Federico Carrozzo
@fede-carrozzo.bsky.social
PhD student - Genome organization and regulation @mariekeoudelaar.bsky.social's Lab @mpi-nat.bsky.social
Reposted by Federico Carrozzo
Happy to share our latest publication, in which we show that the arrangement of nucleosomes around CTCF sites contributes to higher-order organisation of chromatin into TADs: www.embopress.org/doi/full/10....
October 27, 2025 at 11:49 AM
Happy to share our latest publication, in which we show that the arrangement of nucleosomes around CTCF sites contributes to higher-order organisation of chromatin into TADs: www.embopress.org/doi/full/10....
Reposted by Federico Carrozzo
(1/n) Excited to present the latest work from the de Wit lab, where we identify and characterise loop extrusion-mediated fountains in mammalian genomes using acute depletion of 3D genome regulators: doi.org/10.1093/nar/.... A Bluetorial🧵:
Extrusion fountains are restricted by WAPL-dependent cohesin release and CTCF barriers
Abstract. Interphase chromosomes are mainly shaped by loop extrusion and compartmentalisation mechanisms. However, their temporal component and cause-effec
doi.org
July 1, 2025 at 6:34 AM
(1/n) Excited to present the latest work from the de Wit lab, where we identify and characterise loop extrusion-mediated fountains in mammalian genomes using acute depletion of 3D genome regulators: doi.org/10.1093/nar/.... A Bluetorial🧵:
Reposted by Federico Carrozzo
📢We are happy to announce that registration for Horizons 2025 is now open!
📍At the MPI-NAT Göttingen, September 8th-11th.
✅ If you want to apply for the awarded student talks, travel grants, or present your research in a poster, please check out the poster👇
👉Register now: bit.ly/4j5kioh
📍At the MPI-NAT Göttingen, September 8th-11th.
✅ If you want to apply for the awarded student talks, travel grants, or present your research in a poster, please check out the poster👇
👉Register now: bit.ly/4j5kioh
April 29, 2025 at 2:52 PM
📢We are happy to announce that registration for Horizons 2025 is now open!
📍At the MPI-NAT Göttingen, September 8th-11th.
✅ If you want to apply for the awarded student talks, travel grants, or present your research in a poster, please check out the poster👇
👉Register now: bit.ly/4j5kioh
📍At the MPI-NAT Göttingen, September 8th-11th.
✅ If you want to apply for the awarded student talks, travel grants, or present your research in a poster, please check out the poster👇
👉Register now: bit.ly/4j5kioh
Reposted by Federico Carrozzo
Very happy to share the peer-reviewed version of our paper in which we study the formation and function of pair-wise and multi-way enhancer-promoter interactions in gene regulation (see thread below): www.nature.com/articles/s41...
May 13, 2025 at 9:41 AM
Very happy to share the peer-reviewed version of our paper in which we study the formation and function of pair-wise and multi-way enhancer-promoter interactions in gene regulation (see thread below): www.nature.com/articles/s41...
Reposted by Federico Carrozzo
A tool to dissect regulatory DNA in its endogenous context enables the identification of designed small edits (<10 bp) that fine-tune gene expression, with potential therapeutic implications #NBThighlight www.cell.com/cell/abstrac...
Rewriting regulatory DNA to dissect and reprogram gene expression
Martyn and Montgomery et al. present Variant-EFFECTS, a high-throughput technology
developed to precisely measure the effects of CRISPR-mediated edits on gene expression.
Variant-EFFECTS is reproducib...
www.cell.com
April 17, 2025 at 1:38 PM
A tool to dissect regulatory DNA in its endogenous context enables the identification of designed small edits (<10 bp) that fine-tune gene expression, with potential therapeutic implications #NBThighlight www.cell.com/cell/abstrac...
Reposted by Federico Carrozzo
Nature research paper: Extensive mutual influences of SMC complexes shape 3D genome folding
https://go.nature.com/4bkCeIk
https://go.nature.com/4bkCeIk
Extensive mutual influences of SMC complexes shape 3D genome folding - Nature
Orthogonal acute inducible degradation cell lines are used to delineate the mechanisms of how extrusive cohesin, cohesive cohesin and condensin interact to remodel chromosome architecture from interphase to mitosis.
go.nature.com
February 27, 2025 at 10:01 AM
Nature research paper: Extensive mutual influences of SMC complexes shape 3D genome folding
https://go.nature.com/4bkCeIk
https://go.nature.com/4bkCeIk
Reposted by Federico Carrozzo
🔥New Night Science paper!!
Discovery happens when your initial plans fall apart but it requires you to have a particular mindset: it's not extraverted, orderly, neurotic or agreeable that's the most important – discovery requires an OPENNESS to new ideas and unexpected insights.
Discovery happens when your initial plans fall apart but it requires you to have a particular mindset: it's not extraverted, orderly, neurotic or agreeable that's the most important – discovery requires an OPENNESS to new ideas and unexpected insights.
April 2, 2025 at 11:28 AM
🔥New Night Science paper!!
Discovery happens when your initial plans fall apart but it requires you to have a particular mindset: it's not extraverted, orderly, neurotic or agreeable that's the most important – discovery requires an OPENNESS to new ideas and unexpected insights.
Discovery happens when your initial plans fall apart but it requires you to have a particular mindset: it's not extraverted, orderly, neurotic or agreeable that's the most important – discovery requires an OPENNESS to new ideas and unexpected insights.
Reposted by Federico Carrozzo
Our new findings on how chromosomes get ready for cell division are now published in @cellpress.bsky.social!
Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩
www.sciencedirect.com/science/arti...
Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩
www.sciencedirect.com/science/arti...
March 24, 2025 at 3:29 PM
Our new findings on how chromosomes get ready for cell division are now published in @cellpress.bsky.social!
Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩
www.sciencedirect.com/science/arti...
Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩
www.sciencedirect.com/science/arti...
Reposted by Federico Carrozzo
1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
March 17, 2025 at 11:56 AM
1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
Reposted by Federico Carrozzo
Scientists led by Melina Schuh & @ninadini.bsky.social @schuhlab.bsky.social have shown in mice that aged egg cells repair their #DNA less efficiently than young ones, and that repair becomes more error-prone with advancing maternal age. ⬇️
www.mpinat.mpg.de/4946141/pr_2...
www.mpinat.mpg.de/4946141/pr_2...
March 5, 2025 at 9:50 AM
Scientists led by Melina Schuh & @ninadini.bsky.social @schuhlab.bsky.social have shown in mice that aged egg cells repair their #DNA less efficiently than young ones, and that repair becomes more error-prone with advancing maternal age. ⬇️
www.mpinat.mpg.de/4946141/pr_2...
www.mpinat.mpg.de/4946141/pr_2...
Reposted by Federico Carrozzo
New preprint from the @gerlichlab.bsky.social @imbavienna.bsky.social!
How do DNA breaks locate homology sites in the vast space of the human genome? We show how cohesin guides homology search for faithful repair!
Read more 👉 https://doi.org/10.1101/2025.02.10
Follow along for key insights! 🧵
How do DNA breaks locate homology sites in the vast space of the human genome? We show how cohesin guides homology search for faithful repair!
Read more 👉 https://doi.org/10.1101/2025.02.10
Follow along for key insights! 🧵
February 12, 2025 at 5:15 PM
New preprint from the @gerlichlab.bsky.social @imbavienna.bsky.social!
How do DNA breaks locate homology sites in the vast space of the human genome? We show how cohesin guides homology search for faithful repair!
Read more 👉 https://doi.org/10.1101/2025.02.10
Follow along for key insights! 🧵
How do DNA breaks locate homology sites in the vast space of the human genome? We show how cohesin guides homology search for faithful repair!
Read more 👉 https://doi.org/10.1101/2025.02.10
Follow along for key insights! 🧵