We had a good line up of speakers at the 50 years anniversary meeting of the german society of cell biology @dgz.bsky.social in Heidelberg. Tony gave the plenary, Koichiro talked about spatial control of P granules and Silja received a price for her Master thesis and gave a talk. Congratulations!

Congratulations to our PhD student David @rnadavid.bsky.social for his successful defense of his PhD thesis! @mpi-cbg.de imprs.mpi-cbg.de
As you see the lab was very creative with his hat! David gave his insights on the nucleocapsid protein and even better arranged a great buffet for celebrations!

"Our key finding is that TDP-43 aggregation requires a double event. One event is the increase in TDP-43 con- centration within stress granules surpassing a critical threshold, and the other is oxidative stress promoting TDP-43 self-interaction"

Importantly, demixing of TDP-43 occurs in iPS-motor neurons, in a disease mouse model and in patients

Molecular dynamics simulations (MD) reveal that the TDP-43 hydrophobic patch (HP) interactions and disulfide bond formation in the RRM1 are the homotypic interactions of TDP-43

Oxidation is a prerequisite for intra-condensate demixing of TDP-43.

Demixing of TDP-43 promotes a liquid-to-solid transition in reconstituted G3BP1-RNA condensates

TDP-43 undergoes intra-condensate demixing inside stress granules

We are very happy that XiaoYan's (Andy!) paper is out, congratulations to all authors
@cellpress.bsky.social
@xiaoyan52802927.bsky.social
www.cell.com/cell/fulltex...
Demixing of TDP-43 inside stress granules generates pathological aggregates linked to ALS/FTD
@mpi-cbg.de @biotec-tud.bsky.social

and improves cellular fitness in motoneurons

lipoamide improves nuclear localisation of FUS and TDP-43

The redox state of SFPQ mediates stress granule dissolution

Thermal protein profiling with @savitsky_lab revealed that lipoamide interacts with disordered proteins in cells

lipoamide dissolves stress granules in cells

Great to see the David's @rnadavid.bsky.social talk at the RNA binding protein meeting at the @embl.org Heidelberg live in Dresden in the lab!

What drives demixing of TDP-43?
#EMBLRBP @events.embl.org