Shiv Grewal
@grewalsh.bsky.social
Scientist; NASonline.org member; Alum Cambridge University; Studies Epigenetics; Dog lover; Views are my own
https://en.m.wikipedia.org/wiki/Shiv_I.S._Grewal
https://en.m.wikipedia.org/wiki/Shiv_I.S._Grewal
Pinned
Shiv Grewal
@grewalsh.bsky.social
· Jan 3
🔬Decoding Silencing: How Heterochromatin Transcribes to Silence Itself!
🧬 Discover how a pioneer transcription factor-like complex infiltrates repressive heterochromatin, producing transcripts with hidden introns that kickstart RNAi-mediated heterochromatin formation www.nature.com/articles/s41...
🧬 Discover how a pioneer transcription factor-like complex infiltrates repressive heterochromatin, producing transcripts with hidden introns that kickstart RNAi-mediated heterochromatin formation www.nature.com/articles/s41...
Reposted by Shiv Grewal
Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...
The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate - Nature Cell Biology
Marin et al. report the role of lamin proteins and the lamin B receptor (LBR) in chromatin positioning at the nuclear periphery. Knockout of all lamins and LBR in mouse embryonic stem cells leads to h...
www.nature.com
July 22, 2025 at 5:10 PM
Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...
Reposted by Shiv Grewal
Grateful for the warm welcome @tifrhyderabad.bsky.social :) Thrilled to be part of this vibrant scientific community and eager to build an exciting research program!
We are delighted to welcome our newest faculty member, Sahana Holla (@sahanaholla.bsky.social). She is investigating the biological significance of 3D genome organization during development & disease, with an interdisciplinary approach combining genomics, proteomics, and advanced imaging.
July 1, 2025 at 5:35 PM
Grateful for the warm welcome @tifrhyderabad.bsky.social :) Thrilled to be part of this vibrant scientific community and eager to build an exciting research program!
So proud of you, @sahanaholla! Watching your journey has been such a joy. Wishing you all the best as you begin this exciting new chapter at TIFRH. They’re lucky to have you!
Thrilled to share that I’ve joined @tifrhyderabad.bsky.social as an Assistant Professor! Grateful to my mentors (esp @grewalsh.bsky.social and KN Balaji), colleagues, friends, family & EVERYONE who made this possible. Excited to explore Epigenetics & the 3D Genome with the brilliant minds in India!
June 29, 2025 at 12:08 PM
So proud of you, @sahanaholla! Watching your journey has been such a joy. Wishing you all the best as you begin this exciting new chapter at TIFRH. They’re lucky to have you!
Reposted by Shiv Grewal
Remembering Dave’s goodness gives me hope every day.
It was an honor to speak at the Rockefeller University symposium celebrating David Allis—a true visionary who transformed the field of chromatin and gene expression. His legacy continues to inspire us all. Grateful to the organizers for such a meaningful and inspiring event.
June 18, 2025 at 6:23 AM
Remembering Dave’s goodness gives me hope every day.
It was an honor to speak at the Rockefeller University symposium celebrating David Allis—a true visionary who transformed the field of chromatin and gene expression. His legacy continues to inspire us all. Grateful to the organizers for such a meaningful and inspiring event.
June 18, 2025 at 3:26 AM
It was an honor to speak at the Rockefeller University symposium celebrating David Allis—a true visionary who transformed the field of chromatin and gene expression. His legacy continues to inspire us all. Grateful to the organizers for such a meaningful and inspiring event.
Reposted by Shiv Grewal
What was that you said? You are looking for new #RNA research to read in the weekend?
You are in luck!
📣 📣 Check out the new preprint from our lab!!!! 📣 📣
www.biorxiv.org/content/10.1...
You are in luck!
📣 📣 Check out the new preprint from our lab!!!! 📣 📣
www.biorxiv.org/content/10.1...
AGO2 slicing of a domesticated retrotransposon is necessary for normal vasculature development
Argonaute (AGO) mediated slicing of RNA, also known as RNAi, is a highly conserved phenomenon that is evolutionarily linked to the repression of transposons and other repeats. Although RNAi is no long...
www.biorxiv.org
April 4, 2025 at 5:35 PM
What was that you said? You are looking for new #RNA research to read in the weekend?
You are in luck!
📣 📣 Check out the new preprint from our lab!!!! 📣 📣
www.biorxiv.org/content/10.1...
You are in luck!
📣 📣 Check out the new preprint from our lab!!!! 📣 📣
www.biorxiv.org/content/10.1...
Reposted by Shiv Grewal
Who does that? We rented a train JUST for the conference, that will take the participants from Prague to the woods of Bohemia. There'll be talks ON THE TRAIN. In Prague we'll have 5 locations with different atmospheres.
#theconferencetoendallconferences Register now:
woodstock.img.cas.cz
#theconferencetoendallconferences Register now:
woodstock.img.cas.cz
April 1, 2025 at 4:58 PM
Who does that? We rented a train JUST for the conference, that will take the participants from Prague to the woods of Bohemia. There'll be talks ON THE TRAIN. In Prague we'll have 5 locations with different atmospheres.
#theconferencetoendallconferences Register now:
woodstock.img.cas.cz
#theconferencetoendallconferences Register now:
woodstock.img.cas.cz
Reposted by Shiv Grewal
What RNA polymerase gets up to in the genome and how mutations happen! Just out in Nature! Many thanks to many collaborators & congrats 1st author Jingjing Liu! www.nature.com/articles/s41...
February 21, 2025 at 4:20 PM
What RNA polymerase gets up to in the genome and how mutations happen! Just out in Nature! Many thanks to many collaborators & congrats 1st author Jingjing Liu! www.nature.com/articles/s41...
Reposted by Shiv Grewal
Our collaboration with the Muir lab revealed that N-terminal histone modifications can 'detoxify' K27M inhibition by altering PRC2-substrate interactions. Acetylation showed the greatest impact, supported by xenograft data from the Monje group. pubs.acs.org/doi/epdf/10....
January 28, 2025 at 12:36 PM
Our collaboration with the Muir lab revealed that N-terminal histone modifications can 'detoxify' K27M inhibition by altering PRC2-substrate interactions. Acetylation showed the greatest impact, supported by xenograft data from the Monje group. pubs.acs.org/doi/epdf/10....
Reposted by Shiv Grewal
We used cryoET and biophysical approaches in vitro together with molecular biology in differentiated cells to show that chromatin compacted by PRC1-CBX8 is porous and accessible while PRC1 is dynamic in it. 🧪🧬 #cryoET #Epigenetics #Polycomb www.nature.com/articles/s41...
Dynamic PRC1–CBX8 stabilizes a porous structure of chromatin condensates - Nature Structural & Molecular Biology
Here the authors show that a gene-inactivating protein complex packs inactive genes into a dynamic and accessible structure. The study challenges the traditional views that restricted accessibility an...
www.nature.com
January 16, 2025 at 9:24 PM
We used cryoET and biophysical approaches in vitro together with molecular biology in differentiated cells to show that chromatin compacted by PRC1-CBX8 is porous and accessible while PRC1 is dynamic in it. 🧪🧬 #cryoET #Epigenetics #Polycomb www.nature.com/articles/s41...
🔬Decoding Silencing: How Heterochromatin Transcribes to Silence Itself!
🧬 Discover how a pioneer transcription factor-like complex infiltrates repressive heterochromatin, producing transcripts with hidden introns that kickstart RNAi-mediated heterochromatin formation www.nature.com/articles/s41...
🧬 Discover how a pioneer transcription factor-like complex infiltrates repressive heterochromatin, producing transcripts with hidden introns that kickstart RNAi-mediated heterochromatin formation www.nature.com/articles/s41...
January 3, 2025 at 3:46 PM
🔬Decoding Silencing: How Heterochromatin Transcribes to Silence Itself!
🧬 Discover how a pioneer transcription factor-like complex infiltrates repressive heterochromatin, producing transcripts with hidden introns that kickstart RNAi-mediated heterochromatin formation www.nature.com/articles/s41...
🧬 Discover how a pioneer transcription factor-like complex infiltrates repressive heterochromatin, producing transcripts with hidden introns that kickstart RNAi-mediated heterochromatin formation www.nature.com/articles/s41...
Happy New Year 2025! 🎉 As we step into another year of exploration and discovery, may curiosity guide us, innovation inspire us, and collaboration propel us forward. Here’s to breakthroughs, learning, and making the world a better place through science! 🌟 #HappyNewYear
January 1, 2025 at 2:16 PM
Happy New Year 2025! 🎉 As we step into another year of exploration and discovery, may curiosity guide us, innovation inspire us, and collaboration propel us forward. Here’s to breakthroughs, learning, and making the world a better place through science! 🌟 #HappyNewYear
Reposted by Shiv Grewal
Breaking News: Manmohan Singh, a former prime minister of India who helped transform the country’s economy, died at 92.
Manmohan Singh, Indian Premier Who Spurred Economic Boom, Dies at 92
The country’s first Sikh prime minister, he introduced free-market reforms that turned India into an economic powerhouse and sought reconciliation with Pakistan.
www.nytimes.com
December 26, 2024 at 6:35 PM
Breaking News: Manmohan Singh, a former prime minister of India who helped transform the country’s economy, died at 92.
Reposted by Shiv Grewal
In this episode of the Epigenetics Podcast, we talked with @maxvcg.bsky.social from the @ijmonod.bsky.social about his work on epigenetic consequences of DNA methylation in development. #podcast #chromatin #epigenetics
Listen here: https://buff.ly/3ZXWGuy
Listen here: https://buff.ly/3ZXWGuy
December 20, 2024 at 8:37 AM
In this episode of the Epigenetics Podcast, we talked with @maxvcg.bsky.social from the @ijmonod.bsky.social about his work on epigenetic consequences of DNA methylation in development. #podcast #chromatin #epigenetics
Listen here: https://buff.ly/3ZXWGuy
Listen here: https://buff.ly/3ZXWGuy
Reposted by Shiv Grewal
Scared to share this after 10 freaking years of waiting, but here we go: We found that temperature *perception* can change the biology of the next generations, even when “it’s just in the parents' head”. Read how C. elegans neurons control epigenetic inheritance!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Perception of Temperature Even in the Absence of Actual Change is Sufficient to Drive Transgenerational Epigenetic Inheritance
Can processes occurring in one individuals nervous system influence the physiology of the descendants? Here we explored the provocative hypothesis that parents sensation or perception of environmental...
www.biorxiv.org
December 5, 2024 at 7:32 PM
Scared to share this after 10 freaking years of waiting, but here we go: We found that temperature *perception* can change the biology of the next generations, even when “it’s just in the parents' head”. Read how C. elegans neurons control epigenetic inheritance!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Shiv Grewal
Thrilled to join the amazing community here on Bluesky! 🌟 Kicking off our first post with exciting news: the advanced version of our preprint is now published in Nucleic Acids Research! 🙌 [Read here: academic.oup.com/nar/advance-...
Here’s a quick recap of our findings previously shared on X: 👇
Here’s a quick recap of our findings previously shared on X: 👇
A systematic quantitative approach comprehensively defines domain-specific functional pathways linked to Schizosaccharomyces pombe heterochromatin regulation
Abstract. Heterochromatin plays a critical role in regulating gene expression and maintaining genome integrity. While structural and enzymatic components h
academic.oup.com
November 29, 2024 at 9:30 AM
Thrilled to join the amazing community here on Bluesky! 🌟 Kicking off our first post with exciting news: the advanced version of our preprint is now published in Nucleic Acids Research! 🙌 [Read here: academic.oup.com/nar/advance-...
Here’s a quick recap of our findings previously shared on X: 👇
Here’s a quick recap of our findings previously shared on X: 👇
“Happy Thanksgiving! 🦃🍁 Wishing everyone a day filled with gratitude, love, and good food! Let’s take a moment to count our blessings and cherish the ones we hold dear 🧡 #Thanksgiving #Gratitude”
November 28, 2024 at 3:06 PM
“Happy Thanksgiving! 🦃🍁 Wishing everyone a day filled with gratitude, love, and good food! Let’s take a moment to count our blessings and cherish the ones we hold dear 🧡 #Thanksgiving #Gratitude”
Reposted by Shiv Grewal
📢 Preprint! How does the environment of a father before conception influence offspring?
Even more, how do paternal genetics & ages interact with exposures to affect F1 outcome?
We tested this systematically, with intriguing findings & some cautionary tales🧵...
www.biorxiv.org/content/10.1...
Even more, how do paternal genetics & ages interact with exposures to affect F1 outcome?
We tested this systematically, with intriguing findings & some cautionary tales🧵...
www.biorxiv.org/content/10.1...
Embryonic Signatures of Intergenerational Inheritance across Paternal Environments and Genetic Backgrounds
The paternal preconception environment has been implicated as a modulator of phenotypic traits and disease risk in F1 offspring. However, the prevalence and mechanisms of such intergenerational epigen...
www.biorxiv.org
November 26, 2024 at 4:35 PM
📢 Preprint! How does the environment of a father before conception influence offspring?
Even more, how do paternal genetics & ages interact with exposures to affect F1 outcome?
We tested this systematically, with intriguing findings & some cautionary tales🧵...
www.biorxiv.org/content/10.1...
Even more, how do paternal genetics & ages interact with exposures to affect F1 outcome?
We tested this systematically, with intriguing findings & some cautionary tales🧵...
www.biorxiv.org/content/10.1...
Reposted by Shiv Grewal
Very happy to see @grothlab.bsky.social , @helink.bsky.social and @grewalsh.bsky.social all migrating over here! All pillars of the the #epigenetics and chromatin community.
November 26, 2024 at 9:44 AM
Very happy to see @grothlab.bsky.social , @helink.bsky.social and @grewalsh.bsky.social all migrating over here! All pillars of the the #epigenetics and chromatin community.