Michael Fox
@foxmdphd.bsky.social
Raymond D. Adams Endowed Chair and Professor of Neurology at Harvard Medical School / Mass General Brigham; Director of the Center for Brain Circuit Therapeutics @braincircuits.bsky.social
Pinned
Michael Fox
@foxmdphd.bsky.social
· Nov 16
Reposted by Michael Fox
Mongay-Ochoa et al. review advanced methods for mapping brain connections and identify common topographical patterns of pathology spread across different neurological disorders, including MS, AD and PD. tinyurl.com/3sz8ayup
September 19, 2025 at 8:33 PM
Mongay-Ochoa et al. review advanced methods for mapping brain connections and identify common topographical patterns of pathology spread across different neurological disorders, including MS, AD and PD. tinyurl.com/3sz8ayup
Reposted by Michael Fox
Pruckner et al. show that the structural effects of neurosurgery extend beyond the resected tissue into connected networks through transneuronal degeneration. They were able to reliably predict these changes from preoperative MRI. tinyurl.com/a6rxvbey
October 7, 2025 at 9:21 AM
Pruckner et al. show that the structural effects of neurosurgery extend beyond the resected tissue into connected networks through transneuronal degeneration. They were able to reliably predict these changes from preoperative MRI. tinyurl.com/a6rxvbey
Reposted by Michael Fox
🧪 Research Spotlight: Ziad Nahas, MD, MSCR, is studying how brain networks regulate mood in #BipolarDisorder & how instability drives shifts between depression & mania with PACE
👉 Goal: Test if targeting networks can improve mood & reveal mechanisms behind switches.
🔗 bit.ly/4gTbBwU
👉 Goal: Test if targeting networks can improve mood & reveal mechanisms behind switches.
🔗 bit.ly/4gTbBwU
November 19, 2025 at 3:31 PM
🧪 Research Spotlight: Ziad Nahas, MD, MSCR, is studying how brain networks regulate mood in #BipolarDisorder & how instability drives shifts between depression & mania with PACE
👉 Goal: Test if targeting networks can improve mood & reveal mechanisms behind switches.
🔗 bit.ly/4gTbBwU
👉 Goal: Test if targeting networks can improve mood & reveal mechanisms behind switches.
🔗 bit.ly/4gTbBwU
Reposted by Michael Fox
🧪 Research Spotlight: Michael Fox, MD, PhD (@foxmdphd.bsky.social) of Mass General Brigham (@mgbresearch.bsky.social) will map brain circuits driving symptoms in #BipolarDisorder
👉 Goal: Go beyond imaging correlations to identify the circuits causing symptoms.
🔗 bit.ly/4gTbBwU
👉 Goal: Go beyond imaging correlations to identify the circuits causing symptoms.
🔗 bit.ly/4gTbBwU
November 5, 2025 at 3:00 PM
🧪 Research Spotlight: Michael Fox, MD, PhD (@foxmdphd.bsky.social) of Mass General Brigham (@mgbresearch.bsky.social) will map brain circuits driving symptoms in #BipolarDisorder
👉 Goal: Go beyond imaging correlations to identify the circuits causing symptoms.
🔗 bit.ly/4gTbBwU
👉 Goal: Go beyond imaging correlations to identify the circuits causing symptoms.
🔗 bit.ly/4gTbBwU
Reposted by Michael Fox
This is 🤯
All publicly available. Looks like an amazing new histology-based human probabilistic atlas and parcellation tool.
#neuroskyence #mri #brainmapping
A probabilistic histological atlas of the human brain for MRI segmentation | Nature share.google/5AD0iW7pxgb4...
All publicly available. Looks like an amazing new histology-based human probabilistic atlas and parcellation tool.
#neuroskyence #mri #brainmapping
A probabilistic histological atlas of the human brain for MRI segmentation | Nature share.google/5AD0iW7pxgb4...
A probabilistic histological atlas of the human brain for MRI segmentation - Nature
NextBrain is an open source, probabilistic atlas of the entire human brain, assembled using artificial-intelligence-enabled registration and segmentation methods to reconstruct the multimodal serial h...
share.google
November 6, 2025 at 5:35 AM
This is 🤯
All publicly available. Looks like an amazing new histology-based human probabilistic atlas and parcellation tool.
#neuroskyence #mri #brainmapping
A probabilistic histological atlas of the human brain for MRI segmentation | Nature share.google/5AD0iW7pxgb4...
All publicly available. Looks like an amazing new histology-based human probabilistic atlas and parcellation tool.
#neuroskyence #mri #brainmapping
A probabilistic histological atlas of the human brain for MRI segmentation | Nature share.google/5AD0iW7pxgb4...
Reposted by Michael Fox
Nice case report led by Ben Shofty's team adding prospective evidence for tract based reprogramming in deep brain stimulation for obsessive compulsive disorder out in @biologicalpsych.bsky.social:
www.biologicalpsychiatryjournal.com/article/S000...
🧵
www.biologicalpsychiatryjournal.com/article/S000...
🧵
October 30, 2025 at 10:26 PM
Nice case report led by Ben Shofty's team adding prospective evidence for tract based reprogramming in deep brain stimulation for obsessive compulsive disorder out in @biologicalpsych.bsky.social:
www.biologicalpsychiatryjournal.com/article/S000...
🧵
www.biologicalpsychiatryjournal.com/article/S000...
🧵
Can we identify brain circuit targets to treat symptoms of bipolar disorder? Thanks to funding from @bipolardiscoveries.org our team @braincircuits.bsky.social will be working hard to find out! Honored to be one of these excellent teams.
www.news-medical.net/news/2025102...
www.news-medical.net/news/2025102...
BD² expands global effort to examine the key mechanisms of bipolar disorder
Today, BD², or Breakthrough Discoveries for thriving with Bipolar Disorder, announced its third round of Discovery Research grants, totaling nearly $18 million – expanding a comprehensive global effor...
www.news-medical.net
October 28, 2025 at 3:36 PM
Can we identify brain circuit targets to treat symptoms of bipolar disorder? Thanks to funding from @bipolardiscoveries.org our team @braincircuits.bsky.social will be working hard to find out! Honored to be one of these excellent teams.
www.news-medical.net/news/2025102...
www.news-medical.net/news/2025102...
Reposted by Michael Fox
From a new @thelancet.com article today entitled "Health care in the USA: money has become the mission" www.thelancet.com/journals/lan...
October 21, 2025 at 10:49 PM
From a new @thelancet.com article today entitled "Health care in the USA: money has become the mission" www.thelancet.com/journals/lan...
Reposted by Michael Fox
Suzanne Haber was just elected to the National Academy of Medicine! Her work on the organization of the cortex and basal ganglia has had a huge impact. Please take the opportunity to congratulate her the next time you see her. www.urmc.rochester.edu/news/story/u...
University of Rochester Neurobiologist Suzanne Haber Elected to National Academy of Medicine
An internationally recognized scientist, her work has transformed our understanding of the brain networks that play a central role in many mental health disorders, including obsessive compulsive disor...
www.urmc.rochester.edu
October 21, 2025 at 2:48 PM
Suzanne Haber was just elected to the National Academy of Medicine! Her work on the organization of the cortex and basal ganglia has had a huge impact. Please take the opportunity to congratulate her the next time you see her. www.urmc.rochester.edu/news/story/u...
Reposted by Michael Fox
Fantastic talk by Joe Taylor on the „philosophers scan“ and how imaging can help neuromodulation at the Brainclinics TMS Masterclass in Nijmegen!
October 1, 2025 at 11:48 AM
Fantastic talk by Joe Taylor on the „philosophers scan“ and how imaging can help neuromodulation at the Brainclinics TMS Masterclass in Nijmegen!
Reposted by Michael Fox
Could the Parkinson’s drug levodopa prime the brain to respond better to intensive rehabilitation following a stroke or injury? Enter the idea: Let’s give dopamine pills after a stroke? Spoiler alert: This new large, randomized trial published in JAMA revealed no added benefit in recovery.
September 29, 2025 at 12:45 PM
Could the Parkinson’s drug levodopa prime the brain to respond better to intensive rehabilitation following a stroke or injury? Enter the idea: Let’s give dopamine pills after a stroke? Spoiler alert: This new large, randomized trial published in JAMA revealed no added benefit in recovery.
Honored to moderate a panel on noninvasive mapping of human brain circuits at MGB Neuroscience Day.
Great insights from @anastasiayendiki.bsky.social
@mghmartinos.bsky.social, @fredschaper.bsky.social
@braincircuits.bsky.social, Alex Golby and Pravan Nanda @mgbneurosurgres.bsky.social.
Great insights from @anastasiayendiki.bsky.social
@mghmartinos.bsky.social, @fredschaper.bsky.social
@braincircuits.bsky.social, Alex Golby and Pravan Nanda @mgbneurosurgres.bsky.social.
September 25, 2025 at 8:16 PM
Honored to moderate a panel on noninvasive mapping of human brain circuits at MGB Neuroscience Day.
Great insights from @anastasiayendiki.bsky.social
@mghmartinos.bsky.social, @fredschaper.bsky.social
@braincircuits.bsky.social, Alex Golby and Pravan Nanda @mgbneurosurgres.bsky.social.
Great insights from @anastasiayendiki.bsky.social
@mghmartinos.bsky.social, @fredschaper.bsky.social
@braincircuits.bsky.social, Alex Golby and Pravan Nanda @mgbneurosurgres.bsky.social.
Reposted by Michael Fox
Boom: The results of the ADAPT-PD personalized brain stimulation trial showed promise for treating Parkinson’s. First longer-term results for adaptive DBS in PD. Adaptive stimulation automatically adjusts in real time to a person’s brain signals. @parkinsondotorg.bsky.social
September 23, 2025 at 12:47 PM
Boom: The results of the ADAPT-PD personalized brain stimulation trial showed promise for treating Parkinson’s. First longer-term results for adaptive DBS in PD. Adaptive stimulation automatically adjusts in real time to a person’s brain signals. @parkinsondotorg.bsky.social
Reposted by Michael Fox
What is the update for skin biopsies to differentiate Parkinson's vs. MSA? Spoiler alert: under confocal microscope, skin biopsies look different in PD vs MSA. Donadio and colleagues describe in a new paper in Brain the uses of intraneural phosphorylated α-synuclein. @parkinsondotorg.bsky.social
September 21, 2025 at 1:59 PM
What is the update for skin biopsies to differentiate Parkinson's vs. MSA? Spoiler alert: under confocal microscope, skin biopsies look different in PD vs MSA. Donadio and colleagues describe in a new paper in Brain the uses of intraneural phosphorylated α-synuclein. @parkinsondotorg.bsky.social
Reposted by Michael Fox
In #DeepBrainStimulation
the two major developments across the last decade have been
1. Adaptive DBS and
2. Connectomic DBS
In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:
Could the two be united into a common framework?
www.nature.com/articles/s41...
A 🧵
the two major developments across the last decade have been
1. Adaptive DBS and
2. Connectomic DBS
In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:
Could the two be united into a common framework?
www.nature.com/articles/s41...
A 🧵
September 3, 2025 at 7:59 PM
In #DeepBrainStimulation
the two major developments across the last decade have been
1. Adaptive DBS and
2. Connectomic DBS
In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:
Could the two be united into a common framework?
www.nature.com/articles/s41...
A 🧵
the two major developments across the last decade have been
1. Adaptive DBS and
2. Connectomic DBS
In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:
Could the two be united into a common framework?
www.nature.com/articles/s41...
A 🧵
Can connectomic DBS go beyond where to stimulate to inform who and when? Great discussion @dbsthinktank.bsky.social with @rolstonjohn.bsky.social @julianneumann.bsky.social suggest yes! @braincircuits.bsky.social
September 5, 2025 at 1:44 AM
Can connectomic DBS go beyond where to stimulate to inform who and when? Great discussion @dbsthinktank.bsky.social with @rolstonjohn.bsky.social @julianneumann.bsky.social suggest yes! @braincircuits.bsky.social
Reposted by Michael Fox
🧪 And House appropriators say: no cuts to NIH budget!
House subcommittee version just came out (link below). Holds NIH flat at $48 billion.
To be clear: this is far from over. But a good sign that science still matters across both sides of aisle.
YOUR VOICE MATTERS!!
House subcommittee version just came out (link below). Holds NIH flat at $48 billion.
To be clear: this is far from over. But a good sign that science still matters across both sides of aisle.
YOUR VOICE MATTERS!!
September 1, 2025 at 10:37 PM
🧪 And House appropriators say: no cuts to NIH budget!
House subcommittee version just came out (link below). Holds NIH flat at $48 billion.
To be clear: this is far from over. But a good sign that science still matters across both sides of aisle.
YOUR VOICE MATTERS!!
House subcommittee version just came out (link below). Holds NIH flat at $48 billion.
To be clear: this is far from over. But a good sign that science still matters across both sides of aisle.
YOUR VOICE MATTERS!!
Reposted by Michael Fox
A nasal spray reduced the risk of Covid infections in a double blind, placebo controlled randomized trial
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
September 2, 2025 at 3:16 PM
A nasal spray reduced the risk of Covid infections in a double blind, placebo controlled randomized trial
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Reposted by Michael Fox
Remarkable. Uncontrollable laughing or crying can happen *without* emotion ("pseudobulbar affect"). Here's a video of one individual whose crying is triggered by real or imagined rubbing of his finger & thumb. Intense response but not sadness. /1
static-content.springer.com/esm/art%3A10...
static-content.springer.com/esm/art%3A10...
August 29, 2025 at 7:37 PM
Remarkable. Uncontrollable laughing or crying can happen *without* emotion ("pseudobulbar affect"). Here's a video of one individual whose crying is triggered by real or imagined rubbing of his finger & thumb. Intense response but not sadness. /1
static-content.springer.com/esm/art%3A10...
static-content.springer.com/esm/art%3A10...
Reposted by Michael Fox
🚨 New preprint out! 🚨
“Translating the Transcriptome: A Connectomics Approach for Gene-Network Mapping and Clinical Application”
🔗 doi.org/10.1101/2025... 
🧵 A short thread:
“Translating the Transcriptome: A Connectomics Approach for Gene-Network Mapping and Clinical Application”
🔗 doi.org/10.1101/2025... 
🧵 A short thread:
August 22, 2025 at 2:21 PM
🚨 New preprint out! 🚨
“Translating the Transcriptome: A Connectomics Approach for Gene-Network Mapping and Clinical Application”
🔗 doi.org/10.1101/2025... 
🧵 A short thread:
“Translating the Transcriptome: A Connectomics Approach for Gene-Network Mapping and Clinical Application”
🔗 doi.org/10.1101/2025... 
🧵 A short thread:
Sending off 2 of our best research assistants to graduate programs that are lucky to have them. Congrats Grace and Jessy and we look forward to your ongoing success! @braincircuits.bsky.social
August 19, 2025 at 11:09 PM
Sending off 2 of our best research assistants to graduate programs that are lucky to have them. Congrats Grace and Jessy and we look forward to your ongoing success! @braincircuits.bsky.social
Reposted by Michael Fox
News from ENIGMA-Epilepsy! 🧠
Our latest study links polygenic risk for TLE-HS to cortical thinning in kids—mirroring patterns in adult patients.
Early imaging-genetics insights could reveal interplay of epilepsy risk and phenotypes before symptoms emerge.
Read more 👉 doi.org/10.1093/brai...
Our latest study links polygenic risk for TLE-HS to cortical thinning in kids—mirroring patterns in adult patients.
Early imaging-genetics insights could reveal interplay of epilepsy risk and phenotypes before symptoms emerge.
Read more 👉 doi.org/10.1093/brai...
August 18, 2025 at 11:42 AM
News from ENIGMA-Epilepsy! 🧠
Our latest study links polygenic risk for TLE-HS to cortical thinning in kids—mirroring patterns in adult patients.
Early imaging-genetics insights could reveal interplay of epilepsy risk and phenotypes before symptoms emerge.
Read more 👉 doi.org/10.1093/brai...
Our latest study links polygenic risk for TLE-HS to cortical thinning in kids—mirroring patterns in adult patients.
Early imaging-genetics insights could reveal interplay of epilepsy risk and phenotypes before symptoms emerge.
Read more 👉 doi.org/10.1093/brai...
Reposted by Michael Fox
🚨 New Preprint 🚨
Targeting intracranial electrical stimulation (ES) to network regions defined within individuals causes network-level effects
By Cyr et al.
***
Q: Can we use individualized network maps from precision fMRI to modulate a targeted network via intracranial ES?
A: Yes!
🧵:
Targeting intracranial electrical stimulation (ES) to network regions defined within individuals causes network-level effects
By Cyr et al.
***
Q: Can we use individualized network maps from precision fMRI to modulate a targeted network via intracranial ES?
A: Yes!
🧵:
August 5, 2025 at 3:31 PM
🚨 New Preprint 🚨
Targeting intracranial electrical stimulation (ES) to network regions defined within individuals causes network-level effects
By Cyr et al.
***
Q: Can we use individualized network maps from precision fMRI to modulate a targeted network via intracranial ES?
A: Yes!
🧵:
Targeting intracranial electrical stimulation (ES) to network regions defined within individuals causes network-level effects
By Cyr et al.
***
Q: Can we use individualized network maps from precision fMRI to modulate a targeted network via intracranial ES?
A: Yes!
🧵:
Reposted by Michael Fox
Can specialized physical therapy help you to live longer with Parkinson’s? What if physical therapy did more than improve balance and reduce falls? Specialized physical therapy, like that provided through the PDNet model linked to a modest but real reduction in mortality for people w/ Parkinson’s.
July 24, 2025 at 1:42 PM
Can specialized physical therapy help you to live longer with Parkinson’s? What if physical therapy did more than improve balance and reduce falls? Specialized physical therapy, like that provided through the PDNet model linked to a modest but real reduction in mortality for people w/ Parkinson’s.
Is there a brain circuit target for restoring consciousness after brain injury? New work by @rolstonjohn.bsky.social @braincircuits.bsky.social says yes!
Just dropped in @natcomms.nature.com: we show that re-engaging a thalamic–ventral tegmental circuit with deep brain stimulation can reignite consciousness in patients with severe brain injury. Work led by Aaron Warren, with @andreashorn.org @foxmdphd.bsky.social @ others! tinyurl.com/4kz8j89b
A human brain network linked to restoration of consciousness after deep brain stimulation - Nature Communications
In people with severe brain injuries, stimulation restored consciousness by engaging a deep brain circuit for wakefulness—revealing a target that may also guide treatment in stroke and epilepsy.
www.nature.com
July 21, 2025 at 11:26 PM
Is there a brain circuit target for restoring consciousness after brain injury? New work by @rolstonjohn.bsky.social @braincircuits.bsky.social says yes!