Indranil Malik
@indranilmalik.bsky.social
RNA | Neurodegeneration | Teaching and research @IITHyderabad ||
DVM | PhD ||
WBUAFS (India) | TAMU | UMich ||
https://sites.google.com/bt.iith.ac.in/malik-lab/home
DVM | PhD ||
WBUAFS (India) | TAMU | UMich ||
https://sites.google.com/bt.iith.ac.in/malik-lab/home
Reposted by Indranil Malik
1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from?
Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
Antiviral reverse transcriptases reveal the evolutionary origin of telomerase
Defense-associated reverse transcriptases (DRTs) employ diverse and distinctive mechanisms of cDNA synthesis to protect bacteria against viral infection. However, much of DRT family diversity remains ...
www.biorxiv.org
October 17, 2025 at 5:22 PM
1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from?
Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
Reposted by Indranil Malik
Ever wonder how intronic repeats in C9orf72 get translated into toxic proteins in ALS and FTD? We found that transcription initiates within the intron to generate a novel endogenous efficient mRNA template for RAN translation in patient neurons and mouse models 1/5| PNAS www.pnas.org/doi/10.1073/...
Cryptic intronic transcriptional initiation generates efficient endogenous mRNA templates for C9orf72-associated RAN translation | PNAS
Intronic GGGGCC hexanucleotide repeat expansions in C9orf72 are the most common genetic
cause of amyotrophic lateral sclerosis (ALS) and frontotemp...
www.pnas.org
August 4, 2025 at 8:09 PM
Ever wonder how intronic repeats in C9orf72 get translated into toxic proteins in ALS and FTD? We found that transcription initiates within the intron to generate a novel endogenous efficient mRNA template for RAN translation in patient neurons and mouse models 1/5| PNAS www.pnas.org/doi/10.1073/...
Reposted by Indranil Malik
Op-Ed from Dana Carroll and my father Jerry Kaplan highlighting some amazing history of publicly funded science at the U. of Utah and how this is in grave jeopardy. First NIH grant ever was to U of U!
Proposed cuts to the National Institutes of Health and the National Science Foundation “would cause immense and largely irreversible damage to the successful American scientific enterprise,” write Jerry Kaplan and Dana Carroll in an op-ed.
Voices: Federal funding cuts to genetic research will be devastating for years to come
Proposed cuts to the National Institutes of Health and the National Science Foundation “would cause immense and largely irreversible damage to the successful American scientific enterprise,” write Jerry Kaplan and Dana Carroll in an op-ed.
www.sltrib.com
July 9, 2025 at 12:17 PM
Op-Ed from Dana Carroll and my father Jerry Kaplan highlighting some amazing history of publicly funded science at the U. of Utah and how this is in grave jeopardy. First NIH grant ever was to U of U!
Reposted by Indranil Malik
It is important at this pivotal moment to @standupforscience.bsky.social. Looking forward to sharing my thoughts on why this should be a national priority at tomorrow’s rally in SF:
March 5, 2025 at 4:54 PM
It is important at this pivotal moment to @standupforscience.bsky.social. Looking forward to sharing my thoughts on why this should be a national priority at tomorrow’s rally in SF: