Heinrich Gompf
@hgompf.bsky.social
Formerly @Anaclet_Lab. UC Davis Neurosurgery. Sleep, circadian rhythms research.
Reposted by Heinrich Gompf
A new article from Jordan Cook in our lab and Qijun Tang in the Hattar lab: best practices in long-term fiber photometry recording. We argue that the field needs a standardized framework for experiments and analysis. academic.oup.com/pnasnexus/ad...
Long-term optical monitoring of genetically-encoded fluorescent indicators
Abstract. Over the past several decades, genetically-encoded fluorescent indicators (GEFIs) have revolutionized neuroscience by enabling cell-type-specific
academic.oup.com
November 24, 2025 at 3:29 PM
A new article from Jordan Cook in our lab and Qijun Tang in the Hattar lab: best practices in long-term fiber photometry recording. We argue that the field needs a standardized framework for experiments and analysis. academic.oup.com/pnasnexus/ad...
Reposted by Heinrich Gompf
"Here, we explore human receptors responsive to molecules displaying in vivo oscillatory patterns and identify melatonin receptor 1A (MTNR1A) as a promising molecular sensor to trigger transgene expression."
rdcu.be/eRnoo
rdcu.be/eRnoo
Regulation of therapeutic protein release in response to circadian biomarkers
Nature Communications - Circadian clocks integrate external environmental and internal physiological cues to generate oscillations of secreted endocrine signals. Here the authors build a...
rdcu.be
November 23, 2025 at 3:15 PM
"Here, we explore human receptors responsive to molecules displaying in vivo oscillatory patterns and identify melatonin receptor 1A (MTNR1A) as a promising molecular sensor to trigger transgene expression."
rdcu.be/eRnoo
rdcu.be/eRnoo
Characterization of locus coeruleus neuronal properties with aging in two mouse models of tauopathy
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
Characterization of locus coeruleus neuronal properties with aging in two mouse models of tauopathy - Yasmin Potts, Heather Daykin, Maarten Van Den Bossche, Stuart J McDougall, Laura H Jacobson, 2025
Background The locus coeruleus (LC) is involved in the modulation of sleep and wakefulness. In humans, tau pathology develops in the LC decades before Alzheimer...
journals.sagepub.com
November 21, 2025 at 6:32 PM
Characterization of locus coeruleus neuronal properties with aging in two mouse models of tauopathy
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
Reposted by Heinrich Gompf
This is the cabinet where we keep Ted’s dry food. Conditioned place preference?
November 11, 2025 at 6:16 PM
This is the cabinet where we keep Ted’s dry food. Conditioned place preference?
Reposted by Heinrich Gompf
#SfN25 attendees - make sure to head to the posters when you get to the meeting on Saturday afternoon (V7-V11: Gretchen, Megan, Margaret, Louisa, Bella) and Sunday morning (KK17: Micaela) to hear about our work. We're printing the posters now and they look rad.
November 11, 2025 at 5:00 PM
#SfN25 attendees - make sure to head to the posters when you get to the meeting on Saturday afternoon (V7-V11: Gretchen, Megan, Margaret, Louisa, Bella) and Sunday morning (KK17: Micaela) to hear about our work. We're printing the posters now and they look rad.
Excellent review article by @grandner.bsky.social about A-β. Finishes up a lot of thoughts that I had only begun to ponder.
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
Sage Journals: Discover world-class research
Subscription and open access journals from Sage, the world's leading independent academic publisher.
journals.sagepub.com
November 7, 2025 at 11:31 PM
Excellent review article by @grandner.bsky.social about A-β. Finishes up a lot of thoughts that I had only begun to ponder.
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
Reposted by Heinrich Gompf
Associations between sleep duration, insomnia, depression, anxiety and registry‐based school grades: A longitudinal study among high‐school students - Evanger - 2025 - Journal of Sleep Research - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...
<em>Journal of Sleep Research</em> | ESRS Journal | Wiley Online Library
This study explored the prospective associations between sleep patterns, mental health and registry-based school grades among older adolescents. In the spring of 2019, 1st year high-school students i...
onlinelibrary.wiley.com
October 31, 2025 at 10:49 PM
Associations between sleep duration, insomnia, depression, anxiety and registry‐based school grades: A longitudinal study among high‐school students - Evanger - 2025 - Journal of Sleep Research - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...
International recommendations for sleep and circadian research in aging and Alzheimer's disease: A Delphi consensus study
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
International recommendations for sleep and circadian research in aging and Alzheimer's disease: A Delphi consensus study
INTRODUCTION Research in the field of sleep, aging, and dementia is rapidly growing. Consensus guidance is needed to facilitate high-quality research, comparability, and consistency. METHODS A mod...
alz-journals.onlinelibrary.wiley.com
October 31, 2025 at 6:24 PM
International recommendations for sleep and circadian research in aging and Alzheimer's disease: A Delphi consensus study
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Heinrich Gompf
Welp, antifa did it. They finally burned Portland to the ground. Nothing but smoke left.
October 29, 2025 at 6:00 PM
Welp, antifa did it. They finally burned Portland to the ground. Nothing but smoke left.
Reposted by Heinrich Gompf
My co-authors have yet to move to Bluesky, so I'm pleased to announce our latest work has just been published in @nature.com Neuroscience. Amazing work led by Junheng Li, revealing that falling asleep follows a predictable bifurcation pattern #neuroskyence #sleep
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Falling asleep follows a predictable bifurcation dynamic - Nature Neuroscience
Li et al. propose a conceptual framework to study the phenomenon of falling asleep based on electroencephalogram data. They show that a tipping point marks the brain’s nonlinear wake-to-sleep transiti...
www.nature.com
October 28, 2025 at 5:35 PM
My co-authors have yet to move to Bluesky, so I'm pleased to announce our latest work has just been published in @nature.com Neuroscience. Amazing work led by Junheng Li, revealing that falling asleep follows a predictable bifurcation pattern #neuroskyence #sleep
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Take Me Home, Country Roads
YouTube video by Toots and the Maytals - Topic
youtu.be
October 28, 2025 at 9:05 PM
Reposted by Heinrich Gompf
From a crewmember on yesterday's Teal 74 mission into now-Category 5 Hurricane #Melissa. As clear of an eye as you will see in the Atlantic basin.
October 27, 2025 at 4:11 PM
From a crewmember on yesterday's Teal 74 mission into now-Category 5 Hurricane #Melissa. As clear of an eye as you will see in the Atlantic basin.
Reposted by Heinrich Gompf
The UC Regents finally released the “settlement agreement” the Trump administration proposed in August. It’s a doozy.
UC alumni, faculty, staff, students, parents, donors—and all citizens of California:
Now is the time to let the UC Regents know you do not want them to sign this bad deal.
UC alumni, faculty, staff, students, parents, donors—and all citizens of California:
Now is the time to let the UC Regents know you do not want them to sign this bad deal.
October 25, 2025 at 6:53 AM
The UC Regents finally released the “settlement agreement” the Trump administration proposed in August. It’s a doozy.
UC alumni, faculty, staff, students, parents, donors—and all citizens of California:
Now is the time to let the UC Regents know you do not want them to sign this bad deal.
UC alumni, faculty, staff, students, parents, donors—and all citizens of California:
Now is the time to let the UC Regents know you do not want them to sign this bad deal.
Now let me welcome everybody to the Wilr Wild West.
A state that’s untouchable like Eliot Ness.
A state that’s untouchable like Eliot Ness.
HAPPY FRIDAY, PATRIOTS 🇺🇸 HAVE A PEACEFUL WEEKEND !!
October 25, 2025 at 5:41 AM
Now let me welcome everybody to the Wilr Wild West.
A state that’s untouchable like Eliot Ness.
A state that’s untouchable like Eliot Ness.
Reposted by Heinrich Gompf
Construction of the new ball room is coming along nicely at the White House.
October 24, 2025 at 5:08 PM
Construction of the new ball room is coming along nicely at the White House.
Whoa! A chance to watch the glymphatic system, perchance?
A noninvasive, CSF-specific MRI technique that enables detailed in vivo measurement of CSF mobility in humans, down to the level of perivascular spaces located around penetrating vessels
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Region-specific drivers of CSF mobility measured with MRI in humans - Nature Neuroscience
Brain clearance mechanisms are challenging to visualize in humans. Using magnetic resonance imaging, the authors noninvasively mapped cerebrospinal fluid motion across the brain, showing region-specif...
www.nature.com
October 24, 2025 at 4:58 PM
Whoa! A chance to watch the glymphatic system, perchance?
ka-blammed? LOL!
"In 1980, he ka-blammed the old Bonwit Teller building on Fifth Avenue in Manhattan so that he could raise up Trump Tower."
"In 1980, he ka-blammed the old Bonwit Teller building on Fifth Avenue in Manhattan so that he could raise up Trump Tower."
Construction workers ripped the face off the East Wing to begin building President Trump’s 90,000-square-foot ballroom.
White House’s East Wing Partially Demolished to Build Trump’s Ballroom
The president had pledged that construction wouldn’t “interfere with the current building,” a promise that always seemed unrealistic given the grand scale of the plans.
nyti.ms
October 21, 2025 at 12:08 AM
ka-blammed? LOL!
"In 1980, he ka-blammed the old Bonwit Teller building on Fifth Avenue in Manhattan so that he could raise up Trump Tower."
"In 1980, he ka-blammed the old Bonwit Teller building on Fifth Avenue in Manhattan so that he could raise up Trump Tower."
I suppose their next excuse is it’s an exit hardly anyone ever uses…?
Here is a map showing the exact spot a CHP vehicle was struck by shrapnel after a shell detonated over I-5 during the Trump-Vance missile firings at Camp Pendleton:
October 19, 2025 at 11:17 PM
I suppose their next excuse is it’s an exit hardly anyone ever uses…?
Newsom was right to close down I-5.
The video Trump posted shows he wanted something like this to happen, or at least show he could make it so. We are already in secession territory with this.
The video Trump posted shows he wanted something like this to happen, or at least show he could make it so. We are already in secession territory with this.
An artillery shell fired during 250th anniversary celebration of the Marine Corps at Camp Pendleton on Saturday detonated prematurely over Interstate 5, damaging a California Highway Patrol vehicle on JD Vance's security detail www.nytimes.com/2025/10/19/u...
Artillery Shell Detonated Over Interstate 5 During Marines’ Celebration, California Officials Say
www.nytimes.com
October 19, 2025 at 10:07 PM
Newsom was right to close down I-5.
The video Trump posted shows he wanted something like this to happen, or at least show he could make it so. We are already in secession territory with this.
The video Trump posted shows he wanted something like this to happen, or at least show he could make it so. We are already in secession territory with this.
Receptor-specific noradrenergic modulation of oscillatory dynamics during non-rapid eye movement sleep in adult male rats
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Receptor-specific noradrenergic modulation of oscillatory dynamics during non-rapid eye movement sleep in adult male rats
Cortical slow oscillations (SO, ∼1 Hz), which are hallmarks of non-rapid eye movement (NREM) sleep, temporally organize thalamocortical spindles (10–1…
www.sciencedirect.com
October 17, 2025 at 4:46 PM
Receptor-specific noradrenergic modulation of oscillatory dynamics during non-rapid eye movement sleep in adult male rats
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Heinrich Gompf
Trump: "I'm going to be strongly recommending at the request of govt officials, which is always nice, that you start looking at San Francisco. I think we can make San Francisco -- one of our great cities 10 years ago, 15 years ago, and now it's a mess."
October 15, 2025 at 7:51 PM
Trump: "I'm going to be strongly recommending at the request of govt officials, which is always nice, that you start looking at San Francisco. I think we can make San Francisco -- one of our great cities 10 years ago, 15 years ago, and now it's a mess."
jeebus, he's going to invade San Francisco next.
October 15, 2025 at 7:50 PM
jeebus, he's going to invade San Francisco next.
I'm so glad that the pandemic finally made us figure out that we can appear for the first day of jury duty selection remotely. With the dogs and everything else, that would have been difficult to do in person tomorrow morning.
October 9, 2025 at 10:30 PM
I'm so glad that the pandemic finally made us figure out that we can appear for the first day of jury duty selection remotely. With the dogs and everything else, that would have been difficult to do in person tomorrow morning.
Reposted by Heinrich Gompf
Couch. People from PDX will understand.
What’s the word where you’re from that, when pronounced exactly as it looks, identifies a tourist immediately?
October 9, 2025 at 2:47 AM
Couch. People from PDX will understand.