Igor Fesenko
igorfesenko.bsky.social
Igor Fesenko
@igorfesenko.bsky.social
Peptidomics, microproteins, proteomics, computational biology

https://igorfesenko.github.io
Reposted by Igor Fesenko
hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!
September 15, 2025 at 5:26 PM
Happy to share our manuscript is now published🎉 in @PPLplantarum

A key finding: novel stress inducible peptides in bryophytes

dx.doi.org/10.1111/ppl....
Comparative analysis of small secreted peptide signaling during defense response: insights from vascular and non‐vascular plants
Small secreted peptides (SSPs) play an important role in modulating immune responses in all land plants. However, the evolution of stress peptide signaling in different plant phyla remains poorly und...
dx.doi.org
March 13, 2025 at 2:29 PM
Reposted by Igor Fesenko
Read out latest issue here: www.cell.com/molecular-ce...
March 6, 2025 at 5:51 PM
A fascinating paper demonstrating that proteasome-derived peptides can serve as a natural source of antimicrobial peptides

www.nature.com/articles/s41...
Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature
Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...
www.nature.com
March 6, 2025 at 4:21 PM
Reposted by Igor Fesenko
Hi everyone! We are still welcoming applicants for a computational postdoc position. If your profile fits our lab interests, please do reach out to me for more information or apply directly via the link below. I'm looking forward to reading your application! www.academictransfer.com/en/jobs/3488...
February 18, 2025 at 12:00 PM
Reposted by Igor Fesenko
We’re looking for a postdoc in plant bioengineering to join an exciting interdisciplinary ERC project @UPSC! Work in a vibrant, international environment alongside top researchers, pushing the boundaries of plant science. Apply here: shorturl.at/smdwD
January 21, 2025 at 1:33 PM
Reposted by Igor Fesenko
Very cool paper in Science:
Simulating 500 million years of evolution with a language model
www.science.org/doi/10.1126/...
Simulating 500 million years of evolution with a language model
More than three billion years of evolution have produced an image of biology encoded into the space of natural proteins. Here we show that language models trained at scale on evolutionary data can gen...
www.science.org
January 17, 2025 at 8:28 AM
Reposted by Igor Fesenko
Book review: The astonishing scientists who starved to protect plants during the Second World War

https://go.nature.com/4gSJOfk
The astonishing scientists who starved to protect plants during the Second World War
The trials and tribulations of the world’s first seed bank reveal botanists’ enormous generosity and sacrifice during the siege of Leningrad.
go.nature.com
January 14, 2025 at 3:00 PM
Reposted by Igor Fesenko
### Job alert, please repost! ###

We're recruiting a computational postdoc in evolutionary genetics to help us understand whether recently emerged ncORFs and microproteins play roles in childhood brain cancers. Will you become part of our team? werkenbijprinsesmaximacentrum.nl/en/vacancy/p...
Postdoc computational evolutionary genomics of non-canonical ORFs and microproteins in childhood brain cancer - Werken bij Prinses Maxima Centrum
Background Over recent years, the van Heesch lab has discovered thousands of new “non-canonical” open reading frames (ncORFs) translated from regions of the genome believed not to code for protein. Ma...
werkenbijprinsesmaximacentrum.nl
January 14, 2025 at 3:53 PM
Happy New Year!☃️
January 1, 2025 at 2:56 AM
Reposted by Igor Fesenko
Do you want to go further with your proteomics? Looking for something new in cancer?

Check out microproteins!

Thanks to @science.org for featuring this work, in collaboration with @sebastiaanvheesch.bsky.social, #HUPO, @gencodegenes.bsky.social

www.science.org/content/arti...

🔎 microprotein
🧬 💻
‘Dark proteome’ survey reveals thousands of new human genes
Database confirms that overlooked segments of the genome code for a multitude of tiny proteins
www.science.org
November 26, 2024 at 6:05 PM
Reposted by Igor Fesenko
Small proteins, mighty potential! Whether you're an afficionado or just interested in diving into the world of #microproteins, join us for a Keystone meeting February 2025 in Beverly MA: www.keystonesymposia.org/conferences/...
Microproteins: from Discovery to Applications | Keystone Symposia
Join us at the Keystone Symposia on Microproteins: from Discovery to Applications, February 2025, in Beverly, with field leaders!
www.keystonesymposia.org
November 19, 2024 at 12:25 AM