📣Huge congrats to our postdoc, Takaya Totsuka, on his new paper @currentbiology.bsky.social 🎉 He found that Ca2+ oscillations regulate oocyte spindle rotation! 🐭The project started during his PhD with Prof. Miho Ohsugi.

Free link: authors.elsevier.com/c/1lUqk3QW8S...

🔊New preprint from our lab!

Zygotene cilia regulates meiosis, germ cell development, and fertility in zebrafish, mice, and humans

www.researchsquare.com/article/rs-7...

LIMmunity is growing! 🤰🤱👶

We are looking for curious & driven postdocs to join us at @princetonmolbio.bsky.social & HHMI to explore the fascinating world of maternal-offspring immune partnerships!

Come be part of our collaborative team!

hhmi.wd1.myworkdayjobs.com/en-US/Extern...

Mathematical modelling of the first fate decision

This Research Highlight showcases the work from Maria Avdeeva, Madeleine Chalifoux, Bradley Joyce, Stanislav Y. Shvartsman, Eszter Posfai @eposfai.bsky.social :

journals.biologists.com/dev/article/...

our unexpected results on the importance of a neural cell adhesion molecule in sea anemone epithelialization and gastrulation are just posted in the following preprint.

www.biorxiv.org/content/10.1...

The #devbio project that encompassed the majority of my postdoc is finally out! Huge thanks to my coauthors and our collaborators without whom this work would not have been possible, and my adviser Eszter Posfai who let me play with a light sheet microscope and some colorful mice :)

Thrilled to share our work using live imaging to understand how Epiblast (future embryo proper) and Primitive Endoderm (future extraembryonic tissues) cell fates segregate in the preimplantation mouse embryo. Gargantuan effort led by amazing @rpkimyip.bsky.social, David Denberg and Denis Faerberg!

pYtags - our in vivo biosensors for receptor tyrosine kinases - in all their beauty on the cover of Cell Reports! Read more here: www.cell.com/cell-reports...

We’re hiring! Our lab at WashU has an opening for a Senior/Staff Scientist position. If you're passionate about ovarian physiology, oocyte quality, and excited to contribute to a dynamic and growing team, we’d love to hear from you! Reach out to me directly for more information.

Excited to share that our work building in vivo biosensors for receptor tyrosine kinases (pYtags!) is now out www.cell.com/cell-reports...

For my first science post here, I’m proud to advertise our latest work exploring why germ cell connectivity is really important for meiosis 🐁

Done with some awesome colleagues @florpratto.bsky.social

www.nature.com/articles/s41...

How many cells do you need to establish PCP? The magic number is 3! Beautiful work by Lena Basta in Danelle Devenport's lab. Happy to have contributed. www.science.org/doi/10.1126/...

Interaction between two cells is necessary and sufficient to initiate PCP sorting😀, as shown by Lena P. Basta, Bradley W. Joyce, Dr. Eszter Posfai @eposfai.bsky.social , and Dr. Danelle Devenport. Here is the article. www.science.org/doi/10.1126/...

A duo of preprints on the dynamics of the first cell fate decision in mouse by Madeleine Chalifoux (first grad student in the lab!) and Maria Avdeeva (Flatiron).

We use quantitative live imaging of key cell fate determinants to follow the segregation of inner cell mass and trophectoderm lineages.

Have you ever wanted to *see* receptor activity in embryos? If so, our new preprint is for you! In it, we showcase a new live-cell biosensor for visualizing receptor tyrosine kinase activity in living embryos – pYtags!

www.biorxiv.org/content/10.1...

An intriguing mechanism of germline cyst formation through innovative live imaging in fetal mice gonads, and computational modeling.

Check out my dispatch in @currentbiology.bsky.social on this beautiful work.

kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2…

Fascinating & unexpected from the Rodriguez lab on cell competition acting as a nutrient sensor

Winner cells increase L-Proline uptake in losers, repressing their survival pathway (ISR) to kill them

Explains old observations that starvation prevents competition

www.biorxiv.org/content/10.1...

Sharing my latest preprint as a re-introduction to bsky!

biorxiv.org/content/10.1...
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Everyday, cells like this crawl through your body to protect you. While we know that their front 🔴 and back 🔵 polarity programs work together, how exactly do these two processes communicate?

Check out our new paper in @currentbiology.bsky.social by amazing grad students @ezlevy.bsky.social and @isabellaleite.bsky.social “A tug-of-war between germ cell motility and intercellular bridges controls germline cyst formation in mice”
authors.elsevier.com/a/1k7fg3QW8S...