Great work by Daniela Klaproth-Andrade and the whole team in collab with the Wilhelm lab! Thanks to Valter Bergant and Andreas Pichlmair for the application of Modanovo to the monkeypox virus.

We’re excited to see how Modanovo will push forward de novo sequencing and PTM biology!

Modanovo is open-source and available here: github.com/gagneurlab/M...

We also applied Modanovo to a dataset of human cells infected with monkeypox virus, where it complemented database-driven approaches and revealed biologically relevant phosphosites, highlighting its utility in real-world discovery.

Modanovo achieves strong performance, successfully sequencing peptides carrying biologically relevant PTMs.

Modanovo builds on Casanovo, a transformer model for peptide sequencing. We fine-tuned ot end-to-end expanding Casanovo’s token vocabulary and corresponding layers.

Why Modanovo?
Existing tools often struggle with PTMs, yet PTMs are central to protein regulation and disease. We built a model for 19 amino acid-PTM combinations, leveraging data from in vivo experiments and from PROSPECT-PTM.

Finally, visit our spin-off’s stand #338 OmicsDiscoveries and have a look at the latest platform for RNA-seq oriented analysis and visit their poster P15.110.A on Sunday 1pm.

Vicente will also present the Solvathon concept—a collaborative, focused approach to accelerate diagnosis—in the session “E09 Solving Rare Disease: One for All, All for One” on Tuesday at 9am.

Vicente Yépez is discussing the added value of RNA-seq in rare disease diagnostics and practical recommendations for sequencing, analysis and interpretation, at session “W09 Mutations we almost missed” on Sunday at 14:15.