Fabrice Jean-Pierre
@fabricejpierre.bsky.social
Assistant Professor @USherbrooke | Polymicrobial biofilms, interactions & mechanisms of recalcitrance | he/him
https://www.fjplab.com/
https://scholar.google.ca/citations?user=N5UlGZgAAAAJ&hl=en
https://www.fjplab.com/
https://scholar.google.ca/citations?user=N5UlGZgAAAAJ&hl=en
Pinned
Pseudomonas aeruginosa supports the survival of Prevotella melaninogenica in a cystic fibrosis lung polymicrobial community through metabolic cross-feeding | mBio
Polymicrobial interactions impact disease outcomes in pwCF who suffer from chronic
respiratory infections. Previous work established a CF-relevant polymicrobial community
model that allows experimenta...
journals.asm.org
Happy to finally see this out! Bassam El Halfi (@bassamhafi.bsky.social - my first rotation student when I started my post-doc in @geiselbiofilm.bsky.social) did an amazing job investigating mechanisms of interspecies metabolic interactions. Check it out! #microsky
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Reposted by Fabrice Jean-Pierre
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
www.science.org
November 20, 2025 at 9:42 PM
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Fabrice Jean-Pierre
Apply now to attend the next EMBO Bacterial Networks meeting #EMBOBacNet
🗓️13-18 September 2026
📍Sant Feliu de Guixols, Spain
📝Program and registration info: meetings.embo.org/event/26-bac...
👩🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social
#MicroSky
🗓️13-18 September 2026
📍Sant Feliu de Guixols, Spain
📝Program and registration info: meetings.embo.org/event/26-bac...
👩🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social
#MicroSky
November 20, 2025 at 10:16 AM
Apply now to attend the next EMBO Bacterial Networks meeting #EMBOBacNet
🗓️13-18 September 2026
📍Sant Feliu de Guixols, Spain
📝Program and registration info: meetings.embo.org/event/26-bac...
👩🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social
#MicroSky
🗓️13-18 September 2026
📍Sant Feliu de Guixols, Spain
📝Program and registration info: meetings.embo.org/event/26-bac...
👩🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social
#MicroSky
Reposted by Fabrice Jean-Pierre
Why does daptomycin resistance appear so fast in Enterococcus? We finally have a clue.
DAP resistance in enterococci pops up quickly. What’s been missing is why resistance-associated membrane changes look the way they do, and why the classic path of mutations is so predictable.
DAP resistance in enterococci pops up quickly. What’s been missing is why resistance-associated membrane changes look the way they do, and why the classic path of mutations is so predictable.
A two-component system signaling hub controls enterococcal membrane remodeling in response to daptomycin https://www.biorxiv.org/content/10.1101/2025.11.16.688641v1
November 17, 2025 at 8:27 PM
Why does daptomycin resistance appear so fast in Enterococcus? We finally have a clue.
DAP resistance in enterococci pops up quickly. What’s been missing is why resistance-associated membrane changes look the way they do, and why the classic path of mutations is so predictable.
DAP resistance in enterococci pops up quickly. What’s been missing is why resistance-associated membrane changes look the way they do, and why the classic path of mutations is so predictable.
Reposted by Fabrice Jean-Pierre
Pls share: HHMI - Program Officer - Science Education Alliance
hhmi.wd1.myworkdayjobs.com/en-US/Extern...
hhmi.wd1.myworkdayjobs.com/en-US/Extern...
Program Officer - Science Education Alliance
Primary Work Address: 4000 Jones Bridge Road, Chevy Chase, MD, 20815 Current HHMI Employees, click here to apply via your Workday account. HHMI is focused on supporting and moving science forward in a...
hhmi.wd1.myworkdayjobs.com
November 18, 2025 at 1:11 PM
Pls share: HHMI - Program Officer - Science Education Alliance
hhmi.wd1.myworkdayjobs.com/en-US/Extern...
hhmi.wd1.myworkdayjobs.com/en-US/Extern...
We're hiring! My dept. is looking for a candidate with a research program focusing on plant systems. All areas of molecular and cellular biology research will be considered. Not sure if you'd fit? Reach out to me. Please share! #microsky
November 17, 2025 at 6:18 PM
We're hiring! My dept. is looking for a candidate with a research program focusing on plant systems. All areas of molecular and cellular biology research will be considered. Not sure if you'd fit? Reach out to me. Please share! #microsky
Reposted by Fabrice Jean-Pierre
Bacteria export alarmone synthetases that produce (p)ppApp and (p)ppGpp 🦠🤯
From Boyuan Wang and John Whitney
journals.asm.org/doi/10.1128/...
From Boyuan Wang and John Whitney
journals.asm.org/doi/10.1128/...
Bacteria export alarmone synthetases that produce (p)ppApp and (p)ppGpp | mBio
Alarmone synthetases are intracellular enzymes that promote bacterial survival by
responding to environmental stress. Although extracellular alarmone production has
been reported in Streptomyces, the ...
journals.asm.org
November 15, 2025 at 12:42 PM
Bacteria export alarmone synthetases that produce (p)ppApp and (p)ppGpp 🦠🤯
From Boyuan Wang and John Whitney
journals.asm.org/doi/10.1128/...
From Boyuan Wang and John Whitney
journals.asm.org/doi/10.1128/...
Thanks, George!
A really nice profile of Fabrice Jean-Pierre, a former postdoc in the lab doing great work in his own lab at the University of Sherbrooke. Congrats Fabrice!
cysticfibrosis.ca/blog/dr.-fab...
cysticfibrosis.ca/blog/dr.-fab...
Dr. Fabrice Jean-Pierre: Uncovering the Invisible Battles in CF Lungs
Dr. Fabrice Jean-Pierre’s research digs into a problem many people with cystic fibrosis (CF) know intimately: chronic lung infections. Even as treatments like Trikafta improve lung function and overal...
cysticfibrosis.ca
November 14, 2025 at 2:07 AM
Thanks, George!
Reposted by Fabrice Jean-Pierre
Gac Is a Transcriptional Repressor of the Lyme Disease Spirochete's OspC Virulence-Associated Surface Protein
Castro-Padovani, Saylor, Husted, Krusenstjerna, Jusufovic, and Stevenson
2023, J Bacteriol, 205:e0044022.
doi: 10.1128/jb.00440-22
pubmed.ncbi.nlm.nih.gov/36920207/
#MicroSky
Castro-Padovani, Saylor, Husted, Krusenstjerna, Jusufovic, and Stevenson
2023, J Bacteriol, 205:e0044022.
doi: 10.1128/jb.00440-22
pubmed.ncbi.nlm.nih.gov/36920207/
#MicroSky
November 7, 2025 at 3:51 PM
Gac Is a Transcriptional Repressor of the Lyme Disease Spirochete's OspC Virulence-Associated Surface Protein
Castro-Padovani, Saylor, Husted, Krusenstjerna, Jusufovic, and Stevenson
2023, J Bacteriol, 205:e0044022.
doi: 10.1128/jb.00440-22
pubmed.ncbi.nlm.nih.gov/36920207/
#MicroSky
Castro-Padovani, Saylor, Husted, Krusenstjerna, Jusufovic, and Stevenson
2023, J Bacteriol, 205:e0044022.
doi: 10.1128/jb.00440-22
pubmed.ncbi.nlm.nih.gov/36920207/
#MicroSky
"Functional CFTR may be required for Prevotella melaninogenica regulation of epithelial cell defense against Staphylococcus aureus"
pubmed.ncbi.nlm.nih.gov/41198444/
#microsky
pubmed.ncbi.nlm.nih.gov/41198444/
#microsky
Functional CFTR may be required for Prevotella melaninogenica regulation of epithelial cell defense against Staphylococcus aureus - PubMed
P. melaninogenica enhanced neutrophil and epithelial defense against S. aureus, but the benefits of epithelial cell regulation by P. melaninogenica were lost with CFTR dysfunction. CFTR modulators rescued P. melaninogenica responsiveness in epithelial cells, highlighting the potential for synergisti …
pubmed.ncbi.nlm.nih.gov
November 7, 2025 at 12:38 PM
"Functional CFTR may be required for Prevotella melaninogenica regulation of epithelial cell defense against Staphylococcus aureus"
pubmed.ncbi.nlm.nih.gov/41198444/
#microsky
pubmed.ncbi.nlm.nih.gov/41198444/
#microsky
Reposted by Fabrice Jean-Pierre
Prevotella is the clear favorite of the 4-member cookie community (not like I’m surprised) @bassamhafi.bsky.social @fabricejpierre.bsky.social
November 6, 2025 at 9:14 PM
Prevotella is the clear favorite of the 4-member cookie community (not like I’m surprised) @bassamhafi.bsky.social @fabricejpierre.bsky.social
Reposted by Fabrice Jean-Pierre
An update on my column: Parliamentary committee drops most contentious parts of its demand for data on research funding. It now wants aggregated, not disaggregated data. www.theglobeandmail.com/opinion/arti...
November 6, 2025 at 2:29 AM
An update on my column: Parliamentary committee drops most contentious parts of its demand for data on research funding. It now wants aggregated, not disaggregated data. www.theglobeandmail.com/opinion/arti...
Le BiSP/Micrhub est sur le point de débuter à @usherbrooke.bsky.social ! Deux jours de microbiologie/bactériologie seront à l’honneur en plus d’avoir deux keynotes @lalouxlab.bsky.social et @bjesseshapiro.bsky.social. Nous avons hâte de vous accueillir! @micrhub.bsky.social #microsky
November 5, 2025 at 12:54 PM
Le BiSP/Micrhub est sur le point de débuter à @usherbrooke.bsky.social ! Deux jours de microbiologie/bactériologie seront à l’honneur en plus d’avoir deux keynotes @lalouxlab.bsky.social et @bjesseshapiro.bsky.social. Nous avons hâte de vous accueillir! @micrhub.bsky.social #microsky
We should be paying more attention to this situation. An online letter has been put together and is being circulated to stop this data from being disclosed. Please sign the online letter here, if you are comfortable: docs.google.com/forms/d/e/1F...
November 4, 2025 at 1:22 PM
We should be paying more attention to this situation. An online letter has been put together and is being circulated to stop this data from being disclosed. Please sign the online letter here, if you are comfortable: docs.google.com/forms/d/e/1F...
Reposted by Fabrice Jean-Pierre
The 10th ASM Conference on Biofilms is one week away in Portland, Oregon (11/09-13/25)! Looking forward to seeing many biofilm community members and catching up on the amazing research underway in labs around the world! There is still time to register! #ASMBiofilms
November 2, 2025 at 7:03 PM
The 10th ASM Conference on Biofilms is one week away in Portland, Oregon (11/09-13/25)! Looking forward to seeing many biofilm community members and catching up on the amazing research underway in labs around the world! There is still time to register! #ASMBiofilms
Reposted by Fabrice Jean-Pierre
New in JB: A minireview from my team, led by a recently graduated PhD student Kaitlyn Barrack, compares the microbiota and physiology of the CF gut with features of the gut in inflammatory bowel disease - there are many similarities!
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
October 30, 2025 at 12:42 PM
New in JB: A minireview from my team, led by a recently graduated PhD student Kaitlyn Barrack, compares the microbiota and physiology of the CF gut with features of the gut in inflammatory bowel disease - there are many similarities!
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
Lots of fun in the Bio dept @usherbrooke.bsky.social today! Pumpkin carving and best Halloween costume competition across labs. Can you guess our lab’s costume theme? #microsky
October 31, 2025 at 3:32 PM
Lots of fun in the Bio dept @usherbrooke.bsky.social today! Pumpkin carving and best Halloween costume competition across labs. Can you guess our lab’s costume theme? #microsky
Reposted by Fabrice Jean-Pierre
Canadian researchers should be aware the there is a motion before the Parliamentary Standing Committee on Science and Research to force Tricouncils to hand over disaggregated peer review data on all applications:
Applicant names, profiles, demographics
Reviewers names, profiles, comments, and scores
Applicant names, profiles, demographics
Reviewers names, profiles, comments, and scores
October 30, 2025 at 8:33 PM
Canadian researchers should be aware the there is a motion before the Parliamentary Standing Committee on Science and Research to force Tricouncils to hand over disaggregated peer review data on all applications:
Applicant names, profiles, demographics
Reviewers names, profiles, comments, and scores
Applicant names, profiles, demographics
Reviewers names, profiles, comments, and scores
Reposted by Fabrice Jean-Pierre
O'Toole lab alum doing well at NACFC! Fabrice Jean-Pierre led the session on polymicrobial infections in CF and Rebcca Valls gave a talk that was a top 5 finalist for best jr abstract! Great to see DartCF people doing so well!
October 25, 2025 at 5:57 PM
O'Toole lab alum doing well at NACFC! Fabrice Jean-Pierre led the session on polymicrobial infections in CF and Rebcca Valls gave a talk that was a top 5 finalist for best jr abstract! Great to see DartCF people doing so well!
Had a blast attending #NACFC2025 in Seattle this year! Had the chance to organize and co-chair a session on microbial communities and polymicrobial interactions. A big bonus is having the opportunity to catch up with friends. #microsky #cysticfibrosis
October 25, 2025 at 5:29 PM
Had a blast attending #NACFC2025 in Seattle this year! Had the chance to organize and co-chair a session on microbial communities and polymicrobial interactions. A big bonus is having the opportunity to catch up with friends. #microsky #cysticfibrosis
Reposted by Fabrice Jean-Pierre
Come be my colleague! We have new faculty searches in Virology & Fungal Biology/Medical Mycology. UMN has great people & the Twin Cities are beautiful year-round!
Virology: hr.myu.umn.edu/jobs/ext/365...
Fungal Biology / Medical Mycology: hr.myu.umn.edu/jobs/ext/36547
6
Virology: hr.myu.umn.edu/jobs/ext/365...
Fungal Biology / Medical Mycology: hr.myu.umn.edu/jobs/ext/36547
6
Careers
Minimum qualifications:PhD, MD, or equivalent in a relevant field of study, plus applicable postdoctoral experience.
hr.myu.umn.edu
October 24, 2025 at 6:11 PM
Come be my colleague! We have new faculty searches in Virology & Fungal Biology/Medical Mycology. UMN has great people & the Twin Cities are beautiful year-round!
Virology: hr.myu.umn.edu/jobs/ext/365...
Fungal Biology / Medical Mycology: hr.myu.umn.edu/jobs/ext/36547
6
Virology: hr.myu.umn.edu/jobs/ext/365...
Fungal Biology / Medical Mycology: hr.myu.umn.edu/jobs/ext/36547
6
Reposted by Fabrice Jean-Pierre
New lab paper!
Andrew Frando describes how MexT alters the quorum sensing cascade in P. aeruginosa. /1
With Nicole Smalley; two undergraduates, Jamal Omar and Bobby Parsek; and @dezieleric.bsky.social, @mariecg.bsky.social, and Mylène Trottier at INRS in Montreal
journals.asm.org/doi/10.1128/...
Andrew Frando describes how MexT alters the quorum sensing cascade in P. aeruginosa. /1
With Nicole Smalley; two undergraduates, Jamal Omar and Bobby Parsek; and @dezieleric.bsky.social, @mariecg.bsky.social, and Mylène Trottier at INRS in Montreal
journals.asm.org/doi/10.1128/...
Modulation of the Pseudomonas aeruginosa quorum sensing cascade by MexT-regulated factors | mBio
Bacteria interact with both abiotic and biotic factors in their environment. Quorum
sensing (QS) is one mechanism that bacteria use to communicate with other bacteria
and coordinate behaviors in the p...
journals.asm.org
October 23, 2025 at 5:52 PM
New lab paper!
Andrew Frando describes how MexT alters the quorum sensing cascade in P. aeruginosa. /1
With Nicole Smalley; two undergraduates, Jamal Omar and Bobby Parsek; and @dezieleric.bsky.social, @mariecg.bsky.social, and Mylène Trottier at INRS in Montreal
journals.asm.org/doi/10.1128/...
Andrew Frando describes how MexT alters the quorum sensing cascade in P. aeruginosa. /1
With Nicole Smalley; two undergraduates, Jamal Omar and Bobby Parsek; and @dezieleric.bsky.social, @mariecg.bsky.social, and Mylène Trottier at INRS in Montreal
journals.asm.org/doi/10.1128/...
Reposted by Fabrice Jean-Pierre
New in JB: Black and Wakeman review the challenges of treating polymicrobial infections in various body sites, a topic near and dear to my heart.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
October 23, 2025 at 12:20 PM
New in JB: Black and Wakeman review the challenges of treating polymicrobial infections in various body sites, a topic near and dear to my heart.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
Reposted by Fabrice Jean-Pierre
Two tenure-track faculty positions open in our department:
1) Microbial Ecology and Evolution careers.rpi.edu/en-us/job/49...
2) Cellular Neuroscience careers.rpi.edu/en-us/job/49...
Join our collaborative, interdisciplinary community, which has proved to be a fantastic place to start a lab!
1) Microbial Ecology and Evolution careers.rpi.edu/en-us/job/49...
2) Cellular Neuroscience careers.rpi.edu/en-us/job/49...
Join our collaborative, interdisciplinary community, which has proved to be a fantastic place to start a lab!
Details - Assistant Professor, Microbial Ecology - RPI Jobs
careers.rpi.edu
October 22, 2025 at 4:46 PM
Two tenure-track faculty positions open in our department:
1) Microbial Ecology and Evolution careers.rpi.edu/en-us/job/49...
2) Cellular Neuroscience careers.rpi.edu/en-us/job/49...
Join our collaborative, interdisciplinary community, which has proved to be a fantastic place to start a lab!
1) Microbial Ecology and Evolution careers.rpi.edu/en-us/job/49...
2) Cellular Neuroscience careers.rpi.edu/en-us/job/49...
Join our collaborative, interdisciplinary community, which has proved to be a fantastic place to start a lab!
Reposted by Fabrice Jean-Pierre
The abstract submission deadline for Microbes in Microbiomes has been extended to Wednesday, 26 November 2025 at 23:59 GMT. Submit now: microb.io/474FuXW%F0%9...
Microbes in Microbiomes
18 - 20 February 2026
microb.io
October 22, 2025 at 4:01 PM
The abstract submission deadline for Microbes in Microbiomes has been extended to Wednesday, 26 November 2025 at 23:59 GMT. Submit now: microb.io/474FuXW%F0%9...
Reposted by Fabrice Jean-Pierre
Pls share: Secchi group at ETH Zürich is recruiting two fully funded, four-year PhD positions for an SNSF-funded project investigating the nonlinear rheology of bacterial biofilms. Deadline: 30 November 2025. Full advert and submission details: jobs.ethz.ch/job/view/JOP...
Two PhD positions in Biophysics and rheology of bacterial biofilms
jobs.ethz.ch
October 21, 2025 at 10:39 AM
Pls share: Secchi group at ETH Zürich is recruiting two fully funded, four-year PhD positions for an SNSF-funded project investigating the nonlinear rheology of bacterial biofilms. Deadline: 30 November 2025. Full advert and submission details: jobs.ethz.ch/job/view/JOP...