Helfrid Hochegger
@helfridh.bsky.social
Professor @gdsc-sussex; studying how cells divide and how we get them to stop dividing in cancer. Interested in genetics, imaging, evolution, bioinformatics, python, rust.
https://www.hocheggerlab.org/
https://www.hocheggerlab.org/
Reposted by Helfrid Hochegger
From Sendai to Kyoto: the HFSP Science Summit Japan 2025 connected outstanding scientists and young researchers in a week of collaboration and discovery.
📖 Read the full story → zurl.co/5eYb5
🧪 #sts #HFSPSummitJapan
📖 Read the full story → zurl.co/5eYb5
🧪 #sts #HFSPSummitJapan
November 14, 2025 at 8:15 AM
From Sendai to Kyoto: the HFSP Science Summit Japan 2025 connected outstanding scientists and young researchers in a week of collaboration and discovery.
📖 Read the full story → zurl.co/5eYb5
🧪 #sts #HFSPSummitJapan
📖 Read the full story → zurl.co/5eYb5
🧪 #sts #HFSPSummitJapan
Reposted by Helfrid Hochegger
From an accidental discovery of hidden biology to a new framework to understanding and diagnosing rare disease. Thrilled to share the most recent work from our lab and the amazing Jimmy Ly.
wi.mit.edu/news/alterna...
wi.mit.edu/news/alterna...
Alternate proteins from the same gene contribute differently to health and rare disease | Whitehead Institute
Iain Cheeseman and colleagues reveal the underappreciated role of single genes producing multiple proteins in atypical presentations of rare disease, and present case studies of affected patients thro...
wi.mit.edu
November 7, 2025 at 4:14 PM
From an accidental discovery of hidden biology to a new framework to understanding and diagnosing rare disease. Thrilled to share the most recent work from our lab and the amazing Jimmy Ly.
wi.mit.edu/news/alterna...
wi.mit.edu/news/alterna...
Reposted by Helfrid Hochegger
Two back-to-back stories on mitosis led by my incredible postdoc @krunovuk.bsky.social at @institutrb.bsky.social, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in @natcomms.nature.com
doi.org/10.1038/s414...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
October 21, 2025 at 11:14 AM
Two back-to-back stories on mitosis led by my incredible postdoc @krunovuk.bsky.social at @institutrb.bsky.social, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in @natcomms.nature.com
doi.org/10.1038/s414...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Reposted by Helfrid Hochegger
Today @anthropic.com released PubMed integration for Claude. No hallucinations. Just real science, real data. As a beta tester, this has been game changing— a supercharged research tool. Here are 6 prompts that will transform how you search the literature. A 🧵
www.anthropic.com/news/claude-...
www.anthropic.com/news/claude-...
Claude for Life Sciences
Discover how Claude accelerates life sciences research with new scientific connectors, skills, and improved performance for drug discovery and clinical work.
www.anthropic.com
October 20, 2025 at 5:27 PM
Today @anthropic.com released PubMed integration for Claude. No hallucinations. Just real science, real data. As a beta tester, this has been game changing— a supercharged research tool. Here are 6 prompts that will transform how you search the literature. A 🧵
www.anthropic.com/news/claude-...
www.anthropic.com/news/claude-...
Reposted by Helfrid Hochegger
15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵
October 10, 2025 at 4:47 PM
15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵
Reposted by Helfrid Hochegger
Just over one week until this opportunity closes!
If you’re an ambitious computational scientist looking for a Postdoc position, apply now
If you’re an ambitious computational scientist looking for a Postdoc position, apply now
@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
October 7, 2025 at 7:56 AM
Just over one week until this opportunity closes!
If you’re an ambitious computational scientist looking for a Postdoc position, apply now
If you’re an ambitious computational scientist looking for a Postdoc position, apply now
Reposted by Helfrid Hochegger
We are looking for our next PhD student to join us 🤩 www.mcclellandlab.com to understand cancer radiation therapy's impact on DNA damage repair and chromosomal instability. Prestigious funding from CRUK RadNet. Please contact me informally - deadline 5th Nov! crukradnet.colcc.ac.uk/phd-students...
October 2, 2025 at 3:49 PM
We are looking for our next PhD student to join us 🤩 www.mcclellandlab.com to understand cancer radiation therapy's impact on DNA damage repair and chromosomal instability. Prestigious funding from CRUK RadNet. Please contact me informally - deadline 5th Nov! crukradnet.colcc.ac.uk/phd-students...
Reposted by Helfrid Hochegger
Fantastic meeting with an excellent line up of speakers. Come join us for the Australian Cell Cycle meeting in Melbourne.
Australian Cell Cycle, DNA repair and Telomere meeting draft schedule is now online!
Join us with 5 plenary speakers, 16 invited national speakers, 22 selected speakers, 61 poster presenters and lots and lots of fun science. Less than one month to go.
australiancellcycle.org/draft-schedu...
Join us with 5 plenary speakers, 16 invited national speakers, 22 selected speakers, 61 poster presenters and lots and lots of fun science. Less than one month to go.
australiancellcycle.org/draft-schedu...
September 25, 2025 at 2:03 AM
Fantastic meeting with an excellent line up of speakers. Come join us for the Australian Cell Cycle meeting in Melbourne.
Reposted by Helfrid Hochegger
@currentbiology.bsky.social has always been one of my favorite journals but I think they have now outdone themselves www.cell.com/current-biol.... And picked up by the @nytimes.com as well! www.nytimes.com/2025/08/18/s...
Periodic excretion patterns of seabirds in flight
Uesaka and Sato report on the excretion patterns of seabirds in the open ocean determined
using a rear-facing video logger.
www.cell.com
August 18, 2025 at 5:58 PM
@currentbiology.bsky.social has always been one of my favorite journals but I think they have now outdone themselves www.cell.com/current-biol.... And picked up by the @nytimes.com as well! www.nytimes.com/2025/08/18/s...
As students come back to campus in the UK, 8% of female students are likely to experience rape during their undergraduate years, especially in the first months of their studies.
revoltsexualassault.com/wp-content/u...
revoltsexualassault.com/wp-content/u...
revoltsexualassault.com
September 20, 2025 at 9:19 AM
As students come back to campus in the UK, 8% of female students are likely to experience rape during their undergraduate years, especially in the first months of their studies.
revoltsexualassault.com/wp-content/u...
revoltsexualassault.com/wp-content/u...
Reposted by Helfrid Hochegger
@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
September 18, 2025 at 8:02 PM
@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Reposted by Helfrid Hochegger
We're hiring ! Specifically....we are seeking to appoint a creative and motivated Postdoctoral Training Fellow to study how drug resistance emerges in homologous recombination defective (HRD) breast cancers and how this could be targeted. jobs.icr.ac.uk/vacancies/13...
PDTF - Homologous Recombination Defective Cancers ( Profs Chris Lord and Andrew Tutt) in Chelsea | The Institute of Cancer Research
View details and apply for this PDTF - Homologous Recombination Defective Cancers ( Profs Chris Lord and Andrew Tutt) vacancy in Chelsea .
Salary: Dependent on relevant Postdoctoral exp...
jobs.icr.ac.uk
September 19, 2025 at 7:38 AM
We're hiring ! Specifically....we are seeking to appoint a creative and motivated Postdoctoral Training Fellow to study how drug resistance emerges in homologous recombination defective (HRD) breast cancers and how this could be targeted. jobs.icr.ac.uk/vacancies/13...
Reposted by Helfrid Hochegger
Thanks for sharing our work @bladoux.bsky.social (you just made the lead author @marcoenriquez18.bsky.social very happy 😊)
Tuning collagen nonlinear mechanics with interpenetrating networks drives adaptive cellular phenotypes in three dimensions | Science Advances www.science.org/doi/10.1126/...
Tuning collagen nonlinear mechanics with interpenetrating networks drives adaptive cellular phenotypes in three dimensions
This work demonstrates that changes in the nonlinear elasticity of collagen in hybrid networks tunes cell-matrix interactions.
www.science.org
September 10, 2025 at 6:14 AM
Thanks for sharing our work @bladoux.bsky.social (you just made the lead author @marcoenriquez18.bsky.social very happy 😊)
Reposted by Helfrid Hochegger
Research is never a solo effort.
It takes teamwork. It takes belief. It takes collaboration across disciplines, institutions, and communities.
We know what it takes to beat blood cancer.
#BloodCancerAwarenessMonth
@bloodcanceruk.bsky.social @sussexbcr.bsky.social @sussexcancer.org 🩸
It takes teamwork. It takes belief. It takes collaboration across disciplines, institutions, and communities.
We know what it takes to beat blood cancer.
#BloodCancerAwarenessMonth
@bloodcanceruk.bsky.social @sussexbcr.bsky.social @sussexcancer.org 🩸
September 4, 2025 at 2:18 PM
Research is never a solo effort.
It takes teamwork. It takes belief. It takes collaboration across disciplines, institutions, and communities.
We know what it takes to beat blood cancer.
#BloodCancerAwarenessMonth
@bloodcanceruk.bsky.social @sussexbcr.bsky.social @sussexcancer.org 🩸
It takes teamwork. It takes belief. It takes collaboration across disciplines, institutions, and communities.
We know what it takes to beat blood cancer.
#BloodCancerAwarenessMonth
@bloodcanceruk.bsky.social @sussexbcr.bsky.social @sussexcancer.org 🩸
Reposted by Helfrid Hochegger
Checkout our latest research in @natcomms.nature.com
rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team
rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team
A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells
Nature Communications - Determining how replication forks move across the human genome is critical for the effective use of agents that target replication stress. Here, the authors present...
rdcu.be
September 1, 2025 at 10:04 AM
Checkout our latest research in @natcomms.nature.com
rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team
rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team
Reposted by Helfrid Hochegger
I’m excited to highlight our latest paper, just published in Cell 🎉
We report the existence of a previously uncharacterized signaling pathway that is responsible for activating cell death upon loss of gene expression.
1/n 🧪
www.cell.com/cell/fulltex...
We report the existence of a previously uncharacterized signaling pathway that is responsible for activating cell death upon loss of gene expression.
1/n 🧪
www.cell.com/cell/fulltex...
RNA Pol II inhibition activates cell death independently from the loss of transcription
When RNA polymerase II (RNA Pol II) is inhibited, the inhibition is sensed and signaled
to mitochondria, leading to programmed cell death independently of the loss of RNA
Pol II transcription activity...
www.cell.com
August 15, 2025 at 6:35 PM
I’m excited to highlight our latest paper, just published in Cell 🎉
We report the existence of a previously uncharacterized signaling pathway that is responsible for activating cell death upon loss of gene expression.
1/n 🧪
www.cell.com/cell/fulltex...
We report the existence of a previously uncharacterized signaling pathway that is responsible for activating cell death upon loss of gene expression.
1/n 🧪
www.cell.com/cell/fulltex...
Reposted by Helfrid Hochegger
... and this one too! Again, quite amazing microscopy. Major congrats to Maria + colleagues for getting this story online.
#NEW_PAPER
In this study, the Chan Lab uncover the molecular mechanisms by which human cells safeguard centromeric chromatin during mitosis, via tight dynamic control of the Bloom Syndrome complex (BTRR).
rdcu.be/eCGxF
In this study, the Chan Lab uncover the molecular mechanisms by which human cells safeguard centromeric chromatin during mitosis, via tight dynamic control of the Bloom Syndrome complex (BTRR).
rdcu.be/eCGxF
Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex
Nature Communications - Centromeres play an essential function in faithful chromosome segregation. Here, the authors demonstrate the mechanism by which human cells dynamically modulate the activity...
rdcu.be
August 30, 2025 at 11:28 AM
... and this one too! Again, quite amazing microscopy. Major congrats to Maria + colleagues for getting this story online.
Excited to share our new @NatureComms paper! We developed C-604, a selective inhibitor of Greatwall kinase, and discovered that cancer cells' sensitivity to it depends on a simple ratio: B55α/Greatwall expression levels.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells - Nature Communications
The authors develop and characterise a selective Greatwall inhibitor, C-604, and show that its cytotoxicity stems from PP2A-B55α hyperactivation. They identify B55α and Greatwall levels as biomarkers…
www.nature.com
August 28, 2025 at 11:07 AM
Excited to share our new @NatureComms paper! We developed C-604, a selective inhibitor of Greatwall kinase, and discovered that cancer cells' sensitivity to it depends on a simple ratio: B55α/Greatwall expression levels.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Helfrid Hochegger
We are pleased to annouce that a 3.5-year PhD position is available in the GDSC, for a project jointly supervised by Prof. Hochegger and Dr. Oliver. For additional details, inc. candidate eligibility, and how to apply:
www.sussex.ac.uk/study/fees-f...
www.sussex.ac.uk/study/fees-f...
Life Sciences PhD Genome Stability - Understanding and Targeting Cell Cycle Control in Cancer : University of Sussex
www.sussex.ac.uk
May 23, 2025 at 8:21 AM
We are pleased to annouce that a 3.5-year PhD position is available in the GDSC, for a project jointly supervised by Prof. Hochegger and Dr. Oliver. For additional details, inc. candidate eligibility, and how to apply:
www.sussex.ac.uk/study/fees-f...
www.sussex.ac.uk/study/fees-f...
Tony Oliver’s and my lab have a joint phd position available to investigate mitotic entry control mechanisms
Please forward to prospective students! Thank you
url.uk.m.mimecastprotect.com/s/ukMTCoy6DT...
Please forward to prospective students! Thank you
url.uk.m.mimecastprotect.com/s/ukMTCoy6DT...
PhD Studentship: Understanding and Targeting Cell Cycle Control in Cancer at University of Sussex
At jobs.ac.uk, you can apply for a PhD Studentship: Understanding and Targeting Cell Cycle Control in Cancer. Explore our diverse range of PhD opportunities today.
url.uk.m.mimecastprotect.com
May 21, 2025 at 10:22 AM
Tony Oliver’s and my lab have a joint phd position available to investigate mitotic entry control mechanisms
Please forward to prospective students! Thank you
url.uk.m.mimecastprotect.com/s/ukMTCoy6DT...
Please forward to prospective students! Thank you
url.uk.m.mimecastprotect.com/s/ukMTCoy6DT...
Reposted by Helfrid Hochegger
Delighted to share a chemical-genetic system we developed to rapidly inhibit a serine/threonine phosphatase complex (within secs). This will make it much easier to study #phosphatases. The system is also applicable to other “undruggable” enzymes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A chemical-genetic system to rapidly inhibit the PP2A-B56 phosphatase reveals a role at metaphase kinetochores - Nature Communications
Phosphatase enzymes are challenging to study due to a lack of specific inhibitors. Here, authors develop a chemical-genetic system to inhibit and characterize a major Ser/Thr phosphatase complex, and ...
www.nature.com
April 1, 2025 at 5:58 PM
Delighted to share a chemical-genetic system we developed to rapidly inhibit a serine/threonine phosphatase complex (within secs). This will make it much easier to study #phosphatases. The system is also applicable to other “undruggable” enzymes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Helfrid Hochegger
Lovely retrospective for Dan Dennett.
The late Daniel Dennett was born on this date in 1942. After his passing last spring, we put together a special retrospective episode with his friend and admirer, Jenann Ismael from @jhuartssciences.bsky.social: www.philosophytalk.org/shows/daniel... #PhilSky #philosophy
March 28, 2025 at 4:01 PM
Lovely retrospective for Dan Dennett.
Reposted by Helfrid Hochegger
Thanks to the @simplyoncology.bsky.social guys for this opportunity to talk about everything high grade glioma!
🎙️Out tomorrow on The Simply Oncology Podcast🎙️
We discuss High Grade Gliomas with the superb Professor Anthony Chalmers 🎙️
🚨Part 1 of 2 and we discuss implications of new molecular profiling on prognosis and treatment options.
@simplyoncology.bsky.social @profajchalmers.bsky.social
We discuss High Grade Gliomas with the superb Professor Anthony Chalmers 🎙️
🚨Part 1 of 2 and we discuss implications of new molecular profiling on prognosis and treatment options.
@simplyoncology.bsky.social @profajchalmers.bsky.social
January 18, 2025 at 4:22 PM
Thanks to the @simplyoncology.bsky.social guys for this opportunity to talk about everything high grade glioma!
Reposted by Helfrid Hochegger
Interesting 🧵 about publishing in Math.
tl;dr: All papers in Math are preprinted. When publishers ask big $ for subscriptions or OA, mathematicians simply say "No thanks, we read these papers already on arXiv." Publishers then force unis to buy Math journals by bundling them with Bio journals.
tl;dr: All papers in Math are preprinted. When publishers ask big $ for subscriptions or OA, mathematicians simply say "No thanks, we read these papers already on arXiv." Publishers then force unis to buy Math journals by bundling them with Bio journals.
Mathematik ist ein kleines Feld und hat oft eigene Lösungen, die besser sind als was gemeinhin passiert. Heute zum Abschluss will ich das am Beispiel von #OpenAccess vorführen. Die ganze OA Verschiebung hat der Mathe im wesentlichen Verschlechterungen gebracht. Warum? 🧵
January 3, 2025 at 1:49 PM
Interesting 🧵 about publishing in Math.
tl;dr: All papers in Math are preprinted. When publishers ask big $ for subscriptions or OA, mathematicians simply say "No thanks, we read these papers already on arXiv." Publishers then force unis to buy Math journals by bundling them with Bio journals.
tl;dr: All papers in Math are preprinted. When publishers ask big $ for subscriptions or OA, mathematicians simply say "No thanks, we read these papers already on arXiv." Publishers then force unis to buy Math journals by bundling them with Bio journals.
Reposted by Helfrid Hochegger
Here is my deep dive into Life, the Universe and Everything with Lex Fridman.
Discussions include Astrobiology, Technosignatures, the Physics of Life, Quantum Mechanics and the Philosophy of Science.
Big fun 3 hr + conversation.
www.youtube.com/watch?v=yhZA...
Discussions include Astrobiology, Technosignatures, the Physics of Life, Quantum Mechanics and the Philosophy of Science.
Big fun 3 hr + conversation.
www.youtube.com/watch?v=yhZA...
Adam Frank: Alien Civilizations and the Search for Extraterrestrial Life | Lex Fridman Podcast #455
YouTube video by Lex Fridman
www.youtube.com
December 27, 2024 at 4:51 PM
Here is my deep dive into Life, the Universe and Everything with Lex Fridman.
Discussions include Astrobiology, Technosignatures, the Physics of Life, Quantum Mechanics and the Philosophy of Science.
Big fun 3 hr + conversation.
www.youtube.com/watch?v=yhZA...
Discussions include Astrobiology, Technosignatures, the Physics of Life, Quantum Mechanics and the Philosophy of Science.
Big fun 3 hr + conversation.
www.youtube.com/watch?v=yhZA...