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Apixaban and warfarin being similar is also a red flag

And with LAOO is such a huge selection bias

The SAFE-D trial (pilot; pubmed.ncbi.nlm.nih.gov/39495569/) is now funded to examine apixaban properly

#NephSky

the USRDS here

absolute numbers quite small (cc @spjuraschek.bsky.social ) though age categories slightly different)

💯

See-bee (or Si-Bi) will be way more popular than

Voy (like boy?) zakt?

Interesting. We see the same pattern when you cross into the pediatric population. Girls have higher mortality. Doesn’t make sense to me. pmc.ncbi.nlm.nih.gov/articles/PMC...

I think relative risks can be misleading. Look at how wide the CI are... Need to couple relative comparison with the absolute risk estimate to interpret.

I think you need to control for cause of CKD 5. Without that, not sure what to make of the findings. The risk adjust not relevant at young age. I also don't find the ratio to standardized mortality relevant. The reason males have higher mortality at a lower age will be swamped by CKD5 mortality.

Whoa. That is stark. Are some of it people hand waving symptoms off in women?? Does it persist across social/economic class? Does race matter? I have a lot of questions.

partly explained by lower transplant rates in women

?maybe higher preponderance of lupus in women with associated badness

What else could be contributing?

#NephSky

(2/2) Although no immune deposits are present, the tissue clefts represent the outlines of cholesterol crystals which have lodged within the vascular lumen. This finding is diagnostic of cholesterol microemboli, and it explains the patient’s acute renal failure.