Héctor Climente-González
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hclimente.eu
Héctor Climente-González
@hclimente.eu
AI/ML for early drug target discovery and precision medicine, with a focus on (epi-)genetics. Lead Scientist at Novo Nordisk, London.
Reposted by Héctor Climente-González
🚨 NEW RESEARCH! ⚕️ 🩺 🖥️

Climente-Gonzalez, Oh et al. develop an interpretable #ML model that integrates plasma proteomics with clinical risk factors to improve risk prediction for CVD 🫀 .

https://bit.ly/3ZUqyY8

@hclimente.eu @nkoell.bsky.social
Interpretable machine learning leverages proteomics to improve cardiovascular disease risk prediction and biomarker identification - Communications Medicine
Climente-González, Oh et al. introduce an interpretable machine learning model that integrates plasma proteomics with clinical risk factors and employs an explainable boosting machine algorithm for risk prediction. Authors show that their model outperforms existing models in predicting risk for cardiovascular disease.
bit.ly
June 9, 2025 at 11:31 AM
I've spent the last few weeks digging into InstaDeep's Nucleotide Transformer DNA language model using @hf.co 🤗

If you're keen on seeing how LLM libraries can be applied to DNA, my latest post breaks it all down. Give it a read: hclimente.eu/blog/hf-tran...
DNA language model fine-tuning and inference | Héctor Climente-González
Using Hugging Face transformers
hclimente.eu
May 30, 2025 at 10:23 PM
Reposted by Héctor Climente-González
New post: things have been moving very fast in AI. But has safety caught up to capabilities? open.substack.com/pub/naix/p/w...
Why I'm more worried about AI safety now than 6 months ago
Exponentials are all you need
open.substack.com
May 9, 2025 at 7:59 PM
I have been using uv to manage my Python projects lately. Faster setups, better reproducibility, and it even trimmed down my stack.

Here's a short tutorial if you're curious: hclimente.eu/blog/python-...
An intro to uv | Héctor Climente-González
A Swiss Army Knife for Python data science
hclimente.eu
April 27, 2025 at 2:10 PM
Never too late for cool science! I just put together a post on SHAP values — a popular model-agnostic approach to explain model predictions. Would love to hear your thoughts or critiques!
#MachineLearning #ExplainableAI #XAI #SHAP
SHAP values | Héctor Climente-González
A model-agnostic framework for explaining predictions
hclimente.eu
April 20, 2025 at 1:41 AM
Good read on visualizing ML model performances.
Even More Thoughts on ML Method Comparisons
Introduction A few things motivated this post.   Some recent discussions about the virtues of LightGBM vs XGBoost Posts on TabPFN by Jon...
practicalcheminformatics.blogspot.com
April 4, 2025 at 4:47 AM
Reposted by Héctor Climente-González
In our updated TraitGym preprint (w/ @gonzalobenegas.bsky.social & Gökcen Eraslan), we evaluate Evo 2 on regulatory variants associated with human traits. We see marked performance gains with scale on Mendelian traits, although still a bit behind alignment-based methods.
doi.org/10.1101/2025...
1/n
March 4, 2025 at 7:54 PM
Reposted by Héctor Climente-González
February 26, 2025 at 2:58 PM
Reposted by Héctor Climente-González
Part one of a collaboration with @3blue1brown.bsky.social on presenting the mathematics of the cosmic distance ladder in an accessible fashion.
February 8, 2025 at 5:54 PM
Reposted by Héctor Climente-González
A DNA language model based on multispecies alignment predicts the effects of genome-wide variants https://www.nature.com/articles/s41587-024-02511-w (read free: https://rdcu.be/d5oQZ) 🧬🖥️🧪 https://github.com/songlab-cal/gpn
January 3, 2025 at 9:10 AM