Fleur Ferguson
@fleurmferguson.bsky.social
Assistant Professor, UCSD. Induced proximity, medicinal chemistry, chemical proteomics. https://fergusonlab.ucsd.edu
Reposted by Fleur Ferguson
‼️ Call for Nominations🏅Chi-Huey Wong Chemical Biology Award
1️⃣ Official Nomination Form
2️⃣ Nomination Letter (maximum 1,000 words)
🙅 Self-nominations will not be considered
📅 Nominate before October 31, 2025
👉 Ms. Marene Chan
📧 [email protected]
🌐 chemistry.org.tw/award_chwong/
1️⃣ Official Nomination Form
2️⃣ Nomination Letter (maximum 1,000 words)
🙅 Self-nominations will not be considered
📅 Nominate before October 31, 2025
👉 Ms. Marene Chan
📧 [email protected]
🌐 chemistry.org.tw/award_chwong/
September 10, 2025 at 4:27 PM
‼️ Call for Nominations🏅Chi-Huey Wong Chemical Biology Award
1️⃣ Official Nomination Form
2️⃣ Nomination Letter (maximum 1,000 words)
🙅 Self-nominations will not be considered
📅 Nominate before October 31, 2025
👉 Ms. Marene Chan
📧 [email protected]
🌐 chemistry.org.tw/award_chwong/
1️⃣ Official Nomination Form
2️⃣ Nomination Letter (maximum 1,000 words)
🙅 Self-nominations will not be considered
📅 Nominate before October 31, 2025
👉 Ms. Marene Chan
📧 [email protected]
🌐 chemistry.org.tw/award_chwong/
Incredibly honored to be named a 2025 Pew Scholar in the Biomedical Sciences! 🧬 Grateful to Pew Trusts for this recognition and support, and to my awesome lab team, mentors and colleagues at @ucsdhealthsci.bsky.social Excited for what's ahead!
www.pew.org/en/about/new...
www.pew.org/en/about/new...
Pew Awards 22 Researchers Biomedical Science Grants
www.pew.org
August 12, 2025 at 4:59 PM
Incredibly honored to be named a 2025 Pew Scholar in the Biomedical Sciences! 🧬 Grateful to Pew Trusts for this recognition and support, and to my awesome lab team, mentors and colleagues at @ucsdhealthsci.bsky.social Excited for what's ahead!
www.pew.org/en/about/new...
www.pew.org/en/about/new...
Excited to share our latest work developing molecular glue degraders of ZBTB11, now out in @natchembio.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ZBTB11 depletion targets metabolic vulnerabilities in KRAS inhibitor-resistant PDAC - Nature Chemical Biology
Depletion of a transcriptional factor ZBTB11 using molecular glue degraders can overcome oxidative-phosphorylation-mediated KRAS inhibitor resistance in pancreatic ductal adenocarcinoma with low acute...
www.nature.com
August 11, 2025 at 1:51 PM
Excited to share our latest work developing molecular glue degraders of ZBTB11, now out in @natchembio.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Fleur Ferguson
New work out today introducing PCIPs, heterobifunctional chemical inducers of proximity that inhibit DNA repair by recruiting BET proteins to PARP2. Great work uncovering a new form of event-driven pharmacology by Bryce/Eric/Erin and the rest of the team. (1/3)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Rewiring DNA repair with PARP-based chemical inducers of proximity
Chemical inducers of proximity (CIPs) can elicit durable, and often neomorphic, biological effects through the formation of a ternary complex, even at low equilibrium occupancy of their targets. This ...
www.biorxiv.org
July 31, 2025 at 3:07 PM
New work out today introducing PCIPs, heterobifunctional chemical inducers of proximity that inhibit DNA repair by recruiting BET proteins to PARP2. Great work uncovering a new form of event-driven pharmacology by Bryce/Eric/Erin and the rest of the team. (1/3)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Fleur Ferguson
📣 Calling all ubiquitin aficionados - one week to go before abstract deadline (July 18th)!! Join us on the coast in Lorne, Australia. www.lorneubiquitin.org
#ubiquitin
#ubiquitin
July 11, 2025 at 7:08 AM
📣 Calling all ubiquitin aficionados - one week to go before abstract deadline (July 18th)!! Join us on the coast in Lorne, Australia. www.lorneubiquitin.org
#ubiquitin
#ubiquitin
Reposted by Fleur Ferguson
We are looking to hire an Assistant/Associate Professor interested in creating an innovative (and exciting) program of research in chemical biology, medicinal chemistry, ML/AI, drug discovery - all in the context of cancer biology!
careers.dana-farber.org/job/11813/as...
careers.dana-farber.org/job/11813/as...
Faculty/Health Educator Job: Assistant/Associate Professor, Chemical Biology at Dana-Farber Cancer Institute in 450 Brookline Ave, Boston, MA
Assistant/Associate Professor, Chemical Biology job
careers.dana-farber.org
June 30, 2025 at 7:30 PM
We are looking to hire an Assistant/Associate Professor interested in creating an innovative (and exciting) program of research in chemical biology, medicinal chemistry, ML/AI, drug discovery - all in the context of cancer biology!
careers.dana-farber.org/job/11813/as...
careers.dana-farber.org/job/11813/as...
Reposted by Fleur Ferguson
🚨 New preprint!
Excited to share our latest work, led by @sauravk05.bsky.social (Nabet lab) and Jiewei Jiang (Ferguson lab), on targeting oncogenic TRK fusions. We report potent and selective degraders of TPM3-TRKA, a driver of adult and pediatric cancers. www.biorxiv.org/content/10.1...
Excited to share our latest work, led by @sauravk05.bsky.social (Nabet lab) and Jiewei Jiang (Ferguson lab), on targeting oncogenic TRK fusions. We report potent and selective degraders of TPM3-TRKA, a driver of adult and pediatric cancers. www.biorxiv.org/content/10.1...
Development of PROTACs for targeted degradation of oncogenic TRK fusions
Chromosomal translocations leading to the fusion of tropomyosin receptor kinases (TRK) with diverse partner proteins have been identified as oncogenic drivers in many adult and pediatric cancers. Whil...
www.biorxiv.org
June 25, 2025 at 8:10 PM
🚨 New preprint!
Excited to share our latest work, led by @sauravk05.bsky.social (Nabet lab) and Jiewei Jiang (Ferguson lab), on targeting oncogenic TRK fusions. We report potent and selective degraders of TPM3-TRKA, a driver of adult and pediatric cancers. www.biorxiv.org/content/10.1...
Excited to share our latest work, led by @sauravk05.bsky.social (Nabet lab) and Jiewei Jiang (Ferguson lab), on targeting oncogenic TRK fusions. We report potent and selective degraders of TPM3-TRKA, a driver of adult and pediatric cancers. www.biorxiv.org/content/10.1...
Reposted by Fleur Ferguson
Download and distribute our (massive) database of funding opportunities and fellowships for POSTDOCs
Cuts across all fields of research. 293 fellowships with info about deadline, amount, field, eligibility, etc.
Good luck!
Download this database freely here: research.jhu.edu/rdt/funding-...
Cuts across all fields of research. 293 fellowships with info about deadline, amount, field, eligibility, etc.
Good luck!
Download this database freely here: research.jhu.edu/rdt/funding-...
May 8, 2025 at 1:13 PM
Download and distribute our (massive) database of funding opportunities and fellowships for POSTDOCs
Cuts across all fields of research. 293 fellowships with info about deadline, amount, field, eligibility, etc.
Good luck!
Download this database freely here: research.jhu.edu/rdt/funding-...
Cuts across all fields of research. 293 fellowships with info about deadline, amount, field, eligibility, etc.
Good luck!
Download this database freely here: research.jhu.edu/rdt/funding-...
Registration for the 2025 San Diego MedChem Symposium is now open! Come join us for a free event on UCSDs campus.
May 8, 2025 at 11:33 PM
Registration for the 2025 San Diego MedChem Symposium is now open! Come join us for a free event on UCSDs campus.
Reposted by Fleur Ferguson
A big congratulations to the newly minted Dr. Forrest @inesforrest.bsky.social. Super proud! A big thanks to her committee members @michael-erb.bsky.social @wisemanlab.bsky.social @fleurmferguson.bsky.social @shenvi.bsky.social
April 26, 2025 at 12:47 AM
A big congratulations to the newly minted Dr. Forrest @inesforrest.bsky.social. Super proud! A big thanks to her committee members @michael-erb.bsky.social @wisemanlab.bsky.social @fleurmferguson.bsky.social @shenvi.bsky.social
Reposted by Fleur Ferguson
So much fun sharing MrTAC with Keystone and seeing old friends and making new ones @fleurmferguson.bsky.social @stevenbanik.bsky.social @dannomura.bsky.social @danetteldaniels.bsky.social #lysosome #tpd
February 25, 2025 at 7:46 AM
So much fun sharing MrTAC with Keystone and seeing old friends and making new ones @fleurmferguson.bsky.social @stevenbanik.bsky.social @dannomura.bsky.social @danetteldaniels.bsky.social #lysosome #tpd
Reposted by Fleur Ferguson
Really enjoyed this proximity-based therapeutics keystone conference! Appreciate the organizers Fleur @fleurmferguson.bsky.social and Phil for the opportunity and for putting together this wonderful event!
Celebrate the scholarship winners from Proximity-Based Therapeutics: Markella Konstantinidou, @zhilindseylin.bsky.social, Charlene Mae Magtoto, Ashwini Premashankar, & Maximilian R. Stammnitz. Learn more about financial aid at keysym.us/KSFinancialAid.
#keystonesymposia #keystoneconferences
#keystonesymposia #keystoneconferences
February 20, 2025 at 7:37 PM
Really enjoyed this proximity-based therapeutics keystone conference! Appreciate the organizers Fleur @fleurmferguson.bsky.social and Phil for the opportunity and for putting together this wonderful event!
Reposted by Fleur Ferguson
Congratulations to @alesalerno.bsky.social from University of Dundee CeTPD and Christine Ng from @stanford-chemh.bsky.social who have been selected as recipients of our conference travel scholarships to attend the Proximity-based Therapeutics Keystone conference @keystonesymposia.bsky.social!
January 24, 2025 at 6:59 PM
Congratulations to @alesalerno.bsky.social from University of Dundee CeTPD and Christine Ng from @stanford-chemh.bsky.social who have been selected as recipients of our conference travel scholarships to attend the Proximity-based Therapeutics Keystone conference @keystonesymposia.bsky.social!
Reposted by Fleur Ferguson
Big thanks to @womenintpd.bsky.social for this amazing initiative and support in empowering women in the field! Grateful and excited to attend @keystonesymposia.bsky.social soon and make the most of this incredible experience! ✨️
Congratulations to @alesalerno.bsky.social from University of Dundee CeTPD and Christine Ng from @stanford-chemh.bsky.social who have been selected as recipients of our conference travel scholarships to attend the Proximity-based Therapeutics Keystone conference @keystonesymposia.bsky.social!
January 24, 2025 at 7:36 PM
Big thanks to @womenintpd.bsky.social for this amazing initiative and support in empowering women in the field! Grateful and excited to attend @keystonesymposia.bsky.social soon and make the most of this incredible experience! ✨️
Reposted by Fleur Ferguson
Congratulations to both of you! @WomeninTPD first official scholarship award winners ☺️
Congratulations to @alesalerno.bsky.social from University of Dundee CeTPD and Christine Ng from @stanford-chemh.bsky.social who have been selected as recipients of our conference travel scholarships to attend the Proximity-based Therapeutics Keystone conference @keystonesymposia.bsky.social!
January 24, 2025 at 7:40 PM
Congratulations to both of you! @WomeninTPD first official scholarship award winners ☺️
Reposted by Fleur Ferguson
Chemical Biology Postdoc in the Ferguson Lab at UCSD #ScienceJobs #AcademicSky jobrxiv.org/job/univ...
Chemical Biology Postdoc in the Ferguson Lab at UCSD
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
jobrxiv.org
January 7, 2025 at 5:30 PM
Chemical Biology Postdoc in the Ferguson Lab at UCSD #ScienceJobs #AcademicSky jobrxiv.org/job/univ...
Reposted by Fleur Ferguson
We asked a collection of chemical biologists, “What do you think are the most exciting frontiers or the most needed developments in your main field of research?”
You can read that they said in our Feature “Thoughts for the future” – Free to read in January. rdcu.be/d5Ksw
You can read that they said in our Feature “Thoughts for the future” – Free to read in January. rdcu.be/d5Ksw
Thoughts for the future
Nature Chemical Biology - As Nature Chemical Biology approaches its third decade we asked a collection of chemical biologists, “What do you think are the most exciting frontiers or the most...
rdcu.be
January 9, 2025 at 12:56 PM
We asked a collection of chemical biologists, “What do you think are the most exciting frontiers or the most needed developments in your main field of research?”
You can read that they said in our Feature “Thoughts for the future” – Free to read in January. rdcu.be/d5Ksw
You can read that they said in our Feature “Thoughts for the future” – Free to read in January. rdcu.be/d5Ksw
Please share widely - we are hiring, come join our team!
Chemical Biology Postdoc in the Ferguson Lab at UCSD #ScienceJobs #AcademicSky jobrxiv.org/job/univ...
Chemical Biology Postdoc in the Ferguson Lab at UCSD
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
jobrxiv.org
January 8, 2025 at 6:49 PM
Please share widely - we are hiring, come join our team!
Reposted by Fleur Ferguson
Our January issue is live and it’s our 20th Anniversary Issue!
www.nature.com/nchembio/vol...
It includes a collection of Retrospective News & Views on historical developments in the field, a Feature “Thoughts for the future” from chemical biologists on the next challenges, and more.
www.nature.com/nchembio/vol...
It includes a collection of Retrospective News & Views on historical developments in the field, a Feature “Thoughts for the future” from chemical biologists on the next challenges, and more.
January 6, 2025 at 7:46 PM
Our January issue is live and it’s our 20th Anniversary Issue!
www.nature.com/nchembio/vol...
It includes a collection of Retrospective News & Views on historical developments in the field, a Feature “Thoughts for the future” from chemical biologists on the next challenges, and more.
www.nature.com/nchembio/vol...
It includes a collection of Retrospective News & Views on historical developments in the field, a Feature “Thoughts for the future” from chemical biologists on the next challenges, and more.
We are hiring! Apply to join our dynamic team as a #chemicalbiology postdoc or research scientist below.
Chemical biology: jobrxiv.org/job/universi...
Mass spectrometry: jobrxiv.org/job/universi...
Chemical biology: jobrxiv.org/job/universi...
Mass spectrometry: jobrxiv.org/job/universi...
Chemical Biology Postdoc in the Ferguson Lab at UCSD
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
jobrxiv.org
January 7, 2025 at 12:39 AM
We are hiring! Apply to join our dynamic team as a #chemicalbiology postdoc or research scientist below.
Chemical biology: jobrxiv.org/job/universi...
Mass spectrometry: jobrxiv.org/job/universi...
Chemical biology: jobrxiv.org/job/universi...
Mass spectrometry: jobrxiv.org/job/universi...
Reposted by Fleur Ferguson
Here is the link for the Keystone Conference:
www.keystonesymposia.org/conferences/...
Thank you to the organizers @fleurmferguson.bsky.social and Phil Chamberlain for helping us coordinate and setup this opportunity.
www.keystonesymposia.org/conferences/...
Thank you to the organizers @fleurmferguson.bsky.social and Phil Chamberlain for helping us coordinate and setup this opportunity.
Proximity-Based Therapeutics: Targeted Protein Degradation and Other Pharmacological Approaches | Keystone Symposia
Join us at the Keystone Symposia on Proximity-Based Therapeutics: Targeted Protein Degradation and Other Pharmacological Approaches, February 2025, in Santa Fe, with field leaders!
www.keystonesymposia.org
December 23, 2024 at 2:11 PM
Here is the link for the Keystone Conference:
www.keystonesymposia.org/conferences/...
Thank you to the organizers @fleurmferguson.bsky.social and Phil Chamberlain for helping us coordinate and setup this opportunity.
www.keystonesymposia.org/conferences/...
Thank you to the organizers @fleurmferguson.bsky.social and Phil Chamberlain for helping us coordinate and setup this opportunity.
Reposted by Fleur Ferguson
Join us for the final TPD webinar of 2024 on 12/19.
@fleurmferguson.bsky.social & Eric Wang - "ZBTB11 Degraders Target Metabolic Vulnerabilities in K-Ras Inhibitor Resistant PDAC"
Slava Ziegler - "Targeting IDO1 by monovalent degraders exploiting the native IDO1 degradation mechanism"
@fleurmferguson.bsky.social & Eric Wang - "ZBTB11 Degraders Target Metabolic Vulnerabilities in K-Ras Inhibitor Resistant PDAC"
Slava Ziegler - "Targeting IDO1 by monovalent degraders exploiting the native IDO1 degradation mechanism"
December 17, 2024 at 9:42 PM
Join us for the final TPD webinar of 2024 on 12/19.
@fleurmferguson.bsky.social & Eric Wang - "ZBTB11 Degraders Target Metabolic Vulnerabilities in K-Ras Inhibitor Resistant PDAC"
Slava Ziegler - "Targeting IDO1 by monovalent degraders exploiting the native IDO1 degradation mechanism"
@fleurmferguson.bsky.social & Eric Wang - "ZBTB11 Degraders Target Metabolic Vulnerabilities in K-Ras Inhibitor Resistant PDAC"
Slava Ziegler - "Targeting IDO1 by monovalent degraders exploiting the native IDO1 degradation mechanism"
Excited to share our work investigating how ligand residence time influences targeted protein degradation outcomes at scale, and how we can combine kinetic scout degrader approaches with mathematical modeling to accelerate hit finding and optimization!
onlinelibrary.wiley.com/doi/abs/10.1...
onlinelibrary.wiley.com/doi/abs/10.1...
A Kinetic Scout Approach Accelerates Targeted Protein Degrader Development
Bifunctional molecules such as targeted protein degraders induce proximity to promote gain-of-function pharmacology. These powerful approaches have gained broad traction across academia and the pharm....
onlinelibrary.wiley.com
November 27, 2024 at 10:29 PM
Excited to share our work investigating how ligand residence time influences targeted protein degradation outcomes at scale, and how we can combine kinetic scout degrader approaches with mathematical modeling to accelerate hit finding and optimization!
onlinelibrary.wiley.com/doi/abs/10.1...
onlinelibrary.wiley.com/doi/abs/10.1...
Reposted by Fleur Ferguson
New paper out of Katya Vinogradova’s lab! www.sciencedirect.com/science/arti...
Covalent targeting of splicing in T cells
Despite significant interest in therapeutic targeting of splicing, few chemical probes are available for the proteins involved in splicing. Here, we s…
www.sciencedirect.com
November 25, 2024 at 6:50 PM
New paper out of Katya Vinogradova’s lab! www.sciencedirect.com/science/arti...