Christian Frezza
@frezzalab.bsky.social
I post papers on #cancermetabolism and #mitochondrialbiology. I also post about academia, metal music, and mindfulness.
https://www.cecad.uni-koeln.de/research/principal-investigators/prof-dr-christian-frezza/
https://orcid.org/0000-0002-3293-7397
https://www.cecad.uni-koeln.de/research/principal-investigators/prof-dr-christian-frezza/
https://orcid.org/0000-0002-3293-7397
Pinned
Christian Frezza
@frezzalab.bsky.social
· Nov 13
The mindful scientist
A more mindful approach to science can help scientists to handle negative and positive emotions better.
network.febs.org
This is an old post, but I would like to propose it again as I am new here.
This is a topic I am very passionate about. I hope you will enjoy the read, and you will find it useful. Happy to hear your views about the topic.
The mindful scientist network.febs.org/posts/the-mi... #FEBSnet
Reposted by Christian Frezza
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Closing date 27th November
www.crick.ac.uk/careers-stud...
November 17, 2025 at 11:55 AM
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Closing date 27th November
www.crick.ac.uk/careers-stud...
www.nature.com/articles/s42...
Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency
@charlesmbrenner.bsky.social congratulations!
Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency
@charlesmbrenner.bsky.social congratulations!
Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency - Nature Metabolism
In a mouse model of the rare disease citrin deficiency, the authors discovered that the accumulation of glycerol-3-phosphate leads to ChREBP activation and FGF21 induction. The study identifies glycer...
www.nature.com
November 16, 2025 at 7:21 AM
www.nature.com/articles/s42...
Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency
@charlesmbrenner.bsky.social congratulations!
Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency
@charlesmbrenner.bsky.social congratulations!
Good Sunday!. A wonderful selection of papers in #cancermetabolism and #mitochondrialbiology is waiting for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
"99.9 per cent of everything you think, and of everything you do, is for yourself—and there isn't one."
-Wei Wu Wei
"99.9 per cent of everything you think, and of everything you do, is for yourself—and there isn't one."
-Wei Wu Wei
November 16, 2025 at 7:04 AM
Good Sunday!. A wonderful selection of papers in #cancermetabolism and #mitochondrialbiology is waiting for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
"99.9 per cent of everything you think, and of everything you do, is for yourself—and there isn't one."
-Wei Wu Wei
"99.9 per cent of everything you think, and of everything you do, is for yourself—and there isn't one."
-Wei Wu Wei
A whole-brain single-cell atlas of circadian neural activity in mice | Science www.science.org/doi/10.1126/...
A whole-brain single-cell atlas of circadian neural activity in mice
The mammalian brain comprises numerous anatomical regions with distinct functions despite their extensive connectivity. However, how spontaneous neural activity is coordinated across regions over the ...
www.science.org
November 13, 2025 at 7:07 PM
A whole-brain single-cell atlas of circadian neural activity in mice | Science www.science.org/doi/10.1126/...
Termination of the integrated stress response | Science www.science.org/doi/10.1126/...
Termination of the integrated stress response
Stress responses enable cells to detect, adapt to, and survive challenges. The benefit of these signaling pathways depends on their reversibility. The integrated stress response (ISR) is elicited by p...
www.science.org
November 13, 2025 at 7:05 PM
Termination of the integrated stress response | Science www.science.org/doi/10.1126/...
Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation: Cell Host & Microbe www.cell.com/cell-host-mi...
Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation
de Oliveira Formiga et al. present that gut-microbiota-derived cadaverine reprograms
macrophage energy metabolism in a concentration-dependent fashion, promoting either
anti- or pro-inflammatory immun...
www.cell.com
November 13, 2025 at 3:47 PM
Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation: Cell Host & Microbe www.cell.com/cell-host-mi...
www.nature.com/articles/s41...
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy - Nature
Acetyl-coenzyme A functions as a non-canonical signal to trigger mitophagy, and the acetyl-coenzyme A–NLRX1 axis underlies the KRAS-inhibitor-induced mitophagy response and promotes drug resistan...
www.nature.com
November 12, 2025 at 6:02 PM
www.nature.com/articles/s41...
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy
I am very happy to share this paper from a great scientist and surgeon, Cissy Yong, on how warm ischaemia can affect the metabolic profile of a tumour: www.nature.com/articles/s41... 💥 👏
full text access here rdcu.be/ePcEK
full text access here rdcu.be/ePcEK
Tumour sampling conditions perturb the metabolic landscape of clear cell renal cell carcinoma - Nature Communications
Yong et al. highlight how sampling conditions affect metabolic profile in renal cancer, showing that prolonged ischemic exposure disrupts tissue metabolome stability and masks important phenotypes, su...
www.nature.com
November 10, 2025 at 5:09 PM
I am very happy to share this paper from a great scientist and surgeon, Cissy Yong, on how warm ischaemia can affect the metabolic profile of a tumour: www.nature.com/articles/s41... 💥 👏
full text access here rdcu.be/ePcEK
full text access here rdcu.be/ePcEK
Reposted by Christian Frezza
What an egg-cellent Sunday for oocyte papers! This week we have even TWO highlights:
pubmed.ncbi.nlm.nih.gov/41188464/ by T. Kitajima
and pubmed.ncbi.nlm.nih.gov/41184483/ by @binyammogessie.bsky.social
Read the full issue here: biomed.news/bims-cebooc/...
#cebooc
@biomednews.bsky.social
pubmed.ncbi.nlm.nih.gov/41188464/ by T. Kitajima
and pubmed.ncbi.nlm.nih.gov/41184483/ by @binyammogessie.bsky.social
Read the full issue here: biomed.news/bims-cebooc/...
#cebooc
@biomednews.bsky.social
November 9, 2025 at 9:24 AM
What an egg-cellent Sunday for oocyte papers! This week we have even TWO highlights:
pubmed.ncbi.nlm.nih.gov/41188464/ by T. Kitajima
and pubmed.ncbi.nlm.nih.gov/41184483/ by @binyammogessie.bsky.social
Read the full issue here: biomed.news/bims-cebooc/...
#cebooc
@biomednews.bsky.social
pubmed.ncbi.nlm.nih.gov/41188464/ by T. Kitajima
and pubmed.ncbi.nlm.nih.gov/41184483/ by @binyammogessie.bsky.social
Read the full issue here: biomed.news/bims-cebooc/...
#cebooc
@biomednews.bsky.social
Good Sunday, all. The weekly curated issue of papers in #cancermetabolism and #mitochondrialbiology is out, a concentrate of groundbreaking discoveries:
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"There are years that ask questions and years that answer."-Zora Neale Hurston
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"There are years that ask questions and years that answer."-Zora Neale Hurston
November 9, 2025 at 6:28 AM
Good Sunday, all. The weekly curated issue of papers in #cancermetabolism and #mitochondrialbiology is out, a concentrate of groundbreaking discoveries:
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"There are years that ask questions and years that answer."-Zora Neale Hurston
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"There are years that ask questions and years that answer."-Zora Neale Hurston
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT | Science www.science.org/doi/10.1126/...
Great work from @rjdlab.bsky.social !!
Great work from @rjdlab.bsky.social !!
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...
www.science.org
November 7, 2025 at 7:35 AM
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT | Science www.science.org/doi/10.1126/...
Great work from @rjdlab.bsky.social !!
Great work from @rjdlab.bsky.social !!
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis: Molecular Cell www.cell.com/molecular-ce...
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis
Zheng et al. demonstrate that mitochondria remodel the structure and composition of
mitochondrial ribosomes in response to metabolic state. This structural “gear-switching”
mechanism fine-tunes mitoch...
www.cell.com
November 6, 2025 at 6:37 PM
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis: Molecular Cell www.cell.com/molecular-ce...
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis: Molecular Cell www.cell.com/molecular-ce...
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis
Zheng et al. demonstrate that mitochondria remodel the structure and composition of
mitochondrial ribosomes in response to metabolic state. This structural “gear-switching”
mechanism fine-tunes mitoch...
www.cell.com
November 6, 2025 at 4:57 PM
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis: Molecular Cell www.cell.com/molecular-ce...
As a mindfulness advocate, it is important to stress that meditation can have downsides if approached carelessly. It’s crucial to prepare and practice moderation. If meditation causes distress, that’s okay! Adjust your approach to your mindfulness journey.
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
Sage Journals: Discover world-class research
Subscription and open access journals from Sage, the world's leading independent academic publisher.
journals.sagepub.com
November 6, 2025 at 10:42 AM
As a mindfulness advocate, it is important to stress that meditation can have downsides if approached carelessly. It’s crucial to prepare and practice moderation. If meditation causes distress, that’s okay! Adjust your approach to your mindfulness journey.
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
www.nature.com/articles/s41...
Lymph node environment drives FSP1 targetability in metastasizing melanoma
Lymph node environment drives FSP1 targetability in metastasizing melanoma
Lymph node environment drives FSP1 targetability in metastasizing melanoma - Nature
Targeting FSP1 in lymph nodes has considerable potential for blocking melanoma progression.
www.nature.com
November 5, 2025 at 5:04 PM
www.nature.com/articles/s41...
Lymph node environment drives FSP1 targetability in metastasizing melanoma
Lymph node environment drives FSP1 targetability in metastasizing melanoma
www.nature.com/articles/s41...
Secretome translation shaped by lysosomes and lunapark-marked ER junctions
Secretome translation shaped by lysosomes and lunapark-marked ER junctions
Secretome translation shaped by lysosomes and lunapark-marked ER junctions - Nature
Live-cell imaging of mRNA encoding secretome proteins and translated nascent peptide markers show that secretome translation occurs at endoplasmic reticulum junctions near lysosomes, requires lun...
www.nature.com
November 5, 2025 at 5:03 PM
www.nature.com/articles/s41...
Secretome translation shaped by lysosomes and lunapark-marked ER junctions
Secretome translation shaped by lysosomes and lunapark-marked ER junctions
Following a recent article about the different layers of conceptualisation in a science project, this is about a pet peeve of mine. I would love to hear your views.
network.febs.org/posts/thinki...
network.febs.org/posts/thinki...
Thinking like a Scientist: The Limits of Genome Editing and Omics
Second part of Thinking like a Scientist, reflecting on how genome editing and multi-omics, while powerful, can introduce conceptual flaws that distort our understanding of gene function and biologica...
network.febs.org
November 4, 2025 at 11:21 AM
Following a recent article about the different layers of conceptualisation in a science project, this is about a pet peeve of mine. I would love to hear your views.
network.febs.org/posts/thinki...
network.febs.org/posts/thinki...
Wonderful work from @mito-oncogene.bsky.social and @edreznik.bsky.social on the role of mito ribosomal RNA in cancer.
Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask?
rdcu.be/eN1jm
rdcu.be/eN1jm
Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer
Nature Genetics - Analysis of 14,106 tumor genomes highlights recurrent mutations in mitochondrial ribosomal RNA encoded within the mitochondrial genome. Mutations occur at hotspot positions and...
rdcu.be
November 4, 2025 at 8:01 AM
Wonderful work from @mito-oncogene.bsky.social and @edreznik.bsky.social on the role of mito ribosomal RNA in cancer.
Good Sunday, mitolovers. Here is a wonderful selection of papers in #cancermetabolism and #mitochondrialbiology:
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"Coming back to where you started is not the same as never leaving."-Terry Pratchett
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"Coming back to where you started is not the same as never leaving."-Terry Pratchett
November 2, 2025 at 5:49 AM
Good Sunday, mitolovers. Here is a wonderful selection of papers in #cancermetabolism and #mitochondrialbiology:
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"Coming back to where you started is not the same as never leaving."-Terry Pratchett
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"Coming back to where you started is not the same as never leaving."-Terry Pratchett
Glutamine synthetase deficiency enhances CD8 T cell survival and stress resilience in the tumor microenvironment url: academic.oup.com/jimmunol/art...
Glutamine synthetase deficiency enhances CD8 T cell survival and stress resilience in the tumor microenvironment
Abstract. Cellular immunotherapy has revolutionized the treatment of hematologic malignancies yet has had limited success in the solid tumor microenvironme
academic.oup.com
November 1, 2025 at 2:39 PM
Glutamine synthetase deficiency enhances CD8 T cell survival and stress resilience in the tumor microenvironment url: academic.oup.com/jimmunol/art...
The ER thioredoxin-related transmembrane protein TMX2 controls redox-mediated tethering of ER-mitochondria contacts: Cell Reports www.cell.com/cell-reports...
The ER thioredoxin-related transmembrane protein TMX2 controls redox-mediated tethering of ER-mitochondria contacts
Chen et al. describe how TMX2, a thioredoxin-related transmembrane protein, moderates
oxidative conditions at the endoplasmic reticulum-mitochondria contact site (ERMCS).
This allows TMX2 to limit mit...
www.cell.com
November 1, 2025 at 9:25 AM
The ER thioredoxin-related transmembrane protein TMX2 controls redox-mediated tethering of ER-mitochondria contacts: Cell Reports www.cell.com/cell-reports...
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cyclehttps://
www.sciencedirect.com/science/article/abs/pii/S1097276525008196
Congratulations @bensahralab.bsky.social !!
www.sciencedirect.com/science/article/abs/pii/S1097276525008196
Congratulations @bensahralab.bsky.social !!
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle
The de novo purine synthesis pathway is fundamental for nucleotide production, yet the role of mitochondrial metabolism in modulating this process rem…
www.sciencedirect.com
October 29, 2025 at 5:23 AM
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cyclehttps://
www.sciencedirect.com/science/article/abs/pii/S1097276525008196
Congratulations @bensahralab.bsky.social !!
www.sciencedirect.com/science/article/abs/pii/S1097276525008196
Congratulations @bensahralab.bsky.social !!