Francisco Dionisio
@franciscodionisio.bsky.social
Antibiotic Resistance, evolutionary ecology of bacteria, plasmids, phages
Reposted by Francisco Dionisio
The Stand Up For Science protests have kicked off worldwide. Thousands of scientists demonstrated in solidarity with their US counterparts across France to defend the scientific community. (📹 @Margot_Brunet_)
#3E #FranceProtests #USprotests #March7Science #StandUpForScience #Mar7
#3E #FranceProtests #USprotests #March7Science #StandUpForScience #Mar7
March 7, 2025 at 6:02 PM
The Stand Up For Science protests have kicked off worldwide. Thousands of scientists demonstrated in solidarity with their US counterparts across France to defend the scientific community. (📹 @Margot_Brunet_)
#3E #FranceProtests #USprotests #March7Science #StandUpForScience #Mar7
#3E #FranceProtests #USprotests #March7Science #StandUpForScience #Mar7
Reposted by Francisco Dionisio
O esqueleto da criança do Lapedo volta a dar-nos novidades www.publico.pt/2025/03/08/c... #lapedochild #homosapiens #neanderthal
O esqueleto da criança do Lapedo volta a dar-nos novidades
O achado arqueológico da criança do Lapedo foi datado por um novo método e os resultados permitem burilar o que sabemos sobre a sua sepultura e como as crianças eram tratadas no Paleolítico Superior.
www.publico.pt
March 8, 2025 at 10:33 AM
O esqueleto da criança do Lapedo volta a dar-nos novidades www.publico.pt/2025/03/08/c... #lapedochild #homosapiens #neanderthal
Reposted by Francisco Dionisio
My first-author PhD paper is out in @naturecomms.bsky.social: A “double trouble” approach—combining membrane disruption with a key cellular pathway—dramatically limits bacterial #resistance. Discover “Exploring the principles behind antibiotics with limited resistance” #AMR #DrugDevelopment #MEvoSky
🚨 Our latest research in @naturecomms.bsky.social shows a promising strategy for less resistance-prone #antibiotics. For details, see the thread below and read the paper “Exploring the principles behind antibiotics with limited resistance” here: #MEvoSky www.nature.com/articles/s41...
Exploring the principles behind antibiotics with limited resistance - Nature Communications
This study shows that only those dual-targeting antibiotics limit resistance in Gram-negative pathogens that also target the membrane of the bacteria. This mechanism provides a basis for designing fut...
www.nature.com
February 25, 2025 at 11:02 AM
My first-author PhD paper is out in @naturecomms.bsky.social: A “double trouble” approach—combining membrane disruption with a key cellular pathway—dramatically limits bacterial #resistance. Discover “Exploring the principles behind antibiotics with limited resistance” #AMR #DrugDevelopment #MEvoSky
Reposted by Francisco Dionisio
Many years to get this one out, while gaining huge respect for people doing clinical trials (perseverance!). We show that antibiotic treatments spur changes in the phage composition of the human gut, with bursts of virulent phages that may facilitate homeostasis. Check Eugen's thread!👇
Excited🚨to share our first work on the human gut phageome doi.org/10.1101/2025...
Always inspiring to work with @epcrocha.bsky.social , Erick D, Camille d'H and everyone else within this super dynamic consortium
@inrae-france.bsky.social[email protected][email protected]! Many thanks for this great journey!🙌
Always inspiring to work with @epcrocha.bsky.social , Erick D, Camille d'H and everyone else within this super dynamic consortium
@inrae-france.bsky.social[email protected][email protected]! Many thanks for this great journey!🙌
Third-generation cephalosporin antibiotics induce phage bursts in the human gut microbiome.
The use of antibiotics disrupts the gut microbiota, potentially leading to long-term health issues and the spread of resistance. To investigate the impact of antibiotics on phage populations, we follo...
doi.org
February 10, 2025 at 12:21 PM
Many years to get this one out, while gaining huge respect for people doing clinical trials (perseverance!). We show that antibiotic treatments spur changes in the phage composition of the human gut, with bursts of virulent phages that may facilitate homeostasis. Check Eugen's thread!👇
Reposted by Francisco Dionisio
Excited🚨to share our first work on the human gut phageome doi.org/10.1101/2025...
Always inspiring to work with @epcrocha.bsky.social , Erick D, Camille d'H and everyone else within this super dynamic consortium
@inrae-france.bsky.social[email protected][email protected]! Many thanks for this great journey!🙌
Always inspiring to work with @epcrocha.bsky.social , Erick D, Camille d'H and everyone else within this super dynamic consortium
@inrae-france.bsky.social[email protected][email protected]! Many thanks for this great journey!🙌
Third-generation cephalosporin antibiotics induce phage bursts in the human gut microbiome.
The use of antibiotics disrupts the gut microbiota, potentially leading to long-term health issues and the spread of resistance. To investigate the impact of antibiotics on phage populations, we follo...
doi.org
February 10, 2025 at 6:08 PM
Reposted by Francisco Dionisio
Shame on you @asm.org, shame on you.
It has been brought to my attention that my article has been censored to exclude certain terms:
asm.org/Articles/202...
web.archive.org/web/20250114...
#MicroSky
asm.org/Articles/202...
web.archive.org/web/20250114...
#MicroSky
February 4, 2025 at 5:17 PM
Shame on you @asm.org, shame on you.
Reposted by Francisco Dionisio
The overview of AMR that you always wanted (someone else to write) - amazing!
Truly brilliant paper with great figures! @lancetmicrobe.bsky.social
www.thelancet.com/journals/lan...
Truly brilliant paper with great figures! @lancetmicrobe.bsky.social
www.thelancet.com/journals/lan...
Antimicrobial resistance: a concise update
Antimicrobial resistance (AMR) is a serious threat to global public health, with approximately
5 million deaths associated with bacterial AMR in 2019. Tackling AMR requires a multifaceted
and cohesive...
www.thelancet.com
February 5, 2025 at 10:02 AM
The overview of AMR that you always wanted (someone else to write) - amazing!
Truly brilliant paper with great figures! @lancetmicrobe.bsky.social
www.thelancet.com/journals/lan...
Truly brilliant paper with great figures! @lancetmicrobe.bsky.social
www.thelancet.com/journals/lan...
Reposted by Francisco Dionisio
New pre-print!!! What types of genes end up on plasmids and why? The take home message of this paper is that beneficial genes move from plasmids to chromosome, causing the ecological value of plasmids to decay over time.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Chromosomal capture of beneficial genes drives plasmids towards ecological redundancy
Plasmids are a ubiquitous feature of bacterial genomes, but the evolutionary forces driving genes to become associated with plasmids are poorly understood. To address this problem, we compared the fit...
www.biorxiv.org
January 24, 2025 at 11:10 PM
New pre-print!!! What types of genes end up on plasmids and why? The take home message of this paper is that beneficial genes move from plasmids to chromosome, causing the ecological value of plasmids to decay over time.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Francisco Dionisio
🚨 New preprint! We know that plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by @jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14
Dissecting pOXA-48 fitness effects in clinical enterobacteria using plasmid-wide CRISPRi screens
Conjugative plasmids are the main vehicle for the spread of antimicrobial resistance (AMR) genes in clinical bacteria. AMR plasmids allow bacteria to survive antibiotic treatments, but they also produ...
www.biorxiv.org
January 24, 2025 at 12:26 PM
🚨 New preprint! We know that plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by @jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14