Christian Frezza
@frezzalab.bsky.social
I post papers on #cancermetabolism and #mitochondrialbiology. I also post about academia, metal music, and mindfulness.
https://www.cecad.uni-koeln.de/research/principal-investigators/prof-dr-christian-frezza/
https://orcid.org/0000-0002-3293-7397
https://www.cecad.uni-koeln.de/research/principal-investigators/prof-dr-christian-frezza/
https://orcid.org/0000-0002-3293-7397
Good Sunday!. A wonderful selection of papers in #cancermetabolism and #mitochondrialbiology is waiting for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
"99.9 per cent of everything you think, and of everything you do, is for yourself—and there isn't one."
-Wei Wu Wei
"99.9 per cent of everything you think, and of everything you do, is for yourself—and there isn't one."
-Wei Wu Wei
November 16, 2025 at 7:04 AM
Good Sunday!. A wonderful selection of papers in #cancermetabolism and #mitochondrialbiology is waiting for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
"99.9 per cent of everything you think, and of everything you do, is for yourself—and there isn't one."
-Wei Wu Wei
"99.9 per cent of everything you think, and of everything you do, is for yourself—and there isn't one."
-Wei Wu Wei
Good Sunday, all. The weekly curated issue of papers in #cancermetabolism and #mitochondrialbiology is out, a concentrate of groundbreaking discoveries:
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"There are years that ask questions and years that answer."-Zora Neale Hurston
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"There are years that ask questions and years that answer."-Zora Neale Hurston
November 9, 2025 at 6:28 AM
Good Sunday, all. The weekly curated issue of papers in #cancermetabolism and #mitochondrialbiology is out, a concentrate of groundbreaking discoveries:
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"There are years that ask questions and years that answer."-Zora Neale Hurston
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"There are years that ask questions and years that answer."-Zora Neale Hurston
Good Sunday, mitolovers. Here is a wonderful selection of papers in #cancermetabolism and #mitochondrialbiology:
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"Coming back to where you started is not the same as never leaving."-Terry Pratchett
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"Coming back to where you started is not the same as never leaving."-Terry Pratchett
November 2, 2025 at 5:49 AM
Good Sunday, mitolovers. Here is a wonderful selection of papers in #cancermetabolism and #mitochondrialbiology:
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"Coming back to where you started is not the same as never leaving."-Terry Pratchett
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"Coming back to where you started is not the same as never leaving."-Terry Pratchett
Good Sunday, all! Here is an exciting selection of papers in #cancermetabolism and #mitochondrialbiology: biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"Inside us there is something that has no name, that something is what we are."-José Saramago
@biomednews.bsky.social #keepreading
"Inside us there is something that has no name, that something is what we are."-José Saramago
October 26, 2025 at 6:25 AM
Good Sunday, all! Here is an exciting selection of papers in #cancermetabolism and #mitochondrialbiology: biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"Inside us there is something that has no name, that something is what we are."-José Saramago
@biomednews.bsky.social #keepreading
"Inside us there is something that has no name, that something is what we are."-José Saramago
Good Sunday, mitolovers! 🌟 Exciting news in the world of #cancermetabolism and #mitochondrialbiology! 🧬 Check out the papers from last week here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading📚
"Knowledge is an unending adventure at the edge of uncertainty."-Jacob Bronowski
"Knowledge is an unending adventure at the edge of uncertainty."-Jacob Bronowski
October 19, 2025 at 5:35 AM
Good Sunday, mitolovers! 🌟 Exciting news in the world of #cancermetabolism and #mitochondrialbiology! 🧬 Check out the papers from last week here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading📚
"Knowledge is an unending adventure at the edge of uncertainty."-Jacob Bronowski
"Knowledge is an unending adventure at the edge of uncertainty."-Jacob Bronowski
Good Sunday, all. Your weekly curated summary of papers in #cancermetabolism and #mitochondrialbiology is ready, don't miss it as it is full of exceptional discoveries: biomed.news/bims-camemi/... Biomed News #keepreading
"To see takes time, like to have a friend takes time." -Georgia O'Keeffe
"To see takes time, like to have a friend takes time." -Georgia O'Keeffe
October 12, 2025 at 5:41 AM
Good Sunday, all. Your weekly curated summary of papers in #cancermetabolism and #mitochondrialbiology is ready, don't miss it as it is full of exceptional discoveries: biomed.news/bims-camemi/... Biomed News #keepreading
"To see takes time, like to have a friend takes time." -Georgia O'Keeffe
"To see takes time, like to have a friend takes time." -Georgia O'Keeffe
Good Sunday, all. Here is a wonderful selection of papers in #cancermetabolism and #mitochondrialbiology ready for you! biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
Without courage, wisdom bears no fruit. -Baltasar Gracián
Without courage, wisdom bears no fruit. -Baltasar Gracián
October 5, 2025 at 6:00 AM
Good Sunday, all. Here is a wonderful selection of papers in #cancermetabolism and #mitochondrialbiology ready for you! biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
Without courage, wisdom bears no fruit. -Baltasar Gracián
Without courage, wisdom bears no fruit. -Baltasar Gracián
Good Sunday, all. Last week has seen some amazing papers in #cancermetabolism and #mitochondrialbiology. Don't miss the curated summary: biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"Forever is composed of nows." -Emily Dickinson
@biomednews.bsky.social #keepreading
"Forever is composed of nows." -Emily Dickinson
September 28, 2025 at 5:21 AM
Good Sunday, all. Last week has seen some amazing papers in #cancermetabolism and #mitochondrialbiology. Don't miss the curated summary: biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"Forever is composed of nows." -Emily Dickinson
@biomednews.bsky.social #keepreading
"Forever is composed of nows." -Emily Dickinson
Good Sunday, all. This week has seen some beautiful papers in #cancermetabolism and #mitochondrialbiology. Don't miss the curated summary, find it here:
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading 💥 📚
"The real meditation is how you live your life."-Jon Kabat-Zinn
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading 💥 📚
"The real meditation is how you live your life."-Jon Kabat-Zinn
September 21, 2025 at 5:21 AM
Good Sunday, all. This week has seen some beautiful papers in #cancermetabolism and #mitochondrialbiology. Don't miss the curated summary, find it here:
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading 💥 📚
"The real meditation is how you live your life."-Jon Kabat-Zinn
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading 💥 📚
"The real meditation is how you live your life."-Jon Kabat-Zinn
Good Sunday, all! A very rich curated summary of papers in #cancermetabolism and #mitochondrialbiology is waiting for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
"Worry does not empty tomorrow of its sorrow; it empties today of its strength." -Corrie ten Boom
"Worry does not empty tomorrow of its sorrow; it empties today of its strength." -Corrie ten Boom
September 14, 2025 at 5:25 AM
Good Sunday, all! A very rich curated summary of papers in #cancermetabolism and #mitochondrialbiology is waiting for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
"Worry does not empty tomorrow of its sorrow; it empties today of its strength." -Corrie ten Boom
"Worry does not empty tomorrow of its sorrow; it empties today of its strength." -Corrie ten Boom
Good Sunday, all! After a technical glitch last week, we are back again, with TWO exciting curated selections of papers in #cancermetabolism and #mitochondrialbiology @biomednews.bsky.social. Check them here #keepreading:
biomed.news/bims-camemi/...
biomed.news/bims-camemi/...
biomed.news/bims-camemi/...
biomed.news/bims-camemi/...
September 7, 2025 at 6:07 AM
Good Sunday, all! After a technical glitch last week, we are back again, with TWO exciting curated selections of papers in #cancermetabolism and #mitochondrialbiology @biomednews.bsky.social. Check them here #keepreading:
biomed.news/bims-camemi/...
biomed.news/bims-camemi/...
biomed.news/bims-camemi/...
biomed.news/bims-camemi/...
A belated but exciting summary of papers in #cancermetabolism and #mitochondrialbiology is ready for you! biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
"People think of education as something that they can finish."-Isaac Asimov
"People think of education as something that they can finish."-Isaac Asimov
August 26, 2025 at 8:49 AM
A belated but exciting summary of papers in #cancermetabolism and #mitochondrialbiology is ready for you! biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
"People think of education as something that they can finish."-Isaac Asimov
"People think of education as something that they can finish."-Isaac Asimov
It was a privilege to host Prof Willelm Koppenol today, who told us about Otto Warburg's life and science. It was such a fascinating topic and discussion! Thanks for visiting us!
May 26, 2025 at 10:05 AM
It was a privilege to host Prof Willelm Koppenol today, who told us about Otto Warburg's life and science. It was such a fascinating topic and discussion! Thanks for visiting us!
NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging: Cell Metabolism www.cell.com/cell-metabol...
April 30, 2025 at 3:49 PM
NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging: Cell Metabolism www.cell.com/cell-metabol...
What sort of nudging is this?
April 29, 2025 at 7:49 AM
What sort of nudging is this?
For my Italian friends, this book is amazing.
"Life is strange. First you take the exams, and then you take the course."
"Life is strange. First you take the exams, and then you take the course."
January 26, 2025 at 12:31 PM
For my Italian friends, this book is amazing.
"Life is strange. First you take the exams, and then you take the course."
"Life is strange. First you take the exams, and then you take the course."
Hi all, our lab will soon recruit a PhD student working within a very exciting MSCA Horizon Doctoral network working on ageing, UNION, which gathers some fantastic scientists. Please apply if your profile fits our project (see attached advert).
Looking forward to working with you!
Looking forward to working with you!
January 23, 2025 at 8:37 AM
Hi all, our lab will soon recruit a PhD student working within a very exciting MSCA Horizon Doctoral network working on ageing, UNION, which gathers some fantastic scientists. Please apply if your profile fits our project (see attached advert).
Looking forward to working with you!
Looking forward to working with you!
Good Sunday all! Some exciting papers in #cancermetabolism and #mitochondrialbiology were published last week. Don't miss them, check them here:
biomed.news/bims-camemi/... @biomednews.bsky.social
"Nobody needs to go anywhere else. We are all, if we only knew it, already there." Aldous Huxley
biomed.news/bims-camemi/... @biomednews.bsky.social
"Nobody needs to go anywhere else. We are all, if we only knew it, already there." Aldous Huxley
January 12, 2025 at 6:53 AM
Good Sunday all! Some exciting papers in #cancermetabolism and #mitochondrialbiology were published last week. Don't miss them, check them here:
biomed.news/bims-camemi/... @biomednews.bsky.social
"Nobody needs to go anywhere else. We are all, if we only knew it, already there." Aldous Huxley
biomed.news/bims-camemi/... @biomednews.bsky.social
"Nobody needs to go anywhere else. We are all, if we only knew it, already there." Aldous Huxley
Good morning, all. The first curated issue of papers in #cancermetabolism and #mitochondrialbiology of 2025 is ready and full of exciting findings. Don't miss it, check it here:
biomed.news/bims-camemi/...
@biomednews.bsky.social
"I am a book I neither wrote nor read."-Delmore Schwartz
biomed.news/bims-camemi/...
@biomednews.bsky.social
"I am a book I neither wrote nor read."-Delmore Schwartz
January 5, 2025 at 7:04 AM
Good morning, all. The first curated issue of papers in #cancermetabolism and #mitochondrialbiology of 2025 is ready and full of exciting findings. Don't miss it, check it here:
biomed.news/bims-camemi/...
@biomednews.bsky.social
"I am a book I neither wrote nor read."-Delmore Schwartz
biomed.news/bims-camemi/...
@biomednews.bsky.social
"I am a book I neither wrote nor read."-Delmore Schwartz
We are
Autumnal
On the trees,
As the leaves.
This leaf on a tree this morning reminded me of the beautiful piece by G Ungaretti.
Autumnal
On the trees,
As the leaves.
This leaf on a tree this morning reminded me of the beautiful piece by G Ungaretti.
December 7, 2024 at 9:40 AM
We are
Autumnal
On the trees,
As the leaves.
This leaf on a tree this morning reminded me of the beautiful piece by G Ungaretti.
Autumnal
On the trees,
As the leaves.
This leaf on a tree this morning reminded me of the beautiful piece by G Ungaretti.
We also applied SiRCle to a PanCan cohort and found common signatures across ccRCC and PanCan, in addition to the regulatory layer that defines tissue identity. (12/14)
December 5, 2024 at 1:29 PM
We also applied SiRCle to a PanCan cohort and found common signatures across ccRCC and PanCan, in addition to the regulatory layer that defines tissue identity. (12/14)
Using this novel integrated test, we found that tumour stage and patient age impact ccRCC’s metabolic fingerprint, with increased expression of OXPHOS genes at higher stages. (11/14)
December 5, 2024 at 1:29 PM
Using this novel integrated test, we found that tumour stage and patient age impact ccRCC’s metabolic fingerprint, with increased expression of OXPHOS genes at higher stages. (11/14)
Hence, we developed a novel integrated test to identify changes between patient cohorts. This is based on a variational autoencoder to learn gene-wise relationships across the three data layers. (10/14)
December 5, 2024 at 1:29 PM
Hence, we developed a novel integrated test to identify changes between patient cohorts. This is based on a variational autoencoder to learn gene-wise relationships across the three data layers. (10/14)
SiRCle clustering elucidates the distinct layers where metabolic changes in ccRCC are orchestrated: DNA hypomethylation regulates the increased expression of glycolytic enzymes, whilst the TCA cycle is regulated by translationally suppressing the enzymes. (8/14)
December 5, 2024 at 1:29 PM
SiRCle clustering elucidates the distinct layers where metabolic changes in ccRCC are orchestrated: DNA hypomethylation regulates the increased expression of glycolytic enzymes, whilst the TCA cycle is regulated by translationally suppressing the enzymes. (8/14)
Transcription factor (TF) analysis revealed the drivers of genes in SiRCle clusters at the transcriptional or methylation layer. Indeed, HIF1 TFs target genes in TPDE and MDE, SiRCle clusters enriched for angiogenesis-related GO terms. (7/14)
December 5, 2024 at 1:29 PM
Transcription factor (TF) analysis revealed the drivers of genes in SiRCle clusters at the transcriptional or methylation layer. Indeed, HIF1 TFs target genes in TPDE and MDE, SiRCle clusters enriched for angiogenesis-related GO terms. (7/14)