Igor Fesenko
igorfesenko.bsky.social
Igor Fesenko
@igorfesenko.bsky.social
Peptidomics, microproteins, proteomics, computational biology

https://igorfesenko.github.io
Excitingly, treating moss plants with sulfated PSY and PSY-like peptides stimulated cell elongation #peptides
March 13, 2025 at 2:29 PM
Congratulations!🎉
March 6, 2025 at 4:51 PM
We also showed that enhanced protein degradation leads to the generation of peptides with antimicrobial activity, functioning as a first line of defense against pathogens

bmcplantbiol.biomedcentral.com/articles/10....
Specific pools of endogenous peptides are present in gametophore, protonema, and protoplast cells of the moss Physcomitrella patens - BMC Plant Biology
Background Protein degradation is a basic cell process that operates in general protein turnover or to produce bioactive peptides. However, very little is known about the qualitative and quantitative ...
bmcplantbiol.biomedcentral.com
March 6, 2025 at 4:21 PM
This aligns with our previous study on plants, where we proposed the concept of “active management” of peptide pools under stress conditions #peptides #antimicrobial

bmcplantbiol.biomedcentral.com/articles/10....
Phytohormone treatment induces generation of cryptic peptides with antimicrobial activity in the Moss Physcomitrella patens - BMC Plant Biology
Background Cryptic peptides (cryptides) are small bioactive molecules generated via degradation of functionally active proteins. Only a few examples of plant cryptides playing an important role in pla...
bmcplantbiol.biomedcentral.com
March 6, 2025 at 4:21 PM
What is the difference between small and weeny?
February 21, 2025 at 2:29 AM
Thank you so much, Nikos! Yes, we significantly improved the manuscript with our collaborators in the wet lab
February 20, 2025 at 6:21 PM
The overexpression of species-specific microprotein which we predicted to interact with calcium transporter (Bax protein family) resulted in downregulation of protein level in cell
February 19, 2025 at 7:16 PM
Complete information on the predicted microproteins is available here colab.research.google.com/github/IgorF...
Google Colab
colab.research.google.com
February 19, 2025 at 7:16 PM
Compared to the preprint, our esteemed collaborators validated selected microproteins by western blotting
February 19, 2025 at 7:16 PM