Lightnews — Scholar-powered news

LightNews

Arkana Labs

@arkanalabs.bsky.social

800 followers 760 following 730 posts

We're a center for renal & neuromuscular pathology focused on one thing: improving care for patients. #renal #pathsky #renalpath #neuropath #neuromuscular #kidneypath

Posts Media Videos Starter Packs

Arkana Labs @arkanalabs.bsky.social · 12h

Classic pattern of diffuse, global, hypocellular, expansile amyloid deposition confined to glomeruli, in a case of AFIB amyloid (identified by mass spec).

#UnderTheScope #kidneypath #renalpath #pathology #pathsky #nephsky

Arkana Labs @arkanalabs.bsky.social · 1d

A sample from the pathology teaching slide set on Focal Segmental Glomerulosclerosis in Adults, jointly prepared by Arkana Laboratories and @goKDIGO. http://KDIGO.org/guidelines/gd/

#KDIGO #pathology #renal #renalpath #kidneypath #nephsky

Arkana Labs @arkanalabs.bsky.social · 1d

Here is today’s #eyeSCANdy! Acellular scanning EM showing normal glomerular tuft at top and segmental necrosis at bottom.

Photo courtesy of Dr. Stephen Bonsib. #renal #pathology #kidneypath #nephsky

Arkana Labs @arkanalabs.bsky.social · 2d

6/Nasr S, D’Agati V. Nodular Glomerulosclerosis in the Non-diabetic Smoker. J Am Soc Nephrol 2007; 18: 2032-2036.

Arkana Labs @arkanalabs.bsky.social · 2d

5/ References:
Markowitz GS, Lin J, et al. Idiopathic Nodular Glomerulosclerosis is a Distinct Clinical Pathologic Entity Linked to Hypertension and Smoking. Human Pathology 2002 August; 33 (a): 826-35.

Arkana Labs @arkanalabs.bsky.social · 2d

4/ While light chain deposition disease can also lead to a nodular sclerosis pattern of injury, the immunofluorescence panel was negative in this case and no deposits were present by electron microscopy.

Arkana Labs @arkanalabs.bsky.social · 2d

3/ Of note, in the absence of diabetes, nodular glomerulosclerosis can also be seen in what is known as idiopathic nodular glomerulosclerosis, thought to be secondary to hypertension and/or smoking (see references).

Arkana Labs @arkanalabs.bsky.social · 2d

2/ Clinically, the patient carried a diagnosis of type II diabetes for >10 years with a recent hemoglobin A1c of 12%.

Arkana Labs @arkanalabs.bsky.social · 2d

1/ The light mxicroscopic image of a PAS-stain demonstrates severe, nodular glomerulosclerosis compatible with nodular diabetic glomerulopathy, RPS class III.

#renalpath #kidneypath #pathology #renal #pathsky #nephsky

Arkana Labs @arkanalabs.bsky.social · 2d

This biopsy illustrates a rare example of glomerular involvement. Most emboli are identified “upstream” within interlobular and/or arcuate arteries. Prior to this biopsy, the patient had recently undergone an arterial catheterization procedure.

#nephsky #pathsky

Arkana Labs @arkanalabs.bsky.social · 2d

Cholesterol emboli involving the kidney may manifest clinically as acute kidney injury, hematuria, proteinuria (both non-nephrotic and nephrotic range), and even new onset hypertension.

#TeachingPoints #kidneypath #renal #pathology #nephx #pathx

Reposted by Arkana Labs

Arkana Labs @arkanalabs.bsky.social · 10d

Improving biopsy adequacy rates is essential to improving patient care.

To understand more about the renal biopsy adequacy crisis, listen to our podcast: youtu.be/GSUhu9ysNyM?...

#Renal #kidneypath #nephrology #nephsky

Arkana Labs @arkanalabs.bsky.social · 3d

What is your diagnosis in a patient (non-smoker) with worsening proteinuria and a negative immunofluorescence panel?

#DiagnoseThis #pathology #renal #kidneypath #nephsky #pathsky

Arkana Labs @arkanalabs.bsky.social · 6d

What Dr. Singh saw #UnderTheScope today: GBM spicules "eyelashes" in a case of AL lambda amyloidosis.

#renalpath #kidneypath #pathsky #nephsky

Arkana Labs @arkanalabs.bsky.social · 7d

Glomerular microangiopathic changes and hyaline-like lesions secondary to VEGF inhibitor therapy. This patient had received 3 doses of Avastin before developing neprotic-range proteinuria.

#kidneypath #renal #pathology #pathsky #nephsky

Arkana Labs @arkanalabs.bsky.social · 8d

Here is today’s #eyeSCANdy! Spicular amyloid deposit showing blunt conical formations with interconnecting fibrils.

Photo courtesy of Dr. Stephen Bonsib. #renal #pathology #kidneypath #pathsky #nephsky

Arkana Labs @arkanalabs.bsky.social · 9d

A sample from the pathology teaching slide set on Infection-related Glomerulonephritis: Schistosomal Glomerulonephritis, jointly prepared by Arkana Laboratories and @goKDIGO. http://KDIGO.org/guidelines/gd/

#KDIGO #pathology #renal #renalpath #kidneypath #nephsky #pathsky

Reposted by Arkana Labs

Juan Carlos Q Vélez, MD @juancarlosqvelez.bsky.social · 16d

Strong signal for better kidney biopsy adequacy favoring 16G needle over 18G (w/ = complication rate) in pediatric pts 12-18 years-old, extending established norm 4 adults. Only 4 children <12, a smaller 18G needle is safer. #KidneyBiopsyAcademy @kidneycon.bsky.social @arkanalabs.bsky.social

aspneph.bsky.social @aspneph.bsky.social · 16d

Adequacy and safety of pediatric native kidney biopsy using 16- and 18-gauge needles

Adequacy and safety of pediatric native kidney biopsy using 16- and 18-gauge needles - Pediatric Nephrology

Background The native kidney biopsy is an important diagnostic procedure in pediatric nephrology. Recent meta-analyses did not find the size of the needle as a risk factor for bleeding complications,…

Arkana Labs @arkanalabs.bsky.social · 9d

3/ By electron microscopy this case demonstrated numerous, randomly arranged fibrils that measured ~10 nm characteristic of amyloid fibrils within mesangial areas with extension into numerous capillary loops. Congo red stain was positive in glomeruli.

Arkana Labs @arkanalabs.bsky.social · 9d

2/ This finding is classically seen with amyloidosis. Other glomeruli in this case demonstrated areas of PAS-weak to negative staining of mesangial areas which is another feature that should raise suspicion for possible amyloidosis.

Arkana Labs @arkanalabs.bsky.social · 9d

1/ The light microscopic image of a Jones silver stain shows a glomerulus with demonstrates numerous elongated, fine spicules which some regard as the "eyelash sign".

#renalpath #kidneypath #pathology #renal #pathX

Arkana Labs @arkanalabs.bsky.social · 9d

However, the prominent IgG deposits also involving the associated arteriole in this case are an important clue that helps argue for a secondary etiology. This patient, in fact, was found to have systemic lupus erythematosus. (2/2)

#TeachingPoints #kidneypath #renal

Arkana Labs @arkanalabs.bsky.social · 9d

This immunofluorescence (IF) image shows extensive granular glomerular capillary wall IgG deposits, consistent with membranous glomerulopathy. The glomerular staining pattern as seen by IF is not specific for either primary or secondary membranous glomerulopathy. (1/2)

#pathology #pathsky #nephsky

Arkana Labs @arkanalabs.bsky.social · 10d

Thank you to @juancarlosqvelez.bsky.social, @nephrowhitt.bsky.social, and Dr. Vandana Niyyar for joining @nephrosharma.bsky.social, and @glombandit.bsky.social for this discussion!

#Renal #kidneypath #nephrology #nephsky

Glom Goals: Why Adequacy Matters

Renal pathologists Dr. Shree Sharma and Dr. Tiff Caza sit down with nephrologists Dr. Juan Carlos Velez, Dr. Bill Whittier, and Dr. Vandana Dua Niyyar to discuss the rising renal biopsy inadequacy…

Arkana Labs @arkanalabs.bsky.social · 10d

Improving biopsy adequacy rates is essential to improving patient care.

To understand more about the renal biopsy adequacy crisis, listen to our podcast: youtu.be/GSUhu9ysNyM?...

#Renal #kidneypath #nephrology #nephsky