/ET show how phage bundling supports biofilm formation & pathogenesis.
@mathieucoureuil.bsky.social @pnas.org
www.pnas.org/doi/10.1073/...
Cryo-EM/ET show how phage bundling supports biofilm formation & pathogenesis.
@mathieucoureuil.bsky.social @pnas.org
www.pnas.org/doi/10.1073/...
July 2, 2025 at 1:08 PM
[PUBLICATION] New study with the Bharat lab @cellbiol-mrclmb.bsky.social reveals the structure of the Neisseria meningitidis filamentous phage MDAΦ. 🦠
Cryo-EM/ET show how phage bundling supports biofilm formation & pathogenesis.
@mathieucoureuil.bsky.social @pnas.org
www.pnas.org/doi/10.1073/...
Cryo-EM/ET show how phage bundling supports biofilm formation & pathogenesis.
@mathieucoureuil.bsky.social @pnas.org
www.pnas.org/doi/10.1073/...
[PUBLICATION] PIK3CA mutations in Schwann cells trigger neuropathy by disrupting nearby healthy tissues. This non-cell autonomous effect shifts local metabolism toward aerobic glycolysis. Early alpelisib treatment is key. | Canaud Lab @pnas.org
🔗https://www.pnas.org/doi/10.1073/pnas.2424867122
🔗https://www.pnas.org/doi/10.1073/pnas.2424867122
June 30, 2025 at 1:07 PM
[PUBLICATION] PIK3CA mutations in Schwann cells trigger neuropathy by disrupting nearby healthy tissues. This non-cell autonomous effect shifts local metabolism toward aerobic glycolysis. Early alpelisib treatment is key. | Canaud Lab @pnas.org
🔗https://www.pnas.org/doi/10.1073/pnas.2424867122
🔗https://www.pnas.org/doi/10.1073/pnas.2424867122
[PUBLICATION] Podocyte-specific YAP activation drives crescentic glomerulonephritis via cross-talk with parietal epithelial cells. 🌙
A study from @fabiolaterzi.bsky.social & @marco-pontoglio.bsky.social labs now out in Science Translational Medicine @science.org
👉 www.science.org/doi/10.1126/...
A study from @fabiolaterzi.bsky.social & @marco-pontoglio.bsky.social labs now out in Science Translational Medicine @science.org
👉 www.science.org/doi/10.1126/...
June 27, 2025 at 1:23 PM
[PUBLICATION] Podocyte-specific YAP activation drives crescentic glomerulonephritis via cross-talk with parietal epithelial cells. 🌙
A study from @fabiolaterzi.bsky.social & @marco-pontoglio.bsky.social labs now out in Science Translational Medicine @science.org
👉 www.science.org/doi/10.1126/...
A study from @fabiolaterzi.bsky.social & @marco-pontoglio.bsky.social labs now out in Science Translational Medicine @science.org
👉 www.science.org/doi/10.1126/...
🗓️ Join us on July 4, for a #seminar with David Sabatini, group leader at @iocbprague.bsky.social.
Dr. Sabatini will explore nutrient sensing by the mTOR pathway. Don’t miss it! @mario-pende.bsky.social
Dr. Sabatini will explore nutrient sensing by the mTOR pathway. Don’t miss it! @mario-pende.bsky.social
June 27, 2025 at 10:36 AM
🗓️ Join us on July 4, for a #seminar with David Sabatini, group leader at @iocbprague.bsky.social.
Dr. Sabatini will explore nutrient sensing by the mTOR pathway. Don’t miss it! @mario-pende.bsky.social
Dr. Sabatini will explore nutrient sensing by the mTOR pathway. Don’t miss it! @mario-pende.bsky.social
[PUBLICATION] mTORC1 coordinates ependymal cell differentiation by regulating an alternative cell cycle and centrosomal proteins.
A new collaboration between the Pende and Spassky labs!
🔗 www.embopress.org/doi/full/10....
@mario-pende.bsky.social @ibensens.bsky.social @emboreports.org
A new collaboration between the Pende and Spassky labs!
🔗 www.embopress.org/doi/full/10....
@mario-pende.bsky.social @ibensens.bsky.social @emboreports.org
June 26, 2025 at 8:17 AM
[PUBLICATION] mTORC1 coordinates ependymal cell differentiation by regulating an alternative cell cycle and centrosomal proteins.
A new collaboration between the Pende and Spassky labs!
🔗 www.embopress.org/doi/full/10....
@mario-pende.bsky.social @ibensens.bsky.social @emboreports.org
A new collaboration between the Pende and Spassky labs!
🔗 www.embopress.org/doi/full/10....
@mario-pende.bsky.social @ibensens.bsky.social @emboreports.org
[PUBLICATION] First report of successful pregnancies after treatment with alpelisib for PIK3CA-related overgrowth spectrum.
➡️Fertility preserved
➡️No embryotoxicity
➡️Disease remained responsive after treatment pause
📖 Read more: www.nature.com/articles/s41...
@ejhg-journal.bsky.social
➡️Fertility preserved
➡️No embryotoxicity
➡️Disease remained responsive after treatment pause
📖 Read more: www.nature.com/articles/s41...
@ejhg-journal.bsky.social
June 19, 2025 at 2:44 PM
[PUBLICATION] First report of successful pregnancies after treatment with alpelisib for PIK3CA-related overgrowth spectrum.
➡️Fertility preserved
➡️No embryotoxicity
➡️Disease remained responsive after treatment pause
📖 Read more: www.nature.com/articles/s41...
@ejhg-journal.bsky.social
➡️Fertility preserved
➡️No embryotoxicity
➡️Disease remained responsive after treatment pause
📖 Read more: www.nature.com/articles/s41...
@ejhg-journal.bsky.social
🗓️ Join us on June 20, for a #seminar with Jean-Emmanuel Sarry, team leader at CRCT Oncopole. Dr. Sarry will explore Mitohormesis and metabolic adaptations in response to therapeutic stress in acute myeloid leukemia. Don’t miss it!
June 13, 2025 at 12:02 PM
🗓️ Join us on June 20, for a #seminar with Jean-Emmanuel Sarry, team leader at CRCT Oncopole. Dr. Sarry will explore Mitohormesis and metabolic adaptations in response to therapeutic stress in acute myeloid leukemia. Don’t miss it!
🗓️ Join us on June 13, for a #seminar with Han Li, Principal Investigator and leader of the cellular plasticity in age-related pathologies group at @pasteur.fr. Prof. Li will explore senescence induced-cellular plasticity in health & disease. Don’t miss it! @mario-pende.bsky.social
June 6, 2025 at 12:01 PM
🗓️ Join us on June 13, for a #seminar with Han Li, Principal Investigator and leader of the cellular plasticity in age-related pathologies group at @pasteur.fr. Prof. Li will explore senescence induced-cellular plasticity in health & disease. Don’t miss it! @mario-pende.bsky.social
✨ Calling all postdocs! The 2025-2026 #ParisPostdocs Seminars are now accepting applications.
Present your work, connect across 13 top Paris institutes — including INEM — and boost your visibility 🚀.
Present your work, connect across 13 top Paris institutes — including INEM — and boost your visibility 🚀.
Big news! Applications for the 2025/2026 Paris Postdocs Seminars series are now open ⭐
Don’t miss the chance to present your scientific work in one of our 13 participating institutes and increase your network!
📆 Register by June 15th, 2025 here: docs.google.com/forms/d/e/1F...
#ParisPostdocs
Don’t miss the chance to present your scientific work in one of our 13 participating institutes and increase your network!
📆 Register by June 15th, 2025 here: docs.google.com/forms/d/e/1F...
#ParisPostdocs
Paris Postdocs Seminars - 2025/2026 series
Application form for the 2025/2026 Paris Postdocs Seminar series
docs.google.com
June 5, 2025 at 12:03 PM
✨ Calling all postdocs! The 2025-2026 #ParisPostdocs Seminars are now accepting applications.
Present your work, connect across 13 top Paris institutes — including INEM — and boost your visibility 🚀.
Present your work, connect across 13 top Paris institutes — including INEM — and boost your visibility 🚀.
🗓️ Join us on Friday, June 6, for a #seminar with Elvira Mass, Head of the Department of Developmental Biology of the Immune System at LIMES Institute @unibonn.bsky.social.
Prof. Mass will explore the developmental programming of tissue-resident macrophages. Don’t miss it!
@venteclefn.bsky.social
Prof. Mass will explore the developmental programming of tissue-resident macrophages. Don’t miss it!
@venteclefn.bsky.social
June 3, 2025 at 10:38 AM
🗓️ Join us on Friday, June 6, for a #seminar with Elvira Mass, Head of the Department of Developmental Biology of the Immune System at LIMES Institute @unibonn.bsky.social.
Prof. Mass will explore the developmental programming of tissue-resident macrophages. Don’t miss it!
@venteclefn.bsky.social
Prof. Mass will explore the developmental programming of tissue-resident macrophages. Don’t miss it!
@venteclefn.bsky.social
Join #ParisPostdocsSeminar this month to hear from our very own Laura Salavessa (@laurasalavessa.bsky.social) as she shares new insights on melanin transfer and uptake in keratinocytes.
📅 Tuesday, 27 May
🕚 11:00–12:00 CET
📍 Institut Pasteur – Amphitheatre Agnès Ullmann
📅 Tuesday, 27 May
🕚 11:00–12:00 CET
📍 Institut Pasteur – Amphitheatre Agnès Ullmann
This month’s #ParisPostdocsSeminar features @laurasalavessa.bsky.social from @inem-necker.bsky.social, presenting her latest results on the transfer and uptake of melanin in keratinocytes for skin homeostasis!
📅 Tuesday, 27 May 2025
🕚 11:00–12:00 CET
📍 Amphitheatre Agnès Ullmann, @pasteur.fr
📅 Tuesday, 27 May 2025
🕚 11:00–12:00 CET
📍 Amphitheatre Agnès Ullmann, @pasteur.fr
May 20, 2025 at 3:01 PM
Join #ParisPostdocsSeminar this month to hear from our very own Laura Salavessa (@laurasalavessa.bsky.social) as she shares new insights on melanin transfer and uptake in keratinocytes.
📅 Tuesday, 27 May
🕚 11:00–12:00 CET
📍 Institut Pasteur – Amphitheatre Agnès Ullmann
📅 Tuesday, 27 May
🕚 11:00–12:00 CET
📍 Institut Pasteur – Amphitheatre Agnès Ullmann
🚨 We're hiring! The IMMEDIAB team is looking for:
🧪 1 Postdoc
🧬 1 Research Assistant / Bioinfo/ Tech
📍 Paris | Start Sept 2025
📄 Full details + apply: www.institut-necker-enfants-malades.fr/careers
@drfalzaid.bsky.social
🧪 1 Postdoc
🧬 1 Research Assistant / Bioinfo/ Tech
📍 Paris | Start Sept 2025
📄 Full details + apply: www.institut-necker-enfants-malades.fr/careers
@drfalzaid.bsky.social
May 20, 2025 at 2:58 PM
🚨 We're hiring! The IMMEDIAB team is looking for:
🧪 1 Postdoc
🧬 1 Research Assistant / Bioinfo/ Tech
📍 Paris | Start Sept 2025
📄 Full details + apply: www.institut-necker-enfants-malades.fr/careers
@drfalzaid.bsky.social
🧪 1 Postdoc
🧬 1 Research Assistant / Bioinfo/ Tech
📍 Paris | Start Sept 2025
📄 Full details + apply: www.institut-necker-enfants-malades.fr/careers
@drfalzaid.bsky.social
[PUBLICATION] Treating patients with somatic PIK3R1 mutations using alpelisib leads to clinical and radiological improvement.
A promising step toward targeted therapy in PIK3R1-related disorders.
📄Read more: www.embopress.org/doi/full/10....
Canaud Lab @emboreports.org
A promising step toward targeted therapy in PIK3R1-related disorders.
📄Read more: www.embopress.org/doi/full/10....
Canaud Lab @emboreports.org
May 20, 2025 at 12:12 PM
[PUBLICATION] Treating patients with somatic PIK3R1 mutations using alpelisib leads to clinical and radiological improvement.
A promising step toward targeted therapy in PIK3R1-related disorders.
📄Read more: www.embopress.org/doi/full/10....
Canaud Lab @emboreports.org
A promising step toward targeted therapy in PIK3R1-related disorders.
📄Read more: www.embopress.org/doi/full/10....
Canaud Lab @emboreports.org
🗓️ Join us on Friday, May 16, for a #seminar with Chantal Desdouets, Head of the "Genomic Instability, Metabolism, Immunity and Liver Tumorigenesis" team at @crcordeliers.bsky.social.
Dr. Desdouets will explore Polyploidy in chronic liver diseases. Don’t miss it! @goffinlab.bsky.social
Dr. Desdouets will explore Polyploidy in chronic liver diseases. Don’t miss it! @goffinlab.bsky.social
May 9, 2025 at 5:25 AM
🗓️ Join us on Friday, May 16, for a #seminar with Chantal Desdouets, Head of the "Genomic Instability, Metabolism, Immunity and Liver Tumorigenesis" team at @crcordeliers.bsky.social.
Dr. Desdouets will explore Polyploidy in chronic liver diseases. Don’t miss it! @goffinlab.bsky.social
Dr. Desdouets will explore Polyploidy in chronic liver diseases. Don’t miss it! @goffinlab.bsky.social
🗓️ Join us for a special #seminar with Bing Su, Director of the Shanghai Institute of Immunology & Chair at Shanghai JiaoTong Univ. School of Medicine.
Prof. Su will explore Sin1-mTOR signaling in immune cell metabolism, growth & survival. Don't miss it! @venteclefn.bsky.social @upcite.bsky.social
Prof. Su will explore Sin1-mTOR signaling in immune cell metabolism, growth & survival. Don't miss it! @venteclefn.bsky.social @upcite.bsky.social
April 29, 2025 at 7:48 AM
🗓️ Join us for a special #seminar with Bing Su, Director of the Shanghai Institute of Immunology & Chair at Shanghai JiaoTong Univ. School of Medicine.
Prof. Su will explore Sin1-mTOR signaling in immune cell metabolism, growth & survival. Don't miss it! @venteclefn.bsky.social @upcite.bsky.social
Prof. Su will explore Sin1-mTOR signaling in immune cell metabolism, growth & survival. Don't miss it! @venteclefn.bsky.social @upcite.bsky.social
🗓️ Join us on Monday, Apr 28, for a #seminar with Christopher Goodnow, Head of the Immunogenomics Lab at @garvaninstitute.bsky.social.
Prof. Goodnow will explore how B cell tolerance breaks and resists rituximab treatment. Don’t miss it! @matthieumahevas.bsky.social
Prof. Goodnow will explore how B cell tolerance breaks and resists rituximab treatment. Don’t miss it! @matthieumahevas.bsky.social
April 25, 2025 at 9:25 AM
🗓️ Join us on Monday, Apr 28, for a #seminar with Christopher Goodnow, Head of the Immunogenomics Lab at @garvaninstitute.bsky.social.
Prof. Goodnow will explore how B cell tolerance breaks and resists rituximab treatment. Don’t miss it! @matthieumahevas.bsky.social
Prof. Goodnow will explore how B cell tolerance breaks and resists rituximab treatment. Don’t miss it! @matthieumahevas.bsky.social
🎉 Congrats to Khaled Tighanimine, former PhD student at INEM (supervised by @mario-pende.bsky.social & Stefano Fumagalli), awarded a @fondationarc.bsky.social Oberling-Haguenau Thesis Prize!
Proud to see his work recognised among this year’s #ARCTrophies winners 👏
Proud to see his work recognised among this year’s #ARCTrophies winners 👏
Six lauréats, quatre Français, un Algérien et un Américain ont été récompensés pour leurs travaux. Un grand bravo au Pr Eric Vivier, au Pr Yang Shi, au Dr Giacomo Cavalli, au Pr Hervé Avet-Loiseau, à Khaled Tighanimine et à Léa Montégut.
April 18, 2025 at 6:45 PM
🎉 Congrats to Khaled Tighanimine, former PhD student at INEM (supervised by @mario-pende.bsky.social & Stefano Fumagalli), awarded a @fondationarc.bsky.social Oberling-Haguenau Thesis Prize!
Proud to see his work recognised among this year’s #ARCTrophies winners 👏
Proud to see his work recognised among this year’s #ARCTrophies winners 👏
🗓️ Join us Friday, Apr 25 for a #seminar with Brendan Manning — Professor and Chair of Molecular Metabolism at Harvard T.H. Chan School of Public Health.
He'll explore the TSC-mTOR pathway in growth and metabolism. Don’t miss it! @bdmanning.bsky.social @met-hsph.bsky.social @mario-pende.bsky.social
He'll explore the TSC-mTOR pathway in growth and metabolism. Don’t miss it! @bdmanning.bsky.social @met-hsph.bsky.social @mario-pende.bsky.social
April 18, 2025 at 8:08 AM
🗓️ Join us Friday, Apr 25 for a #seminar with Brendan Manning — Professor and Chair of Molecular Metabolism at Harvard T.H. Chan School of Public Health.
He'll explore the TSC-mTOR pathway in growth and metabolism. Don’t miss it! @bdmanning.bsky.social @met-hsph.bsky.social @mario-pende.bsky.social
He'll explore the TSC-mTOR pathway in growth and metabolism. Don’t miss it! @bdmanning.bsky.social @met-hsph.bsky.social @mario-pende.bsky.social
🚨 Postdoc Opportunity
Join the "Host-Pathogen Integrative Biology" team at INEM to study endothelial microparticles in cardiovascular dysfunctions during bacterial sepsis.
🌐More info & application: institut-necker-enfants-malades.fr/offre-demplo...
@mathieucoureuil.bsky.social
Join the "Host-Pathogen Integrative Biology" team at INEM to study endothelial microparticles in cardiovascular dysfunctions during bacterial sepsis.
🌐More info & application: institut-necker-enfants-malades.fr/offre-demplo...
@mathieucoureuil.bsky.social
April 15, 2025 at 11:32 AM
🚨 Postdoc Opportunity
Join the "Host-Pathogen Integrative Biology" team at INEM to study endothelial microparticles in cardiovascular dysfunctions during bacterial sepsis.
🌐More info & application: institut-necker-enfants-malades.fr/offre-demplo...
@mathieucoureuil.bsky.social
Join the "Host-Pathogen Integrative Biology" team at INEM to study endothelial microparticles in cardiovascular dysfunctions during bacterial sepsis.
🌐More info & application: institut-necker-enfants-malades.fr/offre-demplo...
@mathieucoureuil.bsky.social
🗓️ Join us on Friday, April 11, for a #seminar with Prof. Philippe Sansonetti @pasteur.fr on Gut dysbiosis and colorectal cancer.
Don’t miss this talk diving into how microbial imbalances shape cancer development — and how we move from observation to mechanistic insight.
Don’t miss this talk diving into how microbial imbalances shape cancer development — and how we move from observation to mechanistic insight.
April 4, 2025 at 12:53 PM
🗓️ Join us on Friday, April 11, for a #seminar with Prof. Philippe Sansonetti @pasteur.fr on Gut dysbiosis and colorectal cancer.
Don’t miss this talk diving into how microbial imbalances shape cancer development — and how we move from observation to mechanistic insight.
Don’t miss this talk diving into how microbial imbalances shape cancer development — and how we move from observation to mechanistic insight.