Joel Geerling
@geerling-lab.bsky.social
Neuroanatomy - Cognitive & Behavioral Neurology - Iowa Neuroscience Institute
Very cool paper — Ten1/Lphn2 expression gradients in the developing brain may be responsible for polysynaptic wiring topography across multiple brain systems (cerebellum, basal ganglia, visual and auditory brainstem).
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
August 15, 2025 at 5:20 PM
Very cool paper — Ten1/Lphn2 expression gradients in the developing brain may be responsible for polysynaptic wiring topography across multiple brain systems (cerebellum, basal ganglia, visual and auditory brainstem).
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Joel Geerling
Follow this link to advocate for research, especially on model organisms. www.fda.gov/news-events/...
July 13, 2025 at 5:50 PM
Follow this link to advocate for research, especially on model organisms. www.fda.gov/news-events/...
Whole-brain tracing of axonal projections from prefrontal cortex in monkey (via fMOST serial confocal imaging). AI template followed by manual, touch-up tracing by “more than 100…annotators,” working a few microns at a time. Unsettlingly impressive.
t.co/cowyQJbujt
t.co/cowyQJbujt
https://www.cell.com/cell/fulltext/S0092-8674(25)00639-7
t.co
July 13, 2025 at 2:15 AM
Whole-brain tracing of axonal projections from prefrontal cortex in monkey (via fMOST serial confocal imaging). AI template followed by manual, touch-up tracing by “more than 100…annotators,” working a few microns at a time. Unsettlingly impressive.
t.co/cowyQJbujt
t.co/cowyQJbujt
Reposted by Joel Geerling
Here is a chat with Bosilijka Tasic and myself about the enhancer-mediated AAVs that we were both centrally involved in publishing. I truly believe these approaches are fundamentally important for both basic and clinical approaches! braininitiative.nih.gov/news-events/...
From the BRAIN Director: Q&A With Dr. Gordon Fishell and Dr. Bosiljka Tasic on Precise Brain Cell Delivery Systems | BRAIN Initiative
Newly published work funded by the NIH BRAIN Initiative offers a precision toolkit for accessing cells in the brain and spinal cord with unprecedented accuracy. The new delivery tools, about 1,000 in ...
braininitiative.nih.gov
June 14, 2025 at 4:54 PM
Here is a chat with Bosilijka Tasic and myself about the enhancer-mediated AAVs that we were both centrally involved in publishing. I truly believe these approaches are fundamentally important for both basic and clinical approaches! braininitiative.nih.gov/news-events/...
Thank you to all who served and sacrificed for our freedom.
(Iowa City VA this morning)
(Iowa City VA this morning)
May 26, 2025 at 4:23 PM
Thank you to all who served and sacrificed for our freedom.
(Iowa City VA this morning)
(Iowa City VA this morning)
An MSL for a famous drug company just sent me an email with the line “You know the drill…” Yes, I do know the drill. It’s called rebranding sales reps to bypass University and hospital ethics restrictions while pretending otherwise.
February 25, 2025 at 4:54 AM
An MSL for a famous drug company just sent me an email with the line “You know the drill…” Yes, I do know the drill. It’s called rebranding sales reps to bypass University and hospital ethics restrictions while pretending otherwise.
Delayed neurodegenerative symptoms in a PSEN2 carrier (dominantly inherited Alzheimer’s “escapee”). Despite tons of amyloid plaque, tau pathology delayed >10y. Analogous to PSEN1 patients with APOE3-Christchurch homozygosity (2019) & RELN-COLBOS (2023).
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia - Nature Medicine
A rare case of asymptomatic dominantly inherited Alzheimer’s reveals confined tau pathology and unique proteomic features, highlighting potential resilience mechanisms decades beyond expected onset.
www.nature.com
February 11, 2025 at 6:39 PM
Delayed neurodegenerative symptoms in a PSEN2 carrier (dominantly inherited Alzheimer’s “escapee”). Despite tons of amyloid plaque, tau pathology delayed >10y. Analogous to PSEN1 patients with APOE3-Christchurch homozygosity (2019) & RELN-COLBOS (2023).
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Joel Geerling
Researchers from the Champalimaud Foundation have shared an open-source lickometer that uses optical fibers for precise lick detection and includes an integrated nosepoke detector and LEDs for visual cue. Read about it in this week's post on OpenBehavior:
edspace.american.edu/openbehavior...
edspace.american.edu/openbehavior...
High-Precision Optical Fiber-Based Lickometer
Visit the post for more.
edspace.american.edu
February 7, 2025 at 8:09 PM
Researchers from the Champalimaud Foundation have shared an open-source lickometer that uses optical fibers for precise lick detection and includes an integrated nosepoke detector and LEDs for visual cue. Read about it in this week's post on OpenBehavior:
edspace.american.edu/openbehavior...
edspace.american.edu/openbehavior...
Reposted by Joel Geerling
Fluorescence Friday - combined RNAscope for GHS-R and immunoreactivity for GFAP and NEUN in the dorsal vagal complex. We are RNAscope newbies and very proud of Katherine Pye for setting this up from scratch in the lab. Apologies for wonky orientation - just run out of steam on Friday!
February 7, 2025 at 5:39 PM
Fluorescence Friday - combined RNAscope for GHS-R and immunoreactivity for GFAP and NEUN in the dorsal vagal complex. We are RNAscope newbies and very proud of Katherine Pye for setting this up from scratch in the lab. Apologies for wonky orientation - just run out of steam on Friday!
Dear professional and scientific associations: please stop sending emails explaining that you don’t know what is happening or what will happen next.
January 29, 2025 at 11:32 PM
Dear professional and scientific associations: please stop sending emails explaining that you don’t know what is happening or what will happen next.
Reposted by Joel Geerling
𝐍𝐨𝐭𝐚𝐛𝐥𝐞 𝐀𝐫𝐭𝐢𝐜𝐥𝐞𝐬 𝐨𝐟 𝟐𝟎𝟐𝟒
In the FINEARTS-HF trial, finerenone resulted in a lower rate of total worsening heart failure events and death from cardiovascular causes than placebo, marking a notable benefit with respect to its primary end point.
Full trial results: nej.md/470x4ix
#MedSky
In the FINEARTS-HF trial, finerenone resulted in a lower rate of total worsening heart failure events and death from cardiovascular causes than placebo, marking a notable benefit with respect to its primary end point.
Full trial results: nej.md/470x4ix
#MedSky
January 7, 2025 at 5:13 PM
𝐍𝐨𝐭𝐚𝐛𝐥𝐞 𝐀𝐫𝐭𝐢𝐜𝐥𝐞𝐬 𝐨𝐟 𝟐𝟎𝟐𝟒
In the FINEARTS-HF trial, finerenone resulted in a lower rate of total worsening heart failure events and death from cardiovascular causes than placebo, marking a notable benefit with respect to its primary end point.
Full trial results: nej.md/470x4ix
#MedSky
In the FINEARTS-HF trial, finerenone resulted in a lower rate of total worsening heart failure events and death from cardiovascular causes than placebo, marking a notable benefit with respect to its primary end point.
Full trial results: nej.md/470x4ix
#MedSky
Lovely video about recent work from the Buzsáki lab at NYU. Accessible explanation of manifold concept (transforming 100s of recordings into a low-dimensional manifold), which reveals the replay of salient spatial patterns (w/ripples) during sleep.
youtu.be/ceFFEmkxTLg?...
youtu.be/ceFFEmkxTLg?...
How Your Brain Chooses What to Remember
YouTube video by Artem Kirsanov
youtu.be
January 7, 2025 at 4:29 PM
Lovely video about recent work from the Buzsáki lab at NYU. Accessible explanation of manifold concept (transforming 100s of recordings into a low-dimensional manifold), which reveals the replay of salient spatial patterns (w/ripples) during sleep.
youtu.be/ceFFEmkxTLg?...
youtu.be/ceFFEmkxTLg?...
Reposted by Joel Geerling
Cool paper. Hyperphosphorylated tau causes issues at the synapse & w/ behavior in new mouse model. No tangles necessary.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds - Nature Neuroscience
Mice expressing humanized mutant tau exhibit synaptic loss and behavioral abnormalities in the absence of abnormal tau conformers, suggesting that hyperphosphorylated tau can be pathological, at least...
www.nature.com
December 26, 2024 at 12:45 PM
Cool paper. Hyperphosphorylated tau causes issues at the synapse & w/ behavior in new mouse model. No tangles necessary.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Interesting read. Also the first example I’ve seen of authors picking a fight with @elonmusk in a high-profile Neuroscience journal:
“The unbearable slowness of being: Why do we live at 10 bits/s?”
t.co/1EfDKbXjFU
“The unbearable slowness of being: Why do we live at 10 bits/s?”
t.co/1EfDKbXjFU
https://www.cell.com/neuron/fulltext/S0896-6273(24)00808-0
t.co
December 24, 2024 at 9:59 PM
Interesting read. Also the first example I’ve seen of authors picking a fight with @elonmusk in a high-profile Neuroscience journal:
“The unbearable slowness of being: Why do we live at 10 bits/s?”
t.co/1EfDKbXjFU
“The unbearable slowness of being: Why do we live at 10 bits/s?”
t.co/1EfDKbXjFU
Heartbreaking and inspiring. Best news article I’ve ever read about FTLD (MAPT, familial):
www.nytimes.com/2024/12/22/h...
www.nytimes.com/2024/12/22/h...
A Woman With a Rare Gene Mutation Fights to Avoid Her Mother’s Fate
A mutant gene is coming to steal Linde Jacobs’s mind. Can she find a way to stop it?
www.nytimes.com
December 22, 2024 at 11:25 PM
Heartbreaking and inspiring. Best news article I’ve ever read about FTLD (MAPT, familial):
www.nytimes.com/2024/12/22/h...
www.nytimes.com/2024/12/22/h...
Reposted by Joel Geerling
Nothing says cozy reading by the fireplace like our new review, “Molecular heterogeneity and development of the VTA”
Thanks @bensaunders.bsky.social and @bellonec.bsky.social for the invitation to contribute to this special issue on #Dopamine!
authors.elsevier.com/a/1kIwj8MqMi...
Thanks @bensaunders.bsky.social and @bellonec.bsky.social for the invitation to contribute to this special issue on #Dopamine!
authors.elsevier.com/a/1kIwj8MqMi...
December 21, 2024 at 6:02 PM
Nothing says cozy reading by the fireplace like our new review, “Molecular heterogeneity and development of the VTA”
Thanks @bensaunders.bsky.social and @bellonec.bsky.social for the invitation to contribute to this special issue on #Dopamine!
authors.elsevier.com/a/1kIwj8MqMi...
Thanks @bensaunders.bsky.social and @bellonec.bsky.social for the invitation to contribute to this special issue on #Dopamine!
authors.elsevier.com/a/1kIwj8MqMi...
It was lovely to have everyone in the Resch and Geerling labs together for a holiday dinner.
December 20, 2024 at 4:52 AM
It was lovely to have everyone in the Resch and Geerling labs together for a holiday dinner.
Hello, Bluesky!
December 11, 2024 at 11:38 PM
Hello, Bluesky!